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This book focuses on nanorobotic agents and stem cells for biomedical applications.It is intended for researchers and clinicians interested in innovative diagnostic and therapeutic strategies based on nanorobots and stem cells.It presents current advances in the field of molecular machines, which could be applied to generate novel therapeutic-diagnostic systems.

The book outlines first the importance of Extra Cellular Matrix (ECM), which is a natural surface for most of cells. In the following chapters the influence of biological, chemical, mechanical, and physical properties of surfaces in micro and nano-scale on stem cell behavior are discussed including the mechanotransduction. Biomimetic and bioinspired approaches are highlighted for developing microenvironment of several tissues, and surface engineering applications are discussed in tissue engineering, regenerative medicine and different type of biomaterials in various chapters of the book. This book brings together innovative methodologies and strategies adopted in the research and development of Advanced Surfaces in Stem Cell Research. Well-known worldwide researchers deliberate subjects including: Extracellular matrix proteins for stem cell fate The superficial mechanical and physical properties of matrix microenvironment as stem cell fate regulator Effects of mechanotransduction on stem cell behavior Modulation of stem cells behavior through bioactive surfaces Influence of controlled micro and nanoengineered surfaces on stem cell fate Nanostructured polymeric surfaces for stem cells Laser surface modification techniques and stem cells applications Plasma polymer deposition: a versatile tool for stem cell research Application of bioreactor concept and modeling techniques in bone regeneration and augmentation treatments Substrates and surfaces for control of pluripotent stem cell fate and function Application of biopolymer-based, surface modified devices in transplant medicine and tissue engineering Silk as a natural biopolymer for tissue engineering

The therapeutic potential of the use of adipose stem cells in regenerative medicine has been increasingly recognized, and in recent years concrete clinical benefits have accrued as these cells have been explored for a variety of applications. This readable and informative textbook tracks the progress that has been made in this fascinating new area of biomedicine. All aspects of the subject are considered, with particular attention to adipose cell biology, adipose tissue engineering strategies, and the diverse clinical applications of adipose stem cells. Funding issues, industrial approaches, regulatory challenges, and future directions are also examined. The two editors have vast experience in the field and have chosen leading experts from different countries to write on each topic. This book will excite the interest of all researchers, clinicians, and students wishing to gain an in-depth understanding of adipose stem cells and their flourishing role in regenerative medicine.

Nanomedicine in Cancer Immunotherapy bridges the two disciplines of nanotechnology and immunology, summarizing the latest research into novel cancer treatments, often personalized to the patient.This book covers a wide range of nanomaterial types for use in cancer immunotherapy, including hydrogel, lipid, exosome, gold and peptide nanoparticles. The preparation, application, pros and cons of each nanomaterial class is reviewed, helping the reader understand the potential for each and tailor their selection to their needs. Nanovaccines are also covered, along with a clinical evaluation and market analysis of nanomedicines for immunotherapy, offering an important clinical and commercial overview of this rapidly developing field.Nanomedicine in Cancer Immunotherapy is an interesting reference for those working in the fields of nanotechnology, immunology and cancer therapeutics, as well as clinicians with an interest in novel nano-based cancer treatments. - Provides a single source for a review of the latest research in the development of nanomaterials for cancer immunotherapy - Introduces the reader to basic principles of immunology and immunotherapy to aid our understanding - Details a wide range of nanomaterial classes for cancer immunotherapy, with advantages and disadvantages thoroughly analyzed

Microfluidics for Cellular Applications describes microfluidic devices for cell screening from a physical, technological and applications point-of-view, presenting a comparison with the cell microenvironment and conventional instruments used in medicine. Microfluidic technologies, protocols, devices for cell screening and treatment have reached an advanced state but are mainly used in research. Sections break them down into practical applications and conventional medical procedures and offers insights and analysis on how higher resolutions and fast operations can be reached. This is an important resource for those from an engineering and technology background who want to understand more and gain additional insights on cell screening processes. - Outlines the major applications of microfluidic devices in medicine and biotechnology - Assesses the major challenges of using microfluidic devices in terms of complexity of the control set-up, ease of use, integration capability, automation level, analysis throughput, content and costs - Describes the major fabrication techniques for assembling effective microfluidic devices for bioapplications

All other scientific disciplines, including chemistry, biology, physics, materials science, and engineering, can benefit from nanoscience and nanotechnology, which involve the study and utilization of incredibly small objects. This book presents the concept of Nano technology and its wide application in medicine. The chapters in this manual have been arranged in such a way as to provide a sequential understanding of the fundamental concepts in Nano technology and its medical application, Targeted Drug Delivery, Fundamentals of Nanobiosensors and Application of Nanomaterials in Nanopharmacology. Apart from these, this book also contains some advanced topics like Applications of Nanomaterials in Nanomedical Devices, Nanotechnology in Tissue Engineering and Gene therapy. Readers from a variety of backgrounds, such as researchers, professors, students, and biological scientists, will find this book to be equally helpful. Additionally, this book can help readers with backgrounds in other fields understand the basics of Nanotechnology and its various application.

This book reviews state of the art of polymeric biomaterials for regenerative medicine and highlights advances in both fundamental science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physiochemical property modulation, as well as their influence on the adhesion and performance of biomolecules, cells, and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies. In the second edition, most of the chapters are updated according to the latest progress of this research field. A new chapter on nerve regeneration is also included.

This book is part of a two-part volume book that highlights the latest advances in innovative bioceramics applied in the highly interdisciplinary area referred to as “translational medicine”. This volume covers the basic principles and techniques used in the manufacture of bioceramics and biocomposites for various biomedical applications including drug delivery, implantable bionics and the development of the cardiac pacemaker, and bone tissue engineering. Furthermore, self-healing materials have been attracting increasing interest in both engineering and medical applications during the past two decades. Self-healing hydrogels are particularly interesting because of their ability to repair structural damages and recover their original functions, specifically in tissue engineering.

This book presents nanomaterials for cancer detection using a variety of state-of-the-art imaging techniques. Clinical applications are also highlighted. The unique size-dependent properties and convenient surfaces for molecular assembly make these nanomaterials essential for a variety of innovative imaging techniques. This book covers important imaging modalities, synthesis of nanoparticles with specific functional properties, and clinical applications including the development of anticancer drugs. The information presented here involves contributions from chemistry, materials science, materials characterization, cell engineering, and clinical testing.The book will be essential reading to experienced clinicians as well as a wide range of scholars and researchers interested in nanotechnology and imaging techniques for cancer detection.

This book presents the development of electrospun materials, fundamental principles of electrospinning process, controlling parameters, electrospinning strategies, and electrospun nanofibrous structures with specific properties for applications in tissue engineering and regenerative medicine, textile, water treatment, sensor, and energy fields. This book can broadly be divided into three parts: the first comprises basic principles of electrospinning process, general requirements of electrospun materials and advancement in electrospinning technology, the second part describes the applications of electrospun materials in different fields and future prospects, while the third part describes applications that can be used in advanced manufacturing based on conjoining electrospinning and 3D printing. Electrospinning is the most successful process for producing functional nanofibers and nanofibrous membranes with superior chemical and physical properties. The unique properties of electrospun materials including high surface to volume ratio, flexibility, high mechanical strength, high porosity, and adjustable nanofiber and pore size distribution make them potential candidates in a wide range of applications in biomedical and engineering areas. Electrospinning is becoming more efficient and more specialized in order to produce particular fiber types with tunable diameter and morphology, tunable characteristics, having specific patterns and 3D structures.With a strong focus on fundamental materials science and engineering, this book provides systematic and comprehensive coverage of the recent developments and novel perspectives of electrospun materials. This comprehensive book includes chapters that discuss the latest and emerging applications of nanofiber technology in various fields, specifically in areas such as wearable textile, biomedical applications, energy generation and storage, water treatment and environmental remediation, and sensors such as biomarkers in healthcare and biomedical engineering. Despite all these advancements, there are still challenges to be addressed and overcome for nanofiber technology to move towards maturation.

Novel Platforms for Drug Delivery Applications covers diverse aspects in the design, synthesis and characterization of novel drug delivery platforms and devices. This book comprehensively details the development, application and performance of various novel molecular frameworks as potent drug delivery vehicles. Chapters cover a range of materials and molecular platforms for drug delivery, from hydrogels, nanocarriers and metal-organic-frameworks, to ꞵ-cyclodextrin and polyphosphazene. Each chapter discusses the benefits and limitations of each drug delivery system, as well as toxicological and safety implications. This book offers an interdisciplinary approach to this fast-moving topic, bridging the disciplines of materials science and pharmacology. - Provides an up-to-date single resource on novel drug delivery platforms, a rapidly evolving field of research - Covers a broad range of materials, systems and release mechanisms, including in vivo and in vitro studies - Describes the synthesis, properties, formulation and application of various novel drug delivery systems

Nanotechnology for Hematology, Blood Transfusion, and Artificial Blood outlines the fundamental design concepts and emerging applications of nanotechnology in hematology, blood transfusion and artificial blood. This book is an important reference source for materials scientists, engineers and biomedical scientists who are looking to increase their understanding of how nanotechnology can lead to more efficient blood treatments. Sections focus on how nanotechnology could offer new routes to address challenging and pressing issues facing rare blood diseases and disorders and how nanomaterials can be used as artificial cell-like systems (compartmentalized biomimetic nanocontainers), which are especially useful in drug delivery. For artificial blood, the nanotechnological approach can fabricate artificial red blood cells, platelet substitutes, and white blood cell substitutes with their inherent enzyme and other supportive systems. In addition, nanomaterials can promote blood vessel growth and reserve red blood cells at a positive temperature. - Provides information on how nanotechnology can be used to create more efficient solutions for blood transfusions and hematology treatments - Explores the major nanomaterial types that are used for these treatments - Assesses the major challenges of using nanomaterials hematology

Nanomedicine explores the modification and enhancement of the properties and performances of typical drugs to treat various diseases. Nano-based medicines have advantages in several ways, such as in nanotherapeutics, nanotheranostics, and nanodiagnostics. Nanomedicine Manufacturing and Applications effectively explores the major manufacturing techniques and applications of nanomaterial-based medicine in the areas of chemotherapy, biochips, insulin pumps, and other treatment methods. This book explains how nanomedicines are developed from nanoparticles as well as their biomedical and other applications related to healthcare. This book is an important reference source for nanoscientists, biomaterials scientists, and biomedical engineers who want to learn more about how nano-based medicines are made and used. - Outlines the process of making nanomedicine as well as nanodrug carriers, with a focus on nanomedicine for cancer treatment. - Explains the formulation and manufacturing process of nanomedicines, showing how to build these materials. - Demonstrates how nano-based medicines are being used to tackle a range of diseases in a way that conventional medicines cannot.

The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine.This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials'community. - The most comprehensive coverage of principles and applications of all classes of biomaterials - Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials - Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. - Online chapter exercises available for most chapters

Sustainable Nanocellulose and Nanohydrogels from Natural Sources explores the use of biopolymers in specific application areas such as electronics, energy, consumer goods, packaging materials, therapeutics, water treatment and engineering, and what makes the particular polymer to engage it in these applications. This is an important reference source for those who would like to learn more about how biopolymeric nanocomposites are used in sustainability and environmental protection. Biopolymers, including plant and sea-based polymers, play an important role in the formation and maintaining the stability of industrial nanocomposites; their common functions being the surface modification and protection for the highly oxidative-unstable cores, as stable base for holding multiple targets, and as a shield for the inorganic and highly toxic metals. These biopolymer-based nanocomposites are being used for applications in the electronics, automobile, construction and biomedical sectors. - Explains the major design and development techniques of novel biopolymer-based nanocomposites - Demonstrates how Nanocelluloses and Nanohydrogels are being used for environmental health and safety - Explores how biopolymer-infused nanocellulose and nanogels are less toxic than their conventional counterparts

This book focuses on the recent advances in the field of orthopaedic biomaterials, with a particular emphasis on their design and fabrication. Biomimetic materials, having similar properties and functions to that of the natural tissue, are becoming a popular choice for making customized orthopaedic implants and bone scaffolds. The acceptability of these materials in the human body depends on the right balance between their mechanical and biological properties. This book provides a comprehensive overview of the state-of-the-art research in this rapidly evolving field. The chapters cover different aspects of multi-functional biomaterials design, and cutting-edge methods for the synthesis and processing of these materials. Advanced manufacturing techniques, like additive manufacturing, used for developing new biomimetic materials are highlighted in the book. This book is a valuable reference for students and researchers interested in biomaterials for orthopaedic applications.

Materials for Biomedical Engineering: Hydrogels and Polymer-Based Scaffolds discusses the use of a wide variety of hydrogels as bioactive scaffolds in regenerative medicine, including updates on innovative materials and their properties. Various types of currently investigated scaffolding materials and hydrogels are discussed, as is their future roles and applications, the main techniques for scaffold fabrication, and their characterization procedures. Readers will be able to use this book as a guide for the selection of the best materials for a specific application. - Provides a valuable resource of recent scientific progress, highlighting the most well-known applications of hydrogels as bioactive scaffolds in regenerative medicine - Includes novel opportunities and ideas for developing or improving technologies in biomaterials, and in related biomedical industries - Features at least 50% of references from the last 2-3 years

This book presents synthesis techniques for the preparation of low-dimensional nanomaterials including 0D (quantum dots), 1D (nanowires, nanotubes) and 2D (thin films, few layers), as well as their potential applications in nanoelectronic systems. It focuses on the size effects involved in the transition from bulk materials to nanomaterials; the electronic properties of nanoscale devices; and different classes of nanomaterials from microelectronics to nanoelectronics, to molecular electronics. Furthermore, it demonstrates the structural stability, physical, chemical, magnetic, optical, electrical, thermal, electronic and mechanical properties of the nanomaterials. Subsequent chapters address their characterization, fabrication techniques from lab-scale to mass production, and functionality. In turn, the book considers the environmental impact of nanotechnology and novel applications in the mechanical industries, energy harvesting, clean energy, manufacturing materials,electronics, transistors, health and medical therapy. In closing, it addresses the combination of biological systems with nanoelectronics and highlights examples of nanoelectronic–cell interfaces and other advanced medical applications. The book answers the following questions: • What is different at the nanoscale? • What is new about nanoscience? • What are nanomaterials (NMs)? • What are the fundamental issues in nanomaterials? • Where are nanomaterials found? • What nanomaterials exist in nature? • What is the importance of NMs in our lives? • Why so much interest in nanomaterials? • What is at nanoscale in nanomaterials? • What is graphene? • Are pure low-dimensional systems interesting and worth pursuing? • Are nanotechnology products currently available? • What are sensors? • How can Artificial Intelligence (AI) and nanotechnology work together? • What are the recent advances in nanoelectronic materials? • What are the latest applications of NMs?

Handbook of Tissue Engineering Scaffolds: Volume Two provides a comprehensive and authoritative review on recent advancements in the application and use of composite scaffolds in tissue engineering. Chapters focus on specific tissue/organ (mostly on the structure and anatomy), the materials used for treatment, natural composite scaffolds, synthetic composite scaffolds, fabrication techniques, innovative materials and approaches for scaffolds preparation, host response to the scaffolds, challenges and future perspectives, and more. Bringing all the information together in one major reference, the authors systematically review and summarize recent research findings, thus providing an in-depth understanding of scaffold use in different body systems. - Dedicated to the specialist topic of composite scaffolds, featuring all human body systems - Covers basic fundamentals and advanced clinical applications - Includes up-to-date information on preparation methodology and characterization techniques - Highlights clinical data and case studies

Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies. - Provides an overview of the methodologies for biological target identification and ligand screening - Includes case studies showing the development of functionalized nanomaterials and their biomedical applications - Highlights the importance of functionalized nanomaterials for drug delivery, diagnostics and regenerative medicine applications

This book describes radionanomedicine as an integrated medicine using exogenous and endogenous This book describes radionanomedicine as an integrated approach that uses exogenous and endogenous nanomaterials for in vivo and human applications. It comprehensively explains radionanomedicine comprising nuclear and nanomedicine, demonstrating that it is more than radionanodrugs and that radionanomedicine also takes advantage of nuclear medicine using trace technology, in which miniscule amounts of materials and tracer kinetic elucidate in vivo biodistribution. It also discusses exogenous nanomaterials such as inorganic silica, iron oxide, upconversion nanoparticles and quantum dots or organic liposomes labelled with radioisotopes, and radionanomaterials used for targeted delivery and imaging for theranostic purposes. Further, it examines endogenous nanomaterials i.e. extracellular vesicles labelled with radioisotopes, known as radiolabelled extracellular vesicles, as well aspositron emission tomography (PET) and single photon emission computed tomography (SPECT), which elucidate the biodistribution and potential for therapeutic success.

This volume provides a state-of-art-report on the new methodologies in tissue engineering and developments in the biomaterials field based on the extracellular matrix-relevant discovery. Extracellular Matrix for Tissue Engineering and Biomaterials opens with an overview of the latest extracellular matrix research and in Part I, focuses on its biology and its role on cell behavior and cell fate relevant for the design of biomimetic surfaces. Part II details issues regarding the strategies currently applied in the research of biologically inspired materials and material systems for the replacement, repair and regeneration of tissues and organs. Part III presents the latest development methods applying knowledge from biology towards nanotechnology, to promote the restoration of the functionality of a living tissue. The book ranges from fundamental biology associated with tissue regeneration for the development of biomimetic approaches to controlling tissue formation, cell function,differentiation and angiogenesis using factors involved in normal tissue development and function. With the breadth and depth of the coverage of this topic, this book will serve as a valuable reference for anyone working in tissue engineering or biomaterials – from scientists, chemists and biologists through physicists, bioengineers and clinicians.

In order to grow replacement tissues, 3D scaffolds are widely used as a template for tissue engineering and regeneration. These scaffolds, which are typically'seeded'with cells, support the growth of new tissues. However, in order to achieve successful tissue growth, the scaffold must meet specific requirements and are often'functionalized'to accentuate particular properties. Functional 3D tissue engineering scaffolds: materials, technologies, and applications, is a comprehensive review of functional 3D scaffolds, providing information on the fundamentals, technologies, and applications. Part 1 focuses on the fundamentals of 3D tissue scaffolds, examining information on materials, properties, and trends. Part 2 discusses a wide range of conventional technologies for engineering functional 3D scaffolds, leading the way to a discussion on CAD and advanced technologies for functional 3D scaffold engineering. Chapters in part 3 study methods for functionalizing scaffolds to support a variety of in vivo functions whilst the final set of chapters provides an important review of the most significant applications of functional 3D scaffolds within tissue engineering. This book is a valuable resource for biomaterial scientists and biomedical engineers in academia and industry, with interests in tissue engineering and regenerative medicine. - Provides a self-contained work for the field of biomaterials and tissue engineering - Discusses all the requirements a scaffold must meet and a wide range of strategies to create them - Highlights significant and successful applications of functional 3D scaffolds

Nanobiomaterials: Nanostructured materials for biomedical applications covers an extensive range of topics related to the processing, characterization, modeling, and biomedical applications of nanostructured ceramics, polymers, metals, composites, self-assembled materials, and macromolecules. Novel approaches for bottom-up and top-down processing of nanostructured biomaterials are highlighted. In addition, innovative techniques for characterizing the in vitro behavior and in vivo behavior of nanostructured biomaterials are considered. Applications of nanostructured biomaterials in dentistry, drug delivery, medical diagnostics, surgery and tissue engineering are examined. - Provides a concise description of the materials and technologies used in the development of nanostructured biomaterials - Provides industrial researchers with an up-to-date and handy reference on current topics in the field of nanostructured biomaterials - Includes an integrated approach that is used to discuss both the biological and engineering aspects of nanostructured biomaterials

This book covers the latest advances, applications, and challenges in orthopedic biomaterials. Topics covered include materials for orthopedic applications, including nanomaterials, biomimetic materials, calcium phosphates, polymers, biodegradable metals, bone grafts/implants, and biomaterial-mediated drug delivery. Absorbable orthopedic biomaterials and challenges related to orthopedic biomaterials are covered in detail. This is an ideal book for graduate and undergraduate students, researchers, and professionals working with orthopedic biomaterials and tissue engineering. This book also:Describes biodegradable metals for orthopedic applications, such as Zn-based medical implantsThoroughly covers various materials for orthopedic applications, including absorbable orthopedic biomaterials with a focus on polymers Details the state-of-the-art research on orthopedic nanomaterials and nanotechnology

Nanofiber Composite Materials for Biomedical Applications presents new developments and recent advances in nanofiber-reinforced composite materials and their use in biomedical applications, including biomaterial developments, drug delivery, tissue engineering, and regenerative medicine. Unlike more conventional titles on composite materials, this book covers the most innovative new developments in nanofiber-based composites, including polymers, ceramics, and metals, with particular emphasis on their preparation and characterization methodology. Selected case studies illustrate new developments in clinical and preclinical use, making the information critical for the development of new medical materials and systems for use in human health care, and for the exploration of new design spaces based on these nanofibers. This book is essential reading for those working in biomedical science and engineering, materials science, nanoscience, biomedical nanotechnology, and biotechnology. - Covers innovative new developments in nanofiber composites, including polymers, ceramics, and metals with particular emphasis on their preparation and characterization methodology - Deals with biomedical applications, including biomaterials developments, drug delivery, tissue engineering, and regenerative medicine - Presents selected case studies on nanofiber composite materials in both clinical and preclinical use

Millions of patients suffer from end-stage organ failure or tissue loss annually, and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility–related problems and donor organ shortage, however, around 20 years ago a new, hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased, failing, or malfunctioning organs—regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds, from basic science to industry to clinical applications. Its 10 parts, illustrated throughout with excellent figures, cover stem cell engineering research, drug delivery systems, nanomaterials and nanodevices, and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science, ceramics, metals for biomaterials, nanotechnology, chemistry, biology, and medicine, especially those interested in tissue engineering, stem cell engineering, and regenerative medicine.

This authoritative reference presents the modern concepts of mesenchymal stem cells (MSCs) and biomaterials as they pertain to the dental field. The book is organized around three main topics: MSCs biology, advanced biomaterials, and clinical applications. The chapters present basic information on stem cell biology and physiology, modern biomaterials that improve bone tissue regeneration, the biomatrices likeplatelet-rich fibrin (PRF) used to functionalize the biomaterials surface, the strategic and safe intraoral seats of harvesting, the new sources for MSCs, as well as the future perspectives and new challenges in these exciting fields. The contributors are top scientists with a great deal of experience in regenerative dentistry and biomedical research. They offer an international perspective and are richly cross-disciplinary, representing academia, research, and industry. MSCs and Innovative Biomaterials in Dentistry is indispensable reading for students, researchers, and clinicians who need to stay up-to-date on the cutting-edge developments of tissue engineering and regenerative medicine applied to dental sciences.

Biomedical Composites, Second Edition, provides revised, expanded, and updated content suitable for those active in the biomaterials and bioengineering field. Three new chapters cover modeling of biocomposites, 3D printing of customized scaffolds, and constructs and regulatory issues. Chapters from the first edition have been revised in order to provide up-to-date, comprehensive coverage of developments in the field. Part One discusses the fundamentals of biocomposites, with Part Two detailing a wide range of applications of biocomposites. Chapters in Part Three discuss the biocompatibility, mechanical behavior, and failure of biocomposites, while the final section looks at the future for biocomposites. Professor Luigi Ambrosio is the Director of the Institute for Composite and Biomedical Materials, Italy. He is a renowned scientist with expertise in biomedical composites and has published over 150 papers in international scientific journals and books, 16 patents, and over 250 presentations at international and national conferences. - Led by an expert editor with many years of experience in academia and widely recognized as an international expert on biomedical composites - Features an overview of biocomposites for a wide range of biomedical applications - Provides revised, expanded, and updated coverage, including three new chapters

Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology, as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology, as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections onregulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine.Volume 1 contains eleven chapters addressing the latest basic science knowledge on the “Biology of Tissue Regeneration”. The principles of cell regeneration control by extracellular matrix and the biology of stem cell niches are explained. Depicted are the principles of molecular mechanisms controlling asymmetric cell division, stem cell differentiation, developmental and regenerative biology, epigenetic and genetic control as well as mathematical modelling for cell fate prediction. Regenerative biology of stem cells in the central nervous and cardiovascular systems leading to complex tissue regeneration in the model species axolotl and zebrafish, as well as the impact of immune signalling on nuclear reprogramming are outlined. These up to date accounts gives the readers advanced insights into the biological principles of the regenerative processes in stem cells, tissues and organisms.

This book gives a concise overview of bionanomaterials with applications for skin regeneration. The advantages and challenges of nanoscale materials are covered in detail, giving a basic view of the skin structure and conditions that require transdermal or topical applications. Medical applications, such as wound healing, care for burns, skin disease, and cosmetic care, such as aging of the skin and photodamage, and how they benefit from bionanomaterials, are described in detail. A final chapter is devoted to the ethical and social issues related to the use of bionanomaterials for skin regeneration. This is an ideal book for researchers in materials science, medical scientists specialized in dermatology, and cosmetic chemists working in formulations. It can also serve as a reference for nanotechnologists, dermatologists, microbiologists, engineers, and polymer chemists, as well as students studying in these fields.

Thin Film Coatings for Biomaterials and Biomedical Applications discusses the latest information on coatings, including their historic use by scientists who are looking to improve the properties and biological responses of the material-host interface. Thin films, in particular, are becoming more widely researched and used as an alternative to traditional sprayed coatings because they have a more uniform structure and therefore greater stability. This book provides readers with a comprehensive guide to thin film coatings and their application in the biomaterials field. Part One of the book details the fundamentals of thin films for biomedical application, while Part Two looks at the special properties of thin films, with a final section reviewing functional thin films and their usage in biomedical applications. - Provides a comprehensive review on the fundamentals, properties, and functions of thin film coatings for biomaterials - Covers a broad range of applications for implantable biomaterials - Written by an international team of contributors who carefully tailor the presented information in a way that addresses industry needs

This book reviews state-of-the-art of polymeric biomaterials for regenerative medicine, and highlights advances in both basic science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physicochemical property modulation, as well as their influence on adhesion and the performance of biomolecules, cells and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeuticstrategies.

This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation.Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer's Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interestedin bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.

This book covers the principles of advanced 3D fabrication techniques, stem cells and biomaterials for neural engineering. Renowned contributors cover topics such as neural tissue regeneration, peripheral and central nervous system repair, brain-machine interfaces and in vitro nervous system modeling. Within these areas, focus remains on exciting and emerging technologies such as highly developed neuroprostheses and the communication channels between the brain and prostheses, enabling technologies that are beneficial for development of therapeutic interventions, advanced fabrication techniques such as 3D bioprinting, photolithography, microfluidics, and subtractive fabrication, and the engineering of implantable neural grafts.There is a strong focus on stem cells and 3D bioprinting technologies throughout the book, including working with embryonic, fetal, neonatal, and adult stem cells and a variety of sophisticated 3D bioprinting methods for neural engineering applications. There is also a strong focus on biomaterials, including various conductive biomaterials and biomimetic nanomaterials such as carbon-based nanomaterials and engineered 3D nanofibrous scaffolds for neural tissue regeneration. Finally, two chapters on in vitro nervous system models are also included, which cover this topic in the context of studying physiology and pathology of the human nervous system, and for use in drug discovery research. This is an essential book for biomedical engineers, neuroscientists, neurophysiologists, and industry professionals.

Nanobiomaterials in Dentistry: Applications of Nanobiomaterials discusses synthesis methods and novel technologies involving nanostructured bio-active materials with applications in dentistry. This book provides current research results for those working in an applied setting. The advantage of having all this information in one coherent text will be the focused nature of the chapters and the ease of which this information can be accessed. This collection of titles brings together many of the novel applications these materials have in biology and discusses the advantages and disadvantages of each application and the perspectives of the technologies based on these findings. At the moment there is no other comparable book series covering all the subjects approached in this set of titles. - Offers an updated and highly structured reference material for students, researchers, and practitioners working in biomedical, biotechnological, and engineering fields - Serves as a valuable resource of recent scientific progress, along with most known applications of nanomaterials in the biomedical field - Features novel opportunities and ideas for developing or improving technologies in nanomedicine and dentistry

This unique handbook (60 chapters) examines the entire'product life cycle,'from the creation of nanomedical products to their final market introduction. While focusing on critical issues relevant to nanoproduct development and translational activities, it tackles topics such as regulatory science, patent law, FDA law, ethics, personalized medicin

Selected, peer reviewed papers from the 2013 International Conference on Bio-Medical Materials and Engineering (ICBME 2013), March 26-27, 2013, Hong Kong

SpringerBriefs in Biotech Patents presents timely reports on intellectual properties (IP) issues and patent aspects in the field of biotechnology. In this volume the limits of patentability are addressed, a question that is often raised when it comes to biotechnological inventions: The first section addresses current issues in the patentability of plants produced by essentially biological processes including the controversy between farmer's privilege and patent exhaustion with respect to seeds in the US. The second section examines the patentability of human embryonic stem cells in Europe and the US, also considering alternative technologies with respect to their practicability and patentability. The third section focuses on the patentability of genes and nucleic acids, especially the issue of patenting of encoding genes and nucleic acids.

A concise overview of tissue engineering technologies and materials towards specific applications, both past and potential growth areas in this unique discipline is provided to the reader. The specific area of the biomaterial component used within the paradigm of tissue engineering is examined in detail. This is the first work to specifically covers topics of interest with regards to the biomaterial component. The book is divided into 2 sections: (i) general materials technology (e.g., fibrous tissue scaffolds) and (ii) applications in the engineering of specific tissues (e.g., materials for cartilage tissue engineering). Each chapter covers the fundamentals and reflects not only a review of the literature, but also addresses the future of the topic. The book is intended for an audience of researchers in both industry and academia that are interested in a concise overview regarding the biomaterials component of tissue engineering, a topic that is timely and only growing as a field.