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Enterococcus faecalis is a gram-positive, coccus shaped, lactic acid bacterium, with demonstrated ubiquity across multiple anatomical sites. Enterococcus faecalis isolates have been isolated from clinical samples as the etiological agent in patients with overt infections, and from body sites previously thought to be sterile but absent of signs and symptoms of infection. E. faecalis is implicated in both human health and disease, recognized as a commensal, a probiotic and an opportunistic multiply resistant pathogen. E. faecalis has emerged as a key pathogen in nosocomial infections. Enterococcus faecalis is a commensal bacterium inhabiting the gastro-intestinal tract of humans. Interestingly, although it is not clear whether E. faecalis is part of the oral cavity microbiome, it is frequently recovered from root canal infections. Specifically, it is the major pathogen found in persistent infections associated with root canal treatment failure. Moreover, E. faecalis is one of the leading multidrug resistant nosocomial pathogens, causing infective endocarditis, and participating in urinary tract, wound, and device- device-related infections. This book discusses the molecular characteristics, its role in nonsocomial infections and the antibacterial effects of Enterococcus faecalis. It begins by discussing the virulence factors of enterococcus faecalis and concludes with E. faecalis in dental infections.

Incidents of methicillin-resistant Staphylococcus aureus (MRSA) have been prominent in the news over the past few years, drawing attention to a type of infection that is resistant to certain antibiotics. Staphylococcus aureus has three features that make it distinct among most other clinically important bacteria. Not only do MRSA infections lead to higher lengths of stay and more cost then MSSA infections, but more importantly, MRSA infections lead to a higher mortality. MRSA is no longer confined to hospitals and hospital-attending people, it has now vigorously invaded recreational, rehabilitation, sporting and teaching facilities.

There is currently increasing interest concerning the biology and disease caused by Acinetobacter species. Such interest, however, developed relatively slowly because of the necessity to clarify the confusing taxonomy of these organisms. Much work was needed to identify various species as members of this genus, to recognize their epidemiologic profile, their pathogenic role and their increasing importance as multi-antibiotic resistant organisms. In recent years improvement of genetic approaches, recognition of plasmids, integrons and chromosomal sources of resistance mechanisms aroused interest on the role of Acinetobacters in disease by many microbiologists and clinicians, especially internists and infectious disease specialists. In this regard, physicians are frequently confronted with extremely difficult therapeutic approaches for treatment and prevention of severe nosocomial infections due to multi antibiotic resistant Acinetobacter. Moreover, recent observations of community acquired infections have been reported, especially in patients with various risk factors such as immuno-deficiencies. Also, it is now becoming evident that Acinetobacter infections occur frequently in violent situations such as earthquake or war zones. The mechanisms of Acinetobacter virulence are becoming increasingly clear, providing new insights into their pathogenic role in community acquired infections. It is apparent the time is appropriate for detailed review of the increasing knowledge concerning important new information, both clinical and therapeutic, especially information concerning virulence, resistance mechanisms and typing of Acinetobacter spp. Many new findings are accumulating in almost an exponential manner since publication of previous books on this subject in 1991 and 1996.

Catheter-Related Infections in the Critically Ill provides an overview from an international perspective on intravascular catheters and the risk of infection. This volume highlights:EpidemiologyDiagnosis Impact of Infection Management and Treatment Prevention - including Education as the Primary Tool for PreventionThe purpose of this book is to provide the practitioner with the most interesting and useful data in the field of catheter-related infection. It is hoped that the strategies to prevent infection detailed by the authors will be implemented and have a measurable impact in decreasing rates of infection in the intensive care unit setting.

Acinetobacter details the clinical aspects of this bacterium responsible for many infections in hospitalized patients. This reference explains the importance of these organisms, both from the patient's viewpoint and the economic perspective, and provides clinicians with the knowledge they need to control these bacteria.