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Objective To evaluate the value of dynamic contrast - enhanced magnetic resonance imaging (MR) in differential diagnosis of benign and malignant breast lesions. Methods 50 cases verified by histopathology with breast diseases were enrolled to exam three dimensional dynamic contrast-enhanced scanning. Morphological characteristics of the lesion were analyzed, the time - signal intensity curve type were measured. Results 50 cases were confirmed by histopathology, among them 24 cases of malignant and 26 cases of benign. Morphological characteristics and curve type were significantly different between breast benign and malignant lesions (P < 0.05). Diagnostic sensitivity of lesion morphological characteristics was 91.7% (22 /24), specificity was 84.6% (22/26), accuracy was 88.0% (44/50). Diagnostic sensitivity of lesion time - signal intensity curve type was 92.3% (24/26), specificity was 73.1% (19/26), the accuracy was 86.0% (43/50). Combination of the two joint diagnostic criteria had 100.0% sensitivity (24/24) and specificity 94.4%, (24/26), 96.0% accuracy (48/50). Conclusion Dynamic contrast-enhanced breast imaging can provide a wealth of morphological information, time-signal intensity curve type reflects hemodynamic information, the combination of benign and malignant disease diagnosis and differential diagnosis has important value. [ABSTRACT FROM AUTHOR]