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Neuroimaging in Parkinson's Disease and Related Disorders discusses the advances of molecular, structural and functional neuroimaging techniques associated with the etiology, pathophysiology, effects and complications of novel therapies in Parkinson's and related disorders. With new neuroimaging methodologies emerging over the past five years, this book provides a comprehensive overview of new technologies and research. Sections discuss the biomarker value of neuroimaging of the brain to understand disease progression in vivo in actual patients with Parkinson's disease and related disorders. Readers will be updated on in vivo pathology and pathophysiology in Parkinson's disease and in a number of related disorders. Also discussed is the association between clinical symptoms, clinical progression, and molecular, structural, and functional changes in the brain of patients with Parkinson's disease and related disorders. - Comprehensive overview of biomarker value of neuroimaging of the brain to understand disease progression in vivo in actual patients with Parkinson's disease and related disorders - Helps readers understand the in vivo pathology and pathophysiology in Parkinson's disease and in a number of related disorders - Discusses the association between clinical symptoms, clinical progression, and molecular, structural, and functional changes in the brain of patients with Parkinson's and related disorders

First published in 1991, this book covers three major areas essential to in vivo biochemical studies with PET and SPECT: synthesis of radiopharmaceuticals, biological modeling, and clinical applications. The book emphasizes advances in the synthesis of radiopharmaceuticals used in PET and SPECT studies of brain flow and oxidatative metabolism, in addition to biological modeling. The most widely used 2-deoxyglucose/2-fluorodeoxyglucose models are discussed, as well as models used in the quantitation of brain receptors. Other topics include a possible model for converting 6-[18F] fluorodopa images into the quantitative rate of dopamine synthesis, evaluations of technetium- and iodine-labeled blood flow tracers, and possibilities for using SPECT to measure other pathophysiological variables. This book will be a valuable reference source to students and specialists interested in these in vivo measurements.

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering recent advances in the field of neurobiology. Topics covered include chromosome 22 deletion syndrome and schizophrenia; characterization of proteome of human cerebrospinal fluid; hormonal pathways regulating intermale and interfemale aggression; neuronal gap junctions; effects of genes and stress on the neurobiology of depression; quantitative imaging with teh MicroPET small-animal PET tomograph; understanding myelination through studying its evolution.

Comprised of two separate volumes, Neuroimaging provides a state-of-the-art review of a broad range of neuroimaging techniques applied to both clinical and research settings. The breadth of the methods covered is matched by the depth of description of the theoretical background. Part B covers the application of neuroimaging in both research and clinical settings for the study of anxiety disorders, dementia, depression, schizophrenia, functional somatic syndromes, stroke, and multiple sclerosis using a range of neuroimaging modalities including CT, PET, SPECT, DTI, structural MRI and fMRI. One chapter is devoted to the study of brain development using structural MRI, and one chapter to the study of pediatric neurobehavioral disorders using fMRI. One of the most exciting recent applications of neuroimaging to the area of genetics is covered, and with the theory and application of neuroreceptor imaging in psychiatry, forms the final two chapters. The two parts of Neuroimaging complement each other providing in-depth information on a broad range of routine and cutting edge techniques that is not available in any other text. This book is superbly written and beautifully illustrated by contributors working at the top of their chosen specialty. - Presents recent applications of neuroimaging to the area of genetics - Discusses the study of brain development using structural MRI - Includes chapters on the theory and application of neuroreceptor imaging in psychiatry

Neurotransmission is a multicomponent process. Transmitters, released by neuronal activity, act on pre- and postsynaptic receptors, and many books detail advances in the receptor field. In addition, after their release from nerve endings, transmitters are removed from the neuronal vicinity by uptake into neuronal or glial cells by specific tra- porter proteins that have been studied intensely over the last 30 years; this information is scattered throughout numerous publishing vehicles. Therefore, the primary aim of this second edition of N- rotransmitter Transporters: Structure, Function, and Regulation is to offer a comprehensive picture of the characterization of neurotransmitter transporters and their biological roles. The transporter field has moved forward in stages. In the first phase, progress came from the use of substrate or blocker ligands selectively targeting transporters, the application of model systems allowing the study of transmitter tra- port shielded from storage, and the development of mathematical models for describing transport phenomena. In the second phase, roughly covering the last decade, advances in DNA techniques allowed the cloning of numerous genes coding for different transporter proteins. In the current, third stage, a wealth of information is being accumulated in studies relating transporter structure with function, experiments addressing regulation by posttranslational transfor- tion, investigations into transport modulation by trafficking processes and genomic influences, characterization of channel properties of tra- porters by electrophysiological approaches, and the creation of transgenic animals under- or overexpressing a given transporter protein.