1. Differences in Dry Eye Questionnaire Symptoms in Two Different Modalities of Contact Lens Wear: Silicone-Hydrogel in Daily Wear Basis and Overnight Orthokeratology.
- Author
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García-Porta, Nery, Rico-del-Viejo, Laura, Martin-Gil, Alba, Carracedo, Gonzalo, Pintor, Jesus, and González-Méijome, José Manuel
- Subjects
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ANALYSIS of variance , *CHI-squared test , *COMPARATIVE studies , *CONTACT lenses , *EYE examination , *HIGH performance liquid chromatography , *HUMAN comfort , *LACRIMAL apparatus , *LONGITUDINAL method , *RESEARCH methodology , *NONPARAMETRIC statistics , *OPTOMETRY , *QUESTIONNAIRES , *RESEARCH funding , *SCALE analysis (Psychology) , *SILICONES , *STATISTICS , *T-test (Statistics) , *VISUAL acuity , *STATISTICAL power analysis , *DATA analysis , *REPEATED measures design , *MANN Whitney U Test , *KRUSKAL-Wallis Test , *FRIEDMAN test (Statistics) - Abstract
Purpose. To compare the ocular surface symptoms and signs in an adult population of silicone-hydrogel (Si-Hy) contact lens (CL) wearers with another modality of CL wear, overnight orthokeratology (OK). Materials and Methods. This was a prospective and comparative study in which 31 myopic subjects were fitted with the same Si-Hy CL and 23 underwent OK treatment for 3 months. Dry eye questionnaire (DEQ) was filled in at the beginning of the study and then after 15 days, 1 month, and 3 months using each CL modality. The tear quality was evaluated with noninvasive tear break-up time. Tear production was measured with Schirmer test. Tear samples were collected with Schirmer strips being frozen to analyze the dinucleotide diadenosine tetraphosphate (Ap4A) concentration with High-Performance Liquid Chromatography (HPLC). Results. After refitting with ortho-k, a reduction in discomfort and dryness symptoms at the end of the day (p<0.05, χ2) was observed. No significant changes were observed in Ap4A concentration in any group. Bulbar redness, limbal redness, and conjunctival staining increased significantly in the Si-Hy group (p<0.05, Kruskal–Wallis test). Conclusion. Discomfort and dryness symptoms at the end of the day are lower in the OK CL group than in the Si-Hy CL group. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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