Search

This book reviews the recent research into biological aspects of suicide behavior and outlines each of the varied, recent approaches to prevent suicide. Suicidal behavior, perhaps, is the most complex behavior that combines biological, social, and psychological factors. A new frontier and new opportunities are opening with the technologies of data acquisition and data analysis. Personalized models based on digital phenotype could provide promising strategies for preventing suicide.

Ist die Psyche nichts als die neuronalen Prozesse im Gehirn? Müssen zentrale mentale Begriffe wie Selbst, Bewusstsein, Unbewusstsein, etc. durch neuronale Mechanismen erklärt werden und die Psychiatrie durch die Neurowissenschaften ersetzt werden? Unser Buch zeigt auf, dass mentale Prozesse und psychische Symptome bei psychiatrischen Erkrankungen wie Schizophrenie, Depression, etc. weder reine geistige noch nur neuronale Prozesse sind. Gehirn ist immer auch schon Umwelt; und es ist die Interaktion der Umwelt-Gehirn-Beziehung, in der psychische Phänomene inklusive ihrer Abnormitäten ihren neuropsychodynamischen Ursprung haben.Der InhaltNeuropsychodynamische GrundlagenNeurosoziale Auffassung des GehirnsPsychoanalytische Konzepte und deren WeiterentwicklungNeuropsychodynamik psychischer StörungenTherapie auf neuropsychodynamischer GrundlageNeurosoziale und neuropsychodynamische ZukunftsperspektivenDie HerausgeberProf. Dr. Heinz Böker, Psychiatrische Universitätsklinik Zürich, Zentrum für Depressionen, Angsterkrankungen und Psychotherapie, Zürich, Schweiz.Prof. Dr. Peter Hartwich, Städtische Kliniken Frankfurt am Main-Höchst, Klinik für Psychiatrie und Psychotherapie/Psychosomatik, Akademisches, Lehrkrankenhaus der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Deutschland.Prof. Dr. Dr. Georg Northoff, University of Ottawa, Institute of Mental Health Research, Royal Ottawa Mental Health Centre, Ottawa/ON, Canada, Zhejang University, Hangzhou/China, Taipeh Medical University Taipeh/Taiwan.

This book addresses the phenomenology, demographics, and neurobehavioral aspects of suicidal behavior and its risk factors, underscoring common neurobehavioral threads among different approaches which may underlie such extreme behavior. It additionally provides an overview of new approaches, such as imaging techniques to identify at-risk individuals or in response to drug treatment associated with suicidal behavior, neurodevelopmental approaches, genetic and epigenetic linkages to suicidal behavior, animal models of specific risk factors, as well as potential biomarkers being employed to help assess risk.

The book highlights important new research using current state-of-the-art approaches by prominent researchers in the field of depression. A broad range of topics is covered, beginning with a description of the phenotypic features of clinical depression, followed by chapters on the cellular and molecular basis, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered. In this way the volume brings together the key disciplines involved in the neurobiological understanding of depression to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators interested in the present state of depression research.

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment

Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft. The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour. This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise. The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders. - The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system - Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others - The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community - Of great value not only for researchers and experts, but also for students and clinicians as a background reference