1. Association between the use of non-antiarrhythmic drugs and postoperative atrial fibrillation
- Author
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Ozaydin, Mehmet, Turker, Yasin, Peker, Oktay, Erdogan, Dogan, Varol, Ercan, Dogan, Abdullah, and Ibrisim, Erdogan
- Subjects
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COMPLICATIONS of cardiac surgery , *ATRIAL fibrillation , *RENIN-angiotensin system , *ACE inhibitors , *STATINS (Cardiovascular agents) , *CORONARY artery bypass - Abstract
Abstract: Purpose: To evaluate the association between statins, N-acetylcysteine (NAC) and angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) and postoperative atrial fibrillation (AF). Methods: A total of 590 patients undergoing coronary artery bypass and/or valve surgery were studied. An AF episode lasting >5 min during hospitalization was accepted as endpoint. Results: AF rate was 18% (n =106). Multivariable positive predictors of AF included age ≥65, left atrial diameter ≥45 mm, cross clamp time; negative predictors included use of left internal mammarian artery, NAC, and ACEIs or ARBs. Conclusions: ACEIs or ARBs and NAC is associated with low incidence of postoperative AF, however, this association was not found with statin or combined use these agents. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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