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International Review of Connective Tissue Research, Volume 1 is a collection of papers that deals with fibroblast, the hormonal control of connective tissues, and calcification of skeletal tissues. One paper reports on the origin, morphology, structure, and the effect of drugs on fibroblasts such as the toxic substance found in sweet pea meal that causes human lathryrism. Another paper discuses hormonal control of connective tissue related to aging, arteriosclerosis, tumors, infection, fertility, and endocrine diseases. The author also describes the repair process of an injured connective tissue; it is characterized by edema, mucinous, and fibrous organization of the extracellular water—a process similar to regeneration and growth. One author describes the structure and general distribution of susceptible blood vessels, as well as, vascular degeneration in diabetes. Another author describes the calcification and formation of bones. He reviews Robison's theory of calcification, the seeding or nucleation concept of calcification, and the role of alkaline phosphatase in calcification. This volume will prove valuable for pathologists, endocrinologists, physiologists, molecular or cellular biologists, gerontologists, and researchers in gene therapy, pharmacology or micro-chemistry.

International Review of Connective Tissue Research, Volume 3 is a collection of papers that deals with the histochemisty of connective tissues. One paper reviews the histochemistry of connective tissues, including fibrous components such as collagen, reticulum, cellulose fibers, elastic fibers. Connective tissues known as osteoblasts and odontoblasts produce bone/cartilage and teeth. One author examines the biochemistry and pathology of the connective tissue of the periodontium that is related to periodontal disease. He also examines the role of oral bacteria in the pathogenesis of periodontitis; he concludes that bacterial enzymes can increase permeability for other bacterial types to directly elicit inflammation. One author analyzes the physical chemistry of gelatin and gelatin transition. He concludes that the rate of fold formation and the stability of the fold-units on single-chain gelatins and on multichain gelatins depend on the relative effectiveness of ions. Single-chain gelatins have the highest rate of network junction point formation; multichain gelatins, with enhanced cyclic junction point formation, have less network-forming properties. Cellular biologists, pathologists, physiologists, gerontologists, and researchers in gene therapy, pharmacology, micro- or molecular chemistry will find this book highly informative.

International Review of Connective Tissue Research, Volume 2 is a collection of papers that deals with the morphological background, physiological, and pathological aspects of studies done on connective tissues. One paper discusses the precipitation of collagen fibers from solution — that fibrils form in vitro and in vivo by similar mechanisms. Another paper examines the importance of elastic tissues in the reactions of connective tissue including diseases of the vascular and pulmonary systems. As simple as elastic tissues appear to be, these can be models in studies of the basic structure and function of other more complicated tissues. One author discusses the physiology of the connective tissues of the reproductive tract; he concludes that defects in the connective tissue functions can cause failure in ovulation or the formation of cystic ovaries. Other authors discuss the diseases of collagen and related tissues (rheumatic fever, rheumatoid arthritis, systemic lupus erythematous, osteoarthritis, osteoporosis), as well as the aging process. One author analyzes the role of collagen fibers in aging: whether factors exist that causes cross-linking or ester cross-links or the dissolution of the collagen macromolecule associated with the aging of collagen. This book can prove helpful for molecular or cellular biologists, pathologists, physiologists, gerontologists, and researchers in gene therapy, pharmacology or micro-chemistry.

International Review of Connective Tissue Research covers a broad range of aspects of connective tissue metabolism and structure, and other relevant material in the field of connective tissue research. The book discusses topics on the immunological reactions of collagen macromolecules and their degradation products; the factors involved in the specific control of collagen protein synthesis; effect of ionizing radiation on connective tissue components; and the physical properties of connective tissue. Physiologists, pathologists and researchers in the field of medicine will find the book invaluable.

International Review of Connective Tissue Research, Volume 6 presents the relationship between structure and function in connective tissue. This book deals with articular cartilage, a connective tissue that depends for its function on the integrity of its surface. Organized into six chapters, this volume begins with an overview of the structure, biology, chemistry, and biochemistry of collagen. This text then summarizes the data on the construction and application of collagen products to medicine and surgery. Other chapters consider the characteristic of the amino acid composition of basement membranes and the structural features of the synovial joint. This book discusses as well the functional properties of collagenous tissues with emphasis on their behavior when internal or external mechanical stresses are applied. The final chapter deals with the structure of fresh connective tissue based on conventional histological procedures such as dehydration, fixation, embedding, and staining. This book is a valuable resource for biochemists, rheologists, and physicists.

International Review of Connective Tissue Research, Volume 5 presents a detailed review of the end products of collagen metabolism, which is important in understanding certain diseases involving the connective tissues. This book discusses the progress in collagen research. Organized into four chapters, this volume begins with an overview of the metabolism of proline and hydroxyproline that are derived from studies using microorganisms. This text then examines the increasing interest in the more complex tissues and elucidates the marked differences one may expect to find in such tissues. Other chapters consider the process of calcification and the various conflicting theories. This book discusses as well the influence of the impurities, such as fluoride and carbonate, on the nature and formation of biological apatite. The final chapter deals with the contrast between the dynamic state of connective tissue cells and the inert aspect of the intercellular substances. This book is a valuable resource for biochemists, physicians, and surgeons.

Submicroscopic Cytochemistry, Volume I: Proteins and Nucleic Acids presents laboratory findings and theoretical aspects involved or derived from submicroscopic cytochemistry study of proteins and nucleic acids. It is a two-volume book, encompassing 14 chapters covering three major topics: the pattern of distribution of nucleic acids at the molecular level in various cells and states of activity and in relation to protein synthesis; the molecular and macromolecular organization of cellular membranes; and the origin and distribution of the major macromolecular aggregates of connective tissue. After a brief introduction to the aspects of submicroscopic cytochemistry, the book discusses morphology, with emphasis on the distribution of cell components and their organization in cells at the macromolecular level. It then presents developed methods to preserve and selectively identify proteins, nucleic acids, lipids, acid mucopolysaccharides, and molecular aggregates very nearly in the position they occupied in the living state. Chapters 8 to 12 describe DNA molecular patterns during cell differentiation and cell maturation, and the alteration of these patterns in certain mouse cells. A discussion on DNA molecular patterns during metaplasia of stratified squamous mouse epithelium and of spinal ganglion cells during regeneration is provided. The concluding chapters examine DNA organization during mitotic cycle in Drosophila eggs and the persistence of chromosome individuality during interphase. This book is a valuable source of information for cytochemists, cell biologists, cell researchers, and protein nucleic acid enthusiasts who wish to expand their knowledge on comprehensive cytochemistry laboratory study.