1. Estimating effects of longitudinal and cumulative exposure to PFAS mixtures on early adolescent body composition.
- Author
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Kuiper, Jordan R, Liu, Shelley H, Lanphear, Bruce P, Calafat, Antonia M, Cecil, Kim M, Xu, Yingying, Yolton, Kimberly, Kalkwarf, Heidi J, Chen, Aimin, Braun, Joseph M, and Buckley, Jessie P
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ADOLESCENT development , *RESEARCH funding , *BODY mass index , *ADIPOSE tissues , *RECEIVER operating characteristic curves , *BODY composition , *SEX distribution , *DESCRIPTIVE statistics , *STATURE , *ENVIRONMENTAL exposure , *LEAN body mass , *CONFIDENCE intervals , *FLUOROCARBONS , *BIOMARKERS , *ADOLESCENCE - Abstract
Few methods have been used to characterize repeatedly measured biomarkers of chemical mixtures. We applied latent profile analysis (LPA) to serum concentrations of 4 perfluoroalkyl and polyfluoroalkyl substances (PFAS) measured at 4 time points from gestation to age 12 years. We evaluated the relationships between profiles and z scores of height, body mass index, fat mass index, and lean body mass index at age 12 years (n = 218). We compared LPA findings with an alternative approach for cumulative PFAS mixtures using g-computation to estimate the effect of simultaneously increasing the area under the receiver operating characteristic curve (AUC) for all PFAS. We identified 2 profiles: a higher PFAS profile (35% of sample) and a lower PFAS profile (relative to each other), based on their average PFAS concentrations at all time points. The higher PFAS profile had generally lower z scores for all outcomes, with somewhat larger effects for males, though all 95% CIs crossed the null. For example, the higher PFAS profile was associated with a 0.50-unit lower (β = −0.50; 95% CI, −1.07 to 0.08) BMI z score among males but not among females (β = 0.04; 95% CI, −0.45 to 0.54). We observed similar patterns with AUCs. We found that a higher childhood PFAS profile and higher cumulative PFAS mixtures may be associated with altered growth in early adolescence. This article is part of a Special Collection on Environmental Epidemiology. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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