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William Bateson brought the work of Mendel (and much more) to the attention of the English-speaking world. He commanded the biological sciences in the decades after Darwin's death in 1882. To understand these years we must first understand Bateson. Through examination of the life of a major contributor to the turn-of-the-nineteenth-century revolution in biology, the authors reconcile the genocentrism of George Williams and Richard Dawkins with the hierarchical thinking of Richard Goldschmidt and Stephen Jay Gould. Aided by Rebecca Saunders, Bateson invented much of the basic terminology of modern genetics and, when addressing Darwin's great problem – the origin of species, introduced the mysterious term'the residue.'While the first edition of this work (2008) related'residue'to relative concentrations of bases in DNA, the second edition reveals this as reflecting fundamental differences in short strings of bases. Thus, the book has come to represent not only Bateson's science and life, but also a revised history of the biosciences that is likely to be increasingly visited, both by scientists and by those who wish to fully understand contemporary debates on racial, eugenic and gender aspects of genetics. In a nutshell, the book describes what we, in modern terms, would call a'colossal intelligence failure.'Mendel handed it to us'on a plate'in 1865 when Bateson was only 4. It took 35 years to'join the dots'with Bateson a primary joiner. Shrugged off by many 20th century scientists as a freak'blip'in what was really an orderly advance, the Mendel episode was but one of a succession of such'blips.'Thus, a multiplicity of post-Mendelian'Mendels'emerge as the story of Bateson's life unfolds.Peter Harper in Human Genetics (2009):'This book puts the record straight and one is left with a feeling of admiration for Bateson as both a scientist and a man, and with no doubt that he, more than anyone else, was largely responsible for the rapid progress in modern genetics during the first decade of the twentieth century.'Michael J. Wade in Evolution (2009):'I strongly recommend this book for its information on an important central figure and for its bringing to life the several controversies at the origins of Genetics. It greatly illuminates the conceptual foundations of evolutionary genetics.'Elof Axel Carlson in Quarterly Review of Biology (2009):'This volume will be of enormous benefit to historians of science who like to follow how ideas are born or die and why participants of different sides of each controversy held such rigid views of their own work and saw little merit in their competitor's research.'Joel S. Schwartz in Choice (2009):'This work includes key events in Bateson's career and is strengthened by discussion of the rediscovery of Mendelian principles by early 20th-century geneticists. Its basic premise isthat Bateson was not merely one of the founders of genetics but played a pivotal role in the development of evolutionary biology by serving as the link between Victorian naturalists and early 20th-century biologists.'Amitabh Joshi in Journal of Genetics (2010):'There is much in this book that I was not aware of, despite a formal training in genetics and a strong amateur interest in the history of biology.… It is certainly a book that any serious student of either genetics or evolution would greatly benefit from reading.'

Our ambition in the organization of this book was to explore the current stus of knowledge about nucleic acids in plants. We wanted the reader to be able to learn how this research is being undertaken. Therefore, we asked the contributing authors to include details of approaches and methods. Where feasible, the have provided protocols that can be followed by those who wish to repeat results, extend data, make improvements, or use them in new applications.

While structure-function relationships of proteins have been studied for a long time, structural studies of RNA face additional challenges. Nevertheless, with the continuous discovery of novel RNA molecules with key cellular functions and of novel pathways and interaction networks, the need for structural information of RNA is still increasing. This volume provides an introduction into techniques to assess structure and folding of RNA. Each chapter explains the theoretical background of one technique, and illustrates possibilities and limitations in selected application examples.

Nucleic Acid Testing for Human Disease describes various techniques including target and signal amplification-based NAT procedures, microarrays, bead-based multiplex assays, in situ hybridization, and SNP techniques. This book discusses RNA expression profiling and laboratory issues such as the need for proper validation of tests intended fo

Visualization of nucleic acids has become indispensable to studying cells, tissues, and organisms. Certain techniques even permit quantification of DNA and/or RNA distribution in tissues, but few current analytical books cover the numerous methods for DNA and RNA visualization. This book provides insight into several classic techniques, histologica

Gene Probes for Bacteria focuses on the preparation and use of nucleic acid probes for identifying bacteria in clinical specimens and in other samples of practical or scientific interest. Organized into 17 chapters, this book addresses which nucleic acid probes are available; how and when to utilize them; what to expect in terms of results obtained with their use; and how to prepare probes. Each chapter is composed of comprehensive manuscript covering different microorganisms. A few bacterial species are treated in more than one chapter to provide a multidimensional picture of important microbes, and to compile the knowledge gained from different laboratories using the same or different probes or methods. This reference material will be of great use to professionals, technicians, and R&D directors in universities, federal and state-dependent service and research institutes, and private and industrial laboratories.

Key Features• Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology• Includes contributions from leaders in their fields• Abundantly referenced

Key Features• Provides a forum for discussion of new discoveries, approaches and ideas in molecular biology• Contributions from leaders in their fields• Abundant references

Praise for the Series'In perusing these chapters, I found much of interest. It is worth investigating.'--P. Brickell in Biotechnology and Applied Biochemistry'Full of interst not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell.'--British Medical JournalKey Features• Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology • Contributions from leaders in their fields • Abundant references

Key Features• Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology • Contributions from leaders in their fields • Abundant references

Key Features• Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology• Contributions from leaders in their fields• Abundantly referenced

'In perusing these chapters, I found much of interest. It is worth investigating.'--P. Brickell in Biotechnology and Applied Biochemistry'Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell.'--British Medical JournalKey Features• Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology • Contributions from leaders in their fields • Abundant references

Praise for the Serial:'Full of interest not only for the molecular biologist - for whom the numerous references will be invaluable - but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell.'--British Medical JournalKey Features• Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology • Contributions from leaders in their fields • Abundant references

FROM THE REVIEWS OF THE PREVIOUS VOLUMES:'In perusing these chapters, I found much of interest. It is worth investigating.'- P. Bricknell in BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY.'Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell.'-BRITISH MEDICAL JOURNAL.• • Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology• Contributions from leaders in their fields• Abundant references

Key Features• Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology • Contributions from leaders in their fields • Abundant references

The book is concerned with the application of physical techniques to the study of the structure and interactions of biopolymers. The treatment is confined to those procedures applicable to solutions. The material has been tested on students in actual classes, thereby permitting the elimination of ambiguities and potential points of difficulty. Stress has been placed upon lucidity of treatment, and difficult steps in derivations have been explained. The mathematical exposition has been made as clear and simple as feasible. Examples of actual data are given.

Praise for the Series:'In perusing these chapters, I found much of interest. It is worth investigating.'--P. Brickell in Biotechnology and Applied Biochemistry'Full of interest not only for the molecular biologist - for whom the numerous references will be invaluable - but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell.'--British Medical JournalKey Features• Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology • Contributions from leaders in their fields • Abundant references

Praise for the Series:'Full of interest not only for the molecular biologist - for whom the numerous references will be invaluable - but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell.'--British Medical JournalKey Features@bul• Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology • Contributions from leaders in their fields • Abundant references

Praise for the Series:'Full of interest not only for the molecular biologist - for whom the numerous references will be invaluable - but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell.'--British Medical JournalKey Features• Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology • Contributions from leaders in their fields • Abundant references

Key Features• Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology• Includes contributions from leaders in their fields• Abundantly referenced