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Summary: Background: Although enteropathy due to angiotensin II receptor blockers (ARBs) has been known for over 10 years, clinicians' awareness of this condition is still low. Aims: To systematically review the literature about clinical phenotypes, distribution of mucosal changes throughout the gastrointestinal tract and prognosis of enteropathy due to ARBs. Methods: According to PRISMA guidelines, we searched PubMed and Embase for relevant articles up to November 6, 2023. We included full‐text papers, letters, case reports and case series describing enteropathy due to ARBs. Patients were classified into subgroups based on endoscopic and histological findings of different regions of the gastrointestinal tract. The protocol was registered with Open Science Framework (https://doi.org/10.17605/OSF.IO/TK67C). Results: We included 94 articles reporting 183 cases (101 female, mean age at diagnosis 69 ± 10 years). The clinical picture at diagnosis was characterised by severe diarrhoea (97%) and weight loss (84%, median −13 kg), leading to hospital admission in 167 (95%) patients. Olmesartan (90%) was most frequently implicated. Villous atrophy (VA) was reported in 164/183 (89%) patients. One hundred and nine had only VA, 12 had pan‐gastrointestinal involvement, 23 had VA and gastric involvement and 19 had VA and colon involvement (predominantly microscopic colitis). Outcomes were reported for 178/183 (97%) patients, who all recovered clinically on ARBs withdrawal. Histological recovery occurred in all 96 patients with VA at baseline who underwent follow‐up duodenal biopsy. Conclusions: Enteropathy due to ARBs is characterised by severe malabsorption often requiring hospital admission and can involve the entire gastrointestinal tract. Clinician awareness can lead to prompt diagnosis and excellent prognosis. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Verma et al papers. To view these articles, visit https://doi.org/10.1111/apt.17891 and https://doi.org/10.1111/apt.17913 [ABSTRACT FROM AUTHOR]

The Alimentary Pharmacology & Therapeutics journal welcomes readers to its first edition of 2024. The journal received 1266 submissions between January and September 2023, accepting 130 of them, resulting in an acceptance rate of 10.3%. The journal aims to maintain a balance between hepatology and 'luminal' gastroenterology papers and offers authors the option to transfer their papers to affiliated journals if not accepted. The journal also discusses a change in the nomenclature for steatotic liver disease and highlights its 2-year impact factor and most highly cited and downloaded papers. The editors express their gratitude to the contributors and invite suggestions for improvement. [Extracted from the article]

LINKED CONTENT: This article is linked to Ogawa et al papers. To view these articles, visit https://doi.org/10.1111/apt.17107 and https://doi.org/10.1111/apt.17693. [ABSTRACT FROM AUTHOR]

Background: Standard clinical methods of assessing volume and providing resuscitation are not always applicable to patients with advanced or decompensated cirrhosis. Despite this being well known from a clinical perspective, there remains relatively little evidence to guide clinicians though fluid management in patients with cirrhosis and, often, multi-organ system dysfunction. Aims: This review summarises the current understanding of the circulatory dysfunction in cirrhosis, modalities for assessing volume status, and considerations for fluid selection. It additionally provides a practical approach to fluid resuscitation. Methods: We review current literature on cirrhosis pathophysiology in steady-state and shock, clinical implications of fluid resuscitation, and strategies to assess intravascular volume. Literature reviewed here was identified by the authors through PubMed search and review of selected papers' references. Results: Clinical management of resuscitation in advanced cirrhosis remains relatively stagnant. Although several trials have attempted to establish the superior resuscitative fluid, the lack of improvement in hard clinical outcomes leaves clinicians without clear guidance. Conclusions: The absence of consistent evidence for fluid resuscitation in patients with cirrhosis limits our ability to produce a clearly evidence-based protocol for fluid resuscitation in cirrhosis. However, we propose a preliminary practical guide to managing fluid resuscitation in patients with decompensated cirrhosis. Further studies are needed to develop and validate volume assessment tools in the specific context of cirrhosis, while randomised clinical trials of protocolized resuscitation may improve care of this patient population. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Løn et al papers. To view these articles, visit https://doi.org/10.1111/apt.17817 and https://doi.org/10.1111/apt.17984 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to García et al papers. To view these articles, visit https://doi.org/10.1111/apt.17938 and https://doi.org/10.1111/apt.17973 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Schneider et al papers. To view these articles, visit https://doi.org/10.1111/apt.17958 and https://doi.org/10.1111/apt.17986 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Ricciuto et al paper. To view this article, visit https://doi.org/10.1111/apt.17936 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Schneider et al papers. To view these articles, visit https://doi.org/10.1111/apt.17958 and https://doi.org/10.1111/apt.17992 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Løn et al papers. To view these articles, visit https://doi.org/10.1111/apt.17817 and https://doi.org/10.1111/apt.18002 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vaishnav et al papers. To view these articles, visit https://doi.org/10.1111/apt.17868 and https://doi.org/10.1111/apt.17976 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vaishnav et al papers. To view these articles, visit https://doi.org/10.1111/apt.17868 and https://doi.org/10.1111/apt.17982 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hey et al paper. To view this article, visit https://doi.org/10.1111/apt.17917 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to García et al papers. To view these articles, visit https://doi.org/10.1111/apt.17938 and https://doi.org/10.1111/apt.17993 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Elsaid et al paper. To view this article, visit https://doi.org/10.1111/apt.17925 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Mücke et al paper. To view this article, visit https://doi.org/10.1111/apt.17899 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Yoon et al paper. To view this article, visit https://doi.org/10.1111/apt.17909 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Thwaites et al papers. To view these articles, visit https://doi.org/10.1111/apt.17944 and https://doi.org/10.1111/apt.17946 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hofer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17908 and https://doi.org/10.1111/apt.17924 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Bokemeyer et al paper. To view this article, visit https://doi.org/10.1111/apt.17926 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sandmann et al papers. To view these articles, visit https://doi.org/10.1111/apt.17878 and https://doi.org/10.1111/apt.17923 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Calabrese et al papers. To view these articles, visit https://doi.org/10.1111/apt.17934 and https://doi.org/10.1111/apt.17955 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Calabrese et al papers. To view these articles, visit https://doi.org/10.1111/apt.17934 and https://doi.org/10.1111/apt.17960 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Thwaites et al papers. To view these articles, visit https://doi.org/10.1111/apt.17944 and https://doi.org/10.1111/apt.17970 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hofer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17908 and https://doi.org/10.1111/apt.17966 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Faqerah et al paper. To view this article, visit https://doi.org/10.1111/apt.17720 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Kang et al paper. To view this article, visit https://doi.org/10.1111/apt.17862 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sandmann et al papers. To view these articles, visit https://doi.org/10.1111/apt.17878 and https://doi.org/10.1111/apt.17962 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hong et al papers. To view these articles, visit https://doi.org/10.1111/apt.17819 and https://doi.org/10.1111/apt.17922 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Lenfant et al papers. To view these articles, visit https://doi.org/10.1111/apt.17753 and https://doi.org/10.1111/apt.17912 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hong et al papers. To view these articles, visit https://doi.org/10.1111/apt.17819 and https://doi.org/10.1111/apt.17937 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Lenfant et al papers. To view these articles, visit https://doi.org/10.1111/apt.17753 and https://doi.org/10.1111/apt.17935 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vasudevan et al papers. To view these articles, visit https://doi.org/10.1111/apt.17831 and https://doi.org/10.1111/apt.17957 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Nash et al paper. To view this article, visit https://doi.org/10.1111/apt.17906 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Prabhakar et al papers. To view these articles, visit https://doi.org/10.1111/apt.17892 and https://doi.org/10.1111/apt.17903 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Martini et al papers. To view these articles, visit https://doi.org/10.1111/apt.17804 and https://doi.org/10.1111/apt.17901 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Verma et al papers. To view these articles, visit https://doi.org/10.1111/apt.17891 and https://doi.org/10.1111/apt.17902 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Riveiro‐Barciela et al paper. To view this article, visit https://doi.org/10.1111/apt.17898 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Ogawa et al papers. To view these articles, visit https://doi.org/10.1111/apt.17107 and https://doi.org/10.1111/apt.17896 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Prabhakar et al papers. To view these articles, visit https://doi.org/10.1111/apt.17892 and https://doi.org/10.1111/apt.17921 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Martini et al papers. To view these articles, visit https://doi.org/10.1111/apt.17804 and https://doi.org/10.1111/apt.17916 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Ogawa et al papers. To view these articles, visit https://doi.org/10.1111/apt.17107 and https://doi.org/10.1111/apt.17910 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vaishnav et al papers. To view these articles, visit https://doi.org/10.1111/apt.17868 and https://doi.org/10.1111/apt.17882 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sandmann et al paper. To view this article, visit https://doi.org/10.1111/apt.17878 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vaishnav et al papers. To view these articles, visit https://doi.org/10.1111/apt.17868 and https://doi.org/10.1111/apt.17893 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Alkhouri et al papers. To view these articles, visit https://doi.org/10.1111/apt.17709 and https://doi.org/10.1111/apt.17881 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Alkhouri et al papers. To view these articles, visit https://doi.org/10.1111/apt.17709 and https://doi.org/10.1111/apt.17907 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vasudevan et al papers. To view these articles, visit https://doi.org/10.1111/apt.17831 and https://doi.org/10.1111/apt.17895 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Gawrieh et al papers. To view these articles, visit https://doi.org/10.1111/apt.17849 and https://doi.org/10.1111/apt.17886 [ABSTRACT FROM AUTHOR]