1. Prenylated phloroglucinol derivatives from Hypericum sampsonii
- Author
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Xin, Wen-bo, Man, Xiao-hua, Zheng, Cheng-jian, Jia, Min, Jiang, Yi-ping, Zhao, Xiang-xiang, Jin, Gui-lin, Mao, Zhu-jun, Huang, Hai-qiu, and Qin, Lu-ping
- Subjects
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ANIMAL experimentation , *ANTI-inflammatory agents , *ANTINEOPLASTIC agents , *BIOLOGICAL models , *PHYSICAL & theoretical chemistry , *DOSE-effect relationship in pharmacology , *MACROPHAGES , *MEDICINAL plants , *MICE , *NITRIC oxide , *SPECTRUM analysis , *PHYTOCHEMICALS , *PLANT extracts , *DESCRIPTIVE statistics , *IN vitro studies , *PHARMACODYNAMICS - Abstract
Abstract: Six new acylphloroglucinol derivatives, sampsonols A-F (1–6), were isolated from the petroleum ether extract of the aerial parts of Hypericum sampsonii. The structures and relative configurations of sampsonols A-F were elucidated by extensive spectroscopic analyses. All these compounds were tested for their in vitro cytotoxic and anti-inflammatory activities. Sampsonols A and B (1 and 2) showed significant cytotoxicity against four human tumor cell lines with IC50 values in the range of 13–28μM, whereas sampsonols C and F (3 and 6) showed potent inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages with IC50 values of 27.3 and 29.3μM, respectively. [Copyright &y& Elsevier]
- Published
- 2012
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