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1. A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097.

Author

Jeay, Sebastien, Gaulis, Swann, Ferretti, Stephane, Bitter, Hans, Moriko Ito, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A., Rynn, Caroline, Jensen, Michael R., Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, Francçois, Holzer, Philipp, Keiichi Masuya, Würthner, Jens, Halilovic, Ensar, and Hofmann, Francesco

Subjects
*PATIENT selection, *P53 protein, *GENE expression
Abstract

The article presents a study reporting the discovery of a novel patient selection strategy for the p53-HDM2 inhibitor NVP-CGM097, currently under evaluation in clinical trials, and identifies a gene expression signature consisting of 13 up-regulated genes.

Published
2015
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