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The book'Biochemical Mechanisms for Metabolic Syndrome'delves into the intricate biochemistry underlying the complex condition known as Metabolic Syndrome. The main focus of the book is to provide a comprehensive overview and in-depth exploration of the various biochemical processes and molecular mechanisms contributing to the development and progression of Metabolic Syndrome. The book is structured into several chapters, each with a specific purpose. The initial chapters, lay the groundwork by introducing the concept of Metabolic Syndrome, its historical context, prevalence, and the risk factors associated with it. Subsequent chapters tackle various aspects of insulin resistance and its underlying mechanisms, lipid metabolism dysregulation, the impact of obesity, and the complex interplay between Metabolic Syndrome and hypertension. The book then shifts focus to exploring the genetic predisposition to Metabolic Syndrome and delves into recently explored indepth cellular and tissue mechanisms, including the role of gut barrier dysfunction and adipose tissue remodeling. Chapters dedicated to molecular mechanisms and signaling pathways offer a deeper understanding of the inflammatory resolution, and endoplasmic reticulum stress in the context of Metabolic Syndrome. Another significant aspect of the book is the exploration of the Brain-Gut-Adipose Axis and endocrine regulation, looking at the impact of gut microbiota-derived metabolites, gut hormones, and neuronal regulation on Metabolic Syndrome. Additionally, omics technologies are covered extensively, ranging from genomics, transcriptomics, proteomics, and epigenomics, to unravel the molecular complexity of Metabolic Syndrome. The latter part of the book delves into therapeutic approaches, including lifestyle interventions, pharmacological interventions, and dietary strategies. It also explores the therapeutic potential of brown adipose tissue, and highlights future directions and emerging research in the field of Metabolic Syndrome biochemistry. Overall, the book will provide a valuable resource for researchers, healthcare professionals, and students seeking a comprehensive understanding of the biochemical intricacies of Metabolic Syndrome and potential avenues for therapeutic interventions.

This book summarizes the principles, protocols, and applications of enzyme-based biosensors in healthcare. After providing a brief history and discussing the development of various biosensors used for medical applications, it explores the principles of enzyme-based biosensors and reviews a number of enzyme immobilization techniques. It then addresses the potential of enzyme-based biosensors in the diagnosis of infectious and non-infectious diseases; illustrates the potential of enzyme-based biosensors for non-invasive monitoring of biochemical biomarkers; and assesses the application of paper-based and microfluidic-based nanobiosensors in medical diagnostics. A one-stop resource on recent advances in enzyme-based biosensors in healthcare, this book will appeal to students, researchers and scientists in a range of disciplines, as well as entrepreneurs, and medical/healthcare professionals.

TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity. Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as: A thorough overview of and introduction to drug metabolism and transporters and drug toxicity An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI An examination of transporters and cochlea toxicity Perfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries.

This book provides a current review of the field of biopharmaceutical pharmacology. Biopharmaceuticals are drugs obtained in biotechnological processes using living organisms such as bacteria and fungi. An analysis was performed from biochemical and physiological point of view. This book covers an essential guide to current knowledge and analysis of biopharmaceuticals (Chapter 1-5). The composition of the biopharmaceuticals is provided. In this book we also discuss the historical point of view of the use of archeological botany, medicinal plants, strategies and main advances in communication between the nature and the advances of biopharmacy (Chapter 6-8). This book reports results from experimental and clinical work (Chapter 9). The book includes data regarding the therapy in combination with chemotherapeutic agents.

Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. - Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies - Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine - Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others

During the last two decades, chemical and cellular studies have contributed enormously to our understanding of metal-induced carcinogenesis, and many hypotheses on the role of metals in pathophysiological processes have been investigated. In addition, new techniques are available to shed light on the mechanism of carcinogenesis in molecular terms. This conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis in September 2000 focused on the latest research in molecular mechanisms of metal-induced toxicity and carcinogenesis. The conference promoted a multidisciplinary investigative approach and included presentations from international experts on state-of-the-art information in this field.

Nitroazoles: Synthesis, Structure and Applications is devoted to the chemistry of nitroazoles, a series of heteroaromatic compounds. The azoles's unique biological properties have attracted increasing attention from chemists as the nitro derivatives of azoles have found wide application in various fields of industrial chemistry, agriculture, and medicine. These applications include medical products such as azomycin, metronidazole, misonidazole, tinidazole, and nitazole; ionic liquids; high energy materials; precursors for nanocompounds; universal bases in peptide nucleic acids; plant growth regulators; and synthons for organic synthesis. This work is addressed to researchers in chemistry, physics, pharmaceutics, and biochemistry, as well as engineers and physicians (especially oncologists). This book can also be used as a textbook for post-doctorate students and graduate students in chemistry, biochemistry, medical pharmacology, agricultural bioapplications, and for all who wish to get acquainted with the chemistry and structure of nitroazoles.