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Nanotechnological Aspects for Next-generation Wound Management provides detailed, up-to-date literature on nanotechnology's role in wound management and its applications using nanoparticles, nanocomposites, carbon-based nanostructures and nanomaterials. Scaffolds, three-dimensional approaches, skin tissue engineering, and polymer-based films are discussed to treat wounds. This one-of-a-kind reference is ideal for health practitioners, clinicians and researchers who will find the book to be excellent reference material for updates on recent trends in nanotechnology for wound management. - Describes the various nanotechnological approaches for wound management - Presents a detailed analysis of the use of artificial intelligence in wound care - Discusses the future aspects related to wound healing and wound management

OrthoBiologics provides state-of-the-art knowledge of current biologic therapies for a variety of orthopaedic conditions in a single source. The content is presented in a straightforward manner, including defining all currently available orthobiologic options, discussing processing characteristics and appropriate clinical use, and finally, summarizing clinical applications and outcomes as well as future potential directions.In addition to covering current approaches and applications, the editors aim for this book to present'best practices'for those practicing and researching orthopaedic pathologies and orthobiologic treatments, including blood and cellular based therapies. The editors are world-renown experts in the field and this book fills a gap in the market. - Presents the current state-of-the-art treatments for orthobiologics, including PRP, stem cell therapy, growth factors, scaffolds, and more - Includes a comprehensive overview of orthobiologics, including definitions, terminology, processing characteristics, clinical outcomes, and more - Presents current information on the ever-changing regulatory environment - Provides real-time information on clinical and surgical utilization of orthobiologics - Written for clinicians, researchers, and students, with content relevant to all those who participate in orthobiologic research and treatment, including orthopaedic surgeons, sports medicine specialists, rheumatologists, physiatrists, and any/all clinicians and researchers with an interest in orthobiologics and regenerative medicine.

'Ant Life'delves into the remarkable world of ants, exploring their global diversity, complex social structures, and ingenious survival strategies. This comprehensive study reveals how these tiny insects have become one of Earth's most successful animal groups. The book focuses on three main areas: ant species diversity, colony organization, and ecological impact, offering readers a deep understanding of ant biology and behavior. The book progresses from an overview of ant evolution to detailed examinations of various species and their behaviors. It explores the highly organized social structures and adaptability that contribute to ants'extraordinary success. Readers will discover fascinating insights into ant colonies'construction of intricate underground cities and their sophisticated communication systems. The interdisciplinary nature of ant research is highlighted, with connections made to fields such as robotics and materials science.'Ant Life'combines detailed scientific explanations with accessible language and engaging anecdotes, making it valuable for both specialists and nature enthusiasts. By examining ants'roles in ecosystems and their potential lessons for human society, the book offers a unique perspective on these remarkable creatures and their importance in the natural world.

The second edition of this book provides a completely updated account of the structure, dynamics, and physics of viral particles: from the moment they emerge by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognize and infect a new host cell and cease to exist as they lose their physical integrity to initiate a new infectious cycle. New insights into the structure of viruses, their physical properties, and mechanisms of action, derived from results obtained in the last decade, have been included, as well as other (bio)physical techniques to study the structure or dynamics of virus particles and components. These include, among many others, new advances in high-resolution electron cryomicroscopy; novel approaches in the use of electron cryotomography or the application of soft X-ray tomography to study viruses in the infected cell; high-speed atomic force microscopy to study virus assembly and dynamics; and the development of new antiviral drugs and vaccines. as well as of many nanomedical and nanotechnological applications of virus particles. New chapters on the study of viruses inside infected cells and on technological applications of modified viral particles have been included in this second edition. The book is still aimed primarily at Master's students, Ph.D. students, and postdoctoral researchers with degrees in biology, chemistry, physics or related scientific disciplines who have an interest in or are working with viruses. It provides an up-to-date overview of many important concepts, techniques, studies and applications in structural and physical virology for specialized researchers working with viruses, regardless of their field of specialization, covering the latest research together with fundamental concepts and well-established facts. In short, this book is basic enough to be used by undergraduate and Ph.D. students, but advanced and up-to-date enough for experienced scientists with an interest in structural and/or physical virology.

This textbook teaches health analytics using examples from the statistical programming language R. It utilizes real-world examples with publicly available datasets from healthcare and direct-to-consumer genetics to provide learners with real-world examples and enable them to get their hands on actual data. This textbook is designed to accompany either a senior-level undergraduate course or a Masters level graduate course on health analytics. The reader will advance from no prior knowledge of R to being well versed in applications within R that apply to data science and health analytics. “I have never seen a book like this and think it will make an important contribution to the field. I really like that it covers environmental, social, and geospatial data. I also really like the coverage of ethics. These aspects of health analytics are often overlooked or deemphasized. I will definitely buy copies for my team.” - Jason Moore, Cedars-Sinai Medical Center “Overall, I have a highly positive impression of the book. It is VERY comprehensive. It covers very extensive data types. I do not recall other books with the same level of comprehensiveness.” - Shuangge Ma, Yale University “The book is comprehensive in both aspects of genetics, and health analytics. It covers any type of information a healthcare data scientist should be familiar with, whether they are novice or experienced. I found any chapter that I looked into comprehensive, but also not too detailed (although in general this book is more than 600 pages of comprehensive and detailed relevant information).” - Robert Moskovtich, Ben-Gurion University of the Negev

This book discusses advances in postharvest and analytical technology for horticulture crops and challenges to meet future needs. The horticulture crops (fruits and vegetables) need a systematic and scientific postharvest handling and management system for securing both physical and chemical attributes while prolonging their shelf life. Postharvest technologies include storage, drying, packaging, extraction of components, and preparation of juice and wine from the collected fruits and vegetables. All these postharvest technologies have emerged and evolved with time to provide meaningful solutions to minimize food loss, maintain quality, and provide fast processing of horticulture crops. Parallel development of analytical techniques has also evolved to monitor the quality of fruits and vegetables during postharvest processing and thus provide a rapid and efficient method for delivering safer food products. This book provides an overview of different postharvest technologies, their mechanisms, and their effect on the quality of horticulture crops. It also emphasizes the assessment of each advanced technology, including its limitations and advantages. Overall, this book provides techniques, research, mechanisms, advances, and challenges of postharvest and analytical technologies for horticulture crops, along with recommendations for future research directions.

The book reviews cutting-edge advancements and their implications across various domains of molecular diagnostics. It covers foundational topics like protein-ligand interactions, lipid-protein interactions within biological membranes, and the application of NMR spectroscopy in understanding membrane structures. The book also explores advanced techniques such as X-ray crystallography, liposome microarray assays, and protein-lipid interaction studies. By integrating experimental and computational methods, it provides a comprehensive guide to understanding the complexities of molecular diagnostics, from basic principles to innovative approaches in drug discovery and therapeutic development. Each chapter offers detailed discussions on specific topics, supported by experimental data and methodological insights, making it an invaluable resource for researchers, clinicians, and students seeking to enhance their knowledge and expertise in molecular diagnostics.

A formação de residentes na área de saúde interessa a toda sociedade. Saídos das residências estes assumem o cuidado especializado nas várias profissões da saúde. Inovações na formação favorecem o desenvolvimento de competências e o trabalho em equipe. Assim, aumentam as publicações científicas. A revisão do escopo aqui apresentada abrange currículo e competência; ensino de habilidades; comunicação; avaliação; gestão e governança, no contexto das políticas de saúde e educação superior.

Microlepidoptera of Europe: Depressariidae is the tenth volume in this series, providing descriptions and illustrations which will enable identification of all 192 species. For preparation more than 10000 specimens have been studied, including East Palearctic species. Barcodes were taken from nearly 3000 specimens. As a result, 28 species were described as new to science, 22 of these present in Europe. For the first time in a guide to species identification in a family of European Microlepidoptera traditional taxonomy based on morphology is backed up by molecular evidence. The last revision of the family which covered all Europe was published in 1910.

This book commences with an introduction to the fundamental principles of light and electron microscopy, laying the groundwork for readers to grasp the significance of ultramicrotomy within these fields. It addresses every aspect of ultramicrotomy, including its history, instrumentation, procedural intricacies, as well as guidelines for maintenance and troubleshooting. A number of images and illustrations have been included to depict every step of the ultramicrotomy procedure to facilitate deeper understanding of the subject. It also talks about different techniques that can be employed for enhancing the quality and precision of the microscopy results. This book is a resource for researchers, faculty members, students, microtomists and microscopists working on sample preparation and analysis through transmission electron microscopy.

Antimicrobial peptides (AMPs) have been sought to be a potential alternative to the current arsenal of antibiotics against undesirable microbes. AMPs synthesized by lactic acid bacteria have attracted significant attention due to their strong activity against a broad range of bacteria including pathogens. The bacteriocin (an AMP) has been known to us since early 1928, a year before penicillin was reported. This is possibly due to their narrower activity compared to antibiotics. However, several AMPs having promising activity have been thoroughly characterized in the past few decades. Renewed interest has developed focusing on industrially important bacteriocins produced by lactic acid bacteria. Some of these AMPs are also active against food spoilage and clinically important pathogens. Similar to antibiotics, large-scale intellectual screening is ongoing in the search for novel AMPs with unique properties. Recent research has revealed that AMPs may also play a role in maintaining gut microflora and keeping us protected from food-borne pathogens. The ongoing genomic studies suggest that there may be more such bioactive compounds waiting to be explored. This book provides an overview of the fundamental knowledge accumulated so far regarding the diversity and potential applications of AMPs produced by lactic acid bacteria. This updated reference book on AMPs from lactic acid bacteria is timely, covering the most important achievements in the field and providing the scientific community particularly graduate students, researchers, and clinicians with the latest updates. The goal of this book is to illustrate and detail the findings made so far, debate the state of the art, and draw new perspectives.

This comprehensive guide is designed for researchers, professionals, and students looking to deepen their knowledge of diatoms, including detailed information on diatom photosynthesis regulation at the molecular scale, as well as their significant ecological roles, all aimed at promoting sustainable advancements and the safeguarding of aquatic ecosystems. Diatoms exert an immense influence on the ecosystem of Earth due to their remarkable abundance and species diversity. Thriving in diverse habitats spanning the oceans, intertidal benthic zones, saline and freshwater environments, and even terrestrial niches like moist soil, forests, and caves, they play an integral role. Diatoms alone account for around 20% of the oxygen generated by photosynthesis, comparable to the combined productivity of tropical rainforests worldwide, while their primary production can reach 40–45% in marine ecosystems. Nevertheless, in contrast to the extensive research on macroscopic photosynthetic organisms, investigations in this domain remain comparatively limited, despite the role of diatoms in global biogeochemical processes. This book presents an exhaustive review of the subject matter, encompassing a wide spectrum of topics ranging from the intricate molecular mechanisms of diatom photosynthesis and light absorption to the dominant role of diatoms as primary producers within ecological frameworks. Beyond this, the book delves into the practical implications stemming from diatoms and their photosynthetic productivity. A strong emphasis is placed on the importance of fundamental research in deepening our understanding of the natural world around us. Diatoms Photosynthesis provides readers with a comprehensive guide to understanding the fundamentals of diatom photosynthesis and their ecological significance in aquatic ecosystems; a guide to the potential of diatom-derived products for sustainable technologies; a roadmap from diatom photosynthesis to implications in applied sciences; a bridge to span the gap between fundamental research on diatoms and their practical applications. Audience This book caters to academic professionals, students, and researchers in the fields of marine biology, ecology, microbiology, and biochemistry. It offers insights and benefits into diatom photosynthesis, diatom physiology, biodiversity, ecosystem health, and sustainable technological advancements.

This book focuses on Robert Rosen's contributions to relational system theory, which is the science of organization and function. This science was originally developed by Nicolas Rashevsky, and further developed by Rashevsky's student Robert Rosen, and continues to be developed by Rosen's student A. H. Louie amongst others. Due to its revolutionary character, it is often misunderstood, and to some, controversial. The formal and conceptual setting for Rosen's relational system theory is category theory. Rosen was the first to apply category theory to scientific problems, outside of pure mathematics, and the first to think about science from the point of view of category theory. To better understand the work of Rosen, this book provides an overview of his theory of modeling, complexity, anticipation, and organism. It presents the foundations of this science and the philosophical motivations behind it along with conceptual clarification and historical context in order to present Rosen's ideas to a wider audience.

Fundamentals of Cellular and Molecular Biology is a comprehensive textbook designed to explain the molecular mechanisms that underpin the functions and structures within living organisms. This resource focuses on improving the reader's understanding and exploration of the cellular and molecular basis of life, emphasizing the latest research findings and technological advancements. The book is structured into 18 chapters that systematically cover topics ranging from the basic structural components of cells to the complex processes of gene expression, protein synthesis, and cell signaling. It offers a detailed examination of DNA replication, repair mechanisms, and the molecular basis of genetic diseases. Additionally, the book explains the application of molecular biology in biotechnology, medicine, and environmental science, as well as advanced topics like cloning, gene therapy, and molecular diagnostics.Key features:- Clear explanations of complex concepts, bridging basic biology concepts with applied scientific fields- Uses real-world examples to illustrate scientific principles- Includes information on the latest research and technological breakthroughs.- Glossaries and references for each chapter- Facilitates learning with diagrams, flowcharts, and tables that summarize critical information, making complex subjects accessible.Fundamentals of Cellular and Molecular Biology is an essential resource for students in life science courses such as biology, biochemistry, biotechnology, and medicine.

A new edition of Peter and Rosemary Grant's classic account of their groundbreaking forty-year study of Darwin's finches40 Years of Evolution is a landmark study of the finches first made famous by Charles Darwin, one that documents as never before the evolution of species through natural selection. In this now-legendary study, renowned evolutionary biologists Peter and Rosemary Grant draw on a vast and unparalleled range of ecological, behavioral, and genetic data to continuously measure changes in finch populations over a period of four decades on the small island of Daphne Major in the Galápagos archipelago. In the years since the book's publication, the field of genomics has developed greatly. In this newly revised edition of 40 Years of Evolution, the Grants combine the results of their historic field study with genomic analyses of their primary findings, resolve unanswered questions from the field, and provide invaluable insights into the genetic basis of beak and body size variation and the history of this iconic adaptive radiation.

The Atlas of Diagnostic Pathology in Nonhuman Primates offers the first extensively illustrated collection of classic lesions in nonhuman primate diseases and pathological conditions, compiled by an international team of expert contributors. Organized by infectious and noninfectious conditions, the atlas comprehensively covers viral, bacterial, fungal, and parasitic diseases, as well as nutritional, toxic, and metabolic causes, and genetic, age-related, neoplastic, and noninfectious inflammatory conditions. Since nonhuman primates are an indispensable resource for efficacy and safety evaluation of novel therapeutic strategies targeting clinically important human diseases, research with monkeys is critical to understand how to prevent and treat emerging infectious diseases such as Zika virus disease, Ebola, Middle East Respiratory Syndrome (MERS), COVID-19/SARS-CoV-2/coronavirus, pandemic flu, and many more. This book is intended to serve veterinary practitioners in university facilities, zoos, biotechnological and pharmaceutical companies, as well as clinicians, researchers, and students engaged in nonhuman primate research.

Artificial Intelligence in Urology: Present and Future summarizes the cutting-edge development and adoption of Artificial Intelligence (AI) technologies in urology. The book explores barriers that prevent the further adoption of AI technologies, provides ethical considerations, and investigates the future role AI is expected to play. In addition, it includes applications of AI technology in the diagnosis and treatment of cancers (prostate, bladder, and more) and kidney stones, and in both adult and pediatric care. This is the perfect reference for researchers developing AI technologies for clinical applications and for clinicians who aim to effectively adopt AI technologies to solve clinical questions. - Describes the state-of-the-art of AI applications in urology by leading experts in the field - Provides a comprehensive review of how different strategies in AI are utilized to solve a wide range of clinical problems—from diagnosis, treatment, and prognostication of urologic diseases - Comprises contents that can be used as a springboard to allow readers to adopt AI technologies in their field of study/practice

Equity, Diversity, and Inclusion in Healthcare: From Knowledge to Practice offers a comprehensive text on the landscape of equity, diversity, and inclusion (EDI) in the health professions. Each chapter is dedicated to a health profession and is authored by an expert in EDI and workforce diversity in their respective discipline (such as medicine, dentistry, nursing, pharmacy, physiotherapy, and so on). Chapters characterize the present state of workforce diversity in the discipline, chronicle historical developments, provide rationale for systemic action, and include possible solutions and interventions in an evidence-based manner. By serving as an all-in-one reference text, this resource is meant for students, healthcare professionals, and organizational leadership who wish to understand and implement EDI in the health professions. - Presents a characterization of the present state of workforce diversity - Provides a review of the longitudinal trends in EDI developments (e.g., improvement, decline, or stagnation of minority group representation) - Introduces a rationale for systemic action, accompanied by solutions, interventions, and possible programs/initiatives to tackle disparities

Human Sexuality Today presents a holistic examination that encourages reflection on how human sexuality impacts lives today. The text helps you understand the key concepts of the discipline in order to make responsible decisions in your daily lives. Employing a conversational writing style, authors Pamela Regan and Bruce King present relevant information in a warm manner that instills positive feelings about sex and sexuality. The 10th Edition has been updated to reflect the latest research in the field. The authors present new discussions of topics such as sexuality during pregnancy, paraphilic disorders, the sexual behavior of teenagers and more. To ensure that the text remains current, each chapter contains the latest data and research findings, including more than 900 new citations.

A new view for studying and understanding biological evolution emerges when the concepts of phylogenetic systematics and exaptation are combined. A new definition of macroevolution is created. Preadaptation is shown to be a null concept and its comparison with exaptation is shown to be inappropriate. This book criticizes the prevailing view, the adaptationist, microevolutionary outlook, which considers adaptation as being the exclusive or main evolutionary process responsible for vertebrates having occupied the terrestrial environment. The authors argue that the macroevolutionary processes are significantly more important to explain an improbable evolutionary event. Their research shows that macroevolutionary processes are the dominant factors involved in the origin of terrestriality. This book is a revised and expanded English translation from the original Portuguese edition Peixes conquistam a terra firme: nova abordagem para um evento acidental único (Editora Baraúna, 2017).

Aquatic Insects of California, with Keys to North American Genera and California Species is an essential reference for scientists, researchers, and enthusiasts working in the study of aquatic insects and their role in freshwater ecosystems. This comprehensive volume bridges the gap between limnology—the study of inland waters—and entomology, providing an in-depth exploration of the central role insects play in aquatic environments. Written by leading authorities in the field, it offers detailed insights into insect ecology, stream and lake management, mosquito control, and the broader implications for fish production and aquatic health. The book aims to integrate the basic principles and methodologies of limnology with the study of insects, providing readers with identification tools through detailed illustrations, keys, and species-level information, particularly focused on the California and adjacent regional fauna. With a strong emphasis on practical identification, Aquatic Insects of California, with Keys to North American Genera and California Species is designed to overcome the historical challenges posed by the immense diversity of aquatic insect species. This volume covers a wide array of genera found across North America, making it an invaluable resource for researchers working beyond the confines of California. Each chapter is authored by experts who share original contributions and offer clear illustrations to enhance the text. As a foundational work in the field, this book equips students, professionals, and environmental managers with the necessary knowledge to understand and manage aquatic insects, ensuring the health and vitality of aquatic ecosystems. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1971.

Alfredo Ferro's impact on information technology has traversed diverse domains, encompassing Computational Logic, Data Mining, Bioinformatics, and Complex Systems. After first studying Mathematics at the University of Catania, he received a Ph.D. in Computer Science from NYU in 1981, working under the supervision of Jacob Theodor (Jack) Schwartz. He returned to the University of Catania where he established the Computer Science undergraduate program, served as the coordinator of the Ph.D. program in Computer Science, cofounded the Ph.D. program in Biology, Human Genetics, and Bioinformatics, and retired as a full professor in 2021.Alfredo's academic career as a computer scientist is characterized by two distinct research phases: Computational Logic until approximately 1995, followed by a notable focus on Data Mining and Bioinformatics. The contributions in this volume reflect the quality and the scope of his personal and collaborative successes.He also taught andinspired many excellent scientists. A pioneering initiative was to establish summer schools for Ph.D. students in 1989, leading to the so-called Lipari School, now the J.T. Schwartz International School for Scientific Research, where Alfredo continues to serve as director. This prestigious series includes schools focused on Computer Science, Complex Systems, and Computational Biology, featuring world-class scientists as lecturers and mentors.

PREMIUM PRACTICE FOR A PERFECT 5—WITH THE MOST PRACTICE ON THE MARKET! Ace the AP Biology Exam with The Princeton Review's comprehensive study guide. Includes 6 full-length practice exams (more than any other major competitor), plus thorough content reviews, targeted test strategies, and access to online extras.Techniques That Actually Work• Tried-and-true strategies to help you avoid traps and beat the test• Tips for pacing yourself and guessing logically• Essential tactics to help you work smarter, not harderEverything You Need for a High Score• Fully aligned with the latest College Board standards for AP® Biology• Comprehensive content review for all test topics• Online digital flashcards to review core content• Access to study plans, a handy list of key terms and concepts, helpful pre-college information, and more via your online Student ToolsPremium Practice for AP Excellence• 6 full-length practice tests (4 in the book, 2 online) with detailed answer explanations• Practice drills at the end of each content review chapter• End-of-chapter key term lists to help focus your studying

This volume on stepwise techniques to culture adult human stem cells begins with the basic methods to culture adult stem cells followed by related methods to supplement stem cell culture. This and future volumes of techniques will allow laboratories across scientific entities – academic and commercial – to adapt the described methods for similar methods with cells from other species. The standardized techniques will allow across the board interpretation of other technologies such as Omics studies. These methods can be a starting platform for culturing stem cells even in laboratories that might not be familiar with the techniques.Scientific and early clinical trials strongly favor the development of translational studies with adult stem cells. A major impediment to progress in the field of regenerative medicine is a lack of standardized methods to culture specific stem cells. Such documented methods would allow for scientific rigor and reproducibility to enhance efficient and safe translation of stem cells to patients. This book fills that gap.

The book titled Biogenic Nanomaterial for Health and Environment covers the synthesis, characterization, and applications of nanomaterials synthesized using living organisms, like bacteria, algae, fungi, plants, and biomolecules derived from them. This book is intended to meet the needs of undergraduate and graduate-level students of chemistry, biology, nanotechnology, and chemical engineering disciplines. The book will also serve as a useful reference work for researchers working in the fields of nanochemistry, material science, biology, and industrial chemistry.FEATURES A systematic overview of the biogenic synthesis nanomaterial. Recent research results and pointers to the advancement in the field. Discussion of putative applications of biogenic nanomaterials in health and the environment, with a main emphasis on biocidal activity, disease diagnosis, drug delivery, and sensing and remediation of pollutants from the environment. This book is compiled in such a way that it aids in understanding the underpinning concepts of the biogenic synthesis of nanoparticles. The biogenic synthesis of nanoparticles delivers more important and effective prospects for nanotechnology researchers. The biomass derived from various organisms acts as a template for the synthesis of nanoparticles with desired structural and featural aspects. The rewards of employing biomass and molecules derived from organism of choice in the synthesis process of nanoparticles are able to enhance the electrochemical consistency, control particle size, reduce toxicity, and escalate reactivity in an eco-friendly way. This book will provide the latest insights into the synthesis of nanomaterials employing biomass, cell extract, or as a whole, of various organisms and their roles in the health and remediation of the environment.

Advances in Clinical Chemistry, Volume 119, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. Topics covered in this new release include Advances in Endotoxin Analysis, SARS-CoV-2 detection and surveillance, Osteopontin in Cancer, Gastrointestinal Hormones: History, Biology, and Measurement, Natriuretic Peptide Testing Strategies in Heart Failure: a 2023 Update, and Defining Allowable Total Error Limits in the Clinical Laboratory. - Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science - Authored by world renowned clinical laboratory scientists, physicians, and research scientists - Presents the international benchmark for novel analytical approaches in the clinical laboratory

John Tyler Bonner, one of our most distinguished and creative biologists, here offers a completely new perspective on the role of size in biology. In his hallmark friendly style, he explores the universal impact of being the right size. By examining stories ranging from Alice in Wonderland to Gulliver's Travels, he shows that humans have always been fascinated by things big and small. Why then does size always reside on the fringes of science and never on the center stage? Why do biologists and others ponder size only when studying something else—running speed, life span, or metabolism?Why Size Matters, a pioneering book of big ideas in a compact size, gives size its due by presenting a profound yet lucid overview of what we know about its role in the living world. Bonner argues that size really does matter—that it is the supreme and universal determinant of what any organism can be and do. For example, because tiny creatures are subject primarily to forces of cohesion and larger beasts to gravity, a fly can easily walk up a wall, something we humans cannot even begin to imagine doing.Bonner introduces us to size through the giants and dwarfs of human, animal, and plant history and then explores questions including the physics of size as it affects biology, the evolution of size over geological time, and the role of size in the function and longevity of living things.As this elegantly written book shows, size affects life in its every aspect. It is a universal frame from which nothing escapes.

A hands-on lab guide in the R programming language that enables students in the life sciences to reason quantitatively about living systems across scalesThis lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty.Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communitiesEncourages good coding practices, clear and understandable modeling, and accessible presentation of resultsHelps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scaleBuilds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulationsBridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their ownStand-alone computational lab guides for Quantitative Biosciences also available in Python and MATLAB

A hands-on lab guide in the Python programming language that enables students in the life sciences to reason quantitatively about living systems across scalesThis lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty.Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communitiesEncourages good coding practices, clear and understandable modeling, and accessible presentation of resultsHelps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scaleBuilds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulationsBridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their ownStand-alone computational lab guides for Quantitative Biosciences also available in R and MATLAB

A hands-on lab guide in the MATLAB programming language that enables students in the life sciences to reason quantitatively about living systems across scalesThis lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty.Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communitiesEncourages good coding practices, clear and understandable modeling, and accessible presentation of resultsHelps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scaleBuilds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulationsBridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their ownStand-alone computational lab guides for Quantitative Biosciences also available in Python and R

'Evolutionary botanist Zimmerman discusses her passion for plants and inveighs against sexism in the sciences in her marvelous debut memoir...Throughout, Zimmerman's enthusiasm and expertise make the science accessible even to those without a background in the subject. The results are as edifying as they are galvanizing.'- Publishers Weekly STARRED Review'Erin Zimmerman has exposed a rooted gender failure in science. Her book is important not for this alone. Her work is essential for understanding the future resilience of all flora on this planet.'-Diana Beresford-Kroeger, author of To Speak for the TreesAn exploration of science, motherhood, and academia, and a stirring account of a woman at a personal and professional crossroads...Growing up in rural Ontario, Erin Zimmerman became fascinated with plants—an obsession that led to a life in academia as a professional botanist. But as her career choices narrowed in the face of failing institutions and subtle, but ubiquitous, sexism, Zimmerman began to doubt herself.Unrooted: Botany, Motherhood, and the Fight to Save an Old Science is a scientist's memoir, a glimpse into the ordinary life of someone in a fascinating field. This is a memoir about plants, about looking at the world with wonder, and about what it means to be a woman in academia—an environment that pushes out mothers and those with any outside responsibilities. Zimmerman delves into her experiences as a new mom, her decision to leave her position in post-graduate research, and how she found a new way to stay in the field she loves.She also explores botany as a “dying science” worth fighting for. While still an undergrad, Zimmerman's university started the process of closing the Botany Department, a sign of waning funding for her beloved science. Still, she argues for its continuation, not only because we have at least 100,000 plant species yet to be discovered, but because an understanding of botany is crucial in the fight against climate change and biodiversity loss.Zimmerman is also a botanical illustrator and will provide 8 original illustrations for the book.

Penile Prosthetic Surgery: Practical Guide to Prosthetic Implant describes the different types of penile prostheses and provides step-by-step surgical procedures in diverse patients experiencing erectile dysfunction. Additionally, access to supplemental videos provide enhanced learning through the opportunity to see procedures carried out. Content covers common tips and tricks for successful surgery and presents possible complications with accompanying solutions. Coverage includes full acknowledgement and examinational of the basic research and underling pathological mechanisms that are present in the erectile dysfunction resistant to medical therapy as well as the counseling that patients may need from both the urological and psychological point of view. This book gives a full comprehension of penile prosthesis surgery from multiple viewpoints, making it the perfect reference for urologists, andrologists and psychologists. - Provides step-by-step surgical procedures related to penile prosthesis. - Reviews the complications and possible solutions of this penile prosthetic surgery. - Delivers supplemental videos of the surgical procedures covered in the book help to enhance learning

The book delves into metabolomics which is a rapidly growing field that focuses on the study of chemical processes involving metabolites. These metabolites are small molecules that serve as substrates, intermediates, and end products of cellular metabolism. The book covers a wide range of tools and methods to facilitate metabolomics analysis, including modelling, gas chromatography, GC-MS, HPLC, MALDI, nuclear magnetic resonance, and many others. The book introduces metabolomics and then delves into tools and methods used in metabolomics research, followed by genome-scale analysis and fluxomics, which explore the complex metabolic networks within cells. The design of biosynthetic pathways is discussed in detail, highlighting their significance in manipulating cellular metabolism. The book also explores biosensors, chromatography techniques, NMR spectroscopy, transcriptional control of metabolite production, microfluidics, and the role of artificial intelligence and machine learning in metabolomics research. Additionally, it delves into cell-free systems, bioprocess optimization, fermentation technology, and industrial-scale production of metabolites. This book fills a significant gap in the market with comprehensive coverage and inclusion of diverse topics making it a valuable resource for students, researchers, scientists, clinicians, policymakers, and practitioners in the field.

Cancer development and progression is the result of biological phenomena that occur across multiple temporal and spatial scales. Recent years have seen a flurry of multi-scale mathematical models developed to generate and test new biological hypotheses related to cancer development, progression, and various treatment approaches. This has led to the development of new computational and analytical approaches aimed at investigating these multi-scale models.This review volume summarises the state of the art related to the modelling, experimental investigation, and data assimilation of multi-scale phenomena during cancer development, evolution, and treatment, as well as the computational and analytical investigation of the multi-scale models developed to reproduce the biological phenomena. The book also identifies the experimental and theoretical open problems that will have to be addressed in the near future in order to advance this field. Modelling and Computational Approaches for Multi-Scale Phenomena in Cancer Research is an excellent resource for both early career and advanced researchers.

What can snorkelling at Shark Bay teach us about humanity? Will the secrets of our sex lives be uncovered by stick insects? What do whale societies reveal about kindness? And why did we evolve to spend a third of our life asleep? Some questions have nipped at humanity's heels for as long as we've been…well, humans. In Why Are We Like This? science journalist Zoe Kean takes us behind the scenes of the evolutionary paradoxes that make up life on this planet. Exploring with scientists, from freezing in Tasmanian sleet to a laboratory of sleeping sharks in North Queensland, we see how these evolutionary mysteries might just uncover the secrets of a better life for humans and the creatures we share the planet with. The ancient ancestors of life on Earth faced the same challenges we do, so let's learn a lesson or two about how they dealt with them. ‘Why Are We Like This? is a witty and inquisitive exploration of humans'place in the web of life. It takes readers on a journey through the history of life on Earth – full of wonder, curiosity and tenderness.'– Tegan Taylor ‘Evolution is not perfect, just good enough. This book brilliantly guides you through this complexity, showing us how we evolved to be marvellously imperfect. Why do we have sex? Why does cancer happen, why do dogs age and sharks sleep? Read this book, and learned up.'– Dr Karl Kruszelnicki

'Everyday Genetics'explores the transformative impact of genetic science on our daily lives, focusing on personalized medicine, consumer genetic testing, and gene editing technologies. The book argues that genetic science has moved beyond the laboratory, influencing our health decisions, family planning, and sense of identity. It provides a comprehensive overview of how genetic advances are reshaping medicine, personal identity, and human potential. Starting with a brief history of genetic science, the book progresses through three main sections, examining personalized medicine, consumer genetic testing, and gene editing. It highlights intriguing developments such as how genetic information is revolutionizing disease diagnosis and treatment, and the potential of CRISPR technology to eliminate genetic diseases. The author presents cutting-edge research and real-world cases, making complex genetic concepts accessible to a general audience through analogies and case studies. What sets this book apart is its focus on practical, everyday implications of genetic science, consistently relating advances to readers'lives. It provides guidance on interpreting genetic test results and addresses ongoing controversies like genetic privacy concerns. By the end, readers are equipped to engage with genetic information in their own lives and participate in broader societal discussions about the future of genetic technologies.

'Fins, Scales, and Tales: The Fascinating World of Fish'plunges readers into the captivating realm of ichthyology, revealing fish as the most diverse vertebrate group on Earth. This comprehensive exploration covers fish diversity, adaptations, and ecological significance, emphasizing their indispensable role in global ecosystems. From the Cambrian explosion to present-day challenges, the book traces the evolutionary journey of fish, highlighting their remarkable adaptability to varied aquatic environments. Organized into four main sections, the book progresses from basic fish biology to complex ecological interactions. It delves into fascinating topics such as how fish serve as bioindicators of ocean health and how their migration patterns are affected by changing ocean currents. The narrative seamlessly blends scientific rigor with accessibility, using vivid descriptions and real-world examples to illustrate key concepts. For instance, readers will discover how certain fish species are being studied for potential medical applications, bridging the gap between marine biology and human health. By presenting fish as integral parts of interconnected systems, the book challenges readers to consider the broader implications of fish biology and ecology. This holistic approach, combined with its engaging style, makes'Fins, Scales, and Tales'an invaluable resource for students, educators, and nature enthusiasts alike, offering insights that can inform conservation efforts and sustainable practices in our rapidly changing world.

'Green Fusion: The Miraculous Alchemy of Photosynthesis'takes readers on a fascinating journey into the world of photosynthesis, exploring its vital role in sustaining life and its potential to revolutionize energy and food production. This engaging book delves into the molecular mechanics, evolutionary history, and global impact of photosynthesis, offering a comprehensive look at one of nature's most extraordinary processes. From ancient Greek philosophers to modern quantum biologists, the book traces the evolution of our understanding of photosynthesis. It presents complex scientific concepts in an accessible manner, using advanced imaging techniques and molecular simulations to visualize the process at an atomic level. The narrative seamlessly weaves together scientific explanations with compelling stories of discovery, making it engaging for both science enthusiasts and general readers alike.'Green Fusion'progresses from basic concepts to detailed explanations of photosynthetic mechanisms, culminating in an exploration of futuristic applications. It argues that by fully comprehending and potentially replicating photosynthesis, we could address pressing issues such as climate change and sustainable energy production. The book's interdisciplinary approach, linking biology with physics, chemistry, and computer science, offers readers a holistic understanding of this remarkable natural phenomenon and its potential to shape our future.

Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company, and a substantial number of biotechnology companies, targeting epigenetic processes to treat diseases ranging from cancer to Huntington's disease and from inflammation to sickle cell anaemia. This book aims to provide an overview of the key topics adopted in current epigenetic drug discovery programmes with a focus on major developments and new technologies. Importantly, the book incorporates case studies and outlines the key challenges and techniques employed to overcome them. The book is an ideal resource for researchers in both industry and academia with an interest in epigenetic and genetic factors involved in drug discovery, target ID and validation. The book is also an excellent introduction for postgraduates interested in the interface between epigenetics and pharmaceuticals.

This book offers an amazing collection of analyzed images from the Red Planet, extremely suggestive of ancestral life on Mars. The book evidences possible remnants of microbial life, and, even further, complex and repetitive structures, analyzed in detail and reminescent of life forms and traits of terrestrial fossils resembling skeletal microalgae and more. This work is a presentation of primary importance for astrobiologists, precambrian micropaleontologists, and lovers of space exploration.

Welcome to the definitive guide Compendium of Clove: Navigating Agriculture, Chemistry, Processing, and Health Benefits, where centuries of tradition meet cutting-edge research on clove. Clove (Syzygium aromaticum) has a rich history dating back millennia, revered for its aromatic allure, medicinal properties, and economic significance across cultures. From the verdant plantations to the laboratory bench, each chapter in this book unfolds the intricate story of clove, bridging historical insights with contemporary studies, exploring its historical and botanical descriptions, community benefits, chemical composition, and diverse industrial applications.This A-Z compendium not only consolidates existing knowledge but also pioneers new frontiers in clove research. It offers a panoramic view that caters to botanists, pharmacognosists, phytochemists, pharmacologists, food scientists, agriculturalists, industrialists, and policymakers alike.KEY FEATURES: The book offers the origins and history of clove distribution, plant habits, and botanical descriptions. It provides insights into cultivation practices of clove, including good agricultural practices (GAP) and post-harvest management of clove. The book underlines how the biochemistry of plants, complete phytochemical screening, characterization, separation, and other factors affect the volatile oils of plants. It underlines clove's pharmacological and clinical aspects and highlights its usage in the food, pharmaceutical, and cosmetics industries. The book showcases market value, trade, and regulatory guidelines of clove in different countries. Whether you seek a botanical expedition or a pharmacological breakthrough, whether your interest lies in chemistry or global economics, this book embarks on a journey that celebrates clove as not just a spice but a cornerstone of interdisciplinary research and industrial enterprise. Join us as we unearth the essence of clove—a testament to nature's bounty and human ingenuity, encapsulated within the pages of this definitive document.

Pennsylvania naturalist William Bartram (1739–1823) is best known as the author of a travelogue describing his botanizing journey through the American South in the late eighteenth century. Writing was not, however, Bartram's only or even preferred method of recording the natural world around him. His deeply unconventional drawings, depicting sentient plants and hybrid organic forms, lie at the heart of his understanding of nature. With this book, Elizabeth Athens considers the strangeness of Bartram's graphic enterprise, exploring the essential role his renderings played in his natural history. For Bartram, the making and interpretation of figures on a surface was a dynamic and collaborative relationship between nature, the observing artist-naturalist, and the audience. This book offers the first in-depth investigation of Bartram's drawing practice as central to his understanding of nature. Through an examination of Bartram's approach to botanical and zoological representation, Athens highlights the struggle between different modes of seeing nature in eighteenth-century Enlightenment science.

Get the Summary of Richard Dawkins's The Greatest Show on Earth in 20 minutes. Please note: This is a summary & not the original book.'The Greatest Show on Earth'by Richard Dawkins is a comprehensive exposition of the evidence for evolution. Dawkins confronts the misconception that evolution is'just a theory,'asserting that it is a fact supported by as much evidence as the Earth's roundness. He explains that scientific theories, or'theorums,'are well-substantiated explanations supported by evidence, and evolution is no exception. The book addresses the delayed acceptance of evolution due to essentialism, the idea that species have an immutable essence, which is incompatible with evolutionary change...

Every cell, tissue, organ and organism is competent to use signs to exchange information reaching common coordinations and organisations of both single cell and group behavior. These sign-mediated interactions we term biological communication. The regulatory system that works in development, morphology, cell fate and identity, physiology, genetic instructions, immunity, memory/learning, physical and mental disease depends on epigenetic marks. The communication of cells, persistent viruses and their defectives such as mobile genetic elements and RNA networks ensures both the transport of regulatory instructions and the reprogramming of these instructions. But how are the different states of the epigenome orchestrated? The epigenetic pathways respond to various signaling cues such as DNA methylation, histone variants, histone modifications, chromatin structure, nucleosome remodeling, and epigenetic interactions. Epigenetic signals are responsible for the establishment, maintenance and reversal of transcriptional states that are fundamental for the cell's ability to memorize past events, such as changes in the external environment, socio-sphere or developmental cues. External signals trigger changes in the epigenome, allowing cells to respond dynamically. Internal signals direct activities that are necessary for body maintenance, and repairing damaged tissues and organs. With the emergence of epigenetic memory, organisms can fix historical and context dependent impressive experiences. Evolution from now on learnt to learn. Learning means organisms can avoid reproduction of always the same. This is key to adaptation. However, inheritance of acquired characteristics is only one of the many examples of the explanatory power of epigenetics. Behavioral epigenetics demonstrates the way in which environmental and social experiences produce individual differences in behaviour, cognition, personality, and mental health. This book assembles experts to outline the various motifs of all kinds of epigenetic regulation of cells throughout their lives.

This book outlines past and new developments in molecular response theory in terms of static and dynamic-induced current densities and showcases an important step forward in the field of molecular density functions and their topological analysis. The book begins with a general perspective on topics such as classical Hamiltonian, quantum mechanical Hamiltonian, and topological analysis of the electron charge density, followed by an in-depth overview of time-dependent and -independent perturbations, and applications. In this book, the author presents a completely new approach that allows the interpretation of electric and magnetic properties through origin-independent density functions. Readers will also find examples of how the new origin-independent density functions are useful for rationalizing the chemical behavior of molecules interacting with impinging radiation. The concepts contained within the book are the basis for a deeper understanding of Nuclear magnetic resonance (NMR) and Electron paramagnetic resonance (EPR) spectroscopies, as well as the mechanisms that give rise to electric polarization and optical activity in chiral systems. A basic knowledge of quantum mechanics and ab initio electronic structure calculation methods such as Hartree-Fock and Density Functional Theory is required. Given its breadth, the book provides an important contribution to the field of Quantum Chemical Topology and appeals to students and researchers interested in learning more about the relationship between electrical and magnetic properties, density functions derivable from them and experimental observables.

Transplant Oncology: A Frontier in Multidisciplinary Cancer Care summarizes new and evolving scientific findings and discoveries in the field of cancer and transplants and gives guidance on future directions and related research. With a strong focus on transplant oncology, the book examines new and evolving topics, including the utilization of immunotherapy in special patient populations as well as the clinical updates on new concepts in the field such as using circulating tumor DNA (ctDNA) as a tool for minimal disease detection, surveillance, and treatment response evaluation as well as rejection assessment and detection in transplant patient for oncological indications. Sections cover applications of transplant medicine and surgery in oncology to improve patient survival outcome and quality of life. The book gives insight into anticancer strategies, such as initiating studies in genomics and cancer immunogenomics based on new insights in liver cancer. In addition, it describes how the adoption of surgical transplantation techniques in oncology has improved conventional resection and bridged the gap between tumor and transplant immunology. This is a must have reference for all those that want to be familiar and up-to-date with the dynamic changes in the field including practicing physicians, scientists, and trainees. - Illustrates the concept and history of transplant oncology as an evolving field for the management of hepatocellular carcinoma - Discusses the utility and safety of immunotherapy in the transplant setting - Summarizes the utilization of immune checkpoint inhibitor therapies in pre-and post-liver transplants for HCC patients and discusses the assessment of immune checkpoint inhibitor regulators that might determine liver transplant outcomes - Highlights new and evolving topics including the utilization of immunotherapy in special patient populations as well as the clinical updates on new concepts in the field, including treatment and rejection assessment

Resistance in Hematologic Malignancies and Cancer brings together the molecular, cellular, and biochemical basis/principles of various mechanisms of resistance to treatment in hematologic malignancies. Even though main mechanisms of resistance are the same in different types of tumours there are specific signalling pathways involved in resistance in hematological malignancies and of course specific treatments In 11 chapters, Resistance in Hematologic Malignancies and Cancer describes the development of treatment resistance in hematological malignancies, the role of MiRNA in resistance, the role of the immune system in resistance prediction, as well as the latest knowledge from clinical research. It gives insight in the complex information about different mechanisms linkage in final loss of cell sensitivity to drug treatment, the orientation in metabolic pathways that could be involved in depressed leukemia cell resistance to drugs and gives information about causes of drug resistance in leukemia cells. By the multidisciplinary approach of the processing this book is a valuable resource for both health professionals, scientists and researchers, health practitioners, students, but will also enable members of the general professional public to orientate themselves in issues that are not directly in their area of expertise - Describes the different mechanisms of resistance; cooperation in net resistance to antileukemic drugs - Provides hallmark information about cell regulation pathways in drug resistance development - Brings information about causes of drug resistance in leukemia and hematologic malignancies including lymphoma and myeloma

This book presents key aspects and recent developments of cryogenic sample electron tomography (cryo-ET) methodology, authored by leading experts in the field. Understanding structure and function of biomolecules in the context of cells is a new frontier in cellular and structural biology. To facilitate such research, cryo-ET is a key method to visualize the molecules of life in their native settings. Cryo-ET enables the imaging of samples that are preserved in a near-native state, at (macro)-molecular resolution and in three dimensions. Thus, this technique is a unique tool to gain insights into how biomolecules collaborate in orchestrating fundamental biological processes, how mutations cause diseases, pathogens cause infections, and to develop novel therapeutics to treat such illnesses. This book provides a unique reference for the emerging field of cryo-ET. The topics covered range from the fundamental principles of imaging to sample preparation, data analysis,and data sharing within the scientific community. It serves as a valuable resource for the next generation of structural biologists, making it suitable both for undergraduate students studying biochemistry, biophysics, and molecular biology and highly valuable for the more experienced and specialized PhD student. Furthermore, it stands as a state-of-the–art source of knowledge for the established senior scientist within the field of structural biology.

Beautifully illustrated and scientifically informed, a celebration of the astonishing diversity of sexual behavior and biology found in nature. From a pair of male swans raising young to splitgill mushrooms with over 23,000 mating types, sex in the natural world is wonderfully diverse. Josh L. Davis considers how, for many different organisms—animals, plants, and fungi included—sexual reproduction and sex determination rely on a surprisingly complex interaction among genes, hormones, environment, and chance. As Davis introduces us to fascinating biological concepts like parthenogenesis (virgin birth), monoecious plants (individuals with separate male and female flowers), and sex-reversed genitals, we see turtle hatchlings whose sex is determined by egg temperature; butterflies that embody male and female biological tissue in the same organism; and a tomato that can reproduce three different ways at the same time. Davis also reveals animal and plant behaviors in nature that researchers have historically covered up or explained away, like queer sex among Adélie penguins or bottlenose dolphins, and presents animal behaviors that challenge us to rethink our assumptions and prejudices. Featuring fabulous sex-fluid fishes and ant, wasp, and bee queens who can choose both how they want to have sex and the sex of their offspring, A Little Queer Natural History offers a larger lesson: that the diversity we see in our own species needs no justification and represents just a fraction of what exists in the natural world.