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Abstract: Ruthenium‐containing organometallic ionic liquids with the B(CN)4 anion were developed that generate microporous amorphous coordination polymers upon UV irradiation. UV light irradiation of [Ru(C5H5)(C6H5R)][B(CN)4] (R=butyl, ethyl, octyl) quantitatively generated a yellow powder of a coordination polymer with the formula [Ru(C5H5){B(CN)4}]n. In this reaction, the arene ligand is eliminated by UV irradiation and coordination polymer is formed by coordination of the cyano groups of the anion to the Ru ion. The photogenerated solids exhibited nitrogen absorption properties due to their microporous structure. This paper proposes a method to fabricate functional coordination polymers by photoirradiation of liquids. [ABSTRACT FROM AUTHOR]

An easily synthesized fluorescein-based luminescent dye has been utilized for the dual-mode detection of histamine at nanomolar concentrations at pH 7.0 in water. The specific response to histamine was achieved by imidazole-catalyzed 'imine formation' reaction. The protocol was subsequently applied for the estimation of histamine in complex biological milieu such as human blood serum and urine samples. Furthermore, the dose-dependent cellular uptake of histamine and de novo synthesis (by thapsigargin treatment) was visualized in RAW 264.7, a mouse macrophage cell line. We have also developed portable paper strips for rapid, on-site detection of histamine without involving costly instruments. [ABSTRACT FROM AUTHOR]

This paper deals with a systematic density functional theory (DFT) study aiming to unravel the mechanism of the thyroxine (T4) conversion into 3,3′,5-triiodothyronine (rT3) by using different bio-inspired naphthyl-based models, which are able to reproduce the catalytic functions of the type-3 deiodinase ID-3. Such naphthalenes, having two selenols, two thiols, and a selenol-thiol pair in peri positions, which were previously synthesized and tested in their deiodinase activity, are able to remove iodine selectively from the inner ring of T4 to produce rT3. Calculations were performed including also an imidazole ring that, mimicking the role of the His residue, plays an essential role deprotonating the selenol/thiol moiety. For all the used complexes, the calculated potential energy surfaces show that the reaction proceeds via an intermediate, characterized by the presence of a XIC (X=Se, S) halogen bond, whose transformation into a subsequent intermediate in which the CI bond is definitively cleaved and the incipient XI bond is formed represents the rate-determining step of the whole process. The calculated trend in the barrier heights of the corresponding transition states allows us to rationalize the experimentally observed superior deiodinase activity of the naphthyl-based compound with two selenol groups. The role of the peri interactions between chalcogen atoms appears to be less prominent in determining the deiodination activity. [ABSTRACT FROM AUTHOR]

Sustainable ionic liquids are promising compounds in green chemistry applications. While using them as solvent or reaction media is an important step towards more environmentally friendly chemistry, their synthesis is usually expensive and not green at all. Herein, a benign route to synthesize task ‐ specific ionic liquids is presented, offering several possible functionalities in the cation and anion (artwork by D. Kraban). More information can be found in the Full Paper by C. Liedel et al. on page 11810. [ABSTRACT FROM AUTHOR]

The potentially chelating imino group of imine‐functionalized Ir and Rh imidazole complexes influences the formation of functionalized protic N‐heterocyclic carbene complexes by tautomerization/metallotropism sequences. Dinuclear complexes were obtained by double metallation of the azole ring (at both C2 and N3), and a new Rh(I)–Ir(I) heterodinuclear complex was prepared in a stepwise manner; this allowed the chemoselectivity of the synthetic approach to be investigated and understood. More information can be found in the Full Paper by A. A. Danopoulos, P. Braunstein et al. on page 2658 ff. [ABSTRACT FROM AUTHOR]