1. A comparison of health state utility values associated with oral potentially malignant disorders and oral cancer in Sri Lanka assessed using the EQ-5D-3 L and the EORTC-8D.
- Author
-
Kularatna, Sanjeewa, Whitty, Jennifer A., Johnson, Newell W., Jayasinghe, Ruwan, and Scuffham, Paul A.
- Subjects
- *
ORAL cancer , *HEALTH outcome assessment , *ALGORITHMS , *SENSITIVITY analysis , *HOSPITALS , *HEALTH facilities , *MOUTH tumors , *ASIANS , *COMPARATIVE studies , *HEALTH status indicators , *RESEARCH methodology , *MEDICAL cooperation , *PSYCHOMETRICS , *QUALITY of life , *QUESTIONNAIRES , *RESEARCH , *EVALUATION research , *CROSS-sectional method , *PSYCHOLOGY - Abstract
Background: It has been suggested that the EQ-5D-3 L preference-based measure of health outcome lacks sensitivity to discriminate between health states in cancer patients. An alternative approach is to use a disease (cancer) specific preference-based measure, such as the EORTC-8D. A limited number of comparisons have been made between generic and disease specific preference-based measures. The aim of this study was to compare the utility scores from the EQ-5D-3 L and the EORTC-8D in a group of patients with oral cancer or with oral potentially malignant disorders (OPMD).Methods: Patients (n = 151) with OPMD or oral cancer were recruited consecutively from six hospitals in Sri Lanka. All participants completed both the EQ-5D-3 L and the EORTC's QLQC-30 instrument. The Sri Lankan EQ-5D-3 L and EORTC-8D scoring algorithms were employed to estimate utility scores. The utility scores from the two instruments were compared for discrimination, responsiveness and correlation.Results: There were significant differences across the two utility scores. The EQ-5D-3 L showed better discrimination than EORTC-8D with higher effect sizes. There were higher ceiling effects observed in the EQ-5D-3 L. There was poor correlation between the dimensions of the two instruments except for the mobility and physical functions.Conclusion: The two instruments captured different aspects of quality of life. The EQ-5D-3 L demonstrated better discrimination than the EORTC-8D. In mild conditions EORTC-8D was more responsive and we recommend further validation of this instrument in diverse cancer conditions. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF