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Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series'Cell Biology and Translational Medicine (CBTMED)'as part of Springer Nature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 16th volume of a continuing series.Chapter'Epithelial Stem Cells: Making, Shaping and Breaking the Niche'is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Gene Regulatory Networks, Volume 139 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics in this release include Mouse hindbrain GRN, Xenopus endoderm GRN – organogenesis, Vertebrate limb GRN, The notochord gene regulatory network in chordate evolution: conservation and divergence from Ciona to vertebrates, Ciona early embryo GRNs, Boolean logic models, Modeling GRN response to morphogen gradient, GRN architecture, Theory of GRN evolution, Evolution of fly segmentation GRNs, GRN evolution in echinoderms, Evolution of network specificity, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Developmental Biology series - Includes the latest information on gene regulatory networks

This book offers one of the most comprehensive reviews in the field of gastrointestinal (GI) physiology, guiding readers on a journey through the complete digestive tract, while also highlighting related organs and glandular systems. It is not solely limited to organ system physiology, and related disciplines like anatomy and histology, but also examines the molecular and cellular processes that keep the digestive system running. As such, the book provides extensive information on the molecular, cellular, tissue, organ, and system levels of functions in the GI system. Chapters on the roles of the gut as an endocrine, exocrine and neural organ, as well as its microbiome functions, broaden readers'understanding of the multi-organ networks in the human body. To help illustrate the interconnections between the physiological concepts, principles and clinical presentations, it outlines clinical examples such as pathologies that link basic science with clinical practice in special “clinical correlates” sections. Covering both traditional and contemporary topics, it is a valuable resource for biomedical students, as well as healthcare and scientific professionals.

The “omics” era has given a new perspective to the findings on the origin and evolution of the process of translation. This book provides insight into the evolution of the translation process and machinery from a modern perspective. Written by leading experts in molecular biology, this text looks into the origins and evolution of the protein synthetic machinery.

A subgroup of homeobox genes, which play an important role in the developmental processes of a variety of multicellular organisms, Hox genes have been shown to play a critical role in vertebrate pattern formation. Hox genes can be thought of as general purpose control genes—that is, they are similar in many organisms and direct the same processes in a variety of organisms, from mouse, to fly, to human. - Provides researchers an overview and synthesis of the latest research findings and contemporary thought in the area - Inclusion of chapters that discuss the evolutionary development of a wide variety of organisms - Gives researchers and clinicians insight into how defective Hox genes trigger developmental abnormalities in embryos

This volume represents the first collection of articles contributed by research leaders working on the Myb family of transcriptional regulatory proteins. In more than twenty chapters the authors discuss the range of biological processes and diverse cell types in which Myb proteins operate. Although concentrating on the three vertebrate Myb family members, homologues from lower species are also discussed because of the light they are able to shed on the evolution and function of these proteins. Individual chapters describe the involvement of Myb proteins, in particular c-Myb, in normal and diseased development and function of many tissues including haemopoietic cells, blood vessels, the gastrointestinal tract and the brain. Several chapters explore the mechanistic details of the action of Myb proteins, especially structural features, their interaction with DNA and other regulatory proteins, and the variety of genes that are regulatory targets for this group of transcription factors. This work will be of interest to those working directly in the field and also to the wider research community investigating the transcriptional regulation of development, differentiation and growth. The therapeutic potential of manipulating Myb function is also discussed making the book appealing to clinician scientists in several fields including haematology, oncology and cardiology.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including NY-ESO-1: review of an immunogenic tumor antigen; Order, disorder, death: lessons from a superorganism; Control of differentiation in progression of epithelial tumors; Cancer vaccines: preclinical studies and novel strategies; Clinical results of vaccine therapy for cancer: learning from history for improving the future; Immunodominance and immunodomination: critical factors in developing effective CD8+ T-cell based cancer vaccines; NK cell receptors as tools in cancer immunotherapy; Innate immune recognition and suppression of tumors; Inhibitors of the HSP90 molecular chaperone: current status.

Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discussesnew strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapyapproaches. The chapters are divided into six sections as follows: - Basic Science of Extracellular Matrix - Cells Responsible for Extracellular Matrix Production - Activation Mechanism of Hepatic Cells and Signal Transduction - Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors - Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases - New Strategies for the treatment of Liver Cirrhosis - Discusses the possibility of gene therapy for liver cirrhosis - Includes information on new aspects of hepatic stellate cells - Written by top experts in basic science and clinical hepatology