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The book discusses the role of gut microbiome composition in colorectal cancer progression, linking intestinal inflammation, tumorigenesis and anti-cancer immune responses. Chapters delve into various areas, including the mechanisms of action of probiotics and prebiotics (such as Lactobacillus and Bifidobacterium strains, and fructans and galactans, respectively), functional foods such as α-carotene, β-carotene, lutein, β-cryptoxanthin, fucoxanthin, isothiocyanates, flavonoids, probiotics, fibre and omega-3. Lycopene, β-cryptoxanthin, and fucoxanthin. Dietary phytochemicals such as polyphenols (curcumin, gingerol, ferulic acid (FA) and hydroxytyrosol); alkaloids (piperine, and protopine); terpenoids (artemisinin, and astaxanthin); iridoid glycoside (picroside II, and morroniside); and flavonoid (quercetin) on cancer, immune responses, and the gut microbiome. It examines the interaction and influence of prebiotics and probiotics in colorectal cancer treatment, their use in managing chemotherapy-related gastrointestinal problems, and their potential as adjuvants. The book also investigates how these gut microbes are associated with tumor progression and anti-cancer treatment efficacy. This knowledge can be used to develop biomarkers that predict immunotherapy effectiveness and improve treatment outcomes through modulation. This book provides a comprehensive update on the latest research and clinical applications in the field, offering valuable insights into the complex interplay between probiotics, the gut microbiome, and colorectal cancer. It serves as an invaluable resource for healthcare professionals, researchers, and students seeking to understand this dynamic area of study.

This second volume of the two-volumes work “Antimicrobials in Livestock” offers an in-depth look at the antimicrobials commonly used in veterinary medical care of the major food producing animals pigs, poultry and cattle as well as horses, bringing to readers'attention also pharmacokinetic and pharmacodynamic characteristics of these drugs. The individual chapters also provide a brief description of preventive tools as well as alternatives to conventional treatment options that could help minimise the use of antibiotics and combat the problems caused by increasing antimicrobial resistance. The focus is on Europe, without neglecting the global context. The complete two-volumes provide an extensive review of various aspects related to the use of antimicrobials in veterinary medicine. Volume I explores the use of antimicrobials in animals from the regulatory, practical as well scientific perspective and is targeted on EU policies and regulatory surroundings, providing also information on risks linked to the extensive use of antibiotics in livestock and highlighting importance of methods of laboratory testing for susceptibility and resistance, starting from phenotype tests and moving towards genetic analysis results providing molecular biology aspects. Each chapter confronts the reader with open questions to stimulate further discussions and future research on the topics covered. Volume II more specifically discusses medical aspects necessary for targeted, responsible, and evidence-based use of antimicrobials in cattle, pigs, poultry, and horses, as well as pharmacokinetics and pharmacodynamics as two of the most important factors necessary for proper dosing schedule setting of effective treatment. While the preface of the first volume started with questions, Volume II's preface ends with them, having the intention to provoke more in depth and innovative thinking and might be the start of a new era, which is needed to keep antimicrobials working and available for the future generations both in human and veterinary medicine.

Understanding the Pandemic: Pathophysiology, Transmission, and Treatment of COVID-19 aims to cover all aspects of COVID-19 infection from the virus, transmission, pathogenesis, immune-inflammation response, systemic injury, organ damage and associated factors comorbidities that drive mortality. Treatment protocols and the vaccination paradigm will also be discussed. Organized into ten sections, the book aims to provide a comprehensive examination of the impact of COVID-19. The book begins a review of coronaviruses, their structure and mechanism of action. The book goes on to discuss the immune response to the virus and its effect on various organs. It examines clinical cases based on an observations and postmortem studies. Other topics include the long-term effects of COVD-19, vaccines, and public health response. • Discusses coronavirus, their similarities and differences in origin and transmission as well as a review of their structure and mechanisms of action• Examines the immune-inflammation responses to COVID-19 and the organ-specific impact of the disease• Covers vaccines and other treatment protocols and public health responses in various geographic locations

This book comprehensively reviews the intricate relationship between environmental toxicants and the gut microbiome. It explores the role of dietary choices and lifestyle in shaping and modulating the gut microbiome's response to environmental toxicants. It examines the intricate relationship between these toxic substances and the composition, function, and overall health implications of the gut microbiome. The chapters provide in-depth insights into the impacts of various toxicants, such as phthalates, pesticides, organic pollutants, bisphenols, and heavy metals, on the delicate microbial balance within our digestive systems. Specific chapters address the impact of lead, mercury, cadmium, and arsenic on the composition and function of the gut microbiome. The book concludes by addressing future prospects and challenges in understanding and mitigating the impacts of environmental toxicants on the gut microbiome and highlighting the importance of these efforts.Key Features: Provides a comprehensive examination of the intricate relationship between environmental toxicants and the gut microbiome Reviews the possible mechanisms underlying bidirectional interactions between environmental pollutants and GI Examines the role of dietary choices and lifestyle factors in modulating the gut microbiome's response to environmental toxicants Covers the impact of toxic substances, phthalates, pesticides, and heavy metals on the gut microbiome Explores the practical implications of toxicant exposure on human health This book is intended for researchers and scientists working in the fields of environmental toxicology, microbiology, pharmacology, and related disciplines.

The book covers antimicrobial resistance in ocular diseases, including the microbiology of the ocular surface, the history and origin of antimicrobials, methods to detect antimicrobial resistance and antimicrobial resistance genes, and the impact of antimicrobial resistance on a variety of ocular diseases. The inclusion of chapters covers bacterial keratitis, fungal keratitis, viral keratitis, acanthamoeba keratitis, endophthalmitis, dry eye disease, post fever retinitis, and uveitis including management and prevention of antimicrobial resistance.Key Features: Focusses on various ocular diseases and their association with antimicrobial resistance; Includes data relevant to drug industry to develop drugs for specific ophthalmic use; Illustrates ocular surface microbiome under various diseased condition;s Highlights the microbes associated with the conjunctiva and cornea of the human eye; Enumerates the changes in the abundance and diversity of the antimicrobial resistant (AMR) microorganisms in the diseased eye. This book is aimed at professionals and researchers in ophthalmology, microbiologists, infectious disease specialists, and public health.

As with the much-praised prior editions, the third edition of Strelkauskas'Microbiology: A Clinical Approach remains a comprehensive introductory textbook written specifically for pre-nursing, nursing and allied health students. Clinically relevant throughout, it uses the theme of infection as its foundation, fitting closely with the'One Health'approach that is considered increasingly central to the effective control of zoonoses and to combatting antimicrobial resistance. The third edition has been thoroughly revised and updated to reflect the latest developments, including the emergence of the SARS-CoV-2 virus and associated COVID-19 pandemic. The book is accompanied by a robust instructor ancillary package that allows educators to incorporate readily the book's unique approach into their lectures and includes additional materials for students to supplement classroom learning and encourage and support study and self-reflection.Key Features: Student-focused, with all elements carefully designed to help students engage with and understand difficult concepts and to spark and hold interest Dedicated learning skill section introduces practical strategies for improving comprehension and retention Numerous text features further support learning and teaching, including chapter overviews, fast facts, case studies and human stories, and ‘why is this important?'highlights A variety of question-and-answer types for self-testing and reflection to support and assess basic learning, to challenge students to integrate important concepts and ask students to apply what they have just learned to a specific clinical setting or problem All supported by a comprehensive suite of online resources including lecturer support material and, for students, interactive questions, lecture notes, MicroMovies and the BugParade The book is an excellent resource to guide and support inter-professional education in the health sciences and an ideal entry-point to the subject for anyone coming from another discipline and invaluable supplementary reading for medical, microbiology and biomedical science students.

This book highlights microbial products and their applications in the health sector. The chapters introduce novel advancements and applications in different pharmaceutical and nutraceutical aspects of applied microbiology. Readers will obtain a detailed overview of the relevance of microbial metabolites to human health and nutrition. Besides knowing the products already developed, they will also get an idea of microbial products currently in the development pipeline and those that are likely to emerge as potential nutraceuticals. Readers will get an interesting and useful perspective on how supplementing food with microbes or their bioactive metabolites can realize the idea of'food as medicine'. This book introduces the biological activities of various microbial fermentation products, and how they are relevant to mitigating various disease conditions (e.g. neuropathy, diabetes, gut dysbiosis, malnutrition, etc.) in humans. One of the highlights of this volume is the exploration of microbial pigments as potential substitutes for synthetic colorants, offering safer and more sustainable alternatives for the food and healthcare industries. The book has equivalent contributions from experts in academia and industry to fill the communication gap between them. Through this book, readers will gain valuable insights into the historical perspectives, contemporary impacts, and future prospects of microbial applications in health and nutrition. From food preservation to biopharmaceutical production, the potential of microbial products to revolutionize our approach to health and wellness is undeniable.

Through five editions, and since 1993, Lactic Acid Bacteria: Microbiological and Functional Aspects has provided readers with information on how and why fermentation by lactic acid-producing bacteria improves the shelf life, palatability, and nutritive value of perishable foods and also how these microbes have been used as probiotics for decades. Thoroughly updated (with the current lactobacilli taxonomy) and fully revised, with a rearrangement of chapters into four sections, the Sixth Edition covers new findings on health effects, properties, production and stability of LAB as well as regulatory aspects globally. The new edition also addresses the technological use of LAB in various fermentations of food, feed, and beverage and their safety considerations. It also includes the rising concept of postbiotics and discusses new targets such as cognitive function, metabolic health, and respiratory health.Key Features: In 42 chapters, divided into 4 sections, findings are presented on health effects, properties and stability of LAB as well as production of target-specific LAB. Covers the revised ‘Lactobacillus'taxonomy Addresses novel topics such as postbiotics Presents new discoveries related to the mechanisms of actions of lactic acid bacteria Covers the benefits of LAB in fermentation of dairy, cereal, meat, vegetable and silage, including non-Western traditional fermented foods from Africa and Asia Discusses the less-known role of LAB as food spoilers Reports on the health benefits of LAB on humans and animals Covers the global regulatory framework related to safety and efficacy

This fully updated second edition demonstrates the major impact that the gut microbiota has on human gastrointestinal health, with a special focus on children. The book also explores the potential use of probiotic microorganisms to protect or improve gastrointestinal health in children. Humans are not a single organism: We are a multi-organic structure composed of ourselves and our microbiota, living in close symbiosis since birth and even before. The enormous impact that the billions of microscopic cells in our gut have on our gastrointestinal and systemic health cannot be overstated. The tremendous progress that has been made in the last decade in our still very incomplete understanding of the gut microbiota opens the door to potential applications in human health that were simply unthinkable before. One of the most interesting aspects of this new scientific horizon is the fact that we can identify (or even create in the lab) many of these'friendly bacteria'and use themto protect or improve our health. Thus, strains of probiotic microorganisms are being identified and studied in a variety of clinical scenarios. One of the most studied areas for probiotics is pediatric gastrointestinal health. Topics covered in this book range from the development of the intestinal microbiota in the fetus and neonate to current and potential applications in various conditions such as necrotizing enterocolitis or infectious or inflammatory diseases of the child. Written by an international group of preeminent experts in these fields in a rigorous, evidence-based manner, the book is intended for pediatric gastroenterologists, pediatricians, and medical scientists alike.

This Volume 1 of a two-volume work provides an up-to-date overview of the latest advances in live biotherapeutics research. It focuses on key areas within probiotics and microbiome studies from the veterinary sciences including their translation into commercial applications. The book is divided into three sections, comprising (I) fundamentals about probiotic resources, (II) probiotics for veterinary health, with chapters on farm animals, pets, wildlife and aquaculture, and (III) industrial applications of probiotics. The broad spectrum of industry-relevant contributions makes this work a valuable resource for industry professionals as well as researchers in functional feed and food biotechnology, applied veterinary microbiology and gastroenterology. Presenting novel and evidence-based research, this volume will drive the commercial enterprise and meets the great demand for good probiotic products in the veterinary medical sector.

This Volume 2 of a two-volume work provides an up-to-date overview of the latest advances in live biotherapeutics research, engineered and genome-edited probiotics. It focuses on key areas within probiotics and microbiome studies in human medicine, including their translation into commercial applications. The book is divided into three sections, comprising (I) biomedical and nutritional benefits of probiotics for human health, (II) post-genomic technologies in probiotics sciences and genome engineering, and (III) biosafety aspects and prospects of biotherapeutics. The broad spectrum of industry-relevant contributions makes this work a valuable resource for industry professionals as well as researchers in functional food and feed biotechnology, applied microbiology and gastroenterology. Presenting novel and evidence-based research, this volume will drive the commercial enterprise and meets the great demand for good probiotic products in the human medical sector.

This book introduces the rapidly evolving field of multi-omics in understanding the human microbiome. The book focuses on the technology used to generate multi-omics data, including advances in next-generation sequencing and other high-throughput methods. It also covers the application of artificial intelligence and machine learning algorithms to the analysis of multi-omics data, providing readers with an overview of the powerful computational tools that are driving innovation in this field. The chapter also explores the various bioinformatics databases and tools available for the analysis of multi-omics data. The book also delves into the application of multi-omics technology to the study of microbial diversity, including metagenomics, metatranscriptomics, and metaproteomics. The book also explores the use of these techniques to identify and characterize microbial communities in different environments, from the gut and oral microbiome to the skin microbiome and beyond. Towards theend, it focuses on the use of multi-omics in the study of microbial consortia, including mycology and the viral microbiome. The book also explores the potential of multi-omics to identify genes of biotechnological importance, providing readers with an understanding of the role that this technology could play in advancing biotech research. Finally, the book concludes with a discussion of the clinical applications of multi-omics technology, including its potential to identify disease biomarkers and develop personalized medicine approaches. Overall, this book provides readers with a comprehensive overview of this exciting field, highlighting the potential for multi-omics to transform our understanding of the microbial world.

Postbiotics: Health and Industry provides a detailed overview on the fundamentals, biological and therapeutic properties, safety, and application of postbiotics in health and industry. Sections cover the fundamentals of postbiotics, which include insights on probiotic microorganisms, postbiotics, and host–microbe interaction, analysis, and characterization of postbiotics. The book goes on to delve into the different types of postbiotics and their mechanisms. Remaining sections explore various health, pharmaceutical, and industrial applications of postbiotics. - Provides an overview on the separation, characterization, and identification of postbiotics from probiotic microbes - Includes classes of postbiotics and their mechanisms of action - Discusses the safety of postbiotics in humans and animals and the use of multiomics to understand the effect of postbiotics on human physiology - Analyzes existing regulatory framework for postbiotics

This comprehensive book explores both the fundamental and practical aspects of microbial genetics, shedding light on viroids, viruses, phytoplasma, bacteria, fungi, and protozoa. Unveiling a fresh perspective, the book tackles traditional taxonomical debates by embracing DNA-based taxonomy, offering a novel approach to understanding phylogeny within this microbe realm. Furthermore, it delves into the exciting realm of metagenomics, revolutionizing the identification and classification of unculturable microorganisms. Written by leading experts, this essential reading material caters to students and researchers in Microbiology, Genetics, and Biotechnology.

Pollen is made up of many chemical constituents such as proteins, sugars, lipids, minerals and phytochemicals. These components make pollen products an excellent source of nutrients and antioxidants for consumers. However, mycotoxigenic fungi are also common in pollen, creating contamination from generated mycotoxins. With adequate monitoring, sampling, processing and storage of pollen the development of mycotoxins can be significantly prevented. Since pollen grain has strong membranes which can limit the bioavailability of some nutrients and phytochemicals, novel methods and pretreatments are required with special emphasis on microbiological pretreatment methodologies. Pollen Chemistry & Biotechnology summarizes current knowledge of the chemical composition of pollen, its importance as a functional food ingredient and its health promoting properties. As Introduction part a short elaborate about botanical characteristics and data, including morphology and anatomy of pollen and bee preferences, is given. Important factors such as the botanical and geographical origin, best practices for preservation of nutritional composition, bioactivity and safety of pollen are covered in full. The nutritional profile of pollen based on data for minerals, lipids and nutrients is presented. A detailed phytochemical profile of pollen based on data for phenolics, flavonoids, carotenoids, vitamins, bioactive compounds is also covered. Areas for the improvement of the bioavailability of different nutrients and bioactive compounds of pollen via applied pretreatments are presented, as are best practices for adequate pollen collection, procession and storage in order to obtain safe products. At the end, an overview about pollen bioactivity as reason to use it as source of pharmaceuticals is made.

This book is a comprehensive guide for industrial bioprocess development, covering major aspects of microbial processes and their role in biotechnology. It provides a selection of hyperproducers, microbial products, and metabolic engineering strategies for industrial production. It covers high cell density cultivation techniques product formation kinetics measurement and limiting parameters in large-scale process development. The first and second section of the book focuses on biotechniques, including spectroscopic concepts of light, wave, and electromagnetic theory, as well as absorption, fluorescence, phosphorescence, infrared, and Raman spectroscopy. It also covers the basic principles, concepts, biological applications, and other advanced techniques. The third section emphasizes microbial inventions and improvements in bioprocess development. It covers microbial products and recent developments in fermentation technology and also includes information on metabolic engineering. The fourth section related to microbial inventions and bioprocesses which include platforms for recombinant gene expression, as well as the development of recombinant heterologous expression systems such as E. coli, yeast, mammalian and insect cells, and plant cells used as biofactories. The fifth section of the book focuses on microbial product waste management in extreme environments, biomass waste management, bio-pulping, bio-bleaching, textiles, biofuels, and animal feed production. The book aims to provide a multidisciplinary opportunity on all aspects of microbial biotechnology. It covers recent international developments that have renewed interest in industrial microbiology and biotechnology. The book is suitable for teachers, researchers, graduate and post-graduate students, environmentalists, microbiologists, and biotechnologists.

This fully updated second edition outlines the currently available clinical, epidemiological and experimental data on Clostridioides difficile infections(CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are taken into consideration for their relevance from epidemiological and evolutionary point of view. The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. New topics included sporulation and membrane vesicles in C. difficile. The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment.

This book is an in-depth and comprehensive resource that addresses the growing crisis of antimicrobial drug resistance (AMR). This book delves into the complexities of AMR, offering a detailed exploration of the mechanisms behind resistance, the environmental and genetic factors that facilitate it, and the broad ecological impacts it has. This book begins with an introduction to antimicrobial drug resistance, setting a foundational understanding of the scope and scale of the problem. It then progresses into a thorough analysis of the mechanisms by which microbes develop resistance, such as genetic mutations and the acquisition of resistance genes through horizontal gene transfer. A significant portion of the book is dedicated to examining the environmental and genetic factors associated with antimicrobial drug resistance. Additionally, the text explores the impact of antimicrobial drugs on micro-biodiversity, shedding light on how these drugs disrupt microbial communities and the balance of ecosystems. This book also considers the indirect effects of antimicrobial drugs on flora and fauna, emphasizing the far-reaching ecological consequences of widespread antimicrobial use. A central theme of the book is the exploration of emerging strategies in antibacterial drug resistance management. It discusses novel mechanisms and interventions that are being developed to combat resistance, highlighting the innovative approaches and the challenges they face. This book also explores anti-virulence therapeutic approaches that target the virulence factors of bacteria rather than their viability, thus reducing the selective pressure for resistance. Other cutting-edge strategies include targeting microbial biofilms, which are structured communities of bacteria that are particularly resistant to antibiotics and developing targeted drug delivery systems to enhance the efficacy of antimicrobial treatments. Natural products are another area of focus, with chapters dedicated to the potential of algal products and lantibiotics as alternatives to traditional antibiotics. Further, the book addresses the challenges of water and sanitation in relation to AMR, emphasizing the role of inadequate infrastructure and poor practices in the spread of resistant microbes. The influence of poultry farming on AMR is examined, highlighting the extensive use of antibiotics in agriculture and its impact on resistance patterns. Advanced topics include the application of computational biology and nanotechnology in the fight against AMR. Computational biology aids in the prediction and design of new antimicrobial agents, while nanotechnology-based approaches offer innovative solutions for overcoming bacterial defences. This book also touches on the implications of the COVID-19 pandemic on antimicrobial drug resistance, discussing how the pandemic has influenced resistance patterns and healthcare practices. It concludes by framing AMR as a global menace with significant social health and environmental implications, stressing the urgent need for coordinated global action. This book is an essential reference for researchers, healthcare professionals, and policymakers. It provides a holistic view of the AMR crisis and offers a diverse array of strategies to mitigate this critical global health threat.

This reference book compiles the latest techniques and applications of microbiome engineering. Microbial communities interact dynamically with their hosts, creating a considerable impact on the host and their ecosystem. This book introduces readers to microbiomes and microbiome engineering. It covers topics like omics tools in microbial research, strategies to engineer human microbiomes, the application of synthetic biology to build smart microbes, and the future of microbiome engineering. It includes the application of microbiome engineering in improving human health, livestock, and agricultural productivity. The book is intended for researchers and students in the fields of microbiology and biotechnology.

Microbial biofilms: Role in Human Infectious Diseases focuses on new and emerging concepts in microbial biofilm research, such as the mechanisms of biofilm formation, biofilm-induced pathogenesis, biofilm detection/and diagnosis, gene exchange within biofilms, strategies to control microbial biofilms and the burden of biofilm associated infections. In addition, it highlights the various anti-biofilm strategies such as surface coating, signal quenching, novel compounds that can be translated to curb biofilm-associated infections and the escalation of antimicrobial resistance determinants. Microbial biofilms can be a serious problem in medical settings as they are associated with significant mortality and morbidity. Infection related to biofilms increases recovery time and the cost of disease management. Biofilms are resistant to known antibiotics and human defense mechanism. In addition, due to close proximity of microbes within biofilms, increase genetic transformation has been detected results in increases frequency of antibiotic gene spread. With the advancement in science and technology, novel strategies have been proposed to combat the impact of biofilms on human health. - Fulfills the knowledge gap in biofilm study - Focuses on new and emerging concepts in microbial biofilm research - Highlights the various anti-biofilm strategies - Provides concise, thorough and up-to-date information about the important role of microbial biofilms in human diseases

Bioactive ingredients, including both bioactive compounds and bioactive live organisms, are present in small amounts in natural sources such as fruits and vegetables. These ingredients have been continuously investigated during the last few decades and the epidemiological data suggest that their intake is associated with significant decreased risk of various disorders and chronic diseases owing to their anti-oxidant, anti-bacterial and anti-inflammatory qualities. Some of these natural ingredients such as catechins, curcumin, resveratrol, oleuropein, quercetin, rutin, hesperidin, sulforaphane, ellagic acid, and anthocyanins, have been studied as factors with possible direct or indirect effect on specific molecular pathways which are playing vital roles in the association with the pathophysiology of the chronic diseases such as cancer. In light of this, natural foods and food-derived products rich in bioactives have received recent growing attention. It has been reported that frequent consumption of fruits, vegetables, and their associated natural products have many health-promoting benefits that protect against degenerative illnesses including heart disease, arthritis, cancer, immune system decline, brain dysfunction, inflammation and cataracts. Functional foods and medicinal supplements containing encapsulated bioactive materials will be the future of new emerging products in the food and pharma industries. Such products present therapeutical and medicinal properties that can prevent and/or cure specific chronic diseases and disorders. Handbook Of Bioactive Ingredients provides a systematic overview of different food bioactive ingredients describing their chemistry, structure, functionality, safety/toxicity, oral delivery and their applications in functional foods. Detailed chapters will describe various bioactive ingredients including polyphenolic compounds such as phenolic acids, flavonoids and anthocyanins, carotenoids, sterols such as non-oxygenated carotenoids, xanthophylls and phytosterols, bioactive peptides such as marine bioactive peptides, animal bioactive peptides, plant bioactive peptides, microbial bioactive peptides, essential fatty acids like fish and marine oils and plant oils, live organisms like probiotics and yeasts, essential oils and oleoresins like monoterpens, sequiterpens and oleoresins, vitamins and minerals including liposoluble vitamins, hydrosoluble vitamins and trace minerals), and other bioactive compounds including prebiotics, oligosaccharides, dietary fibers and beta-glucan. This book is the first comprehensive collection of scientific evidence form published literature on natural bioactive ingredients.

The excessive use of antibiotics has given rise to an increase in microbial resistance, threatening our ability to treat infectious diseases. The growth in resistance to antimicrobials and antibiotics threatens to reverse almost a century of medical progress. urgent action plans to tackle the crisis of Antimicrobial Resistance (AMR) and multi-resistant bacteria are needed. It is a major research task to find effective ways to reduce the release and degradation of antibiotics and ARBs to the environment. Degradations of Antibiotics and Antibiotic Resistance Bacteria from various sources addresses various issues related the generations and degradations, eliminations of antibiotics and antibiotics resistance bacteria. Degradations of Antibiotics and Antibiotic Resistance Bacteria from various sources contains both practical and theoretical latest and broad aspects of antibiotics and antibiotics resistance bacteria management through the various recent methods. Various factors which are responsible for the efficient degradations are highlighted in the Degradations of Antibiotics and Antibiotic Resistance Bacteria from various sources as separate chapters. Socioeconomic and policies on the ARBs are also discussed. - Contains both practical and theoretical latest and broad aspects of antibiotics resistant bacteria - Emphasizes the health impact of antibiotic resistance and genes - Gives insight in the applications of anaerobic digestions for eliminations of ARBs (antibiotic resistance blockers) and ARGs (Antibiotic Resistance Genes) - Shows how ARB's influences the degradation processes and management

Viral, Parasitic, Bacterial, and Fungal Infections: Antimicrobial, Host Defense, and Therapeutic Strategies highlight diverse types of infections, including viral, bacterial, parasitic, fungal, and the therapeutic efficacy of antibiotics, antivirals, antifungals and other medications, nutraceuticals, and phytotherapeutics. This book addresses the molecular, pathophysiological, and cellular pathways involved in the process of infection. It also examines the host defense mechanisms modulated by innate and adaptive immunity. The book starts off with an introduction, which includes etiology, pathophysiology, and diagnosis of infections. It then goes on to cover a wide spectrum of salient features involved in viral, bacterial, parasitic, and fungal infections and effective therapeutic strategies. In addition, there is a complete section of eight chapters elaborating the detailed aspects of COVID-19 infections, Mucormycosis, Omicron, and strategic vaccines and therapeutics. The book further goes on to discuss novel antibiotics, vaccines, bromhexine, boron compounds, phytotherapeutics, and aspects on boosting immune competence. Contributed by experts in the fields of viral, parasitic, bacterial, and fungal infections, the book comprehensively details the various types of infections such as herpes and COVID-19, their molecular mechanisms, and treatment strategies for those engaged in the research of infectious diseases. - Details the pathophysiology of various classes of infections - Examines mechanisms of pathogenesis, immunity, and therapeutics in bacterial, viral, and eukaryotic infectious diseases - Discusses various aspects on herpes, COVID-19 infections, Mucormycosis, Omicron, vaccines, and therapeutics - Covers the salient features on zoonosis, prion disease, and diabetic foot infections - Provides therapeutic strategies of using new antibiotics, vaccines, bromhexine, boron compounds, structurally diverse phytotherapeutics, immune enhancers, and other modalities for treating infections

This book elucidates the role of microbial genomic islands (GEIs) in genome stability, plasticity, evolutionary adaptation, and pathogenicity in the bacterial population. The initial chapters of the book present tools, including bioinformatics, artificial intelligence, machine learning, next-generation sequencing, and molecular biology techniques, for the analysis of the genomic islands. The book also discusses the importance of genomic islands in bacterial speciation, acquisition of genes related to resistome, nitrogen fixation, mobilomes, and nutritional fitness and adaptation. It provides recent advances in understanding microbial genomic islands'distribution, evolution, and mechanistic modes of behavior in pathogenic, non-pathogenic, and environmental species. This book is a valuable source for beginners in molecular microbiology, students, researchers, clinicians, stakeholders, and policymakers interested in understanding the role of GEIs in the adaptive evolution of microorganisms. ​

The discipline of mycology is a fascinating one. It has a major influence on the nutrition, health and environmental safety of mankind. Cultivation of edible and non-edible mushrooms for nutrition, pharmaceuticals, biopolymers and biocomposites will open up new avenues in research as well as the more profitable utilization of agricultural residues. Cultivation and of domesticated and wild mushrooms poses a challenge to fulfill the needs of human/animal nutrition and utilization of agrowastes tangibly. Cultivation of ectomycorrhizal fungi benefits nutrition as well as plant protection. Macrofungi are the major source of several metabolites of nutritional, health, agricultural and industrial significance (e.g., antioxidants, antimicrobials and pigments). Macrofungal bio composites provide alternatives to the use of animal-derived or plant-derived products (e.g., nanopapers, leather and packaging materials). They serve a dual role in providing nutrition and pharmaceuticals (nutraceuticals) to humans as well as livestock. Macrofungi interact with insects symbiotically (e.g., Termitomyces with termites) and provide delicious nutraceutical product. They also control insects by infecting and producing pharmaceutically and metabolite-rich products (e.g., Cordyceps attacks insects). Macrofungi have a strong potential to control pathogens like nematodes in soil (bioremediation). They are also useful as biofertilizers to meet the needs of plant nutrition.The book outlines current advances in macrofungal technology. It highlights different facets of macrofungal cultivation, bioactive compounds, biocomposites, nutraceuticals, benefits with interaction with insects, application as biofertilizers and ecosystem services like bioremediation.

The fourth edition of “Textbook of Microbiology and Immunology” is an extensively revised edition, a healthy mixture of the old and the new contents. Many of the old traditional chapters have been retained with addition of new information along with the inclusion of new chapters more in line with the on-going changes in the syllabus and concepts in Medical Microbiology.While doing so, this book has blended the traditional organism-based learning and a syndrome based approach to infectious disease, together with the introduction of new and modified chapters incorporating the latest information in this field.The book provides an extensive coverage of fundamental topics in general and medical microbiology. The book also lays due emphasis on clinical microbiology with special focus on syndrome based approach to infectious diseases. It includes the basic concepts of microbiology as well as the recent updates and developments in the field of medical microbiology. All the topics havebeen incorporated in seven major sections: General microbiology, Immunology, Bacteriology, Virology, Mycology, and Applied and Clinical Microbiology.The dynamic nature of medical sciences with new guidelines and new diagnostic methods coming into the arena necessitates the incorporation of new information in each new edition of a book. This facet has been addressed with the inclusion of recent information on the various aspects of microbiology, infectious diseases and immunology, in the fourth edition of the Textbook of Microbiology and Immunology,which makes it one of the most authoritative and informative textbooks in medical microbiology.The book is an effort to inform and engage a wide spectrum of readers including medical students, both undergraduates and postgraduates, and residents, and faculty. It aims to be a must-have companion book for graduate and advanced undergraduate as well as postgraduate students of medical microbiology, general and allied microbiology, and of immunology.

••Selected for Doody's Core Titles® 2024 in Microbiology••Understanding Microbial Biofilms: Fundamentals to Applications focuses on the microbial biofilms of different environments. The book provides a comprehensive overview of the fundamental aspects of microbial biofilms, their existence in nature, their significance, and the different clinical and environmental problems associated with them. The book covers both the fundamentals and applications of microbial biofilms, with chapters on the introduction to the microbial community and its architecture, physiology, mechanisms and imaging of biofilms in nature and fungal, algal, and bacillus biofilm control. In addition, the book highlights the molecular and biochemical aspects of bacterial biofilms, providing a compilation of chapters on the bacterial community and communication from different environments. Finally, the book covers recent advancements in various aspects of microbial biofilms including the chapters on their biotechnological applications. All the chapters are written by experts who have been working on different aspects of microbial biofilms. - Illustrates fundamental aspects surrounding microbial biofilms, along with recent advancements - Provides an overview on the principal aspects of biofilms, i.e., formation, regulation, distribution, control, and application - Updates on the progress on biofilm regulation through'omics'- Serves as a classical manual for all researchers, academicians, and students who would want complete insights on biofilms in a single resource - Covers all recent advancements and amendments on microbial biofilms

The novel viral pandemic coronavirus disease 2019 (COVID-19) has sparked uncertainties and controversies as to its origin, epidemiology, and natural course. In this situation, the medical disciplines have strived to contribute to a better understanding of the disease with the best available evidence gained from the scientific method of observation and statistics. The study of the cutaneous manifestations of COVID-19 has evolved with the hope that they may be useful as markers for the disease, for prognostication, and further insights into the pathogenesis of the disease manifestations. In the wake of COVID-19, we have decided to take a more general look at the hair and scalp in infectious disease. Specifically, we must recognize that infectious diseases have wider preconditions besides the infectious agents, to include environmental and societal factors. Unless we also take account of the ecological, immunological, and behavioral circumstances that affect the emergence and spread ofinfectious diseases, including those of the hair and scalp, our knowledge of the pathogens and their connection to clinical disease presentation remain only partial and incomplete. This book aims at illustrating in detail the environmental and individual preconditions, the pathogens, the clinical presentations, and the management of the infectious diseases that affect the hair and scalp, to include superficial and deep bacterial, fungal, and viral infections, infestations, systemic infectious diseases causing hair loss, their effective treatment, and their prevention. Hair in Infectious Disease offers a complete overview of infectious hair disease and guides the practitioner in the choice of the best treatment; it will be a valued companion to board-certified dermatologists and dermatologists in training.

The second volume of the Book-Industrial Microbiology and Biotechnology covers various emerging concepts in microbial technology which have been developed to harness the potential of the microbes. The book examines the microbes-based products that have widespread applications in various domains i.e., agriculture, biorefinery, bioremediation, pharmaceutical, and medical sectors. It focusses on recent advances and emerging topics such as CRISPR technology, advanced topics of genomics, including functional genomics, metagenomics, metabolomics, and structural and system biology approaches for enhanced production of industrially relevant products. It further gives an insight into the advancement of genetic engineering with special emphasis on value-added products via microalgal systems and their techno-economics analysis and life cycle assessment. The book towards the end presents recent advancements in the use of microbes for the production of industrial relevant enzymes, amino acids,vitamins, and nutraceuticals, on vaccine development and their biomedical applications. The book is an essential source for researchers working in allied fields of microbiology, biotechnology, and bioengineering.

A significant portion of basic and applied life science research requires microorganisms as study specimens. Managing Microorganisms aims to be the standard reference for anyone who works with microorganisms, primarily bacteria and fungi. It is applicable to researchers who maintain their own collections of strains, and those who use one of the many public service culture collections. The book includes coverage of: · methods of preservation and characterization for different groups of microorganisms; · best practice guidelines for culture collection management; · how to protect investment in research with microorganisms; · where to source authenticated microorganisms; · how to store, handle and distribute microorganisms effectively and safely; · the factors to consider in designing a sustainable business plan for a culture collection; · the consideration of health and safety issues, and the wider regulatory environment. Managing Microorganisms is an essential reference for anyone working with microorganisms and culture collections. In addition, it will be of great use for academic researchers and students in applied life sciences, especially those who are involved in sourcing and maintaining reference strains, whilst it also will provide a useful guide for consultants, biotechnologists and other members of bioindustry.

This edited volume studies gut microbiota peculiarities in elderly, in senescence-related and environmental-related alterations of gut microbiota in chronic diseases. Aging, as a physiological process mediated through several regulatory pathways and transcription factors, is generally speaking associated to a relentless functional decline and increasing risk of chronic diseases. Growing data on gut microbiota quali-quantitative changes in aging gut, and the opportunity to study by advanced NGS and metabolomic technologies, now offers novel horizons to link such changes to disease risks and to theoretically the weapons for gut microbiota intervention as an effective therapeutic tool. Chapters are divided into clear sections, starting with the aging perspective, then moving from chronic diseases to neurodegenerative diseases and cancer. The final parts focusses on interventions. Contributors are well-reputed and dedicated scientists in clinics and experimentalmedicine from 4 different continents who have provided their contribution keeping the polar star on aging as a guide while investigating their gut microbiota in occurrence and progression of disease together with proposed preventing, monitoring and therapeutic interventions. In the wide offer of books on gut microbiota, this age-thematic volume will be a valuable source of updated information for a wide group of readership including gerontologists, geriatricians, medical specialists of several fields, PhDs, basic scientists and public/private research entities focused on potential intervention in and through gut ecosystem. This book will stimulate a large number of basic scientists and clinicians to review their once organ (or cellular line)-specific knowledge and widen either their pathophysiological mechanisms understanding while providing novel ways to prevent, monitor and treat diseases from eyes to bones.

Kokken, Stäbchen, Pilze, Viren, Prionen, Parasiten und Co.? die Medizinische Mikrobiologie ist komplex und vielfältig. Aber keine Sorge, Ralf-Peter Vonberg und Christina Haese führen Sie Schritt für Schritt in die mikrobiologische Welt ein und erklären Ihnen alles, was Sie über pathogene Mikroorganismen und deren Bekämpfung wissen müssen. Dabei erläutern sie klar strukturiert das Wichtigste über Prävention, Diagnose und Behandlung von Infektionskrankheiten und richten sich dabei nach dem IMPP-Gegenstandskatalog.

Aeromicrobiology provides a detailed and systematic analysis of the microbial communities and toxins collectively called bioaerosols that can be found in air. It provides information on the basics of Aeromicrobiology, the fate and transport of microorganisms in air, and the fundamental differences between intramural and extramural Aeromicrobiology. Leaning heavily on the current state of science, detailed information on the sampling and analysis of bioaerosol samples is provided. Subsequent chapters comprehensively discuss various airborne microbial groups and toxins, while the final chapter is dedicated to bioaerosol control strategies, biosafety, and biosecurity. There are limited resources on Aeromicrobiology. In rare instances where there are resources on Aeromicrobiology, they are often restricted to chapters in books or even supplementary materials. The emergence of new airborne pathogens, the aerosolization of microorganisms hitherto believed not to be airborne, and the proliferation of technologies for sampling, analysis, and control of bioaerosols makes it imperative for this title, which streamlines and succinctly presents the new body of knowledge in the field. - Leans heavily on current state-of-the-art technologies used in sampling and analysis of bioaerosol samples such as metagenomics and sensor-based, hybrid technologies, among others - Dedicates considerable attention to airborne and droplet-borne viruses, against the background of SARS-CoV-2 and related pathogens - Comprehensively attends to regulatory aspects of bioaerosol control, highlighting various policies and regulations aimed at achieving biosecurity and curbing bioterrorism - Helps researchers and policy makers in various fields who are often confronted with the need for basic information delivered in seamless style without loss of essential content

La « Microbiologie de Prescott », un ouvrage de référence, décrit la microbiologie dans ses aspects fondamentaux, médicaux, écologiques, alimentaires et industriels. La'Microbiologie de Prescott'est traduction en français de la 12e édition du grand classique de la Microbiologie, le «Prescott's Microbiology». Un grand soin a été apporté à faire le tour des connaissances actuelles sur la pathogenèse des principaux micro-organismes pathogènes et sur les mécanismes de défense naturelle et acquise de l'hôte contre eux. L'ensemble des chapitres a fait l'objet d'une mise à jour en profondeur, en particulier ceux traitant des sujets autour du SARS-CoV-2, des avancées en matière de cryo-microscopie électronique, de la taxinomie des bactéries, etc.

In this exciting update, readers will learn how feeding direct-fed microbials (including eubiotics, postbiotics, prebiotics, and synbiotics) is becoming increasingly widespread during food animal production. Animal production must improve efficiency of growth, and the use of direct-fed microbial and prebiotic additives to domestic animals has become widely accepted and utilized. The benefits of probiotic-type approaches in cattle, pigs, fish, and poultry, include improved general animal health, reduced foodborne pathogen populations, increased growth rate and feed efficiency, improved milk and egg production, and have been reported world-wide. Successes from probiotic approaches in multiple species have ensured their adoption; however, several fundamental questions remain. Early establishment and retention of an ecological balance in the gastrointestinal tract is an important first step for an external biological additive to be effective in young animals, suggesting that some of the benefits of direct-fed microbials may be due to an early establishment of a “normal” native gut microbial population. Research has indicated that the establishment of a normal population can enhance gut epithelial integrity, preventing inflammation and improving animal health. Thus, it is important that we understand the key processes that occur during the establishment of the gut microbial population that can impact gastrointestinal fermentation and provide protection against pathogens of the animals and of human consumers. Knowing how these processes work and how they impact animal energy and protein expenditures can guide further improvements of available and future commercial products. Exciting research opportunities are discussed in this book, examining different characteristics of DFMs that are fed to animals to meet different production demands in different production scenarios (e.g., beef versus dairy versus swine versusfin fish). The advent of molecular and next-generation sequencing offers methods of developing tailored DFMs, and of early detection of successful DFM establishment in the gut. These techniques will further deepen our insight into understanding the microbial population of the gut and how these populations impact animal health, food safety, and sustainability of animal-derived protein production.

This book gives a comprehensive overview of recent advances in the valorization of agri-food waste and discusses the main process conditions needed to overcome the difficulties of using waste as alternative raw materials. It also discusses specific methodologies, opportunistic microbes for biomass valorization, the sustainable production of agri-food waste, as well as examines the assessment and management of bioactive molecules production from microbial-valorization of agri-food waste. The authors provide technical concepts on the production of various bio-products and their commercial interest including agri-food waste utilization in the microbial synthesis of proteins, the valorization of horticulture waste, the sustainable production of pectin via microbial fermentation, as well as other food and pharmacological applications. This book is intended for bioengineers, biologists, biochemists, biotechnologists, microbiologists, food technologists, enzymologists, and related professionals and researchers. Explores recent advances in the valorization of agri-food waste Provides technical concepts on the production of various bio-products of commercial interest Discusses the main process conditions to overcome the difficulties of using waste as alternative raw materials Introduces technical-economic details on the advantages and disadvantages of exploring the waste recovery chain Explores the main technological advances in the recovery of residues in functional products

Molecular Medical Microbiology, Third Edition presents the latest release in what is considered to be the first book to synthesize new developments in both molecular and clinical research. The molecular age has brought about dramatic changes in medical microbiology, along with great leaps in our understanding of the mechanisms of infectious disease. This third edition is completely updated, reviewed and expanded, providing a timely and helpful update for microbiologists, students and clinicians in the era of increasing use of molecular techniques, changing epidemiology and prevalence, and increasing resistance of many pathogenic bacteria. Written by experts in the field, chapters include cutting-edge information and clinical overviews for each major bacterial group, along with the latest updates on vaccine development, molecular technology and diagnostic technology. - Completely updated and revised edition of this comprehensive and accessible reference on molecular medical microbiology - Includes full color presentations throughout - Delves into in-depth discussions on individual pathogenic bacteria in a system-oriented approach - Includes a clinical overview for each major bacterial group - Presents the latest information on vaccine development, molecular technology and diagnostic technology - Provides more than 100 chapters on all major groups of bacteria

This book examines the role of human microbiome in human health and diseases. The initial chapters present tools for genetic manipulation of gut microbiota and the therapeutic applications of engineered microbiota. They discuss the interaction between human microbiota and host in defining the prominent role of microbes in the development and progression of major human diseases. The book also summarizes the current applications and trends for the development, production and analytical characterization of recombinant therapeutic proteins in microbial systems. It also reviews the role of microbes in the production of vaccines and antibiotics. Further, the book presents bacterial products, including proteins, enzymes, immunotoxins and secondary metabolites, that target cancer cells and cause tumour regression. The chapters also discuss the critical role of gut microbiota dysbiosis in the pathogenesis of autoimmune disease and in bowel-related diseases. Towards the end, the book exploresthe role of intestinal microbiota in metabolic health and the pathogenesis of common metabolic disorders. It presents state-of-the-art insights into important aspects of United Nations—Sustainable Developmental Goal 3.

The Latin American region has been at the forefront in combating infections caused by Escherichia coli strains in humans, animals, and the environment. The continuous emergence and evolution of pathogenic E. coli strains associated with human and animal infections have demonstrated that (i) groups of related pathogenic E. coli are responsible for most infections caused by this bacterial species; (ii) diverse virulence phenotypes expressed during infection defined each one of these pathogroups; (iii) the geographical distribution of pathogroups in Latin America and the evolution of new isolates was defined by the dominant pathogroup and presence of distinct virulence strains; (iv) acquisition of mobile elements or accumulation of point mutations accelerate the development of antibiotic resistance in some of these strains. The Latin American Coalition for Escherichia coli Research (LACER), a multidisciplinary network of over seventy research groups in eleven Latin American countries and the USA, was established in 2009 to apply One Health principles in defining and combating this pathogen. The previous edition of this text, Escherichia coli in the Americas (c. 2016) was the culmination of their wisdom about E. coli, from its role as a commensal bacterium to its characteristics as a pathogen causing disease in animals and humans. This new edition presents recent advances and contextualizes all aspects of E. coli in a One Health perspective, from the environment, to animals, to humans. It addresses E. coli interactions with host microbiota, CNS, and phages. It includes cutting edge insights on hybrid strains, molecular mechanisms of virulence and pathogenesis, resistance, domestic and wild reservoirs, disease surveillance in Latin America, genomic analysis, food safety, and new therapies. Crucially, it also provides translations and analysis of key reports on Escherichia colipublished in Spanish and Portuguese. This book serves as a critical resource for scientists in industry and academia, clinicians managing associated infections, and trainees and students studying basic and clinical aspects of E. coli pathogenesis.

This book explains the potential value of microbiome and microbiome composition associated with human health and diseases. The opening chapters describe the current state of knowledge regarding the human microbiome structure, function, and diversity. The mechanisms of action and the various putative uses of human microbiome are then examined specific to healthy and disease conditions. Readers will find detailed information on its manipulation of human microbiome studies as well as its applied and translational aspects in the current field. The latest knowledge on probiotics, prebiotics, synbiotics, and postbiotics is presented, and specific cases to date are discussed. This book features knowledge from leading researchers working on different aspects of the human microbiome and its manipulation for better health. Overall, this book is an excellent source for microbiome researchers and students from all levels seeking the most up-to-date advancements in the field and also to point toward the future directions.

Basic Biotechniques for Bioprocess and Bioentrepreneurship deals with the entire field of industrial biotechnology, starting from the basic laboratory techniques to scale-up, process development, demonstration, and finally its commercialization. The book compiles currently scattered materials on this topic and updates this information based on practical experience and requirements. The book will be an ideal source for new entrepreneurs who wish to start their own commercial units. - Offers guidance for readers/researchers/start-ups/entrepreneurs on how to develop new microbiological and biotechnical processes - Focuses on basic knowledge and possible solutions to the practical difficulties at all levels in one place through understanding of basic techniques in lab, during bioprocess development, commercialization, technology transfer, marketing, and others which is presently not available in the field - Provides multifaceted coverage, with industry insights from experienced practitioners and leaders in the field - Gives possible best solutions to the practical difficulties at all levels, i.e. lab, scaleup, and commercial stage - Addresses ethical and other regulatory issues

Microbial Biomolecules: Emerging Approach in Agriculture, Pharmaceuticals and Environment Management explores and compiles new aspects of microbial-based biomolecules such as microbial enzymes, microbial metabolites, microbial surfactants, exopolysaccharides, and bioactive compounds and their potential applications in the field of health-related issues, sustainable agriculture and environment contamination management. Written for researchers, scientists, and graduate and PhD students in the areas of Microbiology, Biotechnology, Environmental Science and Pharmacology, this book covers the urgent need to explore eco-friendly and sustainable approaches to healthcare, agriculture and environmental contamination management. - Explores eco-friendly and sustainable approaches to healthcare, agriculture and environmental contamination management - Compiles new aspects of microbial-based biomolecules - Proves that the use of microbes or microbial products are suitable alternatives to manage the current challenges of healthcare issues, chemical pesticides and environmental contamination

This work sheds new light on the interplay between the gut, gut microbiota, and host physiological processes in production animals.The gut microbiome shapes health and susceptibility to disease and has become a leading area of research in the animal sciences. Gut health encompasses a number of physiological and functional features. Nutrient digestion and absorption, host metabolism and energy generation, a stable microbiome, mucus layer development, barrier function, and mucosal immune responses; all of which are required to interact to make an animal perform physiologically and according to its greatest genetic potential.This carefully presented book broadens our vision, approach and results on gut health and the ability to regulate animal production. Understanding the chemistry of microbiomes has broad implications, including providing functional annotations for the microbial genomes, insights into the chemical languages that link microbes to each other and to their host, and translational implications for precision veterinary medicine, environmental health, and sustainable animal agriculture and welfare. Experts working in microbiome research, host immunity, and animal production, veterinarians and researchers in livestock science will understand the great importance of this volume.

This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health. Original research and review articles present and discuss multidisciplinary findings and developments on various aspects of microbiology, infectious diseases, and their diagnosis, treatment and prevention.The book series publishes review and original research contributions, short reports as well as guest edited thematic book volumes. All contributions will be published online first and collected in book volumes. There are no publication costs.Advances in Microbiology, Infectious Diseases and Public Health is a subseries of Advances in Experimental Medicine and Biology, which has been publishing significant contributions in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. 2020 Impact Factor: 2.622. 5 Year Impact Factor: 3.049; Cite Score: 3.9;Eigenfactor Score: 0.03583; Article Influence Score: 0.602

This book highlights important aspects of food biotechnology. It is very thoughtfully divided into five sections. The first section introduces the readers to food biotechnology and discusses functional foods, use of plant and animal biotechnology in improving food quality. The second section deals with food microbiology and includes topics such as application of microbial surfactants, use of probiotics, beneficial microorganisms used in food industry etc. The third section describes important macro and micromolecules in foods. It includes chapters on food enzymes, gluten free formulations, use of biopolymers, biofortification of food and other important topics. The next section discusses novel technologies such as use of nanotechnology in food industry, reverse micelle techniques, genome editing in food crops etc. The book culminates with a section on food quality and management. It describes important topics about biosafety and regulatory issues in food biotechnology. This book is meant for students, researchers and course instructors in food science, food technology and biotechnology. It is also useful for industry experts in the area of food technology.

This timely book discusses antimicrobial drug resistance, specifically, the resistance against the beta-lactam class of antibiotics by Gram-Negative bacteria. The book is broadly divided into five sections. The first section describes the underlying mechanisms of antimicrobial resistance in Gram-negative bacteria. It gives an insight into the beta-lactamases, their types, classification, inhibitors, etc. The second section delves deep into the genetic basis of resistance. It talks about transposons, integrons, insertion sequences associated with antibiotic-resistant genes. The next section describes phenotypic and molecular methods to detect beta-lactam resistance. The fourth section talks about the epidemiology and prevalence of beta-lactamases in the environment. The last section of the book describes the various therapeutic options to combat this growing public threat of antimicrobial resistance. It talks about the current reserve drugs, as well as the newer antibiotic agents that are in the pipeline. This book is essential for clinical practitioners, students, and researchers in basic and medical microbiology.

The abundance of sulfate-reducing bacteria and archaea (SRBA) is impressive and new isolates are being reported continuously. A few decades ago, only two genera of sulfate-reducing bacteria (SRB) had been identified. As of 2018, 92 genera containing more than 420 species of SRB have been isolated and characterized and there are several species of archaea. This book addresses the development of the research with SRBA and includes historical background of this field. Biochemical characterization of the enzymes, cytochromes and electron carriers involved with dissimilatory sulfate reduction are reviewed and the presence of relevant genes in cultured and uncultured SRBA are assessed using genome analysis. The contributions of transmembrane electron transport complexes as related to cell energetics are discussed. This book highlights the unique cellular and molecular features of the SRBA and discusses the biochemical interactions behind their metabolic capabilities which enable SRBA to grow in extreme environments. Examples are provided to detoxify and alleviate pollution situations, to evaluate mechanisms proposed for corrosion of ferrous metals and to examine the effects of SRB on human and animal hosts.

Immunopathology, Diagnosis and Treatment of HPV induced Malignancies focuses on the human papilloma virus infection and associated cancers. In ten chapters, the book explains the deep knowledge about molecular mechanism in HPV pathogenesis and recent advanced tools applied in the field of HPV induced cancer and cures. In a nutshell, the book gives new insights and the associated challenges involved in the identification of promising drug and vaccine targets, current diagnostic tools, and advancements in current therapies against HPV induced cancers and other malignancies. - Highlights the concept of Human papilloma virus infection, its pathogenesis, mechanisms involved in host immune response, clinical manifestations, prophylactic and therapeutic strategies, and recent advancements for the cure of HPV induced cancer - Delineates new insights and challenges involved in the identification of promising drug and vaccine targets, current diagnostic tools, and advancements in current therapies against HPV induced cancer - Provides comprehensive and conceptual knowledge that could be a milestone not only in the field of infectious cancers but also for researchers and scientists working on infectious cancer

This book answers the question “What is it that viruses do?” by presenting three aspects of viral ecology. The first aspect explains how viruses affect the population diversity and energetics of their host communities. Perhaps the most notable example of this concept is our understanding that primary production within ecosystems often depends upon those viruses which serve as controllers of nutrient recycling, connecting the aquatic and terrestrial realms in ways that can be assessed locally and globally. The second aspect describes genetic partnerships which exist between hosts and their viruses. These include processes termed endogeny and lysogeny by which the host carries at least a partial genomic copy of the virus. Fluidity of these collective genomes is expressed on an evolutionary time scale and the mutual life cycles which they produce represent a forging of shared genomic fate that obligates partnership of the virus and its host. The viral sequences represent a source of potential benefit as well as potential peril for the host and can implement phenotypic changes in the host. Hosts often use those changes as tools. As humans, the most notable example would be that mammals rely upon temporary activation of their endogenous viral genes in order to successfully develop a placenta. The third aspect is defending the health of a host, which relies upon activity in two directions. Hosts often use their captured viral genes to identify and subsequently direct battle against invading viruses. This natural concept has been engineered for combating cancer, is useful for suppressing the detrimental consequences of genetic diseases, and has been developed to create targeted antiviral vaccines. But, the defense has to work in two directions and the host can use other symbiotic microorganisms as protection against its viruses. This book will appeal to a wide readership by providing a broad perspective ofviral ecology, and all scientists will find it helpful for gaining a view of fields beyond their specialization.