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This study contributed to the environmental research by analyzing the nexus between innovation in climate change mitigation technologies and carbon dioxide emissions in the United States, with the gross domestic product per capita, international collaboration in green technology development, renewable energy consumption, the labor force, and trade openness as control variables from 1990Q1 to 2018Q4. First, the results suggested that renewable energy consumption, innovation in climate change mitigation technologies, and international collaboration in green technology development are significant mitigating and determining factors for carbon dioxide emissions. Second, the findings also indicated that trade openness and gross domestic product per capita were positively associated with carbon dioxide emissions. Third, the Granger causality test results validated the presence of a bidirectional nexus between innovation in climate change mitigation technologies and carbon dioxide emissions, renewable energy consumption and carbon dioxide emissions, and international collaboration in green technology development and carbon dioxide emissions. Fourth, the results validated a one-way causality between gross domestic product per capita and carbon dioxide emissions. [ABSTRACT FROM AUTHOR]