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The literature on urban vitality tends to focus on the built environment. This paper argues that some important processes in shaping vitality may be overlooked without examining the intensity and diversity of economic and human activities. Using newly developed spatial big data and adopting the methods of multi-indicator measurement and spatial analysis methods, we analyzed the pattern of urban vitality in Chongqing, a provincial city in western China and, on this basis, evaluated the creation and maintenance of urban vitality from the economic and human activities perspective. Our findings indicate that the impacts of economic and human activities are positive and significant. Among the three intensity and diversity indicators, economic intensity and population density show an effect on urban vitality stronger than that of economic diversity. However, economic diversity has the strongest superposition or interactive effect, and is thus an important foundation dynamic. The positive effect of population density on urban vitality is largely a result of Chongqing's jobs-housing balance. The case of Chongqing highlights the importance of topographic features, historical inheritance, large-scale migration, and cultural activities in shaping the distinctive vitality pattern of a city. This study contends that the creation and maintenance of urban vitality can not be fully explained without incorporating the impacts of economic and human activities. It contributes to a comprehensive measurement of urban vitality and enriches its connotations. [ABSTRACT FROM AUTHOR]