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Biotechnology refers to the use or manipulation of an organism or parts of an organism. While the early applications were certainly simpler (though still relevant), modern plant biotechnology is primarily associated with molecular biology, cloning and genetic engineering. Over the last 50 years, several key discoveries have revolutionized the biological sciences and enabled the rapid growth of the biotechnology industry.This book gathers handpicked articles presented by national and international scientists at the International Conference on Biotechnology and Biological Sciences, BIOSPECTRUM 2017. It highlights the works of researchers and students in India and abroad on plant biotechnology and its applications in addressing various agricultural and food production-related issues.The respective papers explore a range of advances in plant biotechnology, e.g.: the cytotoxic potential of Moringaoleifera lam; the use of the entomo-pathogenic fungi Cordyceps sp. as unique and valuable sources of bioactive compounds; and strain improvement strategies for Cordyceps sp. In addition, they discuss the use of low-cost blue green algal biofertilizer comprising four blue green algal strains in rice fields; and the use of lignocellulosic materials as potential renewable energy resources for the production of fuels.This book will be extremely useful for researchers and students of biotechnology and plant science, providing an essential update on the latest findings and trends.

This book covers polyextremophiles, the latest biotechnological advances, and developments in the study of extremophilic diversity with a focus on genetics, proteomics and the impact of climate change. It sets out new perspectives on the polyextremophiles'mechanism of tolerance to extreme conditions, and it also outlines their applications in bioremediation, therapeutics, and astrobiology research. Expert contributors discuss topics such as genes associated with polyextremophiles, the applications of genome editing in extremophiles, secondary metabolites from extremophiles, and the biocatalytic potential of extemozymes isolated from extremophiles. Readers will find in this book several case studies that collate the diverse applications of polyextremophiles for bioremediation, including the use of extremophilic algae in wastewater treatment, nutrient recovery and animal feed production, the treatment of industrial waste, pharmaceuticals and personal care products, and the removal of microplastics, heavy metals and E-waste. Particular attention is given to the use of polyextremophiles for bioremediation of abandoned mining sites. The book also presents bioactive compounds from halophiles and their biomedical applications and discusses the implications of polyextremophiles in astrobiology research. Given its breadth, this book is a valuable contribution to the biotechnology of polyextremophiles by overviewing research to date and exploring challenges and opportunities for future research. It also benefits a broad readership, from scholars, researchers and students to industry professionals interested in the study and development of biotechnological applications of polyextremophiles.

This book provides a comprehensive and authoritative review of cyanobacteria and their applications as solar cell factories. Cyanobacteria are able to perform oxygenic photosynthesis and they are utilized in many different bioprocesses. The book covers two major aspects of a cyano-based bioprocess: the biological whole-cell catalyst and the technical environment in which the catalyst is applied. In the biocatalyst itself electron and carbon flow play an essential role for the performance of the cell and need to be tackled likewise for successful biocatalyst development. In the first chapters of this volume, cyanobacterial biotechnology and the fundamentals of cyanobacterial bioenergetics are introduced followed by an overview on tools and strategies for cyanobacteria engineering. Further on, examples of applications, engineering and production of different industrially relevant compounds in these organisms are provided, and finally process technology specific for cyanobacteria is covered. In this book, particular attention is given to topics such as cyanobacterial bioenergetics, metabolic engineering design strategies, utilizing cyanobacteria in biophotovoltaics, and production of pigments as well as photobiohydrogen in cyanobacteria, among others. This book will provide interested students and researchers in the area of photo-biotechnology with a deeper understanding of the cyanobacterial cell-factory, including the latest innovations and persistent challenges in the field.

This book provides an up-to-date overview of the biological functions of melanins, their biotechnological production, and their industrial applications. The melanins form a group of polymeric pigments found in most organisms. These natural products are generated by the oxidation of phenolic and indolic molecules yielding melanins, which include eumelanin, pheomelanin, pyomelanin, and the allomelanins. These pigments have diverse biological functions, including photoprotection, thermoregulation, antioxidation, virulence, and metal ion sequestration. Melanins have physicochemical properties that have proven useful in the optical, electronic, material, agriculture, cosmetic, pharmaceutical, and medical industries. The chapters in this book provide an in-depth analysis of the current issues and challenges in this field. Topics covered include the properties, biogenesis, and evolution of melanosomes. The book also addresses the synthesis and industrial production of melanins by microorganisms. The metabolic pathways for the synthesis of several types of polymeric pigments in microorganisms and their role in pathogenesis are reviewed. The large-scale production and purification of melanins to provide this product for industrial applications is a formidable challenge. Two chapters present and discuss the state-of-the-art used for the generation of microbial melanin-production strains and the processes for the biotechnological synthesis and purification of these pigments. Melanins are polymers that can interact with metals, a chapter reviews this capacity in the context of technological applications, including electrochemical energy storage and metal recovery. These polymers are materials having favorable characteristics for photonic applications, including UV blocking and broadband absorption. The current advances in the application of these pigments in optically active materials are presented and discussed.

Living organisms are distinguished by their chemical basis. Thus, knowledge of the properties of the elements and the interactions of the resulting compounds is a prerequisite for understanding biology.Chemistry answers the questions of why, among the more than 100 elements of the periodic table (PSE), carbon and not silicon is the dominant element in biology and why precious metals, such as gold and silver, do not play a role. The PSE provides information about why phosphoric acid and not sulfuric acid acts as a bridge in polynucleic acids and why DNA had to evolve from RNA. At the same time, only chemistry makes clear why D-glucose is so central in building biopolymers such as cellulose and glycogen, and why the citrate cycle is logically self-contained and without alternative. Biochemistry is also a synthesis chemistry that differs from'man-made'synthesis chemistry'only'in terms of the framework conditions. Individuals are selected from the multitude of elements of the PSE and the almost infinite number of chemical compounds. The selection is based on the environmental conditions on Earth, such as moderate temperatures, preferably atmospheric pressure, solvent water and as primary reaction partner oxygen.The hypothesis is developed that the guiding principle of modern biology, the theory of evolution, has its roots in the underlying chemistry. This turns Darwinism from its biological head to its chemical feet. For example, the effect of phenols as radical scavengers is a priori chemical, before biological phenomena could evolve from it as differences in distinction in colored flowering plants. The book develops a completely new, chemistry-centered view of'animate nature'and challenges a changed, biologically oriented didactics of chemistry in schools and universities.

This book is a compilation of the latest achievements of leading researchers in marine natural products with extremely diverse structures and biological activities. It presents discussions of isolation, structure elucidation, biosynthesis, total synthesis, and biochemical properties of the compounds with characteristic structures such as macrolides, cyclic depsipeptides, alkaloids, and water-soluble heterocyclic low-molecular-weight compounds, from sponges, bacteria, cyanobacteria, flagellates, and other such organisms. The book especially focuses on heterocyclic natural products as a title in the book series, Topics in Heterocyclic Chemistry.

This updated second edition covers the molecular biology, genome engineering tools and comprehensive analysis techniques for Corynebacterium glutamicum. Aside from modern omics-based approaches, the authors also focus on cell physiology, including cell division, central carbon metabolic pathways, and the respiratory chain. Readers will learn how primary mechanisms like energy metabolism can be applied in processes like biorefinery. Newly added topics include cell envelope structures and aromatic compound metabolism in C. glutamicum. These chapters will be particularly useful for those interested in the microbial production of commodity chemicals, fuels, and proteins. Corynebacteriacea are already some of the most important industrial microorganisms. Understanding the cell physiology of C. glutamicum will help manufacturers to increase their product range and productivity through efficient metabolic engineering.

Recent Developments in Applied Microbiology and Biochemistry, Vol. 2, provides a comprehensive treatment and understanding on application oriented microbial concepts, giving readers insights into recent developments in microbial biotechnology and medical, agricultural and environmental microbiology. - Discusses microbial proteome analyses and their importance in medical microbiology - Explores emerging trends in the prevention of current global health problems, such as cancer, obesity and immunity - Shows recent approaches in the production of novel enzymes from environmental samples by enrichment culture and metagenomics approaches - Guides readers through the status and recent developments in analytical methods for the detection of foodborne microorganisms

This book describes the structural features and properties of important types of hydrocarbons and lipids and gives an overview of their analytical characterization in biological and environmental matrices. It covers the occurrence, biosynthesis and biological functions of these compound types in diverse organisms including bacteria and archaea, algae, higher plants and arthropods. It examines their distribution in the geosphere and fundamental processes controlling the fate of fossil organic matter. Finally, it addresses important aspects of their environmental chemistry and transfer processes between different compartments of bio- and geosphere.Hydrocarbons and lipids comprise extremely diverse organic compounds that play fundamental roles in biosphere and geosphere. They represent important functional components in all living organisms and constitute a major fraction of fossil organic matter in sedimentary systems.All chapters are written by renowned experts in the respective fields.

The book uniquely covers all aspects of anaerobic biodegradation of the environmentally important hydrocarbons. The contributions by international experts cover the molecular characterization of unique biocatalysts for oxygen-independent C-H-bond functionalization, the identification of unifying concepts, and the presentation of state-of-the-art methodologies. The current knowledge of the global importance of anaerobic hydrocarbon degradation is highlighted.

This book is a compilation of the most relevant molecular mechanisms and cellular processes that are involved in the infection processes in relation to lipid metabolism. The authors are international experts in the field of infection biology. Readers will understand infection metabolism and the contribution of lipids and lipid-protein interaction to lipids.Microbial lipids play an important role in almost all cellular phenomena. Microbial infections also contain an important virulence component in microbial lipids. The secretion of lipid vesicles that contain virulence factors, the assembly of lipid membrane microdomains harboring signal transduction pathways relate to infection process and the number of lipid-protein interactions that are necessary for the internalization of pathogens to host cells are some examples of the importance of lipids and lipid metabolism in the development of infections.

This volume on astrobiology of the Springer Briefs in Life Sciences book series addresses the three fundamental questions on origin, evolution, distribution and future of life in the universe: how does life begin and evolve? Is there life beyond Earth and, if so, how can we detect it? What is the future of life on Earth and in the universe? The book provides insights into astrobiological experiments that are being performed on the International Space Station, ISS, and discusses their findings.This extremely exciting volume on astrobiology is intended for scientists of various research fields and for laypersons interested in space research and in the fundamental issues of the universe and life.

Recent Developments in Applied Microbiology and Biochemistry provides a comprehensive treatment and understanding on application oriented microbial concepts, giving readers insights into recent developments in microbial biotechnology and medical, agricultural and environmental microbiology. - Discusses microbial proteomics and their importance in medical microbiology - Explores emerging trends in the prevention of current global health problems, such as cancer and obesity - Shows recent approaches in the production of novel enzymes from environmental samples by enrichment culture and metagenomics approaches - Guides readers through the status and recent developments in analytical methods for the detection of foodborne microorganisms

Concise chapters, written by experts in the field, cover a wide spectrum of topics on lipid and membrane formation in microbes (Archaea, Bacteria, eukaryotic microbes).All cells are delimited by a lipid membrane, which provides a crucial boundary in any known form of life. Readers will discover significant chapters on microbial lipid-carrying biomolecules and lipid/membrane-associated structures and processes.

The new edition focuses on the latest information on mitochondrion-derived organelles, particularly on hydrogenosomes and mitosomes. It has become more and more evident that hydrogenosomes and mitosomes are just two specific members of larger family of organelles derived to various extent from mitochondria due to adaptation to oxygen-poor environment and to the parasitic life style. Since the 1st edition, investigation of free-living protists and commensals has revealed that there is a continuous spectrum of mitochondria-derived organelles from typical aerobic mitochondria, mitochondria with stepwise loss of respiratory chain complexes and with concomitant gain of anaerobic pathways (particularly hydrogenase), via hydrogenosomes and mitosomes to the newly discovered organisms that completely lost mitochondria. Most of the experimental data collected relates to the human pathogens Trichomonas vaginalis harboring hydrogenosomes, and Giardia intestinalis and Entamoeba histolytica with mitosoms. In principle, hydrogenosomes are hydrogen and ATP producing organelles, while the only known function in Giardia mitosomes is synthesis of iron-sulfur clusters, whereas mitosomes of E. histolytica possess the recently discovered sulfur activation pathway. Functions of other unusual mitochondria are mostly predicted based on transcriptomic/genomic analyses as corresponding organisms are not amenable to biochemical studies. Investigations on evolution and function of mitochondria-derived organelles substantially changed conventional views on mitochondrion from textbook models of an oxygen-consuming powerhouse of cells to a large family of organelles, variables in their structure and function in which hydrogenosomes and mitosome represent the most divergent anaerobic members.

This book describes the biochemistry and genetics of aerobic degradation of hydrocarbons and lipids by bacteria and yeasts, as well as the functional genomics of the best-known microorganisms involved in these processes. It forms part of the Handbook of Hydrocarbon and Lipid Microbiology Series, a definitive resource of current knowledge on the diverse aspects of the interactions of microbes with hydrocarbons and lipids. Chapters are mainly focused on the new discoveries of recent years. It is aimed to scientists and others interested in different aspects of the microbiology of hydrocarbons.

The book covers the microbiological, environmental and biotechnological aspects of alkane production. Alkanes are important energy-rich compounds on earth. Microbial synthesis of methane and other alkanes is an essential part of the geochemical cycling of carbon and offers perspectives for our biobased economy. This book discusses different aspects of current knowledge of microbial alkane production. Chapters with state of the art information are written by renowned scientists in the field.The chapters are organised into four themed parts:1. Biochemistry of Biogenesis - Hydrocarbons2. Taxonomy, Ecophysiology and Genomics of Biogenesis - Hydrocarbons3. Biogenic Communities: Members, Functional Roles4. Global Consequences of Methane Production

This book offers a comprehensive overview of the microbiological fundamentals and biotechnological applications of methanotrophs: aerobic proteobacteria that can utilize methane as their sole carbon and energy source. It highlights methanotrophs'pivotal role in the global carbon cycle, in which they remove methane generated geothermally and by methanogens. Readers will learn how methanotrophs have been employed as biocatalysts for mitigating methane gas and remediating halogenated hydrocarbons in soil and underground water. Recently, methane has also attracted considerable attention as a potential next-generation carbon feedstock for industrial biotechnology, because of its abundance and low price. Methanotrophs can be used as biocatalysts for the production of fuels, chemicals and biomaterials including methanobactin from methane under environmentally benign production conditions. Sharing these and other cutting-edge insights, the book offers a fascinating read forall scientists and students of microbiology and biotechnology.

This class-tested textbook examines the basic elements of living systems: energy, chemistry, solvents, and habitats in crucial depth. These elements define the opportunities and limitations for life on other worlds. The book argues that life forms we would recognize may be more common in our solar system than many assume. It also considers, however, the possibility of exotic forms of life based on backbones other than carbon, liquids other than water, and energy other than light. The authors offer an operational definition of life and summarize prevailing thoughts on plausible pathways for the origin of life on Earth and other worlds. They discuss remarkable adaptations to extreme environments, the nature and detection of geo- and biosignatures, the future and fate of living systems, and suggestions for the optimization of future exploratory space missions.The entire text has been thoroughly updated in this third edition, with new sections added on exoplanets, synthetic life,the search for extraterrestrial life, and a tour of the bodies in our Solar System for signs of conditions conducive for life. While informed speculation in this emerging field cannot be avoided, the authors have clearly distinguished between what is known as fact and what are reasonable expectations. They present an objective assessment of the plausibility of life on other worlds that is broad and deep enough for the expert and for use as an advanced text in astrobiology, while avoiding scientific jargon as much as possible to make this intrinsically interdisciplinary subject understandable to a broad range of readers.

This book assembles concisely written chapters by world-leaders in the field summarizing recent advances in understanding microbial responses to hydrocarbons. Subjects treated include mechanisms of sensing, hydrocarbon tolerance and degradation as well as an overview on hydrophobic modification of biomolecules. Other chapters are dedicated to issues related to the reduced bioavailability of hydrocarbons, which differentiates this class of compounds form many others, but which of central importance to understand the ecophysiological consequences. This book should be standard literature in any laboratory working in this area.

This book covers the current states of microbial and related technologies that have been developed for the efficient production of chemicals, fuels and materials by integrating strain and enzyme development, fermentation processes, and downstream processes. The book also covers how microbes and microbial products can be employed to facilitate petroleum recovery. Global consequences of bio-based production of chemicals, fuels and materials are also discussed with insights.

This Microbiology Monographs volume covers the current and most recent advances in genomics and genetics, biochemistry, physiology, and molecular biology of C. reinhardtii. Expert international scientists contribute with reviews on the genome, post-genomic techniques, the genetic toolbox development as well as new insights in regulation of photosynthesis and acclimation strategies towards environmental stresses and other structural and genetic aspects, including applicable aspects in biotechnology and biomedicine. Advancement in Chlamydomonas biology allowed new understandings in biotechnological and biomedical related aspects.

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

This biographical brief outlines the remarkable life and career of British biochemist, Marjory Stephenson (1885-1948). In nine concise chapters, Štrbáňová describes Stephenson's scientific accomplishments and sets these against the socio-political challenges of the time. Stephenson played an important role in the development of biochemistry and molecular biology. She was one of the first scientists to use microorganisms as models for research into cellular biochemical processes and their regulation. Later she went on to coin the term chemical microbiology, which was communicated in her monograph and textbook'Bacterial Metabolism'(1930-1949). Stephenson also actively participated in the establishment of the institutionalized interdisciplinary field of general microbiology which integrated research into diverse forms of microorganisms at various levels of organization. Alongside these scientific achievements, Štrbáňová outlines Stephenson's constant battle with practices of undeclared discrimination, her important role as one of the first women science managers and organizers, and her influential position within the scientific community. A scientist of great merit and a role model to women scientists of all disciplines, the life of Marjory Stephenson is of interest to biochemists, molecular biologists, historians of the chemical and biological sciences, and women scientists of all generations.

This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation and large-scale, high-speed MS sample profiling, new methods based on MALDI or MALDI-like sample preparations, and the advantages of ESI to MALDI MS analysis. This is an ideal book for graduate students and researchers in the field of bioanalytical sciences.This book also:• Showcases new techniques and applications in MALDI MS• Demonstrates how MALDI is preferable to ESI (electrospray ionization)• Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and the various application areas, such as cancer proteomics

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

There has been a resurgence of interest in environmental friendly, sustainable and organic cultural practices that warrants high yield and quality in agricultural crops. To enhance sustainable agricultural production and alleviate food scarcity, spoor of majority of microorganisms, especially plant growth and health promoting bacteria of eminent characteristics that allow them for exploitation in agro-ecosystem. Plant growth promoting rhizobacteria are the soil bacteria inhabiting around/on the root surface and are directly or indirectly involved in promoting plant growth and development via production and secretion of various regulatory chemicals in the vicinity of rhizosphere. Among various beneficial bacteria mediated mechanisms include direct production of phytohormones and biosurfactants experiencing quest of research and concept up gradation that can built emerging paradigm (agriculture model). Research on bacteria-mediated phytohormones is crucially important, provides key understanding of the plant growth and development. Various genera including PGPR group of bacteria are potential source of plant growth regulators. Application of such organism allow plants to survive under abiotic and biotic stress conditions besides govern phytohormone mediated immune response and manage to regulate hormones. Such group of bacteria also produce another important metabolite i.e. biosurfacatants which are involved in many important functions to bacteria itself as well as for the plants and their ecosystem. Biosurfactants may alter nutrient availability, endogenous metabolites such as antibiotics production, root colonization imparting protection from phytopathogens besides eradicating soil contaminants and other pollutants. The role and activities of surfactants produced by bacteria are multifarious in nature. Thus, bacterial phytohormones and biosurfactants are identified as effector molecules in plant- microbe interactions, in pathogenesis and phyto-stimulation which can either be beneficial for the bacteria itself or for the crops. This book highlights current applications and research on bacterial hormones and surfactants to provide a timely overview. The chapters have been contributed by subject experts from around the world and include topics of varied importance which include phytohormones production by rhizospheric and endophytic bacteria, their role in rhizosphere competence, plant growth regulation, bioremediation, biosurfactants as antibiofilm agents and other aspects. This major new work represents a valuable source of information to all those scientists interested in microbial technology with respect to the microbial innovative products and applications towards sustainable agroecosystem.

This volume covers both the basic concepts and theory of bio-macromolecules under pressure and the various frontiers in high-pressure bioscience and biotechnology. A century has passed since Bridgman discovered the irreversible coagulation of egg white by applying pressure at 700 atmospheres in 1914. Today we are able to monitor pressure-dependent changes in protein structure as a reversible process even at atomic scale with modern spectroscopic techniques. We can study the fluctuating reality of protein structures as designed by nature, which is the basis for all dynamism of life on earth. We are currently facing a new era of high-pressure bioscience, in which pressure is no longer an “odd” or “foreign” variable to life, but rather an integrated part of it. Pressure is used as a crucial variable for disclosing the secrets of nature and as a powerful new tool for enhancing certain reactions in bio-macromolecules and even in living cells for our practical and industrial needs. A dramatic advancement of high-pressure bioscience both in the basic and the applied sciences is thus anticipated in near future, for which sharing the current advanced knowledge on structure and dynamics of bio-macromolecules under pressure among researchers in both fields is crucial.This book serves as a valuable resource not only for those working directly in a pressure-related field, but also for those working in many other fields of the biosciences. Particularly, the basic part of it is intended to serve as a classical text book on high-pressure bioscience to a wide audience including students and researchers in both basic and applied fields in years to come. Readers can focus on topics of immediate interest first, but may wish to go over other chapters if interest arises in a later occasion.