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Your search keyword '"Statistical significance"' showing total 2 results
2 results on '"Statistical significance"'

1. Association of Relative Telomere Length and LINE-1 Methylation with Autism but not with Severity.

Author

Salem, Sohair and Ashaat, Engy

Subjects
*STATISTICAL correlation, *PEARSON correlation (Statistics), *T-test (Statistics), *RECEIVER operating characteristic curves, *DATA analysis, *STATISTICAL significance, *RESEARCH funding, *AUTISM, *LOGISTIC regression analysis, *DNA, *SEVERITY of illness index, *DESCRIPTIVE statistics, *DNA methylation, *STATISTICS, *ANALYSIS of variance, *TELOMERES, *DATA analysis software, *BIOMARKERS
Abstract

Autism is associated with genomic instability, which is regulated by telomere length (TL) and index of global methylation (LINE-1). This study will determine relative TL (RTL) and LINE-1 methylation percentage for 69 patients and 33 control subjects to evaluate their potential role as biomarkers for autism. The results displayed a significant decrease of both RTL and LINE-1 methylation in autistic cases relative to controls (P < 0.001). Analysis of receiver operating characteristics curve revealed that both of RTL and LINE-1 methylation percentage have the ability to serve as autism biomarkers (area under the curve = 0.817 and 0.889, respectively). The statistical analysis revealed positive correlation between the two biomarkers (correlation coefficient = 0.439 and P < 0.001). [ABSTRACT FROM AUTHOR]

Published
2024
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2. The Association of the Medicaid 1915(c) Home and Community-Based Services Waivers with Emergency Department Utilization among Youth with Autism Spectrum Disorder.

Author

Liu, Guodong, Velott, Diana L., Kong, Lan, Dick, Andrew W., Mandell, David S., Stein, Bradley D., Murray, Michael J., Ba, Djibril M., Cidav, Zuleyha, and Leslie, Douglas L.

Subjects
*MEDICAID law, *STATISTICAL significance, *HOSPITAL emergency services, *SAMPLE size (Statistics), *CONFIDENCE intervals, *RETROSPECTIVE studies, *REGRESSION analysis, *AUTISM in adolescence, *HEALTH insurance, *DESCRIPTIVE statistics, *SOCIODEMOGRAPHIC factors, *POVERTY, *DATA analysis software, *ODDS ratio, *LONGITUDINAL method, *ADOLESCENCE
Abstract

Using the 2008–2013 Medicaid Analytic eXtract files, this retrospective cohort study was to evaluate the effect of Medicaid home and community-based services (HCBS) waiver programs on emergency department (ED) utilizations among youth with autism spectrum disorder (ASD). Our study showed that the annual ED utilization rates were 13.5% and 18.8% for individuals on autism specific and intellectual and developmental disabilities (IDD) waivers respectively, vs. 28.5% for those without a waiver. Multivariable logistic regression showed that, compared to no waiver, autism specific waivers (adjusted odds ratio: 0.62; 95% Confidence Interval: [0.58–0.66]) and IDD waivers (0.65; [0.64–0.66]) were strongly associated with reduced ED. These findings suggest that HCBS waivers are effective in reducing the incidence of ED visits among youth with ASD. [ABSTRACT FROM AUTHOR]

Published
2022
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