Post-amputation pain of the lower limb may occur due to a neuroma of the sciatic nerve, among other causes. We present the case of a 48 year old woman with stump pain, 15 years after the transfemoral amputation of the lower right limb, which prevents her from using the prosthesis. The presence of a sciatic neuroma of 2.2 × 2.2 × 1.5 cm at 8 cm proximal to the stump is diagnosed. An ultrasoundguided, diagnostic-therapeutic test was performed, infiltrating 0.2% ropivacaine and 0.4% triamcinolone in two sessions. Since the patient shows a good response, Pulsed Radiofrequency (PRF) is applied to the neuroma but there is no satisfactory response to the treatment. Therefore, surgical exeresis is considered as a last option as it has shown good results over pain, despite having a high injury recurrence. More studies on the adequate management of stump-neuroma pain are needed since the existent scientific evidence in this regard is scarce. [ABSTRACT FROM AUTHOR]