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This operations manual offers an accessible, step-by-step guide to launching, running, and achieving success with a life science and biotechnology business incubator. Written by the founder and President Emeritus of the Pennsylvania Biotechnology Center (PABC), one of the most successful biotech and drug discovery incubators in the United States, it is designed to introduce researchers and funders to the broad considerations and minute details of managing an incubation program.As of 2023, there are more than 1100 business incubators in the United States alone, and more than 5000 worldwide. One of the fastest-growing industries of the'new economy,'science business incubators are a tool for regional economic stimulation and commercial development for universities and research organizations. The PABC was founded in 2006 as a state-of-the-art research facility; its purpose and operation is unusual and its success has been remarkable. It was created by the nonprofit Hepatitis BFoundation and its research arm, the Baruch S. Blumberg Institute, to help their effort to find a cure for hepatitis B. But it has proved to be more than a source of funding for those nonprofits – it has become a major economic driver for its region and Pennsylvania, creating thousands of jobs and bringing in billions of dollars to the local economy. The PABC's model has drawn attention from economists, legislators, and the research community. The strategy of bringing nonprofit research organizations and biotech startups under one roof was a founding principle, and has created powerful, lasting collaborations between scientific innovators, entrepreneurs and investors. The partnerships forged at the PABC have led to the discovery, testing, and FDA approval of new drugs for cancer and gastrointestinal diseases and medical devices, as well as multiple multimillion-dollar IPOs, and thousands of jobs. There are currently more than 50 startups housed in the Center's offices, ranging in focusfrom pharmaceuticals and diagnostics, to medical wearables and nanomedicine research.Curing Disease from the Ground Up: How to Operate a Biotechnology Business Incubator tells both a personal story about the ups and downs of leveraging a business incubator to fund and find a cure for a deadly disease, as well as providing a practical guide to running a business incubator. It is a first-hand, expert perspective for running a science business incubator, and explains how the success of the PABC can be learned and replicated. Whether it is developing a mission-focused framework, the practicalities of managing a scalable, business-savvy research nonprofit, identifying ideal tenant partners, or planning for the infrastructure needs of a large research facility, this manual is the first and last stop for entrepreneurial thinkers in this field.

This book describes the basic concepts and recent advances in new discoveries and technologies related to microbial omics and their role in environmental research and human health. The term'omics'refers to a blend of high-throughput analysis and traditional methods including genomics, transcriptomics, proteomics, lipidomics and metabolomics for a variety of applications in the field of life sciences, biomedical sciences, environmental sciences, and related industries. The book aims to fill the existing gap in terms of a comprehensive approach that incorporates recent advances in this dynamic field and provides an answer to why this field requires an interdisciplinary research approach. The focus of this book is on the applications of genomics, epigenomics, metagenomics, integrative omics, machine learning and microbiome research in environmental health, disease, wastewater epidemiology, antibiotic resistance, drug discovery, cancer, production of secondary metabolites of microbial origin, oxidative stress alleviating mechanisms, etc. The overall construction of this book emphasizes three major perspectives, namely, elaborate knowledge from fundamentals to recent advances in technologies about omics in general and its application in microbiology, environment, and health in particular; illustrative figures capable of easy visualization of complex pathways; and serving as a platform for highly demanded bioinformatics strategies including relevant codes, programming scripts, machine learning and use of artificial intelligence strategies needed to streamline the research outcomes. With global contributions from authors from internationally renowned organizations who excel in relevant research, this book will benefit bibliophiles and prospective audiences from the research fraternity, academia, professionals, and experts in the field of life sciences, biomedical as well as industries related to the development of drug design and novel advances in biotechnological applications.

Blockchain is a new type of technology that combines and secures information exchange between different stakeholders such as medical practitioners, patients, healthcare providers, and other applicable parties. Among them, Blockchain Technology is one of the most important areas in the bioinformatics application of biomedical research and healthcare systems utilizing unique requirements and integration features. All the chapters are written by experts and researchers working in various areas of the biomedical and healthcare domain and they also dive into one of the most overlooked methodological, practical, and moral questions to secure and handle the enormous amount of data being generated from IoT-enabled biomedical and healthcare systems. In the beginning, this book presents an overview and then discusses open issues, challenges, and applicability aspect of Blockchain technology in healthcare. Then, this book presents a variety of perspectives on the most pressing questions in the field, for example: how IoT can connect billions of biomedical and healthcare information; how the blockchain-based secure access control mechanisms in biomedical and healthcare work; how to address the Quality-of-Service (QoS) and real-time accessibility requirements for healthcare applications; and how to ensure communication with efficiency. Also, it discusses Blockchain for IoT-enabled healthcare systems and presents a comparative analysis with respect to various performance evaluation metrics too.

Scientific writing is a trade that can and must be learned and not a form of art that is limited to the talented. The real constraint for writing a good scientific article is most of the time not the usage of the English language, but the conversion of outcomes of a set of experiments into a coherent and convincing scientific story. This book is designed to guide junior scientists in the Life Sciences writing their thesis and first manuscripts, along this uphill struggle. All aspects of building up and publishing a forceful scientific narrative are covered, from designing experiments to dealing with the reviewers'comments. This book takes you step by step through the process of writing a paper. It starts by discussing how to collect and organize data and make an outline. The actual writing starts with the Results section, as this is the heart of any research paper. The Discussion interprets your data in the framework of the existing literature and explains the novel insights you obtained. The Introduction is written to pose the questions that are answered in the Discussion and give the necessary background information. It is written after the Results and Discussion to make sure it is a perfect match. The M&M is the easiest to write. A good abstract is essential for attracting readers. How to write that is described in detail. The title is the last piece of the puzzle. The book contains many practical examples that explain the general principles of good writing. These examples are all from the Life Sciences and so are the anecdotes that illustrate the concepts, making the information directly applicable. All kinds of tips and suggestions are provided for improving readability and accessibility of your manuscript, thus making it easier acceptable. In addition, background information on the basics of science is supplied that helps to avoid common mistakes that cause rejection of manuscripts that report on otherwise good science.

Emergence of lifestyle diseases, e.g., type II diabetes, cancers, obesity, cardiovascular disorders, liver cirrhosis, etc., are exponentially increasing day by day. Modern drifts toward the utilization of herbal medicines in different healthcare aspects necessitate (demand) the replacement of synthetic molecules with phytoconstituents because of their biocompatibility, biodegradability, economic extraction process, and ready availability from the natural source. This book provides a thorough insight into the comprehensive and up-to-date trends of phytomedicines in the management of lifestyle diseases and its mechanisms, modern methods of extraction and purification of phytoconstituents, and chemical characterization as well as standardization of phytoconstituents using modern equipments.

This book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.

This book updates knowledge on recent advances in computational, biophysical and bioinformatics tools/techniques and their practical applications in modern drug design and discovery paradigm. It also encompasses fundamental principles, advanced methodologies and applications of various CADD approaches including several cutting-edge areas; presenting recent developments covering ongoing trends in the field of computer-aided drug discovery. Having contributions by a global team of experts, the book is expected to be an ideal resource for drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, biologists, R&D personnel, researchers, students, teachers and those working in the field of drug discovery. It will fill the knowledge gaps that exist in the current CADD approaches and methodologies/ protocols being widely used in both academic and research practices. Further, a special focus on current status of various computational drug design approaches (SBDD, LBDD, de novo drug design, pharmacophore-based search), bioinformatics tools and databases, computational screening and modeling of phytochemicals/natural products, artificial intelligence and machine learning, and network pharmacology and systems biology would certainly guide researchers, students or readers to conduct their research in the emerging area(s) of interest. It is also expected to be highly beneficial to various stakeholders working in the pharmaceutical and biotechnology industries (R&D), the academic as well as research sectors.

This book provides the reader with a thorough understanding of schizophrenia as a complex brain disorder by explaining the various aspects investigated for its cognizance from epigenetics to chemistry and physics to computational approaches. The book covers the key notions of schizophrenia from a variety of facets such as neurogenetics, neurochemistry, neuropharmacology, neurobiology, psychotherapy, psychiatric treatment, cognitive studies, behavioral and societal studies, and computational neurosciences. Individual chapters are focused on crucial topics such as cognitive-behavioral therapy, brain functioning, computational neuroscience, neuro-imaging, and many more. This book explains each section and chapter with utmost clarity to maintain comprehensiveness for every kind of reader. This book covers various classical as well as recent topics from basic to advance level knowledge regarding schizophrenia. The book's contributions regarding its inclusivity of topics, comprehensiveness of language, diversity in knowledge, and focus on the subject will attract all kinds of readers. It can be considered a single comprehensive handy reference book for beginners, including medical students, neuroscientists, researchers, clinicians, and medical practitioners. Cognizance of Schizophrenia will be an invaluable asset for all who are involved in neuroscience research or clinical studies.

Dieser Ratgeber erklärt, wie Forschungsergebnisse aus Universitäten und Hochschulen patentiert und lizenziert oder verkauft werden können. Wichtige Aspekte des Erfindungs-, Patent- und Lizenzrechts werden anhand von Beispielen erläutert.Im ersten Teil werden Fragen beantwortet, was eine patentierbare Erfindung ist und welche Erfindervergütung Forschenden an Hochschulen zusteht. Ausführlich behandelt wird u.a. das Thema, wie Forschungsergebnisse publiziert und trotzdem patentiert werden können.Im zweiten Teil, speziell zum Patentieren, wird gezeigt, wie eine Patentanmeldung aufgebaut ist, wie Patentprüfverfahren ablaufen und was sie kosten. Mit vielen Praxistipps wird erklärt, wie man eine Patentrecherche durchführt und ermittelt, ob ein Patent noch aktiv ist. Zudem wird erläutert, welche Besonderheiten beim Schutz von Erfindungen für medizinische Anwendungen zu beachten sind.Im dritten Teil werden verschiedene vertragliche Lösungen zur Anbahnung sowie zum Abschluss von Lizenz- und anderen Verwertungsvereinbarungen vorgestellt. Häufige Probleme bei der Finanzierung der Weiterentwicklung von Projekten werden adressiert und Lösungen aufgezeigt. Der Schlussteil ist speziell dem Thema der Gründung von akademischen Spin-off-Unternehmen gewidmet. Die aktualisierte und erweiterte 2. Auflage enthält neue Beiträge zu den Themen Software-Schutz und -Lizenzierung und zu den Möglichkeiten, patentgeschützte Technologien weiterzuentwickeln. Neue Beispiele sowie verlinkte Interviews mit Experten illustrieren Best-practice-Fälle.Das Buch eignet sich sowohl als Übersicht für Einsteiger als auch zum gelegentlichen Nachschlagen für gestandene Erfinder. Es richtet sich grundsätzlich an alle Forschenden in den Naturwissenschaften und der Medizin sowie Mitarbeitende des Technologietransfers an Universitäten, Universitätskliniken und Hochschulen. Videos per App: einfach die SN More Media App kostenfrei herunterladen, einBild oder einen Link mit dem Play-Button scannen und sofort das Video auf Smartphone oder Tablet ausspielen.

This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training.The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences, with a focus in this volume related to anatomy, and clinically applied scenarios. The first six chapters in this volume show the wide variety of tools and methodologies that digital technologies and visualisation techniques can be utilised and adopted in the educational setting. This ranges from body painting, clinical neuroanatomy, histology and veterinary anatomy through to real time visualisations and the uses of digital and social media for anatomical education. The last four chapters represent the diversity that technology has to be able to use differing realities and 3D capture in medical visualisation, and how remote visualisation techniques have developed. Finally, it concludes with an analysis of image overlays and augmented reality and what the wider literature says about this rapidly evolving field.