1. SUMO-specific Protease 1 Regulates Mitochondrial Biogenesis through PGC-1α.
- Author
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Rong Cai, Tingting Yu, Chao Huang, Xuefeng Xia, Xiaobing Liu, Jianmin Gu, Song Xue, Yeh, Edward T. H., and Jinke Cheng
- Subjects
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MITOCHONDRIA formation , *PEROXISOME proliferator-activated receptors , *SMALL ubiquitin-related modifier proteins , *PROTEOLYTIC enzymes , *BIOCHEMISTRY - Abstract
Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) is a master regulator of mitochondrial biogenesis in response to changes in the cellular environment, physiological or pathological status of mammals. PGC-1α is known to be modified by SUMO (Small Ubiquitin-like Modifier). However, it is not known whether SUMOylation could affect the function of PGC-1α in mitochondrial biogenesis and that how PGC-1α SUMOylation is regulated. In this study, we have identified the role of Sentrin/SUMO-specific protease 1 (SENP1) as a specific SUMO protease to regulate SUMOylation status of PGC-1α. More importantly, we have also found that SENP1 promotes PGC-1α transcription activity, which is essential for the expression of mitochondrial genes and subsequently mitochondrial biogenesis. Thus, we reveal that the SUMOylation of PGC-1α controlled by SENP1 plays an important role in mitochondrial biogenesis and function. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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