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LINKED CONTENT: This article is linked to Hofer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17908 and https://doi.org/10.1111/apt.18044. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hofer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17908 and https://doi.org/10.1111/apt.18067. [ABSTRACT FROM AUTHOR]

Background: Standard clinical methods of assessing volume and providing resuscitation are not always applicable to patients with advanced or decompensated cirrhosis. Despite this being well known from a clinical perspective, there remains relatively little evidence to guide clinicians though fluid management in patients with cirrhosis and, often, multi-organ system dysfunction. Aims: This review summarises the current understanding of the circulatory dysfunction in cirrhosis, modalities for assessing volume status, and considerations for fluid selection. It additionally provides a practical approach to fluid resuscitation. Methods: We review current literature on cirrhosis pathophysiology in steady-state and shock, clinical implications of fluid resuscitation, and strategies to assess intravascular volume. Literature reviewed here was identified by the authors through PubMed search and review of selected papers' references. Results: Clinical management of resuscitation in advanced cirrhosis remains relatively stagnant. Although several trials have attempted to establish the superior resuscitative fluid, the lack of improvement in hard clinical outcomes leaves clinicians without clear guidance. Conclusions: The absence of consistent evidence for fluid resuscitation in patients with cirrhosis limits our ability to produce a clearly evidence-based protocol for fluid resuscitation in cirrhosis. However, we propose a preliminary practical guide to managing fluid resuscitation in patients with decompensated cirrhosis. Further studies are needed to develop and validate volume assessment tools in the specific context of cirrhosis, while randomised clinical trials of protocolized resuscitation may improve care of this patient population. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Elsaid et al paper. To view this article, visit https://doi.org/10.1111/apt.17925 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vaishnav et al papers. To view these articles, visit https://doi.org/10.1111/apt.17868 and https://doi.org/10.1111/apt.17976 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Vaishnav et al papers. To view these articles, visit https://doi.org/10.1111/apt.17868 and https://doi.org/10.1111/apt.17982 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Hey et al paper. To view this article, visit https://doi.org/10.1111/apt.17917 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Mücke et al paper. To view this article, visit https://doi.org/10.1111/apt.17899 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Yoon et al paper. To view this article, visit https://doi.org/10.1111/apt.17909 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sandmann et al papers. To view these articles, visit https://doi.org/10.1111/apt.17878 and https://doi.org/10.1111/apt.17923 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Sandmann et al papers. To view these articles, visit https://doi.org/10.1111/apt.17878 and https://doi.org/10.1111/apt.17962 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Martini et al papers. To view these articles, visit https://doi.org/10.1111/apt.17804 and https://doi.org/10.1111/apt.17901 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Martini et al papers. To view these articles, visit https://doi.org/10.1111/apt.17804 and https://doi.org/10.1111/apt.17916 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Alkhouri et al papers. To view these articles, visit https://doi.org/10.1111/apt.17709 and https://doi.org/10.1111/apt.17881 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Alkhouri et al papers. To view these articles, visit https://doi.org/10.1111/apt.17709 and https://doi.org/10.1111/apt.17907 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dunne et al paper. To view this article, visit https://doi.org/10.1111/apt.17252 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Cardoso et al papers. To view these articles, visit https://doi.org/10.1111/apt.17650 and https://doi.org/10.1111/apt.17698 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Cardoso et al papers. To view these articles, visit https://doi.org/10.1111/apt.17650 and https://doi.org/10.1111/apt.17725 [ABSTRACT FROM AUTHOR]

Summary: Background: Recent advances in evaluation of body composition show body mass index to be inadequate in differentiating between body compartments in cirrhosis. Given the limitations of body mass index, body composition evaluation using computed tomography has been increasingly used as a non‐invasive clinical tool with prognostic value. Another factor influencing prognosis includes sex‐specific differences in body composition that are seen in cirrhosis. Aim: To review current knowledge regarding the frequency and clinical implications of abnormal body composition features in cirrhosis. Methods: We searched PubMed database and limited the literature search to full‐text papers published in English. Studies using inappropriate landmarks or demarcation of body composition components on computed tomography images were eliminated. Results: Sarcopenia is a well established factor affecting morbidity and mortality in cirrhosis. Other important body composition components that have been overlooked thus far include subcutaneous adipose tissue and visceral adipose tissue. Female patients with cirrhosis and low subcutaneous adiposity have a higher risk of mortality, whereas male patients with high visceral adiposity have a higher risk of hepatocellular carcinoma and recurrence following liver transplantation. Increased adipose tissue radiodensity has been associated with risk of decompensation and mortality. Conclusions: Further evaluation of body composition abnormalities may help with development of targeted therapeutic strategies and improve outcome in patients with cirrhosis. Moreover, recognition of these abnormalities could improve prioritisation for liver transplantation as our current method based solely on liver function might lead to risk misclassification. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Dunne et al paper. To view this article, visit https://doi.org/10.1111/apt.15797. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Patidar et al paper. To view this article, visit https://doi.org/10.1111/apt.17457 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Farina et al paper. To view this article, visit https://doi.org/10.1111/apt.17463 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Artru et al papers. To view these articles, visit https://doi.org/10.1111/apt.16080 and https://doi.org/10.1111/apt.17343 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Artru et al papers. To view these articles, visit https://doi.org/10.1111/apt.16080 and https://doi.org/10.1111/apt.17398 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Wang et al papers. To view these articles, visit https://doi.org/10.1111/apt.17272 and https://doi.org/10.1111/apt.17367 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dunne et al papers. To view these articles, visit https://doi.org/10.1111/apt.17252 and https://doi.org/10.1111/apt.17322 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dunne et al papers. To view these articles, visit https://doi.org/10.1111/apt.17252 and https://doi.org/10.1111/apt.17372 [ABSTRACT FROM AUTHOR]

Summary: Background: Direct‐acting anti‐viral therapy (DAA) has transformed hepatitis C virus (HCV) care, particularly in patients with decompensated cirrhosis. However, their impact on hepatocellular carcinoma (HCC) remains unclear. Aim: To use a national registry of patients with advanced liver disease to explore the relationship between DAA therapy and HCC. Methods: All patients with de novo HCC post DAA therapy were frequency matched with patients who did not develop HCC. Demographic, clinical and laboratory data were obtained. Cross‐sectional imaging and multidisciplinary team reports were reviewed for dates of HCC diagnosis and HCC progression. Patients were categorised by treatment outcome and time of HCC development. Data were examined by multivariable analysis and Kaplan‐Meier estimation. Results: Eighty patients with HCC were compared with 165 patients without HCC, treated between June 2014 and September 2015. Mean follow‐up from start of DAA therapy was 32.4 months. Twenty‐eight patients were diagnosed with early HCC (within 6 months of therapy) and 52 presented late. Baseline nonmalignant lesions (HR: 1.99), thrombocytopaenia (HR: 1.59) and diabetes (HR: 1.68) increased likelihood of HCC. Response to therapy was reduced in patients who developed liver cancer (SVR in patients with HCC = 54/80 (68%), SVR in patients without HCC = 143/165 (87%), P < 0.001, OR: 3.13, 95% CI: 1.64‐5.99). We found no difference between tumour size, progression or survival between viraemic and nonviraemic patients. Conclusion: There is no alteration in prognosis or cancer progression following HCC development after HCV treatment. However, baseline nonmalignant liver lesions, diabetes and thrombocytopaenia increase the risk of HCC, and HCC is associated with a decreased SVR rate. Linked Content This article is linked to Hollande and Pol paper. To view this article, visit https://doi.org/10.1111/apt.15328. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Hall et al papers. To view these articles, visit https://doi.org/10.1111/apt.16968 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Mecci et al paper. To view this article, visit https://doi.org/10.1111/apt.15296. [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Brandman et al papers. To view these articles, visit https://doi.org/10.1111/apt.16874 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Tergast et al papers. To view these articles, visit https://doi.org/10.1111/apt.17066 and https://doi.org/10.1111/apt.17168 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Tergast et al papers. To view these articles, visit https://doi.org/10.1111/apt.17066 and https://doi.org/10.1111/apt.17156 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dunne et al papers. To view these articles, visit https://doi.org/10.1111/apt.16901 and https://doi.org/10.1111/apt.16941 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Brandman et al papers. To view these articles, visit https://doi.org/10.1111/apt.16874 and https://doi.org/10.1111/apt.16931 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Dunne et al papers. To view these articles, visit https://doi.org/10.1111/apt.16901 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Brandman et al papers. To view these articles, visit https://doi.org/10.1111/apt.16874 and https://doi.org/10.1111/apt.16972 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Huang et al papers. To view these articles, visit https://doi.org/10.1111/apt.16844 and https://doi.org/10.1111/apt.16887 [ABSTRACT FROM AUTHOR]

Linked Content This article is linked to Stine et al paper. To view this article visit https://doi.org/10.1111/apt.14937. [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Wijarnpreecha et al and Gillespie & Hayes papers. To view these articles, visit https://doi.org/10.1111/apt.16490 and https://doi.org/10.1111/apt.16512 [ABSTRACT FROM AUTHOR]

LINKED CONTENT: This article is linked to Wijarnpreecha et al papers. To view these articles, visit https://doi.org/10.1111/apt.16490 and https://doi.org/10.1111/apt.16526 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Hu et al and Huang et al papers. To view these articles, visit https://doi.org/10.1111/apt.16116 and https://doi.org/10.1111/apt.16273 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Hu et al and Yueh‐Hsia Chiu et al papers. To view these articles, visit https://doi.org/10.1111/apt.16116 and https://doi.org/10.1111/apt.16339 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Fallahzadeh et al and Maan & Sonneveld papers. To view these articles, visit https://doi.org/10.1111/apt.16283 and https://doi.org/10.1111/apt.16299 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Fallahzadeh et al and Asrani & Everson papers. To view these articles, visit https://doi.org/10.1111/apt.16283 and https://doi.org/10.1111/apt.16311 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Buch et al paper. To view this article, visit https://doi.org/10.1111/apt.16252 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Rocco et al and Celsa & Cammà papers. To view these articles, visit https://doi.org/10.1111/apt.16239 and https://doi.org/10.1111/apt.16250 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Rocco et al papers. To view these articles, visit https://doi.org/10.1111/apt.16239 and https://doi.org/10.1111/apt.16254 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to McDowell et al paper. To view this article, visit https://doi.org/10.1111/apt.16189 [ABSTRACT FROM AUTHOR]

LINKED CONTENT This article is linked to Artru et al, Hey et al and Kumar & Dixit papers. To view these articles, visit https://doi.org/10.1111/apt.16080, https://doi.org/10.1111/apt.16128 and https://doi.org/10.1111/apt.16129 [ABSTRACT FROM AUTHOR]