1. IGFBP5 domains exert distinct inhibitory effects on the tumorigenicity and metastasis of human osteosarcoma.
- Author
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Luther, Gaurav A., Lamplot, Joseph, Chen, Xiang, Rames, Richard, Wagner, Eric R., Liu, Xing, Parekh, Akash, Huang, Enyi, Kim, Stephanie H., Shen, Jikun, Haydon, Rex C., He, Tong-Chuan, and Luu, Hue H.
- Subjects
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INSULIN-like growth factor-binding proteins , *OSTEOSARCOMA , *CANCER invasiveness , *BONE diseases , *TUMOR growth , *PHENOTYPES - Abstract
Abstract: Osteosarcoma (OS) is the most common primary malignancy of bone. We investigated the roles of insulin-like growth factor binding protein 5 (IGFBP5) domains in modulating OS tumorigenicity and metastasis. The N-terminal (to a lesser extent the C-terminal) domain inhibited cell proliferation and induced apoptosis while the C-terminal domain inhibited cell migration and invasion. The Linker domain had no independent effects. In vivo, the N-terminal domain decreased tumor growth without affecting pulmonary metastases while the C-terminal domain inhibited tumor growth and metastases. In summary, the N- and C-terminal domains modulated OS tumorigenic phenotypes while the C-terminal domain inhibited OS metastatic phenotypes. [Copyright &y& Elsevier]
- Published
- 2013
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