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1. Antinociceptive and anti-inflammatory activities of Phlomis umbrosa Turcz extract

Author

Shang, Xiaofei, Wang, Jinhui, Li, Maoxing, Miao, Xiaolou, Pan, Hu, Yang, Yaoguang, and Wang, Yu

Subjects
*PAIN, *PREVENTIVE medicine, *MEDICINAL plants, *ALTERNATIVE medicine, *ANALYSIS of variance, *ANIMAL experimentation, *ANTI-inflammatory agents, *BIOPHYSICS, *COMPUTER software, *DRUG toxicity, *HIGH performance liquid chromatography, *RESEARCH methodology, *MICE, *RESEARCH funding, *STATISTICAL hypothesis testing, *STATISTICS, *T-test (Statistics), *THIN layer chromatography, *PLANT extracts, *DATA analysis, *PHARMACODYNAMICS
Abstract

Abstract: Phlomis umbrosa Turcz has been used as the traditional medicine for thousands of years in China. In this paper, the acetic acid-induced writhing test, the hot plate test, the carrageenan-induced paw edema test, the xylene-induced ear swelling test, and the acetic acid-induced Evans blue leakage and leukocyte infiltration test were used to investigate the antinociceptive and anti-inflammatory activities of the aqueous extract of this plant (25, 50 and 100mg/kg i.p.). Good dose-dependent effects were obtained in most of these tests, except in the hot plate test and the acetic acid-induced Evans blue leakage test. TLC and HPLC analyses showed iridoid glucosides were the main compositions of this extract. These findings suggested that the aqueous extract of P. umbrosa has significant antinociceptive and anti-inflammatory activities. [Copyright &y& Elsevier]

Published
2011
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2. Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A

Author

Xue, Mei, Jiang, Zhen-zhou, Liu, Ji-ping, Zhang, Lu-Yong, Wang, Tao, Wang, Hao, Liu, Li, and Zhou, Zhi-xing

Subjects
*MEDICINAL plants, *PLANT bioassay, *AUTOIMMUNE disease treatment, *RHEUMATOID arthritis, *LABORATORY mice, *IMMUNOSUPPRESSION, *ALTERNATIVE medicine, *ANALYSIS of variance, *ANIMAL experimentation, *ANTI-inflammatory agents, *BIOPHYSICS, *COLORIMETRY, *COMPARATIVE studies, *DOSE-effect relationship in pharmacology, *EDEMA, *HISTOLOGICAL techniques, *IMMUNE system, *MATHEMATICS, *RESEARCH methodology, *MICE, *RATS, *RESEARCH funding, *T-test (Statistics), *PLANT extracts, *PHARMACODYNAMICS
Abstract

Abstract: Tripterygium Glycosides (TG) is effective in the treatment of patients with a variety of inflammatory and autoimmune diseases, especially rheumatoid arthritis (RA) in clinical. Wilforlide A (T1) serves as a quality control standard of TG that be listed in Drug Standard of Ministry of Public Health of the People''s Republic of China. The pharmacologic actions of T1 remain to be unidentified. In this paper, we studied the anti-inflammatory and immune suppressive effect of T1, and compared it with Triptolide (TP), which believed to be the major active component of TG. Carrageenan-induced rat pedal swelling, tampon-induced rat granulation, and mice ear inhibition rate of swelling trail results show that high-dose T1 has obvious anti-inflammatory effect. Colorimetric detection contents of hemolysin, carbon elimination from plasma of mice, mice delayed hypersensitivity immune, and organ index were measured. The results show that T1 has no significant immune suppressive activity, and there has a significant difference with TP and TG. Therefore, we think the content of TP also should be controlled as a supplement standard in order to ensure safe and effective medication. [Copyright &y& Elsevier]

Published
2010
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