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Human Evolutionary Genetics is a groundbreaking text which for the first time brings together molecular genetics and genomics to the study of the origins and movements of human populations. Starting with an overview of molecular genomics for the non-specialist (which can be a useful review for those with a more genetic background), the book shows h

Nowadays, genetics focuses on DNA. Just like the first edition, the theme of this new edition, Introduction to Genetics: A Molecular Approach, is therefore the progression from molecules (DNA and genes) to processes (gene expression and DNA replication) to systems (cells, organisms and populations). This progression reflects both the basic logic of life and the way in which modern biological research is structured. The molecular approach is particularly suitable for students for whom genetics is part of a broader program in biology, biochemistry, the biomedical sciences or biotechnology. This book presents the basic facts and concepts with enough depth of knowledge to stimulate students to move on to more advanced aspects of the subject.This second edition has been thoroughly updated to cover new discoveries and developments in genetics from the last ten years. There are new chapters that introduce important techniques such as DNA sequencing and gene editing, and the applications of genetics in our modern world are covered in chapters describing topics as diverse as gene therapy and the use of ancient DNA to study prehistoric ecosystems. Key Features: This book provides a molecular approach to the study of genetics. It is a highly accessible and well-structured book with chapters organized into four parts to aid navigation. It presents high-quality illustrations to elucidate the various concepts and mechanisms. Each chapter ends with a Key Concepts section, which serves to summarize the most essential points. Self-study questions enable the reader to assess their comprehension of chapter content, and discussion topics facilitate a deeper understanding of the material by encouraging conversation and critical evaluation. Key terms are emboldened throughout the text and are listed at the end of each chapter, and definitions can be found in the Glossary. For instructors who adopt the book, an affiliated question bank is free to download.

Biological Anthropology: The Natural History of Humankind covers the foundations of the discipline as well as modern innovations and discoveries. Each a practicing researcher in the field, authors Craig Stanford, John Allen and Susan Antón offer a specialist approach that gives you everything you need to master the subject. The 5th Edition has been thoroughly updated to reflect the latest findings in the field. Fresh topics include collaborative genomic work with indigenous peoples and the biocultural anthropology of vaccine hesitancy. Other new focus areas include the impact of climate change on human biology, information about new archaeological signals of large game hunting by Neandertals, and new material on determining handedness in the fossil record.

Systems Biology and In-Depth Applications for Unlocking Diseases provides the essence of systems biology approaches in a practical manner illustrating the basic principles essential to develop and model in real life science applications. Methodologies covered show how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment. Systematically written in 4 parts, this book first provides an introduction and history of systems biology; second, it provides the tools and resources needed for the structure and function of biological systems; next, it provides the evidence of systems biology in action to better understand disease connections; and finally, it provides the extensions of systems biology in various scientific fields including pharmacology, immunology, vaccinology, neuroscience, virology, and medicine. Examples include big data techniques, scale networks, mathematical model development, and much more. This is the perfect reference to provide the fundamental base of knowledge needed for systems biologists, professionals in systems medicine, computational biologists, and bioinformaticians, whether needed for immediate application or for building a comprehensive understanding of the field. - Provides detailed and comprehensive coverage of the field of systems biology - Delivers instruction on how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment - Makes effective steps towards personalized medicine in the treatment of disease - Explains effective disease treatment strategies at early diagnosis stages

The Hereditary Cancer Reference gives insight to the young and rapidly expanding field that combines oncology and genetics to achieve risk reduction, early detection, family risk management, and identification targeted treatments. While genetics and oncology are both well-developed knowledge areas, their combination in hereditary cancer yields an opportunity for new works that systemize knowledge for current researchers, practitioners and students. The Hereditary Cancer Reference exams 371 topics through the lens of hereditary cancer. There are no similar books that presents information in this manner. This reference work contains a complete list of terms and definitions which can be easily reference by researchers and clinicians working in this field that need to keep up to date. - Provides conceptual and factual treatments of 371 topics in hereditary cancer - Gives quick access to a comprehensive guide on Hereditary Cancer - Useful reference for researchers and clinicians

A sweeping account of male nurturing, explaining how and why men are biologically transformed when they care for babies It has long seemed self-evident that women care for babies and men do other things. Hasn't it always been so? When evolutionary science came along, it rubber-stamped this venerable division of labor: mammalian males evolved to compete for status and mates, while females were purpose-built to gestate, suckle, and otherwise nurture the victors'offspring. But come the twenty-first century, increasing numbers of men are tending babies, sometimes right from birth. How can this be happening? Puzzled and dazzled by the tender expertise of new fathers around the world—several in her own family—celebrated evolutionary anthropologist and primatologist Sarah Blaffer Hrdy set out to trace the deep history of male nurturing and explain a surprising departure from everything she had assumed to be “normal.”In Father Time, Hrdy draws on a wealth of research to argue that this ongoing transformation in men is not only cultural, but profoundly biological. Men in prolonged intimate contact with babies exhibit responses nearly identical to those in the bodies and brains of mothers. They develop caring potential few realized men possessed. In her quest to explain how men came to nurture babies, Hrdy travels back through millions of years of human, primate, and mammalian evolution, then back further still to the earliest vertebrates—all while taking into account recent economic and social trends and technological innovations and incorporating new findings from neuroscience, genetics, endocrinology, and more. The result is a masterful synthesis of evolutionary and historical perspectives that expands our understanding of what it means to be a man—and what the implications might be for society and our species.

This is the first volume on the Late Minoan III necropolis of Armenoi in western Crete. It sets the scene, introduces the site and its topography, and offers the results of site surveys and their finds.The Late Minoan III Necropolis of Armenoi, Crete (ca. 1390–1190 BC) is the only intact, complete Late Minoan necropolis presently known, of which 232 tombs have been excavated. The research project was the first large-scale genomic sampling of skeletal material from a single site in Bronze Age Greece, as well as being the first time a multi-disciplinary approach with ancient DNA as its focus has been conducted on a large, well-curated necropolis assemblage. As such it provides a unique opportunity to answer archaeological questions, the most important of which are kinship, an analysis of the origin and ancestry of those buried in the tombs, the homogeneity of the population or otherwise, and diet. The analysis program was only possible because the tombs had not been seriously disturbed, and human skeletal remains had survived and been expertly conserved. The results of ancient DNA, stable isotope analysis, osteological analysis, and radiocarbon dating are presented, providing the first detailed record of ancestry and kinship in this iconic period of Eastern Mediterranean prehistory.In addition, the long-debated problem of the location of the wealthy city of da-•22-to, referred to many times in the Linear B tablets, is addressed and key evidence is presented. The rich finds in the Necropolis, the town excavation, and in the environs, support the interpretation that the ‘city'that built the Necropolis is da-•22-to.

Steroids in the Laboratory and Clinical Practice covers both basic chemistry and therapeutic application of steroids in a single source. The comprehensive reference addresses the specificity of steroid determinations to clarify confusion arising from the laboratory results. The book covers important advancements in the field and is a valuable addition in the literature addressing all existing knowledge gaps. This is a must have reference for pathologists, laboratorians, endocrinologists, analytical/clinical chemists and biochemists. - Addresses the normal production of steroids and concentrations found in biological fluids and tissues - Presents the changes in steroid concentrations at life events as reference points for clinical investigations - Reviews the genetic disorders of steroids in relation to specific enzyme changes and clinical presentation

The 5th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Neuroscientific Advances.

What's in Your Genome? describes the functional regions of the human genome, the evidence that 90% of it is junk DNA, and the reasons this evidence has not been widely accepted by the popular press and much of the scientific community. The human genome contains about 25,000 protein-coding and noncoding genes and many other functional elements, such as origins of replication, regulatory elements, and centromeres. Functional elements occupy only about 10 percent of the more than three billion base pairs in the human genome. Much of the rest is composed of ancient fragments of broken genes, transposons, and viruses. Almost all of this is thought to be junk DNA, based on evidence that dates back fifty years. This conclusion is controversial. What's in Your Genome? describes the arguments on both sides of the debate and attempts to explain the reasoning behind those different points of view. The book corrects a number of false narratives that have arisen in recent years and examines how they have affected the debate over junk DNA. In addition, Laurence A. Moran focuses on scientific misconceptions and misinformation and on how the junk DNA controversy has been incorrectly portrayed in both the scientific literature and the popular press. Tracing the earliest indications of junk DNA back to the 1960s, the book explains the success of nearly neutral theory and the importance of random genetic drift, which gave rise to the view that evolution produces sloppy genomes full of junk DNA. What's in Your Genome? aims to offer the most accurate and current account of the human genome.

This book highlights the recent progress on the applications of mutation breeding technology in crop plants. Plant breeders and agriculturists are faced with the new challenges of climate change, human population growth, and dwindling arable land and water resources which threaten to sustain food production worldwide. Genetic variation is the basis which plant breeders require to produce new and improved cultivars. The understanding of mutation induction and exploring its applications has paved the way for enhancing genetic variability for various plant and agronomic characters, and led to advances in gene discovery for various traits. Induced mutagenesis has played a significant role in crop improvement and currently, the technology has resulted in the development and release of more than 3600 mutant varieties in most of the crop plants with great economic impact. The field of ‘mutation breeding'has come long way to become an important approach for crop improvement. This book covers various methodologies of mutation induction, screening of mutants, genome editing and genomics advances and mutant gene discovery. The book further discusses success stories in different countries and applications of mutation breeding in food crops, horticultural plants and plantation crops.This informative book is very useful to plant breeders, students and researchers in the field of agriculture, plant sciences, food science and genetics.

This book explores important chapters of past and recent African history from a multidisciplinary perspective. It covers an extensive time range from the evolution of early humans to the complex cultural and genetic diversity of modern-day populations in Africa. Through a comprehensive list of chapters, the book focuses on different time-periods, geographic regions and cultural and biological aspects of human diversity across the continent. Each chapter summarises current knowledge with perspectives from a varied set of international researchers from diverse areas of expertise. The book provides a valuable resource for scholars interested in evolutionary history and human diversity in Africa. Contributors are Shaun Aron, Ananyo Choudhury, Bernard Clist, Cesar Fortes-Lima, Rosa Fregel, Jackson S. Kimambo, Faye Lander, Marlize Lombard, Fidelis T. Masao, Ezekia Mtetwa, Gilbert Pwiti, Michèle Ramsay, Thembi Russell, Carina Schlebusch, Dhriti Sengupta, Plan Shenjere-Nyabezi, Mário Vicente.

Current Topics in iPSCs provides a deep analysis of the underlying fundamentals that support short and mid-term developments and milestones in the business of mesenchymal stem cell therapies. This volume explores the next frontier of MSC therapies and how the transformational potential of therapeutic adult cells will be realised in all therapy areas. The impacts of clinical and economic benefits are dissected throughout each of the chapters. Written by thought leaders in the field for those curious about the interface of science and business. - Explores the strategy at the forefront of the science of mesenchymal stem cells - Provides an overview of all therapy areas where MSC and MSC-derived products can be used therapeutically - Depicts transformational changes in healthcare that enable the implementation of MSC-powered technology platforms

Exploration in Laboratory Animal Sciences Understanding Life Phenomena updates our knowledge about the newer technologies such as molecular biology, genomics including sequencing, proteomics, transcriptomics, cell culture, stem cell culture, transgenesis and their translation to understand systematics and phylogeny of laboratory animals at molecular level. In seven sections Exploration in Laboratory Animal Sciences Understanding Life Phenomena resolves issues of conservation, applications in environment monitoring, production of drugs and others. Comparative research has enabled use of domestic animal models that translate the advances in basic biosciences to the schemes for human welfare including medicine. Molecular geneticists are unravelling the complexities of mammalian genes and the field of biotechnology is maturing at a fast pace. Additionally, research focused on immunology and animal behavior offer new insight into ways of enhancing animal welfare. The rise in consumption of animal proteins in addition to the challenges of sustaining our natural resources has given animal scientists a vast array of opportunities to engage in integrative systems-based research for meeting the challenges that behold us. Exploration in Laboratory Animal Sciences Understanding Life Phenomena also discusses the manipulation of animals as factories for the production of safe foods, drugs, and sensors and others to meet the contemporary challenges faced by mankind in the new world order created by pandemic of Covid 19. It also includes several chapters on the causation and management of certain diseases and impact of microbes on life. - Provides insight to newer and futuristic technologies to understand disease process and drug design by animal models - Addresses a wide variety of species and covers a wide variety of topics (such as animal species, the laboratory setting, regulatory guidelines, and ethical considerations) to fully prepare for work with all types of animals - Gives a perspective on laboratory animal use that allows to explain the benefits of animal use as required by veterinary technology program accreditation procedure - Includes examples of animal bio-technological techniques (including stem cell and tissue engineering) for their applications to humanity - Offers new insight into ways of enhancing animal welfare by the inclusion of research results focused on immunology and laboratory animal behavior

Advances in high-throughput biological methods have led to the publication of a large number of genome-wide studies in human and animal models. In this context, recent tools from bioinformatics and computational biology have been fundamental for the analysis of these genomic studies. The book Bioinformatics and Human Genomics Research provides updated and comprehensive information about multiple approaches of the application of bioinformatic tools to research in human genomics. It covers strategies analysis of genome-wide association studies, genome-wideexpression studies and genome-wide DNA methylation, among other topics. It provides interesting strategies for data mining in human genomics, network analysis, prediction of binding sites for miRNAs and transcription factors, among other themes. Experts from all around the world in bioinformatics and human genomics have contributed chapters in this book. Readers will find this book as quite useful for their in silico explorations, which would contribute to a better and deeper understanding of multiple biological processes and of pathophysiology of many human diseases.

This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases.The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems.The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability ofthe genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

This book provides the latest information of life science databases that center in the life science research and drive the development of the field. It introduces the fundamental principles, rationales and methodologies of creating and updating life science databases. The book brings together expertise and renowned researchers in the field of life science databases and brings their experience and tools at the fingertips of the researcher. The book takes bottom-up approach to explain the structure, content and the usability of life science database. Detailed explanation of the content, structure, query and data retrieval are discussed to provide practical use of life science database and to enable the reader to use database and provided tools in practice. The readers will learn the necessary knowledge about the untapped opportunities available in life science databases and how it could be used so as to advance basic research and applied research findings and transforming them to the benefit of human life.Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Studying Infectious Diseases, Volume 8 addresses how important induced pluripotent stems cells are and how can they can help treat certain infectious diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different infectious diseases, such as corona virus, coxsackievirus, salmonella infection, influenza virus and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. - Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics - Covers infections by several pathogens, such as coronavirus, coxsackievirus, influenza virus, herpes simplex virus 1, T. gondii, T. cruzi, S. agalactiae, N. meningitidis, Salmonella, and more - Is contributed by world-renowned experts in the field

Forensic DNA Analysis: Technological Development and Innovative Applications provides a fascinating overview of new and innovative technologies and current applications in forensic genetics. Edited by two forensic experts with many years of forensic crime experience with the Italian police and with prestigious academic universities, the volume takes an interdisciplinary perspective, the volume presents an introduction to genome polymorphisms, discusses, forensic genetic markers, presents a variety of new methods and techniques in forensic genetics, and looks at a selection of new technological innovations and inventions now available from commercial vendors. The book is an important resource for scientists, researchers, and other experts in the field who will find it of interest for its exhaustive discussion of the most important technological innovations in forensic genetics. For those newer to the field, the volume will be an invaluable reference guide to the forensic world.

Aging is an inevitable part of life and is becoming a worldwide social, economic and health problem. This is mainly due to the fact that the increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders, such as type II diabetes mellitus, cardiovascular disorders, sarcopenia, and neurodegenerative conditions. New therapeutic approaches are still needed to decrease or slow the effects of such diseases. Advances in -omic technologies, such as genomics, transcriptomics, proteomics and metabolomics, have significantly advanced our understanding of disease in multiple medical areas, as the analysis of multiple molecular networks has simultaneously provided a more integrated view of disease pathways. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan. In turn, this will lead to new therapeutic strategies as well as drug development projects by the pharmaceutical industry. This book presents a series of reviews describing studies that have resulted in identification of new potential drug targets for age-related disorders. Much of this information has come from -omic comparisons of healthy and disease states or from testing the effects of new therapeutic approaches. Authored by experts from around the globe, each chapter is presented in the context of specific chronic diseases or therapeutic strategies. This book is designed for researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians and stakeholders in major drug companies.

The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the AmericanCollege of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset(Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such asmacaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. Themarmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primatemodel to study a number of poorly understood disorders, like autism. - Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications - Includes contributions from renowned and international authors and editors - Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series

The dark heart of race science… and why it's nonsense.Racial differences are rooted in biological reality, right? That's certainly what a small group of anthropologists, psychologists and pundits would have you believe. Portraying themselves as brave defenders of the inconvenient truth, this group took the revival of ‘race science'from alt-right online message boards into mainstream academic journals. They seek to justify raging social inequalities from poverty to incarceration rates with a simple message: some people are just born to be poor. There's just one problem… race science isn't real. The first Europeans had dark skin and black curly hair. Culture was born in Africa, not Western Europe. Gavin Evans examines the latest research on how intelligence develops and laying out new discoveries in genetics, palaeontology, archaeology and anthropology to unearth the truth about our shared past. Skin Deep stands up to the pseudo-science deployed to justify colonial rule, the apartheid regime and the vast inequalities that persist today. As race dominates the political agenda, it's time to put the hateful myths about it to bed.

The articles included in this volume were all presented at the 15th annual British Association for Biological Anthropology and Osteoarchaeology (BABAO) conference held at the University of York on the 13th and 15th of September 2013. Ten papers are presented, on a range of topics and themes, including that of ‘Constructing Identities: Ethnicity and Migration'exploring theoretical approaches to the multiple identities of the body and multidisciplinary approaches to investigating the African origin of African American communities in parts of South America. Papers exploring the theme ‘Treatment of the Body: Understanding and Portrayals'focus on the visibility of prehistoric burial practice in Britain and the Levant (the ‘invisible dead'), and evidence for diversity in late medieval Christian burial practice in Taunton, Somerset. Three papers are incorporated in the theme ‘Investigating Lifeways: Diets, Disease and Occupations', focusing on ancient DNA to investigate Mycobacterium tuberculosis from 18th century mummies from Hungary; a bioarchaeological perspective on military communities in Roman London; and a methodological approach to testing a faster method for recording past activity-patterns in skeletal remains. The final three papers of the volume have both archaeological and methodological aspects, using osteological and archaeological evidence to investigate health in Roman York; exploring ostoarchaeological sampling strategies in the presentation of data from a large-scale sieving programme of a 19th century crypt and detailing a methodological study of estimating age of non-adults.

An illuminating look at the challenges and triumphs of state wildlife professionals at the forefront of the fight to protect the American wilderness.The adage'think globally but act locally'defines the work of American wildlife professionals. Their contributions, from remote outposts to major cities, guard the natural world of the entire country. In State Wildlife Management and Conservation, Thomas J. Ryder brings together wildlife leaders from practical, policy, and academic backgrounds to tell the story of state wildlife agencies, chronicling their efforts to restore and protect our nation's natural resources.Reflecting the core principle of the profession—that the public, not any individual, owns wildlife—the book explains how this tenet became law, laying the groundwork for the history of state-level wildlife management that follows. The authors cover key issues, including the limits of private land ownership, the funding of wildlife regulation, the nuances of humanwildlife conflict, the role of law enforcement, disease control efforts, and the challenges involved in balancing the perspectives of hunters, nonhunters, and animal rights advocates. Detailed essays also discuss state management techniques for a wide range of wildlife, including big game and migratory birds. State Wildlife Management and Conservation is a comprehensive, nationwide account of state management efforts. It will aid professors training the next generation of wildlife professionals, students hoping to enter the profession, and anyone working with wildlife to develop a more sophisticated understanding of what it means to be a state wildlife biologist. Contributors: M. Carol Bambery, Gordon R. Batcheller, Chad J. Bishop, Vernon C. Bleich, Dale Caveny, David K. Dahlgren, Daniel J. Decker, Karie L. Decker, Thomas A. Decker, Billy Dukes, John D. Erb, John R. Fischer, Ann B. Forstchen, Jonathan W. Gassett, Parks Gilbert, Colin M. Gillin, Tim L. Hiller, Daniel Hirchert, Michael W. Hubbard, Mark Humpert, Scott Hygnstrom, Robert P. Lanka, Richard E. McCabe, Jennifer Mock-Schaeffer, Brian Nesvik, Shaun L. Oldenburger, John F. Organ, Ronald J. Regan, Michael A. Schroeder, William F. Siemer, Christian Smith, Randy Stark, Gary J. Taylor, J. Scott Taylor, Daniel J. Thompson, Kurt VerCauteren, Mark P. Vrtiska, H. Bryant White, Steven A. Williams

Pathology of Wildlife and Zoo Animals is a comprehensive resource that covers the pathology of wildlife and zoo species, including a wide scope of animals, disease types and geographic regions. It is the definitive book for students, biologists, scientists, physicians, veterinary clinicians and pathologists working with non-domestic species in a variety of settings. General chapters include information on performing necropsies, proper techniques to meet the specialized needs of forensic cases, laboratory diagnostics, and an introduction into basic principles of comparative clinical pathology. The taxon-based chapters provide information about disease in related groups of animals and include descriptions of gross and histologic lesions, pathogenesis and diagnostics. For each group of animals, notable, unique gross and microscopic anatomical features are provided to further assist the reader in deciding whether differences from the domestic animal paradigm are'normal.'Additional online content, which includes text, images, and whole scanned glass slides of selected conditions, expands the published material resulting in a comprehensive approach to the topic. 2019 PROSE Awards - Winner: Category: Textbook/Biological and Life Sciences: Association of American Publishers Presents a single resource for performing necropsies on a variety of taxa, including terrestrial and aquatic vertebrates and invertebrates Describes notable, unique gross and microscopic anatomical variations among species/taxa to assist in understanding normal features, in particular those that can be mistaken as being abnormal Provides consistent organization of chapters with descriptions of unique anatomic features, common non-infectious and infectious diseases following brief overviews of the taxonomic group Contains full-color, high quality illustrations of diseases Links to a large online library of scanned slides related to topics in the book that illustrate important histologic findings

This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field. The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications. The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines.

How the latest cutting-edge science offers a fuller picture of life in Rome and antiquityThis groundbreaking book provides the first comprehensive look at how the latest advances in the sciences are transforming our understanding of ancient Roman history. Walter Scheidel brings together leading historians, anthropologists, and geneticists at the cutting edge of their fields, who explore novel types of evidence that enable us to reconstruct the realities of life in the Roman world.Contributors discuss climate change and its impact on Roman history, and then cover botanical and animal remains, which cast new light on agricultural and dietary practices. They exploit the rich record of human skeletal material--both bones and teeth—which forms a bio-archive that has preserved vital information about health, nutritional status, diet, disease, working conditions, and migration. Complementing this discussion is an in-depth analysis of trends in human body height, a marker of general well-being. This book also assesses the contribution of genetics to our understanding of the past, demonstrating how ancient DNA is used to track infectious diseases, migration, and the spread of livestock and crops, while the DNA of modern populations helps us reconstruct ancient migrations, especially colonization.Opening a path toward a genuine biohistory of Rome and the wider ancient world, The Science of Roman History offers an accessible introduction to the scientific methods being used in this exciting new area of research, as well as an up-to-date survey of recent findings and a tantalizing glimpse of what the future holds.

Life and Death in Asia Minor combines contributions in both archaeology and bioarchaeology in Asia Minor in the period ca. 200 BC – AD 1300 for the first time. The archaeology topics are wide-ranging including death and territory, death and landscape perception, death and urban transformations from pagan to Christian topography, changing tomb typologies, funerary costs, family organization, funerary rights, rituals and practices among pagans, Jews, and Christians, inhumation and Early Byzantine cremations and use and reuse of tombs. The bioarchaeology chapters use DNA, isotope and osteological analyses to discuss, both among children and adults, questions such as demography and death rates, pathology and nutrition, body actions, genetics, osteobiography, and mobility patterns and diet. The areas covered in Asia Minor include the sites of Hierapolis, Laodikeia, Aphrodisias, Tlos, Ephesos, Priene, Kyme, Pergamon, Amorion, Gordion, Boğazkale, and Arslantepe.The theoretical and methodological approaches used make it highly relevant for people working in other geographical areas and time periods. Many of the articles could be used as case studies in teaching at schools and universities. An important objective of the publication has been to see how the different types of results emerging from archaeological and natural science studies respectively could be integrated with each other and pose new questions on ancient societies, which were far more complex than historical and social studies of the past often manage to transmit.

Much of what we are comes from our ancestors. Through cultural and biological inheritance mechanisms, our genetic composition, instructions for constructing artifacts, the structure and content of languages, and rules for behavior are passed from parents to children and from individual to individual. Mapping Our Ancestors demonstrates how various genealogical or'phylogenetic'methods can be used both to answer questions about human history and to build evolutionary explanations for the shape of history.Anthropologists are increasingly turning to quantitative phylogenetic methods. These methods depend on the transmission of information regardless of mode and as such are applicable to many anthropological questions. In this way, phylogenetic approaches have the potential for building bridges among the various subdisciplines of anthropology; an exciting prospect indeed. The structure of Mapping Our Ancestors reflects the editors'goal of developing a common understanding of the methods and conditions under which ancestral relations can be derived in a range of data classes of interest to anthropologists. Specifically, this volume explores the degree to which patterns of ancestry can be determined from artifactual, genetic, linguistic, and behavioral data and how processes such as selection, transmission, and geography impact the results of phylogenetic analyses.Mapping Our Ancestors provides a solid demonstration of the potential of phylogenetic methods for studying the evolutionary history of human populations using a variety of data sources and thus helps explain how cultural material, language, and biology came to be as they are.

This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring. The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosome evolution. The book offers an informative and provocative guide for newcomers as wellas those already acquainted with the field.

Advances in sequencing technology have allowed scientists to study the human genome in greater depth and on a larger scale than ever before – as many as hundreds of millions of short reads in the course of a few days. But what are the best ways to deal with this flood of data?Algorithms for Next-Generation Sequencing is an invaluable tool for students and researchers in bioinformatics and computational biology, biologists seeking to process and manage the data generated by next-generation sequencing, and as a textbook or a self-study resource. In addition to offering an in-depth description of the algorithms for processing sequencing data, it also presents useful case studies describing the applications of this technology.

Are humans still subject to the forces of evolution? An evolutionary biologist provides surprising insights into the future of Homo sapiens In this intriguing book, evolutionary biologist Scott Solomon draws on the explosion of discoveries in recent years to examine the future evolution of our species. Combining knowledge of our past with current trends, Solomon offers convincing evidence that evolutionary forces still affect us today. But how will modernization—including longer lifespans, changing diets, global travel, and widespread use of medicine and contraceptives—affect our evolutionary future? Solomon presents an entertaining and accessible review of the latest research on human evolution in modern times, drawing on fields from genomics to medicine and the study of our microbiome. Surprising insights, on topics ranging from the rise of online dating and Cesarean sections to the spread of diseases such as HIV and Ebola, suggest that we are entering a new phase in human evolutionary history—one that makes the future less predictable and more interesting than ever before.

In this changing world of what is socially and politically'correct,'polygamy is perhaps the last great taboo. Over the last thousand years, monogamy - at least in name - has been the default setting for coupledom and procreation in the Western world. And yet, throughout history, there have been inklings that'one-man, one-woman'is an uncomfortable institution for human beings. The consistently high rate of marital'cheating'by both sexes, plus the persistent interest in a variety of sexual partners - on the part of women as well as men - suggest strongly that monogamy isn't easy, and certainly isn't'natural,'for either sex. Esteemed writer and evolutionary biologist David P. Barash tackles this uncomfortable finding: that humans are actually biologically and anthropologically inclined toward polygamy. Drawing on decades of research, Barash presents a remarkable array of scientific evidence from evolutionary biology and cross-cultural studies that guide the reader through the hidden impacts of polygamy on such crucial behavior as violence, parenting, sexual preferences, adultery and efforts at monogamy itself, along with mind-bending speculation about the possible role of our polygamous predisposition when it comes to human genius, homosexuality and even monotheism. But take heart, monogamists! Although our species has long been'out of Eden,'this fascinating read is ultimately reassuring that'biology is not destiny.'

For undergraduate courses in Evolution By presenting evolutionary biology as a dynamic, ongoing research effort and organising discussions around questions, this best-selling text helps students think like scientists as they learn about evolution. The authors convey the excitement and logic of evolutionary science by introducing principles through recent and classical studies, and by emphasising real-world applications. In the 5th Edition, co-author Jon Herron takes the lead in streamlining and updating content to reflect key changes in the field. The design and art program have also been updated for enhanced clarity. The full text downloaded to your computer With eBooks you can: search for key concepts, words and phrases make highlights and notes as you study share your notes with friends eBooks are downloaded to your computer and accessible either offline through the Bookshelf (available as a free download), available online and also via the iPad and Android apps. Upon purchase, you'll gain instant access to this eBook. Time limit The eBooks products do not have an expiry date. You will continue to access your digital ebook products whilst you have your Bookshelf installed.

The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.

This book constitutes the refereed proceedings of the 19th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2015, held in Warsaw, Poland, in April 2015. The 36 extended abstracts were carefully reviewed and selected from 170 submissions. They report on original research in all areas of computational molecular biology and bioinformatics.

This book outlines 11 courses and 15 research topics in bioinformatics, based on curriculums and talks in a graduate summer school on bioinformatics that was held in Tsinghua University. The courses include: Basics for Bioinformatics, Basic Statistics for Bioinformatics, Topics in Computational Genomics, Statistical Methods in Bioinformatics, Algorithms in Computational Biology, Multivariate Statistical Methods in Bioinformatics Research, Association Analysis for Human Diseases: Methods and Examples, Data Mining and Knowledge Discovery Methods with Case Examples, Applied Bioinformatics Tools, Foundations for the Study of Structure and Function of Proteins, Computational Systems Biology Approaches for Deciphering Traditional Chinese Medicine, and Advanced Topics in Bioinformatics and Computational Biology. This book can serve as not only a primer for beginners in bioinformatics, but also a highly summarized yet systematic reference book for researchers in this field.Rui Jiangand Xuegong Zhang are both professors at the Department of Automation, Tsinghua University, China. Professor Michael Q. Zhang works at the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

This book constitutes the refereed conference proceedings of the 9th International Conference on Intelligent Computing, ICIC 2013, held in Nanning, China, in July 2013. The 74 revised full papers presented were carefully reviewed and selected from numerous submissions and are organized in topical sections on neural networks, nature inspired computing and optimization, cognitive science and computational neuroscience, knowledge discovery and data mining, evolutionary learning and genetic algorithms machine learning theory and methods, natural language processing and computational linguistics, fuzzy theory and models, soft computing, unsupervised and reinforced learning, intelligent computing in finance, intelligent computing in petri nets, intelligent data fusion and information security, virtual reality and computer interaction, intelligent computing in pattern recognition, intelligent computing in image processing, intelligent computing in robotics, complex systems theory and methods.

This is the eBook of the printed book and may not include any media, website access codes, or print supplements that may come packaged with the bound book. For undergraduate courses in Evolution By presenting evolutionary biology as a dynamic, ongoing research effort and organizing discussions around questions, this best-selling text helps you think like a scientist as you learn about evolution. The authors convey the excitement and logic of evolutionary science by introducing principles through recent and classical studies, and by emphasizing real-world applications. In the Fifth Edition, co-author Jon Herron takes the lead in streamlining and updating content to reflect key changes in the field. The design and art program have also been updated for enhanced clarity.

For decades, Emery and Rimoin's Principles and Practice of Medical Genetics has provided the ultimate source for practicing clinicians to learn how the study of genetics can be integrated into practice. With almost 5,000 pages of detailed coverage, this fully online sixth edition of the classic reference adds the latest information on prenatal diagnosis, genetic screening, genetic counseling, and treatment strategies to complete its coverage of the growing field for medical students, residents and physicians involved in the care of patients with genetic conditions. Clinically oriented information is supported by expanded sections on basic principles of genetics, research approaches, and analytics to embrace the evolving population of students, researchers, and practitioners who are integrating their work to provide advanced diagnosis, prevention and treatment of human disease. With advances in high-throughput technologies propelling the closer integration of lab and clinical work, this edition bridges the gap between high-level molecular genetics and clinical application. - Features 174 review-length contributions that encompass traditional and new areas of the field - including in cancer genetics, genomic technologies, and molecular assays - Provides many thousands of pertinent literature references guiding the reader in identifying related topics - Fully illustrated with hundreds of color images, supporting identification, concept illustration and method processing

Introduction to Genetics: A Molecular Approach is a new textbook for first and second year undergraduates. It first presents molecular structures and mechanisms before introducing the more challenging concepts and terminology associated with transmission genetics.

In Gene Regulatory Sequences and Human Disease, the Editor will introduce the different technological advances that led to this breakthrough. In addition, several examples will be provided of nucleotide variants in noncoding sequences that have been shown to be associated with various human diseases.

Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards “nanoarrays”, which is expected to have great potential in clinical applications. Relevant issues of bioinformatics and statistical analysis of array data are discussed in detail, as well as the barriers to the commercialisation of array-based tests and the vexing IP issues involved. Thus, the book should be very useful tor active array users as well as to newcomers seeking to make the best choice between different technologies.

Charles Darwin is of course best known for The Voyage of the Beagle and The Origin of Species. But he produced many other books over his long career, exploring specific aspects of the theory of evolution by natural selection in greater depth. The eminent evolutionary biologist Steve Jones uses these lesser-known works as springboards to examine how their essential ideas have generated whole fields of modern biology.Earthworms helped found modern soil science, Expression of the Emotions helped found comparative psychology, and Self-Fertilization and Forms of Flowers were important early works on the origin of sex. Through this delightful introduction to Darwin's oeuvre, one begins to see Darwin's role in biology as resembling Einstein's in physics: he didn't have one brilliant idea but many and in fact made some seminal contribution to practically every field of evolutionary study. Though these lesser-known works may seem disconnected, Jones points out that they all share a common theme: the power of small means over time to produce gigantic ends. Called a'world of wonders'by the Times of London, The Darwin Archipelago will expand any reader's view of Darwin's genius and will demonstrate how all of biology, like life itself, descends from a common ancestor.

L'évolution biologique regroupe un ensemble de phénomènes dictés par le hasard des mutations et la nécessité d'être adapté à son environnement. Connaître l'histoire de la vie à partir de ses origines apporte un éclairage essentiel en médecine moderne et constitue un élément important de décision pour les professionnels de santé. Biologie de l'évolution et Médecine a pour vocation d'être le premier ouvrage à introduire les éléments essentiels de la biologie de l'évolution dans l'enseignement de la biologie médicale. Les auteurs décrivent dans un premier temps l'histoire de la vie sur Terre et l'apport des techniques nouvelles de systématique pour définir l'arbre du vivant. Cette présentation relativise la place de l'homme au sein des autres espèces vivantes et remet en question une vue trop anthropocentrique de la médecine. Les mécanismes de l'évolution sont exposés dans un deuxième temps. Les sources de la diversité génétique sont illustrées à partir d'exemples fournis par la génétique moléculaire. Les mécanismes de sélection par dérive génétique (hasard pur) ou sous l'effet de la sélection naturelle dite darwinienne sont détaillés. La dernière partie aborde l'évolution récente de la lignée évolutive qui conduit à l'homme et développe quelques applications de la médecine évolutionniste. Cet ouvrage, destiné à l'enseignement, comporte de nombreux encadrés sur des notions clés ou des applications directes ainsi que des illustrations d'une grande clarté pour permettre au lecteur de maîtriser les concepts importants. Il est écrit par deux auteurs complémentaires qui utilisent depuis longtemps le concept évolutionniste dans leurs recherches biomédicales.

The Human Condition is a collection of papers by leading evolutionary biologists and philosophers of science that reflect on the Darwinian Revolution as it relates to the human condition at levels ranging from the molecular to the theological. The book focuses on understanding the evolutionary origin of humans and their biological and cultural traits. The Human Condition is organized into three parts: Human Phylogenetic History and the Paleontological Record; Structure and Function of the Human Genome; and Cultural Evolution and the Uniqueness of Being Human. This fourth volume from the In the Light of Evolution (ILE) series, based on a series of Arthur M. Sackler colloquia, was designed to promote the evolutionary sciences. Each volume explores evolutionary perspectives on a particular biological topic that is scientifically intriguing but also has special relevance to contemporary societal issues or challenges. Individually and collectively, the ILE series interprets phenomena in various areas of biology through the lens of evolution, addresses some of the most intellectually engaging as well as pragmatically important societal issues of our times, and fosters a greater appreciation of evolutionary biology as a consolidating foundation for the life sciences.

Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician's fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such as the International HapMap project, enable large-scale studies, such as genome-wide association st- ies, which could potentially identify most common genetic variants as well as rare variants of the human DNA that may alter individual's susceptibility to disease and the response to medical treatment. Meanwhile the multi-electrode recording from behaving animals makes it feasible to control the animal mental activity, which could potentially leadto the development of useful brain–machine interfaces. - bracing the sheer volume of genetic, genomic, and other type of data, an essential approach is,?rst of all, to avoid drowning the true signal in the data. It has been witnessed that theoretical approach to biology has emerged as a powerful and st- ulating research paradigm in biological studies, which in turn leads to a new - search paradigm in mathematics, physics, and computer science and moves forward with the interplays among experimental studies and outcomes, simulation studies, and theoretical investigations.

Variation der Kopienzahl von Genen ist eine wichtige Quelle genetischer Variation innerhalb und zwischen Populationen. Die Mutationsmechanismen die zur Variation der Kopienzahl führen, sowie die Prozesse die die Grösse der betreffenden Regionen regulieren sind wenig untersucht. Diese Arbeit behandelt Variation der Kopienzahl in X und Y chromosomalen Mitgliedern einer grossen Genfamilie in Mus musculus ssps. Eine dramatisch erhöhte Amplifikation der Kopienzahl in intersubspezifischen Hybriden zwischen M. m. domesticus and M. m. musculus wird beschrieben. Dieses Phänomen wird sowohl in natürlichen als auch bei im Labor gezüchteten Hybriden beobachtet. Eine extreme Amplifikation der Kopienzahl, die in Hybriden aus der Natur nicht nachgewiesen wird, kann unter Laborbedingungen generiert werden. Dies legt nahe, dass extreme Destabilisierung der Kopienzahl in der Natur durch Selektion verhindert wird. Spezifische Analysen in Hybridmännchen zeigen das weder meiotische Rekombination oder interchromosomale Austauschprozesse benötigt werden, um Variation in der Kopienzahl zu erzeugen. Damit scheinen besonders Intrachromosomale- (Schwesterchromatid-) Austausche in intersubspezifischen Kreuzungen aufzutreten. Belegt wird dies durch eine grössere Anzahl somatischer Variationen in der Kopienzahl in verschiedenen Organen von Hybriden im Vergleich zu reinerbigen Mäusen. In Hybriden korreliert dies mit Fehlregulation der DNA Reparaturprozesse die Schwesterchromatid Austausche regulieren. Es scheint, das die Stabilität der Kopienenzahl von Genen in reinerbigen Populationen durch Kreuzungen mit Tieren aus anderen Populationen herabgesetzt werden kann, und dass dieser Prozess mit Mutationsprozessen zusammen hängt, die während der Entwicklung ablaufen. Dieses Ergebnis eröffnet eine neue Perspektive auf reproduktive Isolation und könnte für den Aufbau genetischer Inkompatibilität zwischen Unterarten von Mäusen eine Rolle spielen.