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A hands-on approach to quantitative reasoning in the life sciencesQuantitative Biosciences establishes the quantitative principles of how living systems work across scales, drawing on classic and modern discoveries to present a case study approach that links mechanisms, models, and measurements. Each case study is organized around a central question in the life sciences: Are mutations dependent on selection? How do cells respond to fluctuating signals in the environment? How do organisms move in flocks given local sensing? How does the size of an epidemic depend on its initial speed of spread? Each question provides the basis for introducing landmark advances in the life sciences while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively about living systems given uncertainty.Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communitiesStand-alone lab guides available in Python, R, and MATLAB help students move from learning in the classroom to doing research in practiceHomework exercises build on the lab guides, emphasizing computational model development and analysis rather than pencil-and-paper derivationsSuitable for capstone undergraduate classes, foundational graduate classes, or as part of interdisciplinary courses for students from quantitative backgroundsCan be used as part of conventional, flipped, or hybrid instruction formatsAdditional materials available to instructors, including lesson plans and homework solutions

How understanding our genetic imperfections can change our view of evolution and enrich what it means to be humanIf we start with the presumption that evolution is a constantly improving process, some aspects of our evolution just do not make sense. We have a high rate of genetic diseases, for example, and much of our DNA seems to be pointless. In The Evolution of Imperfection, Laurence Hurst explores our apparently rotten genetic luck.Hurst, a leading authority on evolution and genetics, argues that our evolutionary imperfections proceed directly from two features: the difficulties of pregnancy and the fact that historically there are relatively few of us. In pregnancy, natural selection can favor chromosomes that kill embryos in species (including ours) that continuously receive resources from the mother. Most fertilized eggs don't make it, and incompatibilities between the fetus and mother can lead to lethal disorders of pregnancy. The historically small population size enhances the role of chance, which in turn leads to both accumulation of unnecessary DNA and more mutation.So what can save us? One answer may lie in genetic medicine, which has given us therapies that make killer conditions preventable and even curable.Hurst suggests that our seeming imperfections could be the key to a new way to understand evolution itself. Looking at circumstances that seem to defy explanation, we might come to a richer understanding of how evolution really works, and what it means to be human.

A biologist's up-close account of how he and fellow biologists cracked long-standing puzzles about honey bee behaviorPiping Hot Bees and Boisterous Buzz-Runners takes readers inside a world seldom seen even by beekeepers, shedding light on twenty of the most compelling mysteries of honey bee behavior.Thomas Seeley has devoted a lifetime to the study of honey bees and their colonies, unraveling the secrets of these wondrous insects in a career spanning six decades. In this book, he weaves illuminating personal stories with the latest science, explaining such mysteries as how worker bees function as scouts to choose a home site for their colony, furnish their home with beeswax combs, and stock it with brood and food while keeping tens of thousands of colony inhabitants warm and defended from intruders. Along the way, he shares the experiences that drew him to these studies, the small observations that led to big breakthroughs, and the sense of excitement that came with probing each mystery.Richly illustrated, Piping Hot Bees and Boisterous Buzz-Runners provides a rare look at how a singularly passionate scientist and his colleagues deciphered the pipings, shakings, and puzzling tremble dances of honey bees, and how this journey of scientific discovery continues to shape our understanding of these remarkably intelligent and vitally important insects.

A new edition of Peter and Rosemary Grant's classic account of their groundbreaking forty-year study of Darwin's finches40 Years of Evolution is a landmark study of the finches first made famous by Charles Darwin, one that documents as never before the evolution of species through natural selection. In this now-legendary study, renowned evolutionary biologists Peter and Rosemary Grant draw on a vast and unparalleled range of ecological, behavioral, and genetic data to continuously measure changes in finch populations over a period of four decades on the small island of Daphne Major in the Galápagos archipelago. In the years since the book's publication, the field of genomics has developed greatly. In this newly revised edition of 40 Years of Evolution, the Grants combine the results of their historic field study with genomic analyses of their primary findings, resolve unanswered questions from the field, and provide invaluable insights into the genetic basis of beak and body size variation and the history of this iconic adaptive radiation.

John Tyler Bonner, one of our most distinguished and creative biologists, here offers a completely new perspective on the role of size in biology. In his hallmark friendly style, he explores the universal impact of being the right size. By examining stories ranging from Alice in Wonderland to Gulliver's Travels, he shows that humans have always been fascinated by things big and small. Why then does size always reside on the fringes of science and never on the center stage? Why do biologists and others ponder size only when studying something else—running speed, life span, or metabolism?Why Size Matters, a pioneering book of big ideas in a compact size, gives size its due by presenting a profound yet lucid overview of what we know about its role in the living world. Bonner argues that size really does matter—that it is the supreme and universal determinant of what any organism can be and do. For example, because tiny creatures are subject primarily to forces of cohesion and larger beasts to gravity, a fly can easily walk up a wall, something we humans cannot even begin to imagine doing.Bonner introduces us to size through the giants and dwarfs of human, animal, and plant history and then explores questions including the physics of size as it affects biology, the evolution of size over geological time, and the role of size in the function and longevity of living things.As this elegantly written book shows, size affects life in its every aspect. It is a universal frame from which nothing escapes.

A hands-on lab guide in the R programming language that enables students in the life sciences to reason quantitatively about living systems across scalesThis lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty.Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communitiesEncourages good coding practices, clear and understandable modeling, and accessible presentation of resultsHelps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scaleBuilds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulationsBridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their ownStand-alone computational lab guides for Quantitative Biosciences also available in Python and MATLAB

A hands-on lab guide in the Python programming language that enables students in the life sciences to reason quantitatively about living systems across scalesThis lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty.Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communitiesEncourages good coding practices, clear and understandable modeling, and accessible presentation of resultsHelps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scaleBuilds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulationsBridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their ownStand-alone computational lab guides for Quantitative Biosciences also available in R and MATLAB

A hands-on lab guide in the MATLAB programming language that enables students in the life sciences to reason quantitatively about living systems across scalesThis lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty.Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communitiesEncourages good coding practices, clear and understandable modeling, and accessible presentation of resultsHelps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scaleBuilds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulationsBridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their ownStand-alone computational lab guides for Quantitative Biosciences also available in Python and R

The hidden role of fungi inside and all around usFrom beneficial yeasts that aid digestion to toxic molds that cause disease, we are constantly navigating a world filled with fungi. Molds, Mushrooms, and Medicines explores the amazing ways fungi interact with our bodies, showing how our health and well-being depend on an immense ecosystem of yeasts and molds inside and all around us.Nicholas Money takes readers on a guided tour of a marvelous unseen realm, describing how our immune systems are engaged in continuous conversation with the teeming mycobiome inside the body, and how we can fall prey to serious and even life-threatening infections when this peaceful coexistence is disturbed. He also sheds light on our complicated relationship with fungi outside the body, from wild mushrooms and cultivated molds that have been staples of the human diet for millennia to the controversial experimentation with magic mushrooms in the treatment of depression.Drawing on the latest advances in mycology, Molds, Mushrooms, and Medicines reveals what scientists are learning about the importance of fungi to our lives, from their vital role in supporting the ecosystems on which we depend to their emerging uses in lifesaving medicine.

A sweeping account of male nurturing, explaining how and why men are biologically transformed when they care for babies It has long seemed self-evident that women care for babies and men do other things. Hasn't it always been so? When evolutionary science came along, it rubber-stamped this venerable division of labor: mammalian males evolved to compete for status and mates, while females were purpose-built to gestate, suckle, and otherwise nurture the victors'offspring. But come the twenty-first century, increasing numbers of men are tending babies, sometimes right from birth. How can this be happening? Puzzled and dazzled by the tender expertise of new fathers around the world—several in her own family—celebrated evolutionary anthropologist and primatologist Sarah Blaffer Hrdy set out to trace the deep history of male nurturing and explain a surprising departure from everything she had assumed to be “normal.”In Father Time, Hrdy draws on a wealth of research to argue that this ongoing transformation in men is not only cultural, but profoundly biological. Men in prolonged intimate contact with babies exhibit responses nearly identical to those in the bodies and brains of mothers. They develop caring potential few realized men possessed. In her quest to explain how men came to nurture babies, Hrdy travels back through millions of years of human, primate, and mammalian evolution, then back further still to the earliest vertebrates—all while taking into account recent economic and social trends and technological innovations and incorporating new findings from neuroscience, genetics, endocrinology, and more. The result is a masterful synthesis of evolutionary and historical perspectives that expands our understanding of what it means to be a man—and what the implications might be for society and our species.

A new account of the central role developmental processes play in evolutionA new scientific view of evolution is emerging—one that challenges and expands our understanding of how evolution works. Recent research demonstrates that organisms differ greatly in how effective they are at evolving. Whether and how each organism adapts and diversifies depends critically on the mechanistic details of how that organism operates—its development, physiology, and behavior. That is because the evolutionary process itself has evolved over time, and continues to evolve. The scientific understanding of evolution is evolving too, with groundbreaking new ways of explaining evolutionary change. In this book, a group of leading biologists draw on the latest findings in evolutionary genetics and evo-devo, as well as novel insights from studies of epigenetics, symbiosis, and inheritance, to examine the central role that developmental processes play in evolution.Written in an accessible style, and illustrated with fascinating examples of natural history, the book presents recent scientific discoveries that expand evolutionary biology beyond the classical view of gene transmission guided by natural selection. Without undermining the central importance of natural selection and other Darwinian foundations, new developmental insights indicate that all organisms possess their own characteristic sets of evolutionary mechanisms. The authors argue that a consideration of developmental phenomena is needed for evolutionary biologists to generate better explanations for adaptation and biodiversity. This book provides a new vision of adaptive evolution.

An essential introduction to the physics of active matter and its application to questions in biologyIn recent decades, the theory of active matter has emerged as a powerful tool for exploring the differences between living and nonliving states of matter. The Restless Cell provides a self-contained, quantitative description of how the continuum theory of matter has been generalized to account for the complex and sometimes counterintuitive behaviors of living materials.Christina Hueschen and Rob Phillips begin by illustrating how classical field theory has been used by physicists to describe the transport of matter by diffusion, the elastic deformations of solids, and the flow of fluids. Drawing on physical insights from the study of diffusion, they introduce readers to the continuum theory protocol—a step-by-step framework for developing equations that describe matter as a continuum—and show how these methods and concepts can be generalized to the study of living, energy-consuming matter. Hueschen and Phillips then present a range of engaging biological case studies across scales, such as the symmetry breaking that occurs in developing embryos, the perpetual flows that take place in giant algal cells, and the herding of wildebeest on the plains of the Serengeti.An essential resource for students and researchers in biological physics and quantitative biology, The Restless Cell gives complete derivations of all calculations and features illustrations by Nigel Orme that seamlessly bridge conceptual models and continuum descriptions of living matter.

One of today's most accomplished biologists and gifted storytellers reveals the rules that regulate all lifeHow does life work? How does nature produce the right numbers of zebras and lions on the African savanna, or fish in the ocean? How do our bodies produce the right numbers of cells in our organs and bloodstream? In The Serengeti Rules, award-winning biologist and author Sean Carroll tells the stories of the pioneering scientists who sought the answers to such simple yet profoundly important questions, and shows how their discoveries matter for our health and the health of the planet we depend upon.One of the most important revelations about the natural world is that everything is regulated—there are rules that regulate the amount of every molecule in our bodies and rules that govern the numbers of every animal and plant in the wild. And the most surprising revelation about the rules that regulate life at such different scales is that they are remarkably similar—there is a common underlying logic of life. Carroll recounts how our deep knowledge of the rules and logic of the human body has spurred the advent of revolutionary life-saving medicines, and makes the compelling case that it is now time to use the Serengeti Rules to heal our ailing planet.Bold and inspiring, The Serengeti Rules illuminates how life works at vastly different scales. Read it and you will never look at the world the same way again.

Why information is the unifying principle that allows us to understand the evolution of complexity in natureMore than 150 years after Darwin's revolutionary On the Origin of Species, we are still attempting to understand and explain the amazing complexity of life. Although we now know how evolution proceeds to build complexity from simple ingredients, quantifying this complexity is still a difficult undertaking. In this book, Christoph Adami offers a new perspective on Darwinian evolution by viewing it through the lens of information theory. This novel theoretical stance sheds light on such matters as how viruses evolve drug resistance, how cells evolve to communicate, and how intelligence evolves. By this account, information emerges as the central unifying principle behind all of biology, allowing us to think about the origin of life—on Earth and elsewhere—in a systematic manner.Adami, a leader in the field of computational biology, first provides an accessible introduction to the information theory of biomolecules and then shows how to apply these tools to measure information stored in genetic sequences and proteins. After outlining the experimental evidence of the evolution of information in both bacteria and digital organisms, he describes the evolution of robustness in viruses; the cooperation among cells, animals, and people; and the evolution of brains and intelligence. Building on extensive prior work in bacterial and digital evolution, Adami establishes that (expanding on Dobzhansky's famous remark) nothing in biology makes sense except in the light of information. Understanding that information is the foundation of all life, he argues, allows us to see beyond the particulars of our way of life to glimpse what life might be like in other worlds.

Timely and provocative reflections on the future of the wild in an increasingly human worldThe Heart of the Wild brings together some of today's leading scientists, humanists, and nature writers to offer a thought-provoking meditation on the urgency of learning about and experiencing our wild places in an age of rapidly expanding human impacts.These engaging essays present nuanced and often surprising perspectives on the meaning and value of “wildness” amid the realities of the Anthropocene. They consider the trends and forces—from the cultural and conceptual to the ecological and technological—that are transforming our relationship with the natural world and sometimes seem only to be pulling us farther away from wild places and species with each passing day. The contributors make impassioned defenses of naturalism, natural history, and nature education in helping us to rediscover a love for the wild at a time when our connections with it have frayed or been lost altogether.Charting a new path forward in an era of ecological uncertainty, The Heart of the Wild reframes our understanding of nature and our responsibility to learn from and sustain it as the human footprint sinks ever deeper into the landscapes around us.With contributions by Bill Adams, Joel Berger, Susan Clayton, Eileen Crist, Martha L. Crump, Thomas Lowe Fleischner, Harry W. Greene, Hal Herzog, Jonathan B. Losos, Emma Marris, Ben A. Minteer, Kathleen Dean Moore, Gary Paul Nabhan, Peter H. Raven, Christopher J. Schell, Richard Shine, and Kyle Whyte.

Data science methods and tools—including programming, data management, visualization, and machine learning—and their application to neuroimaging researchAs neuroimaging turns toward data-intensive discovery, researchers in the field must learn to access, manage, and analyze datasets at unprecedented scales. Concerns about reproducibility and increased rigor in reporting of scientific results also demand higher standards of computational practice. This book offers neuroimaging researchers an introduction to data science, presenting methods, tools, and approaches that facilitate automated, reproducible, and scalable analysis and understanding of data. Through guided, hands-on explorations of openly available neuroimaging datasets, the book explains such elements of data science as programming, data management, visualization, and machine learning, and describes their application to neuroimaging. Readers will come away with broadly relevant data science skills that they can easily translate to their own questions.• Fills the need for an authoritative resource on data science for neuroimaging researchers• Strong emphasis on programming• Provides extensive code examples written in the Python programming language• Draws on openly available neuroimaging datasets for examples• Written entirely in the Jupyter notebook format, so the code examples can be executed, modified, and re-executed as part of the learning process

The visionary science behind the digital human twins that will enhance our health and our futureVirtual You is a panoramic account of efforts by scientists around the world to build digital twins of human beings, from cells and tissues to organs and whole bodies. These virtual copies will usher in a new era of personalized medicine, one in which your digital twin can help predict your risk of disease, participate in virtual drug trials, shed light on the diet and lifestyle changes that are best for you, and help identify therapies to enhance your well-being and extend your lifespan—but thorny challenges remain.In this deeply illuminating book, Peter Coveney and Roger Highfield reveal what it will take to build a virtual, functional copy of a person in five steps. Along the way, they take you on a fantastic voyage through the complexity of the human body, describing the latest scientific and technological advances—from multiscale modeling to extraordinary new forms of computing—that will make “virtual you” a reality, while also considering the ethical questions inherent to realizing truly predictive medicine.With an incisive foreword by Nobel Prize–winning biologist Venki Ramakrishnan, Virtual You is science at its most astounding, showing how our virtual twins and even whole populations of virtual humans promise to transform our health and our lives in the coming decades.

A groundbreaking new perspective on collective behavior across biological systemsCollective behavior is everywhere in nature, from gene transcription and cancer cells to ant colonies and human societies. It operates without central control, using local interactions among participants to allow groups to adjust to changing conditions. The Ecology of Collective Behavior brings together ideas from evolutionary biology, network science, and dynamical systems to present an ecological approach to understanding how the interactions of individuals generate collective outcomes.Deborah Gordon argues that the starting point for explaining how collective behavior works in any natural system is to consider how it changes in relation to the changing world around it. She shows how feedback use—the means by which networks of interactions operate—and the organization of interaction networks evolve to reflect the stability and demands of the environment. Ant colonies function collectively, and the enormous diversity of species in different habitats provides opportunities to look for general ecological patterns. Through an in-depth comparison of ant species, Gordon identifies broad trends in how the diversity of collective behavior in many other collective systems reflects the dynamics of the environment.Shedding light on how individual actions give rise to group behavior, The Ecology of Collective Behavior explains the evolution of collective behavior through innovation in participant interactions, offering new insights into how collective responses function in changing conditions.

An ecologist explores how life itself shapes Earth using the elemental constituents we all shareIt is rare for life to change Earth, yet three organisms have profoundly transformed our planet over the long course of its history. Elemental reveals how microbes, plants, and people used the fundamental building blocks of life to alter the climate, and with it, the trajectory of life on Earth in the past, present, and future.Taking readers from the deep geologic past to our current era of human dominance, Stephen Porder focuses on five of life's essential elements—hydrogen, oxygen, carbon, nitrogen, and phosphorus. He describes how single-celled cyanobacteria and plants harnessed them to wildly proliferate across the oceans and the land, only to eventually precipitate environmental catastrophes. He then brings us to the present, and shows how these elements underpin the success of human civilization, and how their mismanagement threatens similarly catastrophic unintended consequences. But, Porder argues, if we can learn from our world-changing predecessors, we can construct a more sustainable future.Blending conversational storytelling with the latest science, Porder takes us deep into the Amazon, across fresh lava flows in Hawaii, and to the cornfields of the American Midwest to illuminate a potential path to sustainability, informed by the constraints imposed by life's essential elements and the four-billion-year history of life on Earth.

A beautifully illustrated journey into the hidden realm of insectsLife on Earth depends on the busy activities of insects, but global populations of these teeming creatures are currently under threat, with grave consequences for us all. Alien Worlds presents insects and other arthropods as you have never seen them before, explaining how they conquered the planet and why there are so many of them, and shedding light on the evolutionary marvels that enabled them to thrive. Blending glorious imagery with entertaining and informative science writing, this book takes you inside the hidden realm of insects and reveals why their fate carries profound implications for our own.Spectacular photos provide a rare, up-close look at the alien worlds of insectsSheds light on the origins and wondrous diversity of insectsDiscusses how insects first took to the air and colonised the far corners of our planetExplores the extraordinary sensory world of insectsExplains the remarkable success of social insects, from termites and ants to bees and wasps

A bold and revolutionary perspective on the science and cultural history of menstruationMenstruation is something half the world does for a week at a time, for months and years on end, yet it remains largely misunderstood. Scientists once thought of an individual's period as useless, and some doctors still believe it's unsafe for a menstruating person to swim in the ocean wearing a tampon. Period counters the false theories that have long defined the study of the uterus, exposing the eugenic history of gynecology while providing an intersectional feminist perspective on menstruation science.Blending interviews and personal experience with engaging stories from her own pioneering research, Kate Clancy challenges a host of myths and false assumptions. There is no such a thing as a “normal” menstrual cycle. In fact, menstrual cycles are incredibly variable and highly responsive to environmental and psychological stressors. Clancy takes up a host of timely issues surrounding menstruation, from bodily autonomy, menstrual hygiene, and the COVID-19 vaccine to the ways racism, sexism, and medical betrayal warp public perceptions of menstruation and erase it from public life.Offering a revelatory new perspective on one of the most captivating biological processes in the human body, Period will change the way you think about the past, present, and future of periods.

A sweeping new account of the role of power in the evolution of all life on EarthPower has many dimensions, from individual attributes such as strength and speed to the collective advantages of groups. The Evolution of Power takes readers on a breathtaking journey across history and the natural world, revealing how the concept of power unifies a vast range of phenomena in the evolution of life—and how natural selection has placed humanity and the planet itself on a trajectory of ever-increasing power.Drawing on evidence from fossils, living organisms, and contemporary society, Geerat Vermeij documents increases in power at all scales, from body size, locomotor performance, and the use of force in competition to efficiency in production and consumption within ecosystems. He shows how power—which he defines as the rate at which organisms acquire and apply energy—is tied to the emergence of cooperation, and how the modern economy, which for the first time has established a monopoly over the biosphere by a single species, is a continuation of evolutionary trends stretching back to the dawn of life. Vermeij persuasively argues that we can find solutions to the many problems arising from this extreme concentration of power by broadening our exclusively human-centered perspective.A masterful work by one of today's most innovative and forward-thinking naturalists, The Evolution of Power offers a new understanding of our place in the grand sweep of evolutionary history.

How recent breakthroughs in longevity research offer clues about human agingAll of us would like to live longer, or to slow the debilitating effects of age. In How We Age, Coleen Murphy shows how recent research on longevity and aging may be bringing us closer to this goal. Murphy, a leading scholar of aging, explains that the study of model systems, particularly simple invertebrate animals, combined with breakthroughs in genomic methods, have allowed scientists to probe the molecular mechanisms of longevity and aging. Understanding the fundamental biological rules that govern aging in model systems provides clues about how we might slow human aging, which could lead in turn to new therapeutics and treatments for age-related disease.Among other vivid examples, Murphy describes research that shows how changing a single gene in the nematode worm C. elegans doubles its lifespan, extending not only the end of life but also the youthful, healthy part of life. Drawing on work in her own lab as well as other recent research, Murphy chronicles the history and current state of the field, explaining longevity's links to reproduction and mating, sensory and cognitive function, inheritances from our ancestors, and the gut microbiome. Written with clarity and wit, How We Age provides a guide to the science: what we know about aging, how we know what we know, and what we can do with this new knowledge.

An evolutionary case for the existence of free willScientists are learning more and more about how brain activity controls behavior and how neural circuits weigh alternatives and initiate actions. As we probe ever deeper into the mechanics of decision making, many conclude that agency—or free will—is an illusion. In Free Agents, leading neuroscientist Kevin Mitchell presents a wealth of evidence to the contrary, arguing that we are not mere machines responding to physical forces but agents acting with purpose.Traversing billions of years of evolution, Mitchell tells the remarkable story of how living beings capable of choice arose from lifeless matter. He explains how the emergence of nervous systems provided a means to learn about the world, granting sentient animals the capacity to model, predict, and simulate. Mitchell reveals how these faculties reached their peak in humans with our abilities to imagine and to be introspective, to reason in the moment, and to shape our possible futures through the exercise of our individual agency. Mitchell's argument has important implications—for how we understand decision making, for how our individual agency can be enhanced or infringed, for how we think about collective agency in the face of global crises, and for how we consider the limitations and future of artificial intelligence.An astonishing journey of discovery, Free Agents offers a new framework for understanding how, across a billion years of Earth history, life evolved the power to choose, and why it matters.

A natural history of cheating from selfish genes to lying politiciansNature is rife with cheating. Possums play possum, feigning death to cheat predators. Crows cry wolf to scare off rivals. Amphibians and reptiles are inveterate impostors. Even genes and cells cheat. The Liars of Nature and the Nature of Liars explores the evolution of cheating in the natural world, revealing how dishonesty has given rise to wondrous diversity.Blending cutting-edge science with a wealth of illuminating examples—from microscopic organisms to highly intelligent birds and mammals—Lixing Sun shows how cheating in nature relies on two basic rules. One is lying, by which cheaters exploit honest messages in communication signals and use them to serve their own interests. The other is deceiving, by which cheaters exploit the biases and loopholes in the sensory systems of other creatures. Sun demonstrates that cheating serves as a potent catalyst in the evolutionary arms race between the cheating and the cheated, resulting in a biological world teeming with complexity and beauty.Brimming with insight and humor, The Liars of Nature and the Nature of Liars also looks at the prevalence of cheating in human society, identifying the kinds of cheating that spur innovation and cultural vitality and laying down a blueprint for combatting malicious cheating such as fake news and disinformation.

The extraordinary life story of the celebrated naturalist who transformed our understanding of evolutionEnchanted by Daphne is legendary ecologist Peter Grant's personal account of his remarkable life and career. In this revelatory book, Grant takes readers from his childhood in World War II–era Britain to his ongoing research today in the Galápagos archipelago, vividly describing what it's like to do fieldwork in one of the most magnificent yet inhospitable places on Earth. This is also the story of two brilliant and courageous biologists raising a family together while balancing the demands of professional lives that would take them to the far corners of the globe.In 1973, Grant and his wife, Rosemary, embarked on a journey that would fundamentally change how we think about evolution. Over the next four decades, they visited the Galápagos every year to observe Darwin's famous finches on the remote, uninhabited island of Daphne Major. Documenting how eighteen species have diversified from a single ancestral species, they demonstrated that we could actually see and measure evolution in a natural setting. Grant recounts the blind alleys and breathtaking triumphs of this historic research as he and Rosemary followed in Darwin's footsteps—and ushered in a new era in ecology.A wonderfully absorbing portrait of a life in science, Enchanted by Daphne is an unforgettable chronicle of the travels and discoveries of one of the world's most influential naturalists.

The most comprehensive and up-to-date general reference book on honey bee biologyHoney bees are marvelously charismatic organisms with a long history of interaction with humans. They are vital to agriculture and serve as a model system for many basic questions in biology. This authoritative book provides an essential overview of honey bee biology, bringing established topics up to date while incorporating emerging areas of inquiry.Honey Bee Biology covers everything from molecular genetics, development, and physiology to neurobiology, behavior, and pollination biology. Placing special attention on the important role of bees as pollinators in agricultural ecosystems, it incorporates the latest findings on pesticides, parasites, and pathogens. This incisive and wide-ranging book also sheds vital light on the possible causes of colony collapse disorder and the devastating honey bee losses we are witnessing today.The study of honey bees has greatly expanded in recent years and there is more interest in these marvelous creatures than ever before. Honey Bee Biology is the first up-to-date general reference of its kind published in decades. It is a must-have resource for social insect biologists, scientifically savvy beekeepers, and any scientist interested in bees as a model system.

“The most remarkable history of biology that has ever been written.”—Michel FoucaultNobel Prize–winning scientist François Jacob's The Logic of Life is a landmark book in the history of biology and science. Focusing on heredity, which Jacob considers the fundamental feature of living things, he shows how, since the sixteenth century, the scientific understanding of inherited traits has moved not in a linear, progressive way, from error to truth, but instead through a series of frameworks. He reveals how these successive interpretive approaches—focusing on visible structures, internal structures (especially cells), evolution, genes, and DNA and other molecules—each have their own power but also limitations. Fundamentally challenging how the history of biology is told, much as Thomas Kuhn's Structure of Scientific Revolutions did for the history of science as a whole, The Logic of Life has greatly influenced the way scientists and historians view the past, present, and future of biology.

A comprehensive framework for understanding species coexistenceCoexistence is the central concept in community ecology, but an understanding of this concept requires that we study the actual mechanisms of species interactions. Coexistence in Ecology examines the major features of these mechanisms for species that coexist at different positions in complex food webs, and derives empirical tests from model predictions.Exploring the various challenges species face, Mark McPeek systematically builds a model food web, beginning with an ecosystem devoid of life and then adding one species at a time. With the introduction of each new species, he evaluates the properties it must possess to invade a community and quantifies the changes in the abundances of other species that result from a successful invasion. McPeek continues this process until he achieves a multitrophic level food web with many species coexisting at each trophic level, from omnivores, mutualists, and pathogens to herbivores, carnivores, and basic plants. He then describes the observational and experimental empirical studies that can test the theoretical predictions resulting from the model analyses.Synthesizing decades of theoretical research in community ecology, Coexistence in Ecology offers new perspectives on how to develop an empirical program of study rooted in the natural histories of species and the mechanisms by which they actually interact with one another.

The epic story of human evolution, from our primate beginnings more than five million years ago to the agricultural eraOver the course of five million years, our primate ancestors evolved from a modest population of sub-Saharan apes into the globally dominant species Homo sapiens. Along the way, humans became incredibly diverse in appearance, language, and culture. How did all of this happen? In The Five-Million-Year Odyssey, Peter Bellwood synthesizes research from archaeology, biology, anthropology, and linguistics to immerse us in the saga of human evolution, from the earliest traces of our hominin forebears in Africa, through waves of human expansion across the continents, and to the rise of agriculture and explosive demographic growth around the world.Bellwood presents our modern diversity as a product of both evolution, which led to the emergence of the genus Homo approximately 2.5 million years ago, and migration, which carried humans into new environments. He introduces us to the ancient hominins—including the australopithecines, Homo erectus, the Neanderthals, and others—before turning to the appearance of Homo sapiens circa 300,000 years ago and subsequent human movement into Eurasia, Australia, and the Americas. Bellwood then explores the invention of agriculture, which enabled farmers to disperse to new territories over the last 10,000 years, facilitating the spread of language families and cultural practices. The outcome is now apparent in our vast array of contemporary ethnicities, linguistic systems, and customs.The fascinating origin story of our varied human existence, The Five-Million-Year Odyssey underscores the importance of recognizing our shared genetic heritage to appreciate what makes us so diverse.

A comprehensive overview of symbiotic relationships between insects and microbesInsects and Their Beneficial Microbes is an authoritative and accessible synthesis of insect associations with beneficial microorganisms. Angela Douglas distills the vast literature in entomology and microbiology, as well as the burgeoning microbiome literature, to explore the full scope of insect-microbial interactions and their applications to real-world problems in agriculture and medicine.Douglas investigates how insects acquire and support their microbial partners, and examines how microorganisms contribute to insect nutrition, the defense against natural enemies, and the detoxification of natural allelochemicals and chemical insecticides. She analyzes how beneficial microbes can be harnessed to solve real-world problems in insect pest management, including strategies to suppress the transmission of viruses and microbial disease agents by mosquitoes and other insects. She also addresses the use of insects as biomedical models for effective microbial therapies treating a range of chronic human diseases, and considers how knowledge of insect-microbial interactions can promote the health of beneficial insects, especially in the context of environmental pollutants and climate change.Insects and Their Beneficial Microbes provides a much-needed conceptual framework for the growing discipline of insect-microbial interactions, and offers a wealth of insights into insect symbioses from molecular, physiological, ecological, and evolutionary perspectives.

A biophysicist reveals the hidden unity behind nature's breathtaking complexityThe form and function of a sprinting cheetah are quite unlike those of a rooted tree. A human being is very different from a bacterium or a zebra. The living world is a realm of dazzling variety, yet a shared set of physical principles shapes the forms and behaviors of every creature in it. So Simple a Beginning shows how the emerging new science of biophysics is transforming our understanding of life on Earth and enabling potentially lifesaving but controversial technologies such as gene editing, artificial organ growth, and ecosystem engineering.Raghuveer Parthasarathy explains how four basic principles—self-assembly, regulatory circuits, predictable randomness, and scaling—shape the machinery of life on scales ranging from microscopic molecules to gigantic elephants. He describes how biophysics is helping to unlock the secrets of a host of natural phenomena, such as how your limbs know to form at the proper places, and why humans need lungs but ants do not. Parthasarathy explores how the cutting-edge biotechnologies of tomorrow could enable us to alter living things in ways both subtle and profound.Featuring dozens of original watercolors and drawings by the author, this sweeping tour of biophysics offers astonishing new perspectives on how the wonders of life can arise from so simple a beginning.

The first modern scholarly synthesis of animal domesticationAcross the globe and at different times in the past millennia, the evolutionary history of domesticated animals has been greatly affected by the myriad, complex, and diverse interactions humans have had with the animals closest to them. The Process of Animal Domestication presents a broad synthesis of this subject, from the rich biology behind the initial stages of domestication to how the creation of breeds reflects cultural and societal transformations that have impacted the biosphere.Marcelo Sánchez-Villagra draws from a wide range of fields, including evolutionary biology, zooarchaeology, ethnology, genetics, developmental biology, and evolutionary morphology to provide a fresh perspective to this classic topic. Relying on various conceptual and technical tools, he examines the natural history of phenotypes and their developmental origins. He presents case studies involving mammals, birds, fish, and insect species, and he highlights the importance of domestication for the comprehension of evolution, anatomy, ontogeny, and dozens of fundamental biological processes.Bringing together the most current developments, The Process of Animal Domestication will interest a wide range of readers, from evolutionary biologists, developmental biologists, and geneticists to anthropologists and archaeologists.