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LINKED CONTENT: This article is linked to Jayasooriya et al paper. To view this article, visit https://doi.org/10.1111/apt.17370. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Norgard et al paper. To view this article, visit https://doi.org/10.1111/apt.18014 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Yiu et al papers. To view these articles, visit https://doi.org/10.1111/apt.18006 and https://doi.org/10.1111/apt.18057 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vuijk et al papers. To view these articles, visit https://doi.org/10.1111/apt.18000 and https://doi.org/10.1111/apt.18033 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Yiu et al papers. To view these articles, visit https://doi.org/10.1111/apt.18006 and https://doi.org/10.1111/apt.18049 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vuijk et al papers. To view these articles, visit https://doi.org/10.1111/apt.18000 and https://doi.org/10.1111/apt.18053 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Fernandez‐Clotet et al paper. To view this article, visit https://doi.org/10.1111/apt.17968 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Thwaites et al papers. To view these articles, visit https://doi.org/10.1111/apt.17944 and https://doi.org/10.1111/apt.17946 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Thwaites et al papers. To view these articles, visit https://doi.org/10.1111/apt.17944 and https://doi.org/10.1111/apt.17970 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to van de Meeberg et al papers. To view these articles, visit https://doi.org/10.1111/apt.17719 and https://doi.org/10.1111/apt.17743 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to van de Meeberg et al papers. To view these articles, visit https://doi.org/10.1111/apt.17719 and https://doi.org/10.1111/apt.17795 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dignass et al papers. To view these articles, visit https://doi.org/10.1111/apt.17622 and https://doi.org/10.1111/apt.17640 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dignass et al papers. To view these articles, visit https://doi.org/10.1111/apt.17622 and https://doi.org/10.1111/apt.17656 [ABSTRACT FROM AUTHOR]

Summary: Background: 5‐aminosalicylates (5‐ASA) are widely used in inflammatory bowel disease (IBD), but emerging evidence suggests that they may be safely withdrawn in significant subsets of patients. This is important to address: 5‐ASA therapy accounts for up to 25% of total healthcare costs in ulcerative colitis (UC), while almost a third of patients with Crohn's disease (CD) receive long‐term 5‐ASA despite no clear evidence of benefit. Further, rationalising medication burden may improve overall adherence and outcome. Aims: To summarise the rationale for 5‐ASA withdrawal, review the current evidence in both UC and CD and consider the data surrounding colorectal cancer (CRC) prevention, guiding an evidence‐based withdrawal strategy. Methods: PubMed was searched to identify relevant studies. Only papers published in English were reviewed, with priority given to randomised clinical trials and meta‐analyses. Results: For patients with UC, consideration of 5‐ASA withdrawal should be made on a case‐by‐case basis, but it appears safest for those in deep remission without any of the following risk factors: younger age (<40 years), remission for less than 2 years, a history of multiple flares, extensive disease. 5‐ASA withdrawal should also be considered in patients with UC escalated to biologic therapy who have achieved remission and in all patients with CD. Although 5‐ASA therapy may have chemopreventive benefits for CRC, the cost‐benefit ratio appears significant, and this indication is not justified by evidence in those who have achieved remission and are continuing therapy with other agents, or in those in sustained remission without a history of extensive disease. Conclusions: Although the majority of patients with IBD receive 5‐ASA during their disease course, safe withdrawal appears possible in many, with important implications for both health economics and patient experience. A number of unanswered questions, however, remain. [ABSTRACT FROM AUTHOR]

Summary: Background: There is an increasing body of evidence showing that earlier use of biologics improves clinical outcomes in Crohn's disease (CD). Aim: To perform a systematic review and meta‐analysis to assess the impact of early biologic use in the treatment of CD. Methods: PubMed and Embase databases were searched for English language papers and conference abstracts published through April 30, 2019. Studies were selected for inclusion if patients initiated biologics within 2 years of a CD diagnosis or if earlier biologics use (top‐down) was compared with a conventional step‐up strategy. Random‐effects meta‐analyses were conducted to compare clinical remission (CR), relapse and endoscopic healing rates between early biologic treatment (<2 years of disease duration or top‐down treatment strategy) and late/conventional treatment (biologic use after >2 years of disease duration or conventional step‐up treatment strategy). Results: A total of 3069 records were identified, of which 47 references met the selection criteria for systematic review. A total of 18 471 patients were studied, with a median follow‐up of 64 weeks (range 10‐416). Meta‐analysis found that early use of biologics was associated with higher rates of clinical remission (OR 2.10 [95% CI: 1.69‐2.60], n = 2763, P <.00001), lower relapse rates (OR 0.31 [95% CI: 0.14‐0.68], n = 596, P =.003) and higher mucosal healing rates (OR 2.37 [95% CI: 1.78‐3.16], n = 994, P <.00001) compared with late/conventional management. Conclusions: Early biologic treatment is associated with improved clinical outcomes in both adult and paediatric CD patients, not only in prospective clinical trials but also in real‐world settings. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sethi et al papers. To view these articles, visit https://doi.org/10.1111/apt.17313 and https://doi.org/10.1111/apt.17333 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sethi et al papers. To view these articles, visit https://doi.org/10.1111/apt.17313 and https://doi.org/10.1111/apt.17339 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Atia et al paper. To view this article, visit https://doi.org/10.1111/apt.17419 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Arkenbosch et al papers. To view these articles, visit https://doi.org/10.1111/apt.17347 and https://doi.org/10.1111/apt.17377 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Chen et al papers. To view these articles, visit https://doi.org/10.1111/apt.17392 and https://doi.org/10.1111/apt.17471 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Arkenbosch et al papers. To view these articles, visit https://doi.org/10.1111/apt.17347 and https://doi.org/10.1111/apt.17415 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Jayasooriya et al paper. To view this article, visit https://doi.org/10.1111/apt.17370 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Zisman‐Ilani et al paper. To view this article, visit https://doi.org/10.1111/apt.17286 [ABSTRACT FROM AUTHOR]

Dr Nick Kennedy stepped down from his position as Associate Editor with responsibility for IBD-related papers and was replaced by Dr Sree Subramanian. Randomised clinical trial: semaglutide versus placebo reduced liver steatosis but not liver stiffness in subjects with non-alcoholic fatty liver disease assessed by magnetic resonance imaging. Welcome to the first edition of I AP&T i for 2023. [Extracted from the article]

Summary: Background: After ileocaecal resection for Crohn's disease (CD), inflammatory lesions frequently recur on the anastomosis and/or on the neo‐terminal ileum. Aim: To identify predictors of early post‐operative endoscopic recurrence. Methods: From September 2010 to September 2017, the REMIND group conducted a prospective nationwide study in nine French academic centres. Data were collected at the time of surgery and endoscopy, performed 6‐12 months after surgery. Endoscopic recurrence was defined as a Rutgeerts score ≥i2. Baseline factors associated with endoscopic recurrence were searched by univariate and multivariate regression analysis. Results: Two hundred and eighty‐nine CD patients were included. Endoscopy within 1 year following surgery was performed in 225 (78%) patients (104M/121F). Mean age and disease duration were 35 (12.2) and 8.8 (8.9) years respectively. Seventy (32%) patients were active smokers at surgery. One hundred and forty‐two (63%) patients received at least one anti‐TNF therapy before surgery. After surgery, 40 (18%) patients received thiopurines and 66 (29%) received an anti‐TNF agent. Endoscopic recurrence occurred in 107 (47%) patients. In multivariate analysis, male gender (OR = 2.48 [IC 95% 1.40‐4.46]), active smoking at surgery (OR = 2.65 [IC 95% 1.44‐4.97]) and previous resection (OR = 3.03 [IC 95% 1.36‐7.12]) were associated with a higher risk of endoscopic recurrence. Inversely, post‐operative anti‐TNF treatment decreased the risk of endoscopic recurrence (OR = 0.50 [IC 95% 0.25‐0.96]). Conclusions: Male gender, active smoking at surgery and previous intestinal resection are associated with a higher risk of endoscopic post‐operative recurrence, while post‐operative anti‐TNF treatment is associated with a lower risk. Linked Content This article is linked to Yamamoto and Kotze, and Imperatore et al papers. To view these articles visit https://doi.org/10.1111/apt.14985 and https://doi.org/10.1111/apt.14989. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Rønnow Sand et al papers. To view these articles, visit https://doi.org/10.1111/apt.17119 and https://doi.org/10.1111/apt.17234 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Martineau et al paper. To view this article, visit https://doi.org/10.1111/apt.14371. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Sohouli et al papers. To view these articles, visit https://doi.org/10.1111/apt.17109 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Meade et al papers. To view these articles, visit https://doi.org/10.1111/apt.17055 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Zhao et al papers. To view these articles, visit https://doi.org/10.1111/apt.16723 and https://doi.org/10.1111/apt.16873 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Burish et al papers. To view these articles, visit https://doi.org/10.1111/apt.16615 and https://doi.org/10.1111/apt.16898 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hanzel et al papers. To view these articles, visit https://doi.org/10.1111/apt.16609 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Allocca et al papers. To view these articles, visit https://doi.org/10.1111/apt.16700 and https://doi.org/10.1111/apt.16734 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Allocca et al papers. To view these articles, visit https://doi.org/10.1111/apt.16700 and https://doi.org/10.1111/apt.16754 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hanzel et al papers. To view these articles, visit https://doi.org/10.1111/apt.16609 and https://doi.org/10.1111/apt.16709 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hanzel et al papers. To view these articles, visit https://doi.org/10.1111/apt.16609 and https://doi.org/10.1111/apt.16724 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Burisch et al papers. To view these articles, visit https://doi.org/10.1111/apt.16615 and https://doi.org/10.1111/apt.16640 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Burisch et al papers. To view these articles, visit https://doi.org/10.1111/apt.16615 and https://doi.org/10.1111/apt.16680 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Takenaka et al papers. To view these articles, visit https://doi.org/10.1111/apt.16551 and https://doi.org/10.1111/apt.16579 [ABSTRACT FROM AUTHOR]

This article is linked to Komaki et al papers. To view these articles visit https://doi.org/10.1111/apt.14274 and https://doi.org/10.1111/apt.13990. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Almradi et al paper. To view this article, visit https://doi.org/10.1111/apt.16248 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Goodsall et al and Abushamma & Deepak papers. To view these articles, visit https://doi.org/10.1111/apt.16288 and https://doi.org/10.1111/apt.16308 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Mesonero et al paper. To view this article, visit https://doi.org/10.1111/apt.16315 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Goodsall et al papers. To view these articles, visit https://doi.org/10.1111/apt.16288 and https://doi.org/10.1111/apt.16313 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Biemans et al paper. To view this article, visit https://doi.org/10.1111/apt.15745 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Almradi et al paper. To view this article, visit https://doi.org/10.1111/apt.16248 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Lansdrop et al paper. To view this article, visit https://doi.org/10.1111/apt.16228 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Khalili et al paper. To view this article, visit https://doi.org/10.1111/apt.15889 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Rimola et al and Debnath & Rathi papers. To view these articles, visit https://doi.org/10.1111/apt.16069 and https://doi.org/10.1111/apt.16146 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Rimola et al papers. To view these articles, visit https://doi.org/10.1111/apt.16069 and https://doi.org/10.1111/apt.16163 [ABSTRACT FROM AUTHOR]