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This book constitutes the thoroughly refereed post-proceedings of the RECOMB 2004 Satellite Workshop on Comparative Genomics, RCG 2004, held in Bertinoro, Italy in October 2004. The 10 revised full papers presented were carefully reviewed and improved for inclusion in the book. The papers address a broad variety of aspects of comparative genomics ranging from new quantitative discoveries about genome structures and processes to theorems on the complexity of computational problems inspired by genome comparison.

Over the course of a scientific career spanning more than fifty years, Alex Grossmann (1930-2019) made many important contributions to a wide range of areas including, among others, mathematics, numerical analysis, physics, genetics, and biology. His lasting influence can be seen not only in his research and numerous publications, but also through the relationships he cultivated with his collaborators and students. This edited volume features chapters written by some of these colleagues, as well as researchers whom Grossmann's work and way of thinking has impacted in a decisive way. Reflecting the diversity of his interests and their interdisciplinary nature, these chapters explore a variety of current topics in quantum mechanics, elementary particles, and theoretical physics; wavelets and mathematical analysis; and genomics and biology. A scientific biography of Grossmann, along with a more personal biography written by his son, serve as an introduction. Also included are the introduction to his PhD thesis and an unpublished paper coauthored by him. Researchers working in any of the fields listed above will find this volume to be an insightful and informative work.

This book includes papers presented at the 2017 Joint meeting of Fodder Crops and Amenity Grasses Section and Protein Crops Working Group of EUCARPIA-Oil and Protein Crops Section. The theme of the meeting “Breeding Grasses and Protein Crops in the Era of Genomics” has been divided into six parts: (1) Utilisation of genetic resources and pre-breeding, (2) Genetic improvement of quality and agronomic traits, (3) Breeding for enhanced stress tolerance (4) Implementation of phenomics and biometrics, (5) Development of genomic tools and bioinformatics and (6) Reports of Parallel Sessions.

This volume contains 18 peer-reviewed papers based on the presentations at the 10th Annual International Workshop on Bioinformatics and Systems Biology (IBSB 2010) held at Kyoto University from July 26 to July 28, 2010. This workshop started in 2001 as an event for doctoral students and young researchers to present and discuss their research results and approaches in bioinformatics and systems biology. It is part of a collaborative educational program involving leading institutions and leaders committed to the following programs:Boston — Graduate Program in Bioinformatics, Boston University Berlin — The International Research Training Group (IRTG) “Genomics and Systems Biology of Molecular Networks”Kyoto — The JSPS International Training Program (ITP) “International Research and Training Program of Bioinformatics and Systems Biology”Tokyo — Global COE Program “Center of Education and Research for Advanced Genome-Based Medicine”

This volume contains 17 peer-reviewed papers based on the presentations at the 9th Annual International Workshop on Bioinformatics and Systems Biology (IBSB 2009) held at the Life Science Engineering Building of Boston University from July 27 to 29, 2009. This workshop started in 2001 as a platform for doctoral students and young researchers to present and discuss their research results and approaches in bioinformatics and systems biology. It is part of a collaborative educational program involving leading institutions and leaders committed to the following institutions and programs:Boston University Graduate Program in BioinformaticsCharité - Universitätsmedizin BerlinFreie Universität BerlinGlobal COE Program — Center of Education and Research for Advanced Genome-Based Medicine, University of TokyoThe International Research Training Group (IRTG) Genomics and Systems Biology of Molecular NetworksInternational Research and Training Program on Bioinformatics and Systems Biology, Kyoto University Bioinformatics CenterMax-Delbrück Center for Molecular Medicine in BerlinMax Planck Institute for Molecular Genetics in BerlinMax Planck Institute of Molecular Plant Physiology in Potsdam

Contributed papers.

'This volume contains the papers presented at the 3rd RECOMB Comparative Genomics meeting, which was held in Dublin, Ireland, on September 18-20, 2005.'

This book presents a new era in parasitology research and involves several contributions on translational results. Readers are equipped with the recent advances of parasitomics (the OMICS study of parasites). World-renowned experts in the field of molecular biology and omics provide a glance of how omics have revolutionized our understanding of parasites and vectors, including the implications of these advances. A particular focus is on comprehending the biology, diagnostics, surveillance, response to treatment, prevention, and control of parasites. Final, cutting-edge studies on disease vectors round out this volume. Overall, five thematic book sections provide a clear overview and smooth findability of contents. Parasitic diseases represent an important burden for healthcare systems, particularly in endemic countries. In recent decades, there have been several advances in dissecting the genome, transcriptome and proteome of parasites allowing researchers worldwide to exploit this information and ameliorate our understanding of parasitoses and infections. For the first time, this collection will permit scientists, students, and all medical professionals around the world to update their knowledge and uncover the impact of going from basic science to implementation in order to mitigate parasitic diseases. In this way, the present work makes an indispensable contribution to practical progress regarding research on Neglected Tropical Diseases (NTDs) and the Sustainable Development Goal (SDG) 2, Good Health and Well-Being.

This textbook illustrates the importance and significance of molecular genetic testing in reproductive disorders. The present book covers the genetic testing in various reproductive system anomalies, including disorders of sexual development, male infertility (Y deletions, autosomal mutations, sperm DNA fragmentation), female infertility (PCOS and POF), mitochondrial DNA testing for oocyte quality, recurrent pregnancy loss, pre-term birth, endometrial receptivity, prenatal genetic screening, reproductive carrier screening, preimplantation genetic screening, endometrial cancer, cervical cancer and other related reproductive health disorders. Microbiome testing and its contribution to genetic testing in reproductive medicine are also discussed. Genetic testing in some of these has already come into practice, genetic testing for others is established but not clinically practiced, and genetic testing for others is yet in infancy as there is only limited data available. For the disorderswhere sufficient genetic data to undertake genetic testing is not available, we have tried to put together the evidence for proposing such tests in the near future. Apart from this, the book also covers ethical, moral and technical challenges in genetic testing in reproductive medicine. The book aims to set up a standard with regard to genetic testing in the reproductive medicine field, encourage further data generation, and provide food for thought in the areas of lacunae. The book serves graduate students, researchers, clinicians, professors, and patients in the field of reproductive medicine.​

The book introduces readers to the latest developments in biotechnological methods used for improving the cultivation of silkworms. The text focuses on implementing biotechnological approaches, ranging from basic to advanced techniques, on enhancing silk production, increasing abiotic stress resilience, improving disease tolerance, and developing resistance in silkworm crops. With the current climate crisis and growing demand for high-quality silk, biotechnological applications have become essential in addressing the urgent need to increase silk production. The field of sericulture has made significant breakthroughs, such as identifying DNA markers, linkage association, genome-wide association studies, generating mutants, and introducing transgenic silkworms. Developing silkworms with improved cocoon yield and disease resistance is crucial to boost silk production. The book covers fundamental principles and recent advancements and delves into various methodologies employed inseri-biotechnology for improving silkworm crops. These methodologies include next-generation sequencing for DNA sequencing, using molecular markers to enhance abiotic stress tolerance (specifically high temperature and humidity conditions), expression analysis, RNA interference, gene knockout approaches to bolster disease resistance, and transcriptomics to enhance economically significant parameters such as silk content. The book explains these topics in detail and includes contemporary research appraisals, extensive discussions, and an evaluation of the benefits and risks associated with the use of biotechnological tools. This book serves as an invaluable reference for researchers and academics in biotechnology, molecular biology, and sericulture while also serving as an informative starting point for budding researchers.

Das Buch der Gene und Genome bietet einen prägnanten Überblick über die Fortschritte in der Genetik und Genomik und liefert den mit diesem Gebiet nicht vertrauten Leserinnen und Lesern eine knappe Beschreibung vieler Anwendungen und Auswirkungen in diesem Bereich. Angesichts der beträchtlichen Investitionen in Genetik und Genomik in den letzten Jahrzehnten und der vielen neuen Entdeckungen und Entwicklungen wird dieses Buch den Leserinnen und Lesern helfen, die Bedeutung von Genetik und Genomik für uns alle zu verstehen. Dieser spannende neue Titel enthält Informationen darüber, wie Genetik und Genomik unser Verständnis von Gesundheit und Medizin, Evolution und Biologie verbessert haben und wie sie die Grenzen von Ethik und sozialen Werten verschieben.Setzt keine Vorkenntnisse voraus; Leicht verständlicher Schreibstil, der es auch weniger erfahrenen Personen ermöglicht, die'Sprache'der Gene und Genome zu lesen und zu sprechen;Einbeziehung von Fallbeispielen, die zeigen, wie Gene und Genomik das Verständnis von Gesundheit, Medizin, Evolution und Biologie verbessert haben, aber auch Ethik und soziale Werte berücksichtigen;Empfohlene Lektüre, die das Selbststudium erleichtert; Klar und aktuell.

Every cell, tissue, organ and organism is competent to use signs to exchange information reaching common coordinations and organisations of both single cell and group behavior. These sign-mediated interactions we term biological communication. The regulatory system that works in development, morphology, cell fate and identity, physiology, genetic instructions, immunity, memory/learning, physical and mental disease depends on epigenetic marks. The communication of cells, persistent viruses and their defectives such as mobile genetic elements and RNA networks ensures both the transport of regulatory instructions and the reprogramming of these instructions. But how are the different states of the epigenome orchestrated? The epigenetic pathways respond to various signaling cues such as DNA methylation, histone variants, histone modifications, chromatin structure, nucleosome remodeling, and epigenetic interactions. Epigenetic signals are responsible for the establishment, maintenance and reversal of transcriptional states that are fundamental for the cell's ability to memorize past events, such as changes in the external environment, socio-sphere or developmental cues. External signals trigger changes in the epigenome, allowing cells to respond dynamically. Internal signals direct activities that are necessary for body maintenance, and repairing damaged tissues and organs. With the emergence of epigenetic memory, organisms can fix historical and context dependent impressive experiences. Evolution from now on learnt to learn. Learning means organisms can avoid reproduction of always the same. This is key to adaptation. However, inheritance of acquired characteristics is only one of the many examples of the explanatory power of epigenetics. Behavioral epigenetics demonstrates the way in which environmental and social experiences produce individual differences in behaviour, cognition, personality, and mental health. This book assembles experts to outline the various motifs of all kinds of epigenetic regulation of cells throughout their lives.

This textbook teaches health analytics using examples from the statistical programming language R. It utilizes real-world examples with publicly available datasets from healthcare and direct-to-consumer genetics to provide learners with real-world examples and enable them to get their hands on actual data. This textbook is designed to accompany either a senior-level undergraduate course or a Masters level graduate course on health analytics. The reader will advance from no prior knowledge of R to being well versed in applications within R that apply to data science and health analytics. “I have never seen a book like this and think it will make an important contribution to the field. I really like that it covers environmental, social, and geospatial data. I also really like the coverage of ethics. These aspects of health analytics are often overlooked or deemphasized. I will definitely buy copies for my team.” - Jason Moore, Cedars-Sinai Medical Center “Overall, I have a highly positive impression of the book. It is VERY comprehensive. It covers very extensive data types. I do not recall other books with the same level of comprehensiveness.” - Shuangge Ma, Yale University “The book is comprehensive in both aspects of genetics, and health analytics. It covers any type of information a healthcare data scientist should be familiar with, whether they are novice or experienced. I found any chapter that I looked into comprehensive, but also not too detailed (although in general this book is more than 600 pages of comprehensive and detailed relevant information).” - Robert Moskovtich, Ben-Gurion University of the Negev

Antimicrobial resistance (AMR) is increasing globally at an incredible rate, and many infectious diseases have already reached an alarming stage of resistance to existing treatments. WHO reports that nearly1.27 million people currently die each year due to resistant infections, and AMR is projected to account for 10 million annual deaths globally by 2050. There is an urgent need for novel approaches to address this issue. Omics technologies are powerful research tools used extensively to study pathogen biology and the activity of microbial agents. These tools, paired with systems biology approaches, can provide novel insights into antimicrobial susceptibility and resistance, and aid in the development of new, more effective measures to combat resistant pathogens. This book provides a comprehensive overview of omics technologies to study pathogen biology, including proteomics, genomics, transcriptomics, metabolomics, and microbiome analysis, and the role of systems biology in developing strategies to combat resistant pathogens. It addresses environmental reservoirs and mobile genetic agents in AMR, host-pathogen interactions and physiology in the development of resistance, drug repurposing and development, and cutting-edge tools such as machine learning, AI for big data analysis, and genomic surveillance. The final section discusses future perspectives on omics-systems biology in AMR, and identifies opportunities for scientific collaboration in the global fight against antimicrobial resistance. This book serves as a comprehensive and accessible resource for researchers in academia and industry focused on immunology, drug development, biotechnology, and systems biology.

This fully revised 3rd edition of Fungal Genomics highlights the impact of genomics on the field of fungal biology in four sections: Part I Genome Sequences and Beyond: Examines the impact of genome-based information and techniques on research ranging from the discovery of giant transposons to the analysis of less-studied extremotolerant fungi as well as studies of three-dimensional chromatin organization in fungi. Part II Cell and Developmental Biology: Explores advances in high-throughput genetics/genomics and RNA editing in fungi, the role of codons in gene regulation, and the analysis of epigenetic regulation in early-diverging fungi. Part III Biotechnology: Covers the search for plant biomass-converting enzymes in fungal genomes and work with industrially important fungi. Part IV Interactions - Symbioses, Mutualisms, and Pathogens: Explains the genomic analysis of the emerging human pathogen Candida auris as well as genomic signatures in ectomycorrhizal fungi. This book is a must-read for anyone interested in the exciting field of fungal genomics.

This book provides a comprehensive overview of genomics and its diverse applications. Chapters cover genomics data generation methods, computational tools, gene annotation, transcriptomics, DNA barcoding, next-generation sequencing, functional genomics, metagenomics, synthetic genomics, microarray analysis, nutrigenomics, genome editing, and more. This book offers a valuable source of information for not only beginners in genomics, but also for students, researchers, scientists, clinicians, practitioners, policymakers, and stakeholders who are interested in harnessing the potential of genomics in many areas.

The Applied Genomic Epidemiology Handbook: A Practical Guide to Leveraging Pathogen Genomic Data in Public Health provides rationale, theory, and implementation guidance to help public health practitioners incorporate pathogen genomic data analysis into their investigations. During the SARS-CoV-2 pandemic, viral whole genome sequences were generated, analyzed, and shared at an unprecedented scale. This wealth of data posed both tremendous opportunities and challenges; the data could be used to support varied parts of the public health response but could be hard for much of the public health workforce to analyze and interpret, given a historical lack of experience working with pathogen genomic data.This book addresses that gap. Structured into eight wide-ranging chapters, this book describes how the overlapping timescales of pathogen evolution and infection transmission enable exploration of epidemiologic dynamics from pathogen sequence data. Different approaches to sampling and genomic data inclusion are presented for different types of epidemiologic investigations. To support epidemiologists in diving into pathogen genomic data analysis, this book also introduces the analytic tools and approaches that are readily used in public health departments and presents case studies to show step-by-step how genomic data are used and evaluated in disease investigations.Despite the breadth of scientific literature that uses pathogen genomic data to investigate disease dynamics, there remains little practical guidance to help applied epidemiologists build their ability to explore epidemiologic questions with pathogen genomic data. This handbook was written to serve as that guide. Including case studies, common methods, and software tools, this book will be of great interest to public health microbiologists or lab directors, bioinformaticians, epidemiologists, health officers, academics, as well as students working in a public health context.

This book discusses the importance of plants in terms of their natural bioactive products and medicinal, nutraceutical and health benefits. Plants are natural sources of many pharmaceutical compounds used in traditional and modern medicine, and their mass production and efficient use is imperative in view of the new emerging diseases. This book covers breakthroughs in the research of plant natural products by focusing on how different state-of-the-art biotechnologies facilitate their discovery, the molecular basis of their biosynthesis, as well as synthetic biology. Research on plant's natural products in the pre-genomic era was focused on discovering bioactive molecules with pharmaceutical activities, and identifying individual genes responsible for biosynthesis. In the post-genomics era, however, integration of inter-disciplinary approaches and detailed analysis of all accessible data from multi-informatics is necessary. This would accelerate the full characterization of biosynthetic and regulatory circuit for producing plant natural products.This book is an important reference book for the researchers working in the field of plant natural products and pharmaceutical industries at global level.

With the rapid increase in the global population and changing climatic impacts on agriculture, this book demonstrates how genome editing will be an indispensable technique to overcome ongoing and prospective agricultural challenges.This book examines the role of genome editing in improving crop yields and contributing to global food security. It summarizes a range of genome editing techniques and discusses the roles they can play in producing a new generation of high-yielding, climate-ready crops. This includes site-specific nucleases, precision genome engineering, clustered regularly interspaced short palindromic repeats, and bioinformatics. It showcases how these gene editing techniques can tailor plants to not only increase yield-related traits but to also make them better suited to their environment and to be resistant to pests and extreme climatic events, such as droughts. The book also examines genome editing regulations and policies, the commercialization of genome-edited crops, and biosafety and biosecurity concerns. Overall, this book reveals and showcases how genome editing can improve crop resilience and production to address current and future agricultural challenges and alleviation of global food security concerns.This book will be of great interest to students and scholars of agricultural science, crop and plant science, genome editing, sustainable agriculture, biotechnology, and food security.

This book illustrates the recent advancements in the role of functional foods in preventing age-related disorders. It correlates age-related diseases and the effect of dietary compounds from different functional foods, herbs, and nutraceuticals. Notably, the book describes unique nutrition problems in many chronic diseases such as bone disease, cardiovascular disorders, brain disorders, immune disorders, and cancers. The book also discusses the use of functional foods for controlling osteoporosis, improving bone strength, maintaining dental health, controlling obesity, gut health, and maintaining immune function using functional ingredients such as probiotics and prebiotics. Further, it presents the state of the art of aging and nutrigenomics research and the molecular mechanisms underlying the beneficial effects of bioactive nutrients on major aging-related disorders. Finally, the book embodies the latest findings and the mechanisms of actions of functional foods in aging anddegenerative diseases and their beneficial uses in the aged population. ​

This book dispenses a comprehensive coverage of up-to-date account of genomics and genome editing enriched smart plant breeding approaches for enhancing genetic gains in vegetable crops in the post-genomics era. The main focus of the present volume is to illuminate the applications of new techniques evolved in the post-genomics era. The techniques covered are high-throughput sequencing of DNA and RNA, genome editing, epigenetics and epigenomics, genotype by sequencing (GBS), QTL-seq and RNA-seq for transcriptome analysis. Vegetables are the important component of healthy diet, source of energy and hold a promising position in building up a strong immunity. Zero hunger and attaining the food and nutritional security is the top priority of United Nations development goals. Smart breeding of food and vegetable crops to fight the challenges ahead in sustainable manner by keeping the harmony with nature is an important approach to fulfill the United Nations Sustainable Development Goals (UN-SDGs). This edited book highlights the modern results in smart vegetable breeding in the post genomics era and forecasts crucial areas of future needs. It is an important reference for the, readers, students, researchers, scientists in academia and research industries to provide them comprehensive information of innovative approaches for crop improvement in the post-genomics era and in the era of and climate change. Even the readers, academia, social activists, and others fond of reading will get a fair idea of journey travelled so far and future roadmap for fighting the challenges ahead to meet the sustainable development goals.

The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics.This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to improve diagnostics, prognostics, and genomic surveillance, and to facilitate development of effective treatments and vaccines. Chapters are written by an international team of experts and explore methods in the areas of genomics, transcriptomics, proteomics, and metabolomics. Techniques used toassess physiological function at the molecular level and artificial intelligence approaches used for more effective validation and translation of biomarker candidates into clinical use are also discussed. This book is an excellent resource for researchers studying biomarkers, virology, metabolic diseases, and infectious diseases, as well as clinical scientists, physicians, drug company scientists, and healthcare workers.

Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook about genomes and how they are investigated. As with previous Genomes editions, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution. The genomes of all types of organism are covered: viruses, bacteria, fungi, plants, and animals, including humans and other hominids.Genome sequencing and assembly methods have been thoroughly revised to include new developments in long-read DNA sequencing. Coverage of genome annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the chapters that describe the three main types of genomes: eukaryotic, prokaryotic (including eukaryotic organelles), and viral (including mobile genetic elements). Coverage of genome expression and replication is truly genomic, concentrating on the genome-wide implications of DNA packaging, epigenome modifications, DNA-binding proteins, non-coding RNAs, regulatory genome sequences, and protein-protein interactions. Also included are examples of the applications of metabolomics and systems biology. The final chapter is on genome evolution, including the evolution of the epigenome, using genomics to study human evolution, and using population genomics to advance plant breeding. Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important.Genomes 5 is the ideal text for upper-level courses focused on genomes and genomics.Key Features A highly accessible and well-structured book with chapters organized into four parts to aid navigation Superb artwork illustrates the key concepts and mechanisms Each chapter has a set of short-answer questions and in-depth problems to test the reader's understanding of the material Thoroughly up to date with references to the latest research from the 2020s

This book entitled'Genetics, Genomics and Breeding of Bamboos'provides a comprehensive overview on the economically and ecologically important non-timber plant group bamboo. The book focuses on the most recent advances in bamboo research in diverse fields including botany, genetic resources, traditional and molecular breeding, disease and pest resistance, tissue culture and genetic transformation and genomics perspective. The different chapters are authored by internationally reputed experts on this plant and is a good source of information for students, scientists, farmers, and bamboo resource management advisers on this plant, which is gaining increase importance on international commerce.

What's in Your Genome? describes the functional regions of the human genome, the evidence that 90% of it is junk DNA, and the reasons this evidence has not been widely accepted by the popular press and much of the scientific community. The human genome contains about 25,000 protein-coding and noncoding genes and many other functional elements, such as origins of replication, regulatory elements, and centromeres. Functional elements occupy only about 10 percent of the more than three billion base pairs in the human genome. Much of the rest is composed of ancient fragments of broken genes, transposons, and viruses. Almost all of this is thought to be junk DNA, based on evidence that dates back fifty years. This conclusion is controversial. What's in Your Genome? describes the arguments on both sides of the debate and attempts to explain the reasoning behind those different points of view. The book corrects a number of false narratives that have arisen in recent years and examines how they have affected the debate over junk DNA. In addition, Laurence A. Moran focuses on scientific misconceptions and misinformation and on how the junk DNA controversy has been incorrectly portrayed in both the scientific literature and the popular press. Tracing the earliest indications of junk DNA back to the 1960s, the book explains the success of nearly neutral theory and the importance of random genetic drift, which gave rise to the view that evolution produces sloppy genomes full of junk DNA. What's in Your Genome? aims to offer the most accurate and current account of the human genome.

This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.

Genomics and the Global Bioeconomy, a new volume in the Translational and Applied Genomics series, empowers researchers, administrators, and sustainability leaders to apply genomics and novel omics technologies to advance the global bioeconomy and sustainability. Here, more than 15 international experts illustrate—with concrete examples across various industries and areas of global need—how genomics is addressing some of the most pressing global challenges of our time. Chapters offer an in-depth, case-based treatment of various topics, from genomics technologies supporting sustainability development goals to novel synthetic biology advancements improving biofuel production, conservation, sustainable food production, bioremediation, and genomic monitoring. Editors Catalina Lopez-Correa and Adrian Suarez-Gonzalez skillfully bring clarity to this diverse and increasingly impactful research, uniting various perspectives to inspire fresh innovation in driving the global bioeconomy. - Presents concrete examples and detailed discussions that illustrate how to use genomics and omics technologies to drive the global bioeconomy - Examines how genomics is addressing the most pressing environmental, agricultural, economic, and natural resources challenges of our time - Features chapter contributions from international experts who are applying genomic technologies across various fields, from agriculture to biofuel production, bioremediation, biodiversity monitoring, and conservation

This up-to-date and comprehensive textbook is essential reading material for advanced undergraduate and graduate students with a course module in genetics and developmental biology. The book provides clear, concise, and rigorous foundational concepts of genetics. It opens with an introductory chapter that provides an overview of genetics. The book includes separate and detailed sections on classical genetics, molecular genetics, and population genetics. It covers basic and foundational principles such as Mendelian genetics, chromosomal theory, transcription, translation, mutation, and gene regulation. It further includes chapters on advanced topics such as molecular genetic techniques, genomics, and applied molecular genetics. The concluding section includes chapters on population genetics, developmental genetics, and evolutionary genetics. The chapters are written by authors with in-depth knowledge of the field. The book is replete with interesting examples, case studies, questions and suggested reading. It is useful to students and course instructors in the field of human genetics, developmental biology, life sciences, and biotechnology. It is also meant for researchers who wish to further their understanding about the fundamental concepts of genetics.

Over the past decade, neuroproteomics has shed light on the molecular features of schizophrenia by depicting biological processes involved with its establishment, maintenance and treatment. These studies have also pointed to potential biomarkers applicable to diagnosis and medication monitoring. Edited by a leader in the field of neuroproteomics with contributions from subject experts, this new volume will address recent findings and compile evidence from difference perspectives—such as human samples, animal models, pluripotent stem cell-derived in vitro pre-clinical models—and provide findings to inform the development of innovative future treatment strategies.This volume will be useful for a broad audience of researchers and professionals, including biologists, neurologists, psychiatrists, analytical chemists, and pharmacists, among others.

This book provides insight into the use of molecular and genomic techniques to the study of populations of critically important species at various geographical scales. It delves into a wide range of issues relevant to biodiversity conservation, such as population differentiation, landscape genomics, ecological interactions, phylogenetics, phylogeography, metagenomics, molecular methods, and data processing. The current rate of biodiversity loss is unprecedented and valuable genetic resources are being lost at an alarmingly rate. Effective strategies to conserve these genetic resources are essential to maintain healthy ecosystems with inter-dependent species. The book is an invaluable resource for training undergraduate and graduate students, postdoctoral fellows, and for young researchers. This book is particularly useful for the policy makers and academics who want to learn about important concepts in population and conservation genetics and genomics.

High-throughput molecular technologies ('omics') can help to decipher the contributions of different physiological systems and identify candidate molecules that are representative of different physiological pathways thereby allowing the discovery of biomarkers. Notably, the omics technologies along with and computational methods, bioprospecting, and artificial intelligence will continue to lead to better understanding of biological mechanisms that are responsible for physical attributes, or phenotypes. Research breakthroughs obtained through these technologies can be used to enhance productivity of food animals, meet the increasing demand for animal-sourced foods, enhance high-quality nutrient availability, ensure nutrient safety, mitigate the effects of climate variability, and result in new technologies that provide continued improvement in food security worldwide. Such breakthroughs are an urgent necessity because over the past 50 years, there has been an unprecedented increase in the world's population, which will reach ten billion by the year 2050. Innovative and technological advancements that enhance all aspects of food production will arise from basic, fundamental research. Besides food, animal by-products have found many applications in the fields of pharmaceuticals, cosmetics, and household and industrial products. Hence, the need to ameliorate the productivity, reproductivity, growth performance, and disease resistance in animals has created a worldwide interest in gaining a deeper understanding of animal biology, biotechnology and genomics, and proteomics. The present volume thoroughly discusses the omics studies in domestic and non-domestic animals and their role in mitigation of various challenges ahead. The volume thus focuses on i. Omics (genomics, proteomics, transcriptomics, metabolonomics) technologies in identifying, characterizing biodiversity ii. Role of molecular techniques for improvement of domestic and non-domestic organisms iii. Animal and alternative model systems (using stem cells, tissue engineering, cell free systems, 3D platforms etc.) for studying life phenomenaiv. Genetically modified organisms as factories for the products

Genomic selection (GS) is a promising tool in the field of breeding especially in the era where genomic data is becoming cheaper. The potential of this tool has not been realized due to its limited adaptation in various crops. Marker Assisted Selection (MAS) has been the method of choice for plant breeders while using the genomic information in the breeding pipeline. MAS, however, fails to capture vital minor gene effects while focusing only on the major genes, which is not ideal for breeding advancement especially for quantitative traits such as yield. The main aim of statistical methodologies coming under the umbrella of GS on using the whole genome information is to predict potential candidates for breeding advancement while optimizing the use of resources such as land, manpower, and most importantly time. Lack of proper understanding of the methods and their applications is one of the reasons why breeders shy away from this tool. The book is meant for biologists, especially breeders, and provides a comprehensive idea of the statistical methodologies used in GS, guidance on the choice of models, and design of datasets. The book also encourages the readers to adopt GS by demonstrating the current scenarios of these models in some of the important crops among oilseeds, vegetables, legumes, tuber crops, and cereals. For ease of implementation of GS, the book also provides hands-on scripts on GS data design and modeling in a popular open-source statistical program. Additionally, prospective in GS model development and thereby enhancement in crop improvement programs is discussed.

This book collates the basic and advanced concepts of plant biotechnology and genomics along with the future trends. It discusses the combination of conventional breeding techniques with genomic tools and approaches leading to a new genomics-based plant breeding technology supporting crop plants that respond better to biotic and abiotic stress, and pathogen attacks. Plant genomics play an important role in developing more efficient plant cultivars which are essential for the neo green revolution needed to feed the world's rapidly growing population. Plant genomic data is being utilized in genetic engineering to ensure that better and resilient varieties of crops are available ensuring food security. This book is of immense interest to teachers, researchers, crop scientists, capacity builders, and policy makers. Also, the book serves as additional reading material for undergraduate and graduate students of agriculture, biotechnology, genomics, soil science, and environmental sciences. National and International agricultural scientists and policy makers will also find this to be a useful read.

This book is open access under a CC BY 4.0 licenseThis open access book brings together the latest genome base prediction models currently being used by statisticians, breeders and data scientists. It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool. To do so, for each tool the book provides background theory, some elements of the R statistical software for its implementation, the conceptual underpinnings, and at least two illustrative examples with data from real-world genomic selection experiments. Lastly, worked-out examples help readers check their own comprehension.The book will greatly appeal to readers in plant (and animal) breeding, geneticists and statisticians, as it provides in a very accessible way the necessary theory, the appropriate R code, and illustrative examples for a complete understanding of each statistical learning tool. In addition, it weighs the advantages and disadvantages of each tool.

This edited book covers all aspects of omics approaches used for the varietal improvement of millets in changing climatic conditions. Millets are the collection of small-grained cereal grasses, that are grown for human carbohydrate needs. They are among the oldest crops, mainly divided into two groups – Major and small millets based on seed size. Small millets are earlier considered orphan crops, but recently due to their nutritional values, they are getting importance in cultivation. This book explores the genomics, transcriptomics, proteomics, metabolomics, bioinformatics, and other omics tools that are being widely used to get a clear understanding of mechanistic approaches taken by plant genes to tolerate stress. Various reports are published based on field breeding on these crops, and recently the genome of some of the small millets is released, and many omics studies are published related to its application in varietal improvements. This book reviewed all those recent studies and is of interest to research students, plant breeding scientists, teachers that are working in agriculture and plant biotech universities. Along with this, the book serves as reference material for undergraduate and graduate students of agriculture, and biotechnology. National and international agricultural scientists, policymakers will also find this to be a useful read.

Genomic Medicine Skills and Competencies discusses core and practical aspects of genetic and genomic education and training for medical field. Many aspects of genomic applications in science, biotechnology, clinical medicine and healthcare require core and specialist knowledge, skills development and competencies for carrying out diverse tasks. Several knowledge-based courses and opportunities for skills and competencies development and assessment are now available and the main required subjects are discussed in this volume. The book focuses on all major aspects of genetic and genomic education training that are currently offered and evaluated and is a valuable resource for researchers, clinicians, physicians, nurses, genetic counselors, bioinformatics technicians, and other professionals who are interested in learning more about such promising field. - Illustrates the need for acquiring and/or enhancing skills and competencies keeping up with the new advances and expanding scientific and technical knowledge in genome sciences as applied to the practice of clinical genomic and precision medicine - Focuses on the professional and specific needs of medical and healthcare professionals practicing (or planning to practice) genomic medicine and health genomics - Discusses the impact of effective genomic education and training for delivering the advances and new knowledge in the field of genome sciences and technologies that have spanned as a result of the COVID-19 pandemic in preparedness to what is next

This textbook provides a concise introduction and useful overview of the field of human population genomics, making the highly technical and contemporary aspects more accessible to students and researchers from various fields. Over the past decade, there has been a deluge of genetic variation data from the entire genome of individuals from many populations. These data have allowed an unprecedented look at human history and how natural selection has impacted humans during this journey. Simultaneously, there have been increased efforts to determine how genetic variation affects complex traits in humans. Due to technological and methodological advances, progress has been made at determining the architecture of complex traits. Split in three parts, the book starts with the basics, followed by more advanced and current research. The first part provides an introduction to essential concepts in population genetics, which are relevant for any organism. The second part covers the genetics of complex traits in humans. The third part focuses on applying these techniques and concepts to genetic variation data to learn about demographic history and natural selection in humans. This new textbook aims to serve as a gateway to modern human population genetics research for those new to the field. It provides an indispensable resource for students, researchers and practitioners from disparate areas of expertise.

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding　field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. - A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects - Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability - Contains applications of genome instability research and outcomes for human disease - Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

This book summarizes the advanced computational methods for mapping high-density linkages and quantitative trait loci in the rice genome. It also discusses the tools for analyzing metabolomics, identifying complex polyploidy genomes, and decoding the extrachromosomal genome in rice.Further, the book highlights the application of CRISPR-Cas technology and methods for understanding the evolutionary development and the de novo evolution of genes in rice.Lastly, it discusses the role of artificial intelligence and machine learning in rice research and computational tools to analyze plant-pathogen co-evolution in rice crops.

Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism. - Compiles applied case studies and methodologies, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes - Discusses the main challenges in studying the genetics of rare diseases through genomic approaches and possible or ongoing solutions - Explores opportunities for novel therapeutics - Features chapter contributions from leading researchers and clinicians

Introduction to Molecular Genomics introduces the college student to the fundamental concepts of molecular biology and genomics. The text puts an emphasis on important topics in the subject that contribute to the learner's understanding. These topics include molecular genomics, biodiversity and molecular phenomenon behind evolution of species, modern molecular methods for enhanced genomics research, DNA modifications at the molecular level for transgenic animal species, the role of cell environment on the gene expression, to name a few. The book has been designed to suit the requirements of educational courses in molecular biology, genomics and biochemistry.

This book explores the answers to fundamental questions about the human mind and human behaviour with the help of two ancient texts. The first is Oedipus Rex (Oedipus Tyrannus) by Sophocles, written in the 5th century BCE. The second is human DNA, with its origins around 4 billion years ago, and continuously revised by chance and evolution. With Sophocles as a guide, the authors take a journey into the Genomic era, an age marked by ever-expanding insights into the human genome. Over the course of this journey, the book explores themes of free will, fate, and chance; prediction, misinterpretation, and the burden that comes with knowledge of the future; self-fulfilling and self-defeating prophecies; the forces that contribute to similarities and differences among people; roots and lineage; and the judgement of oneself and others.Using Oedipus Rex as its lens, this novel work provides an engaging overview of behavioural genetics thatdemonstrates its relevance across the humanities and the social and life sciences. It will appeal in particular to students and scholars of genetics, education, psychology, sociology, and law.

This edited book provides a comprehensive overview of modern strategies in fruit crop breeding in the era of climate change and global warming. It demonstrates how advances in plant molecular and genomics-assisted breeding can be utilized to produce improved fruit crops with climate-smart traits. Agriculture is facing a number of challenges in the 21st century, as it has to address food, nutritional, energy and environmental security. Future fruit varieties must be adaptive to the varying scenarios of climate change, produce higher yields of high-quality food, feed, and fuel and have multiple uses. To achieve these goals, it is imperative to employ modern tools of molecular breeding, genetic engineering and genomics for ‘precise'plant breeding to produce ‘designed'fruit crop varieties.This book is of interest to scientists working in the fields of plant genetics, genomics, breeding, biotechnology, and in the disciplines of agronomy and horticulture.

The popular introduction to the genomic revolution for non-scientists—the revised and updated new edition Welcome to the Genome is an accessible, up-to-date introduction to genomics—the interdisciplinary field of biology focused on the structure, function, evolution, mapping, and editing of an organism's complete set of DNA. Written for non-experts, this user-friendly book explains how genomes are sequenced and explores the discoveries and challenges of this revolutionary technology. Genomics is a mixture of many fields, including not only biology, engineering, computer science, and mathematics, but also social sciences and humanities. This unique guide addresses both the science of genomics and the ethical, moral, and social questions that rise from the technology. There have been many exciting developments in genomics since this book's first publication. Accordingly, the second edition of Welcome to the Genome offers substantial new and updated content to reflect recent major advances in genome-level sequencing and analysis, and demonstrates the vast increase in biological knowledge over the past decade. New sections cover next-generation technologies such as Illumina and PacBio sequencing, while expanded chapters discuss controversial ethical and philosophical issues raised by genomic technology, such as direct-to-consumer genetic testing. An essential resource for understanding the still-evolving genomic revolution, this book: Introduces non-scientists to basic molecular principles and illustrates how they are shaping the genomic revolution in medicine, biology, and conservation biology Explores a wide range of topics within the field such as genetic diversity, genome structure, genetic cloning, forensic genetics, and more Includes full-color illustrations and topical examples Presents material in an accessible, user-friendly style, requiring no expertise in genomics Discusses past discoveries, current research, and future possibilities in the field Sponsored by the American Museum of Natural History, Welcome to the Genome: A User's Guide to the Genetic Past, Present, and Future is a must-read book for anyone interested in the scientific foundation for understanding the development and evolutionary heritage of all life.

Data in the genomics field is booming. In just a few years, organizations such as the National Institutes of Health (NIH) will host 50+ petabytes—or over 50 million gigabytes—of genomic data, and they're turning to cloud infrastructure to make that data available to the research community. How do you adapt analysis tools and protocols to access and analyze that volume of data in the cloud?With this practical book, researchers will learn how to work with genomics algorithms using open source tools including the Genome Analysis Toolkit (GATK), Docker, WDL, and Terra. Geraldine Van der Auwera, longtime custodian of the GATK user community, and Brian O'Connor of the UC Santa Cruz Genomics Institute, guide you through the process. You'll learn by working with real data and genomics algorithms from the field.This book covers:Essential genomics and computing technology backgroundBasic cloud computing operationsGetting started with GATK, plus three major GATK Best Practices pipelinesAutomating analysis with scripted workflows using WDL and CromwellScaling up workflow execution in the cloud, including parallelization and cost optimizationInteractive analysis in the cloud using Jupyter notebooksSecure collaboration and computational reproducibility using Terra

Are you your genes? De-Sequencing: Identity Work with Genes explores this perplexing question, showing how different forms of knowledge must be contextualized to become meaningful. It is generally assumed that the genomic sequence adds up to the identity-forming material life is made of. Yet identity cannot itself adopt the form of a sequence. As the authors in this volume show, the genome must be ‘de-sequenced'by human language to render it interpretable and meaningful in a social context. The book unpacks this type of ‘sequence-speech'in engaging detail, adopting a personal, social, cultural, and bio-political approach to examine the transformation of human identity and reflexivity in the era of genetic citizenship.

This book provides an overview of the field of pain genomics and the genomics of related, or co-occuring, symptoms, the current state-of-the-science, and challenges that remain. It brings differing views in the field together and provides examples of translational science from using cellular and rodent models to human clinical trials. This book's structure leads the reader through the physiology of pain and genomics into how pain is studied, mechanisms of acute and chronic pain, various protocols that are used throughout the field along with the pros/cons of the current methods used, and project into the future of pain genomics. This work is intended for classroom teaching, for nurses, for novice researchers in symptom science and pain research as well as students and postdoctoral fellows.

Phylogenomics: A Primer, Second Edition is for advanced undergraduate and graduate biology students studying molecular biology, comparative biology, evolution, genomics, and biodiversity. This book explains the essential concepts underlying the storage and manipulation of genomics level data, construction of phylogenetic trees, population genetics, natural selection, the tree of life, DNA barcoding, and metagenomics. The inclusion of problem-solving exercises in each chapter provides students with a solid grasp of the important molecular and evolutionary questions facing modern biologists as well as the tools needed to answer them.

A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics.Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required.The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.

This book discusses 14 model organisms and are used by thousands of researchers, teachers, and students each year in laboratories and classrooms, around the globe. Though acknowledged in innumerable scientific journal articles, little is generally known about the origin of these collections, how the organisms contained within them have been acquired, and how they are maintained and distributed. While some collections such as Drosophila have long histories others, such as the collection of Brachionus, are relatively new. They vary greatly in size. Yet, all have contributed and are continuing to contribute to global research efforts in many areas of scientific research as diverse as tissue regeneration, skin cancer, evolution, water purity, gene function, and hundreds of others. In addition to providing the raw materials for national and international research programs, these collections also provide educational tools used by colleges and high schools. The chapters in this book attempt to provide a brief look at the individual organisms, how they came to be accepted as model organisms, the history of the individual collections, examples of how the organisms have been and are being used in scientific research, and a description of the facilities and procedures used to maintain them.Features:• Provides an in-depth look at the collections of 14 model organisms that have enabled innumerable scientific breakthroughs over decades, and that continue to do so. • Includes detailed descriptions of the operating procedures used for the maintenance of each model organism collection. • Discusses the holdings of the collections of model organisms and its relevance to past, current and future scientific research. • Written by the leaders in the field of the management of model organisms.