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••Selected for Doody's Core Titles® 2024 in Clinical Genetics•• Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications. - Features chapter contributions from leading international scientists and clinicians - Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more - Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics-based approaches - Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine

The crop plants cater not only to our basic F5 (food, feed, fiber, fuel, and furniture) needs but also provide a number of nutraceuticals with potential nutritional, safety and therapeutic properties. Many crop plants provide an array of minerals, vitamins, and antioxidant-rich bioactive phytochemicals. Increasing incidences of chronic diseases such as cancer, diabetes and HIV, and malnutrition necessitate global attention to health and nutrition security with equal emphasis to food security. This compendium compiles results of researches on biochemical, physiological and genetic mechanisms underlying biosynthesis of the health and nutrition related nutraceuticals. It also explores the precise breeding strategies for augmentation of their content and amelioration of their quality in crop plants under all commodity categories including cereals and millets, oilseeds, pulses, fruits and nuts, and vegetables. The compendium comprise 5 sections dedicated to these 5 commodity groups and presents enumeration on the concepts, strategies, tools and techniques of nutraceutomics. These sections include 50 chapters devoted to even number of major crop plants. These chapters present deliberations on the biochemistry and medicinal properties of the nutracuticals contained; genetic variation in their contents; classical genetics and breeding for their quantitative and qualitative improvement; tissue culture and genetic engineering for augmentation of productivity and quality; and sources of genes underlying their biosynthesis. They also include comprehensive enumeration on genetic mapping of the genes and QTLs controlling the contents and profile of the nutraceuticals and molecular breeding for their further improvement through marker assisted selection and backcross breeding tools. Prospects of post-genomic precise breeding strategies including genome-wide association mapping, genomic selection, allele mining, and genome editing are also discussed. This compendium fills the gap in academia, and research and development wings of the private sector industries interested in an array of subjects including genetics, genomics, tissue culture, genetic engineering, molecular breeding, genomics-assisted breeding, bioinformatics, biochemistry, physiology, pathology, entomology, pharmacognosy, IPR, etc., and will also facilitate understanding of the policy making agencies and people in the socio-economic domain and research sponsoring agencies.

Genetic disorders have been the focus of scientists for a long time. The emergence of next-generation sequencing techniques has ushered a new era in genetics and several developments have occurred in human genetics. The scientific perspective has also been widened with omics technologies that allow researchers to analyze genetic sequences and their expression products. An integrated approach is being used not only for diagnosis but also for disease management and therapeutic purposes.This book highlights emerging areas of omics technology and its application in the diagnosis and management of human genetic disorders. The book covers three areas of research and implementation:1) Diagnosis (covering conventional strategies to next-generation platforms). This section focuses on the role of in silico analysis, databases and multi-omics of single-cell which will help in designing better management strategies.2) Disease Management and therapeutic interventions. This section starts with genetic counselling and progresses to more specific techniques such as pharmacogenomics and personalized medicine, gene editing techniques and their applications in gene therapies and regenerative medicine.3) Case studies. This section discusses the applications and success of all the above-mentioned strategies on selected human disorders.This book serves as a handy reference for students and academics studying advanced omics techniques in biochemistry and molecular genetics as part of courses in life sciences, pharmacology and medicine.

Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. - Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease - Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research - Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare - Features chapter contributions from a wide range of international researchers in the field

This book provides the latest information of life science databases that center in the life science research and drive the development of the field. It introduces the fundamental principles, rationales and methodologies of creating and updating life science databases. The book brings together expertise and renowned researchers in the field of life science databases and brings their experience and tools at the fingertips of the researcher. The book takes bottom-up approach to explain the structure, content and the usability of life science database. Detailed explanation of the content, structure, query and data retrieval are discussed to provide practical use of life science database and to enable the reader to use database and provided tools in practice. The readers will learn the necessary knowledge about the untapped opportunities available in life science databases and how it could be used so as to advance basic research and applied research findings and transforming them to the benefit of human life.Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.