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Deep Learning in Diabetes Mellitus Detection and Diagnosis focuses on deep learning-based approaches in the field of diabetes mellitus detection and diagnosis, including preprocessing techniques that are an essential part of this subject. This is the first book of its kind to cover deep learning-based approaches in the specific field of diabetes mellitus. This book includes a detailed introductory overview as well as chapters on current applications, preprocessing of data using deep learning, deep learning techniques, complexity, challenges, and future directions. It will be of great interest to researchers and professionals working on diabetes mellitus as well as general medical applications of machine learning.Features: Highlights how the use of deep neural networks-based applications can address new questions and protocols, as well as improve upon existing challenges in diabetes mellitus detection and diagnosis Assists scholars and students who might like to learn about this area as well as others who may have begun without a formal presentation, with no complex mathematical equations Involves exceptional subject coverage and includes the principles needed to understand deep learning

This book delves into the vital role of plants and their bioactive compounds in human health, emphasizing their medicinal and nutritional significance. It highlights the growing concern of drug resistance in anticancer and antimicrobial medications, compelling clinicians, and researchers worldwide to seek alternative solutions. Plants offer a diverse array of compounds, serving as a promising resource for novel and safe drug candidates and potentially enhancing drug efficacy while being easily metabolized in the human body. Their cost-effectiveness, safety profile, and minimal side effects make them an ideal source for developing new drug regimens. The book aims to attract students, teachers, and researchers across various disciplines, covering topics such as biochemistry, pharmacology, botany, medicinal chemistry, virology, nutrition, clinical biochemistry, and biomedicine. The book will explore the medicinal and nutritional importance of plants and their products, showcasing their applications in medicine, industries, cosmetics, therapeutics, and preventive measures.

Zinc in Plants: Current Knowledge and Recent Advances addresses zinc hunger, the transport of zinc in the soil-plant interphase, zinc and abiotic stress in plants, and zinc and plant disease. Written by experts in the field, this title is an essential resource to all scientists and students interested in plant physiology, biochemistry and agriculture. During their life, plants encounter various challenges, including their normal development under changing environmental conditions. Zinc (Zn) is an essential component of thousands of proteins in plants, although it is toxic in excess, and is essential for many processes throughout the plant lifecycle. - Provides an overview on the origin, chemistry and behavior of zinc in soil - Discusses zinc deficiency and toxicity along with causes and remediation - Presents the latest advances in zinc signaling, regulation and genotypic variation

Medicinal herbs and trees are some of the most trusted sources of traditional cures for most common diseases, even in the present day. The onset of COVID- 19 has increased the popularity of medicinal and herbal plants as well as their products over modern medicines in several instances. There is a considerable gap between demand and supply as most of these plants are not conventionally cultivated and are collected from forests. Most of the knowledge of the identification and utilization of medicinal and herbal plants is orally passed on from one generation to another and only occasionally documented.Propagation to Pharmacopeia: Modern Approaches in Medicinal Plants explores various aspects of medicinal and herbal plants, including cultivation, biotechnological aspects, diversity, bioprospecting, sustainable utilization of medicinal plants, extension, ethnobotany/ modern and traditional uses, and conservation of medicinal plants. This book will serve the purpose of providing scientific information about medicinal plants and herbal plants, their uses, biotechnological aspects, chemical profiling, and conservation.Features: A systematic overview of trees and herbs with medicinal importance Outline of medicinal plants, formulations, and herbal medicines effective to treat SARS-CoV-2 Strategies for ameliorated production, extraction, and quantification of plant secondary metabolites Approaches for propagation, genetic transformation, and conservation of medicinal plant germplasms This book serves as a resource of helpful information for academicians, biotechnologists, foresters, agriculture practitioners, researchers, as well as those in industries manufacturing herbal drugs, nutraceuticals, and supplementary products. From this book, readers will gain extensive knowledge of widely used medicinal and herbal plants and a perspective on how they can be cultivated, commercialized, and sustainably utilized for the benefit of human health.

Glycosphingolipids in the Central Nervous System: Diversity in Structure, Metabolism, Distribution, and Function comprehensively covers progress made in the discovery, profiling and understanding of the metabolism, function and functional mechanism of GSLs in the CNS –as well as their synthesis, relationships with and therapeutic applications to neurodegenerative disorders, and related CNS diseases. Due to the important roles of GSLs in the CNS and various CNS-related diseases, the interest in these biomolecules is growing. GSLs are the principal glycolipids on the cell surface and an essential constituent of the cell membrane. They are widespread, but especially enriched in the central nervous system (CNS) in vertebrates. The diversity of GSL structures forges the molecular foundation for their broad spectrum of activity. - Presents a systematic review of literature and potential future developments in Glycosphingolipid research - Highlights interdisciplinary interplay between various aspects of the neuronal system and its structural and functional properties - Provides an overview, general trends, cases studies, summaries and future implications

This book covers the basic concepts and applications of photoredox processes. This book highlights the applications of photoredox reactions in waste management, photoremediation, photodeposition, photocatalysis, sustainable therapeutic approaches, natural product synthesis and derivatization to photocatalytic degradation and beyond. The challenges associated with the application of synthetic transformations are the hazardous economic reaction conditions. It further discusses the application of these mechanisms in drug derivatization and degradation. The book also covers the topic of nano-photocatalyst for drug-free therapeutics. This book is useful for researchers and professionals in the various areas of applied chemistry and biotechnology and allied fields.

This book explores the functional materials derived from biomass for environmental remediation applications. It covers different sources of biomass, its classification, production and various functional materials that are derived from them and suitable for energy production. Various topics covered in this book include classification of biomass, conversion and utilization techniques, functional materials, different applications in environmental remediation, biofuels and many more. This book is highly useful for students, researchers and professionals working in the field of materials and environmental science.

This book highlights the comprehensive overview of the current status and future potential of biopolymers in the textile industry, including the properties and performance of different types of biopolymers, the applications of biopolymers in various textile products, the challenges and limitations associated with their use, and the environmental impact and economic benefits of biopolymers in the textile industry. The textile industry is one of the largest and most important industries in the world, but it also has a significant environmental impact due to the use of non-renewable and non-biodegradable materials. Biopolymers, which are derived from renewable biological sources such as plants and microorganisms, have the potential to be a sustainable alternative to traditional textile materials. However, the use of biopolymers in the textile industry is still a relatively new and rapidly evolving field, and there is a need for more information and understanding about the opportunitiesand limitations associated with their use.

Emergence of lifestyle diseases, e.g., type II diabetes, cancers, obesity, cardiovascular disorders, liver cirrhosis, etc., are exponentially increasing day by day. Modern drifts toward the utilization of herbal medicines in different healthcare aspects necessitate (demand) the replacement of synthetic molecules with phytoconstituents because of their biocompatibility, biodegradability, economic extraction process, and ready availability from the natural source. This book provides a thorough insight into the comprehensive and up-to-date trends of phytomedicines in the management of lifestyle diseases and its mechanisms, modern methods of extraction and purification of phytoconstituents, and chemical characterization as well as standardization of phytoconstituents using modern equipments.

Cyanobacteria, the ancient photoautotrophs on the Earth have always been regarded as the most important organism to sustain life in the planet. They are among the first pioneering communities on various harsh habitat, hydrarch or xerarch, which finally facilitate the emergence of vast communities including higher plants. Being the progenitor of chloroplast, the cyanobacterial metabolisms has always fascinated microbiologist. Additionally, the ability of these prokaryotes to produce valuable and prolific sources of natural products signified their role in array of industrial sectors. Further, the attempts to engineer the cyanobacterial metabolisms in way to enhance production of these metabolites are gradually increasing. Therefore, in this book, we proposed to accumulate the knowledge of cyanobacterial metabolisms and molecules as an asset for students, researchers, and biotechnologists. Cyanobacteria: Metabolisms to Molecules will cover diversity, fundamental metabolisms, crucial metabolities and their synthesis, and bioinformatics. - Casts light on cyanobacterial assistance and their potential role in sustainable developments - Provides significant insights into the fundamentals of cyanobacterial metabolism as well as lesser known topics - Determines the role of cyanobacteria in public health

​Nutraceuticals are defined as any food bioactive compounds or supplements which provide health and medicinal benefits, usually in the prevention of disease and sometimes playing a role in their treatment as well. Nutraceuticals are a combination of a variety of nutrients ranging from vitamins and minerals to certain amino acids. Nutrients are an essential part of the diet and serve a variety of roles in human physiology through various enzymes which govern biocatalysis in various metabolic pathways including tissue and DNA repair and body defense and immunity. Nutrients that are routinely prescribed as dietary supplements include multivitamins, minerals and certain specific amino acids. Nutraceuticals not only serve a pivotal role in tissue repair and body defense mechanism but also play a crucial role in various signal transduction and metabolic pathways. The deficiency of any crucial nutrient can negatively affect metabolic and transduction pathways which can lead toa variety of diseases and disorders. The preventive use of nutraceuticals is a promising new trend for a variety of diseases and disorders. Nutraceuticals: A New Millennium Approach for Preventive Medicine focuses on the preventive use of nutraceuticals to avoid various diseases and disorders. The chapters cover nutrients and human physiology, metabolism and xenobiotics, plus their use in the prevention and treatment of a wide range of diseases and disorders from cancer to cardiovascular disorders to diabetes and renal diseases. Further chapters study the role nutraceuticals play in the treatment of depression and mental illnesses, neurogenerative diseases and autoimmune diseases. The relationship between nutrients and suboptimal health is explored as are links between nutrition and infertility. As these food supplements continue to gain in popularity with consumers, it is increasingly important to understand their benefits and limitations in the prevention and treatment of various diseases and disorders, and this book offers a fully up-to-date snapshot for researchers.

The book provides currently available information on the changing climate and its impact on functional and adaptive features of plants. The book also cover cutting edge research on key determinants of plant growththat provides a direction towards execution of programs and practices that will assist resilience of crop production systems to the changing climate. This book will represent the updated scientific information regarding soil and plant productivity under changing climate which will be beneficial to academics and researchers working on climate change, agronomy, stress physiology, biotechnology. It provides an in-depth discussion on the latest techniques to enhance plant responses to new environmental conditions that can be directly applied on field.

This book provides a comprehensive overview of recent developments to valorize fish waste as a source of useful products. In the first few chapters, an introductory section unearths global fish waste production, its detrimental effects and its role in the circular economy. The next section of the book discusses recent applications of fish waste and by-products utilization for the production of useful products such as fertilizers, biogas, biodiesel, fish sauce, enzymes and many more. This book will serve as an important source of recent research developments and applications of fish waste generated at different stages of fish processing. This book will also act as an important reference to the research group conducting research on fish and fish by-product utilization and valorization.

Das beliebte, auf die Approbationsordnung abgestimmte Lehrbuch bietet einen praxisbezogenen Einstieg in die Chemie, der aufzeigt, welche Bedeutung die Chemie für den Mediziner im Arbeitsalltag hat. Jedes Kapitel beginnt mit einem Fallbeispiel aus der medizinischen Praxis, das den Rahmen für die Untersuchung der chemischen Grundlagen absteckt und sich als roter Faden durch das gesamte Kapitel zieht. Das Buch ist umfassend bebildert und bietet Studierenden anhand von zahlreichen Merksätzen, Definitionen und Tabellen die nötige Orientierung. Neben Beispielaufgaben mit vorgerechneter Lösung finden sich am Kapitelende zahlreiche Übungsaufgaben, deren Lösungen im Anhang gegeben werden. Online stehen zusätzliche Übungen zur Vorbereitung auf die Prüfung zur Verfügung. Für die Neuauflage wurde das Buch durchgehend aktualisiert und um neue Praxisbeispiele ergänzt.

This book provides a methodical compilation of deriving composites from the hidden treasure of the aquatic world.Continuous and rapid progress in the composite industries have increased the demand for resilient, economically viable, and sustainable composite materials having enhanced mechanical, thermal and electrical properties which better suits there respective applications.If the materials/organisms used for the production or conversion of composites are renewable, degradable and easily and abundantly available then it gives great opportunity to the researchers to work on different options or processes to make them a viable technology. This work describes the organisms and materials present in the aquatic environment for the production of composite materials. Elaborating the versatile green expedients and their potential applications in the field of composites. Since, growing ecological and environmental consciousness has driven efforts for development of new innovative materials for various end-use applications.Therefore the LCA an circular bio-economy will be discussed to be efficient and sustainable. This book is ideal for the students, academicians, researchers and industry players. It also cover the present scenario, applications and future perspectives of composites derived from aquatic organisms. This compiled book features chapters that discuss the conversion of different materials and organisms present in aquatic environment to composite materials like micro-algae, seaweeds, chitosan, collagen, agar cyanobacteria etc.in a viable manner.

As a result of their unique physical properties, biological membrane mimetics such as biopolymers are used in a broad range of scientific and technological applications. This comprehensive book covers new applications of biopolymers in the research and development of industrial scale nutraceutical and functional food grade products. All the major food biopolymers are included, from plant, animal and marine sources. Coverage also includes biopolymer-based drug delivery mechanisms intended for biological applications such as bio-detection of pathogens, fluorescent biological labels, and drug and gene delivery. This is the first interdisciplinary book to address this area specifically and is essential reading for those who produce the functional biopolymer materials as well as those who seek to incorporate them into appropriate nutraceutical, food and drug delivery products.

This book focuses on green nanoremediation addressing aspects related to the use of nanomaterials generated through green synthesis protocols to efficiently restore polluted environs. Nanomaterials'characteristics such as large surface area, capacity to easily reach into contaminated sites, good reactivity, and possibility of being developed to present photocatalytic activity and/or to deal with targeted substances by chemical surface modification are useful specially to perform remediation. As an alternative to conventional physicochemical methods, the green-based synthesis protocols reject the use of harmful reagents, prevent waste production, apply renewable energy source and/or materials, and consider in first place offering the smallest negative impact possible to living beings and to the ecosystem. Green synthesis in nanotechnology field involves the use of seaweeds, bacteria, cyanobacteria, yeasts, fungi, plants (living ones, biomass, extracts) and/or bio-derived products to generate the nanomaterials. The introductory chapter will be dedicated to nanomaterials'characteristics that enable them to be used in environmental remediation. The first part of the book will be dedicated to organic and inorganic pollution and the threats they pose to living forms; advantages, disadvantages and mechanisms of nanoremediation; comparison between conventional strategies of environmental pollution remediation and the green nanoremediation; carbon-based and non-carbon-based green nanomaterials capable of promoting environs'remediation; cost/benefits of using nanomaterials and nanoinformatics to a safe nanotechnology. The second part will be dedicated to green nanoremediation of water and soil, microbe-based, algae-based and plant-based synthesis of nanomaterials to nanoremediation. This part will also contain chapters dedicated to relevant nanomaterials for green nanoremediation protocols, nano-phytoremediation strategies, strategies to evaluate the efficiency of protocols related to this kind of remediation, main interactions of green nanomaterials and microbes during nanoremediation and, as a consequence of it, biocompatibility of green nanomaterials. This book's main purpose is to offer readers extensive knowledge on green nanoremediation as a feasible strategy to fight pollution's harmful consequences and clean environmental pollution, but also present the challenges that should be surpassed.

In this second volume, various materials such as Magnetic-based biocomposites, wheat bran/straw-based biomaterials, peel-based biomaterials, luffa Based Biomaterials, composite polymeric membranes, rice husk, hydroxyapatite etc for treating textile waste water are highlighted. One of the major pollutants in the textiles and fashion sector is textile waste water. Textile wastewater can lead to serious environmental issues if discharged without proper and sufficient treatment. The materials employed along with the technologies available to trate the waste water are the key. There are a lot of advancements in terms materials, technologies employed for textile waste water treatment. Sustainable bio-nano materials and macro molecules play a major role in the efficient textile waste treatment.

This book highlights current efforts and research in Malaysia on conversion of bio-resources to renewable energy of biofuel as an alternative way of producing energy from fossil-based fuels. The book starts with the renewable energy developments and policies in Malaysia and discusses the main renewable resources available. It addresses the use of more environmentally friendly technologies which can lead to the reduction of pollution and thus sustaining the ecology for treatment of bio-resources. The book also presents new initiatives in bioenergy production with theories, applications, and challenges of biological processes of biofuel production such as bioethanol, biobutanol, biogas, microbial fuel cell (MFC), and biodiesel. It discusses the potential of renewable energy resources to meet the energy needs without damaging/affecting the environment.

Bioenhancers have been used in Ayurveda historically and are now being investigated for their pharmacological effi cacy. Herbal bioenhancers work on the gastrointestinal tract to improve absorption and drug bioavailability by acting on the drug metabolic process. Many herbal drugs show low activity due to their poor lipid solubility or improper molecular size. Piperine, gingerol, naringin, quercetin, niaziridin, glycyrrhizin, allicin, curcumin, genistein and others are able to enhance the bioavailability of active pharmaceuticals. This book details various facets of herbal bio-enhancers in a single comprehensive text.

This book covers the latest findings of a wide variety of viral, prokaryotic and eukaryotic macromolecular protein complexes and builds upon the solid macromolecular foundations established by previous volumes of the Subcellular Biochemistry series. Thus, an almost encyclopaedic coverage of the broad field of protein complex structure and function has been established. The 17 interesting chapters included in this book have been organised into four sections: Soluble Protein Complexes, Membrane Protein Complexes, Fibrous Protein Complexes and Viral Protein Complexes. Significant topics present here are: Fatty Acid Synthase, the Fork Protection Complex, Ribonucleotide Reductase, the Kinetochore, G proteins, the FtsEX Complex, the Kainate Receptor, the Photosystem I-antenna, the Mycobacterial Arabinofuranosyltransferases, the the Bacterial Flagellum, the Actomyosin Complex, Motile Cilia, SLS Collagen Polymorphic Structures, and the Reovirus Capsid and Polymerase. Up-dates/expansion of chapter topics present in earlier volumes are now included in chapters here, e.g., those on Ferritin-like proteins and the Multi-tRNA Synthetase. The book is richly illustrated throughout, the result of an impressive integration of structural data from X-ray crystallography and cryo-electron microscopy. The functional aspects of protein-protein interactions are also given a high priority.

In this first volume, various materials such as chitosan, lignin-based biomaterials, cellulosic based bio materials, carbon materials, Polysaccharide-composites materials, Aromatic-Based Synthetic Macromolecules, Agricultural wastes, etc for treating textile waste water are highlighted. One of the major pollutants in the textile and fashion industry is (textile) waste water. Textile wastewater can lead to serious environmental issues if discharged without proper and sufficient treatment. The materials employed along with the technologies available to trate waste water are the key. There are a lot of advancements in terms materials, technologies employed for textile waste water treatment. Sustainable bio-nano materials and macro molecules play a major role in the efficient treatment of textile waster.

Thousands of organisms fall under the umbrella of fungal species, many with unique properties; some innocuous, some useful and some harmful. This book covers the chemical composition and nutraceutical and pharmaceutical properties of edible fungi. It provides updates, future trends and perspectives on edible fungi, their nutritional properties, chemical features and different biological activities ascribed to them. Linking their functional use with different food products, it details the many health related properties of edible fungi. Phenolic acids, fatty acids, macromolecules, and different terpenes and steroids are presented as compounds with health improving properties. The book also discusses current technologies for mushroom cultivation and cultural use of mushrooms around the globe. Intended for food scientists and technologists, this book offers insights into current research and developments on edible fungi and will stimulate additional research in this area. It could also be considered as a supplementary text for courses such as applied or medical mycology.

Understanding and addressing the current opioid crisis requires knowledge of endogenous opioids (endorphins and enkephalins), but there is now evidence for a benzodiazepine crisis. Are there endogenous benzodiazepine-like substances—and what do they do? How do they affect antianxiety drugs and their adverse effects? Do they explain enigmatic prolonged benzodiazepine withdrawal syndrome? This book raises important questions about the clinical consequences of ignoring the existence of or understanding the potential influence of endogenous benzodiazepines on the therapeutic effect of benzodiazepines, their adverse effects, and the problems of withdrawal from them and other benzodiazepine receptor agonists.FEATURES Discusses endogenous benzodiazepine-like substances—what do they do, and do they affect antianxiety drugs and their adverse effects? Presents information on enigmatic prolonged benzodiazepine withdrawal syndrome Describes the compounds acting at the BDZ binding sites, both exogenous (classical BDZ drugs and BDZ from food and plants) and endogenous (endozepines) Assesses the putative interactions in physiology, pathology, and pharmacology of the compounds acting at the BDZ binding sites Dr. Raffa is Adjunct Professor at the University of Arizona College of Pharmacy and Professor Emeritus at Temple University School of Pharmacy. He has co-authored or edited several books on pharmacology and thermodynamics, is a co-editor of two journals, is a past president of the Mid-Atlantic Pharmacology Society, and is the recipient of research and teaching awards. Dr. Amantea is Associate Professor of Pharmacology at the Department of Pharmacy, Health and Nutritional Sciences of the University of Calabria (Italy), where she is the leader of the Stroke Research Unit at the Section of Preclinical and Translational Pharmacology operating in the frame of the Italian Stroke Organization (ISO) Basic Science. She is a member of the Editorial Board and the Guest Editor of the 2016 Neuroscience section of Current Opinion in Pharmacology (Elsevier), and the founder and the editor of the CRC Press Frontiers in Neurotherapeutics series.

NEGLECTED TROPICAL DISEASES AND PHYTOCHEMICALS IN DRUG DISCOVERY Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections. This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals. The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of: Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.

Turmeric belongs to the family Zingiberaceae and is a yellow spice of high economic importance due to its medicinal value. Cultivated in tropical and sub-tropical regions around the world, it is used extensively as a colouring, flavouring and preserving agent. In recent years, several drugs derived from natural products have been developed and current drug research is actively investigating the possible therapeutic roles of many Ayurvedic medicines, most notable among those being examined is turmeric. The wide range of pharmacological activities attributed to turmeric come mainly from curcuminoids and two related compounds, demethoxycurcumin and bisdemethoxycurcumin. This comprehensive book brings together the research carried out on constituents obtained from turmeric and highlights their chemical and biological activities. Comprising 17 chapters, each written by experts in their respective field and curated by authorities, it will be invaluable to all those who are involved in the production, processing, marketing, and the use of turmeric. Appealing to researchers and professionals in natural products, nutraceuticals and food chemists, this book is exposing some of the myths and showing areas for possible future use.

Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, Plant-derived Bioactives: Chemistry and Mode of Action, discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, Plant-derived Bioactives: Production, Properties and Therapeutic Applications, explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.

Plants have been a source of medicines and have played crucial role for human health. Despite tremendous advances in the field of synthetic drugs and antibiotics, plants continue to play a vital role in modern as well as traditional medicine across the globe. In even today, one-third of the world's population depends on traditional medicine because of its safety features and ability to effectively cure diseases. This book presents a comprehensive guide to medicinal plants, their utility, diversity and conversation, as well as biotechnology. It is divided into four main sections, covering all aspects of research in medicinal plants: biodiversity and conservation; ethnobotany and ethnomedicine; bioactive compounds from plants and microbes; and biotechnology. All sections cover the latest advances. The book offers a valuable asset for researchers and graduate students of biotechnology, botany, microbiology and the pharmaceutical sciences. It is an equally important resource for doctors (especially those engaged in Ayurveda and allopathy); the pharmaceutical industry (for drug design and synthesis); and the agricultural sciences.

Die technischen Fortschritte und neuen Möglichkeiten der molekularen Biologie – Genomanalysen, Expressionsanalysen, konfokale Lasermikroskopie, Proteomics – lassen die Physiologie von Wirbeltieren, genauso wie die von Nicht-Wirbeltieren, in einem neuen Licht erscheinen. Bei der Darstellung der Endokrinologie von Mensch und Tier wird dieser Entwicklung Rechnung getragen: Die Schwerpunkte liegen auf Hormonbiochemie, Hormonphysiologie, Hormonrezeptoren, endokrinen Organen und Regelkreisen und der Regelung endokriner Rhythmen. Die Betrachtung des Hormonsystems reicht von seinen Ursprüngen bei Invertebraten, seiner Evolution, den Wechselwirkungen mit Nerven- oder Immunsystem bis zu Stoffwechselstörungen bei menschlichen Gen-Defekten. Die 4. Auflage ist deutlich erweitert. Das Thema Stoffwechsel nimmt, verteilt über mehrere Kapitel, eine wesentlich größeren Raum ein. Komplett neu ist auch die Embryologie der endokrinen Organe.

This Reference Work provides a comprehensive overview of bioactive compounds found in underutilized fruits and nuts around the world and it elucidates their pharmacological, biological and health effects. In this book, readers will learn about the potential applications of bioactive molecules presented in several underutilized fruits and nuts rich in carbohydrates, lipids, fats, proteins, polyphenols, carotenoids, vitamins, organic acids, and volatile compounds. Readers will also discover more about the nutraceutical importance of these underutilized crops, and will also find specific case studies of the therapeutic potential of undertilized fruits and nuts. Written by highly renowned scientists of the field, this reference work appeals to a wide readership, from students and researchers to healthcare and industry professionals interested in plant biotechnology, biology, pharmacology and food engineering.

Cancer is a major global public health problem. Among different environmental and lifestyle factors contributing to cancer risk, diet is a key one. On the one hand, obesity and increased consumption of red and processed meat, ethanol, sugar and saturated fatty acids are associated with increased cancer risk. On the other hand, consumption of micronutrients such as vitamin D, selenium, zinc, folate and bioactive compounds from fruits and vegetables is associated with decreased risk. Written by an influential, international team of experts, this book presents and discusses current topics on nutrition and cancer prevention. It covers both nutritional influences on different cancers plus specific chapters on the commonly occurring cancers. Nutritional genomics-based studies show that some dietary components modulate carcinogenesis through complex cellular and molecular mechanisms. A better understanding of these different cellular and molecular mechanisms is needed to establish efficient dietary recommendations for cancer prevention. This book will provide such an understanding, serving as an important book for all those working in nutritional health, food science and cancer research.

Legalization of cannabis extracts around the world has led to a resurgence of interest into research surrounding endocannabinoids (eCBs) and the endocannabinoid system. This system is formed of a complex array of receptors, metabolic enzymes and transporters that finely tune the manifold biological activities of eCBs and there is an urgent need for the development of selective drugs to dissect the contribution of eCBs to the aetiology of various diseases. New Tools to Interrogate Endocannabinoid Signalling comprehensively covers the innovative research into both natural and synthetic compounds that affect this pathway and taking a target-based approach, assesses their potential for therapeutic use. With contributions from global leaders in the field, this timely volume will be a valuable resource to pharmaceutical researchers and medicinal chemists working in natural products and endocannabinoid drug discovery in academia and industry.

Early anthropological evidence for plant use as medicine is 60,000 years old as reported from the Neanderthal grave in Iraq. The importance of plants as medicine is further supported by archeological evidence from Asia and the Middle East. Today, around 1.4 billion people in South Asia alone have no access to modern health care, and rely instead on traditional medicine to alleviate various symptoms. On a global basis, approximately 50 to 80 thousand plant species are used either natively or as pharmaceutical derivatives for life-threatening conditions that include diabetes, hypertension and cancers. As the demand for plant-based medicine rises, there is an unmet need to investigate the quality, safety and efficacy of these herbals by the “scientific methods”. Current research on drug discovery from medicinal plants involves a multifaceted approach combining botanical, phytochemical, analytical, and molecular techniques. For instance, high throughput robotic screens have been developed by industry; it is now possible to carry out 50,000 tests per day in the search for compounds which act on a key enzyme or a subset of receptors. This and other bioassays thus offer hope that one may eventually identify compounds for treating a variety of diseases or conditions. However, drug development from natural products is not without its problems. Frequent challenges encountered include the procurement of raw materials, the selection and implementation of appropriate high-throughput bioassays, and the scaling-up of preparative procedures. Research scientists should therefore arm themselves with the right tools and knowledge in order to harness the vast potentials of plant-based therapeutics. The main objective of Plant and Human Health is to serve as a comprehensive guide for this endeavor. Volume 1 highlights how humans from specific areas or cultures use indigenous plants. Despite technological developments, herbal drugs still occupy a preferential place in a majority of the population in the third world and have slowly taken roots as alternative medicine in the West. The integration of modern science with traditional uses of herbal drugs is important for our understanding of this ethnobotanical relationship. Volume 2 deals with the phytochemical and molecular characterization of herbal medicine. Specifically, It will focus on the secondary metabolic compounds which afford protection against diseases. Lastly, Volume 3 focuses on the physiological mechanisms by which the active ingredients of medicinal plants serve to improve human health. Together this three-volume collection intends to bridge the gap for herbalists, traditional and modern medical practitioners, and students and researchers in botany and horticulture.

In this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo, is discussed. Therapeutic potential of CPPs and commercial developments are discussed. The present, second edition of this book is the updated and expanded version of the first edition, published in 2019. The development of the field of cell-penetrating peptides in these five years has been obvious and exciting. This second edition of the book has been partly reorganized and comprehensively expanded with the exciting research in 2019-2023. Around 2500 novel scientific articles have become available, most of them are reviewed in the second edition. Additional rapidly growing areas of high impact presented in this second edition are therapeutic developments (Chapter 16) and delivery of oligonucleotides and proteins/peptides (Chapters 5 and 6) including novel reports on genome editing with CPP assistance. Also, several additional examples are available now on clinical trials using CPPs (Chapter 15). The book is written for researchers and students in the field.

Genomics and genome technology is having, and continues to have, a major impact on all areas of bioscience research providing insights into the key area of molecular mechanisms of cells in health and disease. This is causing a profound effect on biomedical science and is accelerating the development of new diagnostic applications. This book provides a timely, graduate level introduction to the fast-paced area of genomics and clinical diagnostic technologies and introduces the concept of applications based on this area. The initial chapters focus on principal molecular technologies that underpin the information in the later chapters. In addition to introductory areas of nucleic acids and techniques in molecular biology, bioinformatics and proteomics, other key diagnostic areas such as the use of immunological reagents are covered. The later chapters provide more specialised examples of currently used diagnostic technologies and insights into selected key diagnostic challenges including specific examples of molecular microbial diagnostics and molecular biomarkers in oncology. The running themes through the chapters provides an insight into current and future perspectives in this rapidly evolving field.

Caenorhabditis elegans - An Overview and Emerging Roles in Studying Disease explores different disease models that have been successfully validated in this nematode, either to unravel disease mechanisms or to perform drug screenings. This nonpathogenic organism has helped to firstly identify genetic mechanisms important in cancer (Ras and Bcl oncogene signaling), aging (insulin signaling), and nervous system development (UNC-6/Netrin signaling). Human conditions such as aging/frailty (Chapter One), metabolic syndrome (Chapter Two), neurodegenerative diseases (Chapters Three and Four) and neurodegeneration induced by chemicals (Chapters Three and Five) are recapitulated in C. elegans. The construction of transgenic animals that mimic the diseases, the advances in understanding molecularly these conditions, potential new treatments and limitations of the models are reviewed in these chapters. Notably, the authors that contributed to this book are from different parts of the world due to the widespread use of this nematode in research.

This unique book describes the latest information in the fundamental understanding of the biophysics and biochemistry of articular cartilage using the state-of-the-art practices in NMR and MRI. This is the first book of its kind, written by physicists and chemists on this important tissue, whose degradation contributes to osteoarthritis and related joint diseases. Connecting the fundamental science with the clinical imaging applications, the experts Editors provide an authoritative addition to the literature. Ideal for practising physical scientists and radiologists with an interest in the fundamental science as well as instrument manufacturers and clinical researchers working with articular cartilage.

Mass spectrometry is one of the most widespread technologies in chemistry and has been increasingly used in biology with the rise of omics sciences. This book summarizes some important methodological approaches in mass spectrometry and applications in the field of chemical biology. The core chapters build on basic concepts introduced in the opening chapter and explore established fields such as high throughput screening, proteomics and metabolomics. Emerging applications of mass spectrometry in elucidating biosynthetic pathways, enzyme mechanisms and protein-protein interactions are then presented. Connections between these diverse research fields are highlighted throughout. The book concludes with a discussion of databases and future perspectives. This book will be a useful tool to early chemical biology researchers wishing to incorporate mass spectrometry as a tool in their research.

MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the'battery of life'are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching.Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.

Das beliebte, auf die Approbationsordnung abgestimmte Lehrbuch bietet einen praxisbezogenen Einstieg in die Chemie, der aufzeigt, welche Bedeutung die Chemie für den Mediziner im Arbeitsalltag hat. Jedes Kapitel beginnt mit einem Fallbeispiel aus der medizinischen Praxis, das den Rahmen für die Untersuchung der chemischen Grundlagen absteckt und sich als roter Faden durch das gesamte Kapitel zieht. Das Buch ist umfassend bebildert und bietet Studierenden anhand von zahlreichen Merksätzen, Definitionen und Tabellen die nötige Orientierung. Neben Beispielaufgaben mit vorgerechneter Lösung finden sich am Kapitelende zahlreiche Übungsaufgaben, deren Lösungen im Anhang gegeben werden. Online stehen zusätzliche Übungen zur Vorbereitung auf die Prüfung zur Verfügung.Für die Neuauflage wurde das Buch durchgehend aktualisiert und um neue Praxisbeispiele ergänzt.

Building on key reactions presented in Volume 1, Synthetic Methods in Drug Discovery Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting areas such as Csp2-Csp3 couplings, catalytic amide bond forming reactions, hydrogen borrowing chemistry and methods to access novel motifs and monomers. This book provides both academic and industrial perspectives on key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Moreover, key opportunities in expanding chemical space are presented, including the increasingly important syntheses that introduce three-dimensional molecular shape. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins.Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.

This series provides inorganic chemists and materials scientists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Volume 58 continues to report recent advances with a significant, up-to-date selection of contributions by internationally-recognized researchers. The chapters of this volume are devoted to the following topics: • Tris(dithiolene) Chemistry: A Golden Jubilee • How to find an HNO needle in a (bio)-chemical Haystack • Photoactive Metal Nitrosyl and Carbonyl Complexes Derived from Designed Auxiliary Ligands: An Emerging Class of Photochemotherapeutics • Metal--Metal Bond-Containing Complexes as Catalysts for C--H Functionalization Iron Catalysis in Synthetic Chemistry • Reactive Transition Metal Nitride Complexes Suitable for inorganic chemists and materials scientists in academia, government, and industries including pharmaceutical, fine chemical, biotech, and agricultural.

Deimination is a relatively new post-translational modification of proteins, whose recognition is ever-increasing. First linked to the pathology of rheumatoid arthritis (RA), deimination is a process by which selected positively charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl arginine deiminase (PAD) family of enzymes.Although the medical literature is rich with articles about the possible significance of deiminated proteins in RA, Protein Deimination in Human Health and Disease is the first publication to compile this knowledge and the growing amount of new information now known about the presence of deiminated proteins in the eye, skin, hair, gums, lung and nervous system, as well. As a result, this process has now been linked to numerous additional conditions besides RA, including cancer, glaucoma, Alzheimer's disease, Parkinson's disease, multiple sclerosis, spinal cord and peripheral nerve injury, Creutzfeldt-Jakob disease, among many others.Chronicling the earliest studies of deimination up to the present, this volume distills what is currently known about citrullination of proteins in the human body and is the first book of its kind on the topic.

This publication compiles data generated by proteomics and metabolomics about psychiatric disorders. Leading researchers in these fields review the basic principles of proteomics and metabolomics and propose the new directions to be followed in molecular psychiatry. The chapters divided into two sections - Schizophrenia/Psychotic Disorders and Mood Disorders - deal with findings in diverse tissues from human and preclinical models in order to unravel the biology and biochemistry behind the establishment and course of these illnesses as well as potential biomarkers for clinical applications. More than an update, this publication indicates the next steps to discover biomarkers and understand psychiatric disorders more comprehensively. This publication is valuable reading for psychiatrists, neuroscientists and analytical chemists interested in the basics of proteomics and metabolomics, psychiatric definitions and the most advanced hypotheses about the pathobiology of schizophrenia, depression and bipolar disorder.

Contractions of vertebrate skeletal and cardiac muscles are controlled by Ca2+ signaling through the troponin complex in the sarcomeres, which are the contractile machinery consisting of interactive myofilaments. Since the abundance of troponin subunit proteins in myocytes and their muscle-specific expression, troponin I (TnI) and troponin T (TnT) have been broadly applied as serum biomarkers for the clinical diagnosis of acute myocardial infarction and other heart and muscle injuries. Intensive research from protein structure to genetic diversity to posttranslational modification and pathological mutations has comprehensively established the molecular structure of troponin. The advanced knowledge gained from basic research of troponin allows for a better understanding of the current methodology for troponin-based diagnostic applications. To help clinicians, diagnostic laboratory staff and methodology developers, this book provides comprehensive yet concise summaries of the current knowledge cover a broad range of topics including a detailed review of the structural features and adaptive modifications of troponin subunits and impacts on immunological detections; a comprehensive summary of the evolution of troponin assays; an evaluation of current assay platforms, quality specifications for cardiac troponin assays; the use of high-sensitivity cardiac troponin assays; electrochemical strategies for the detection of cardiac troponins; cardiac troponins in the evaluation of myocardial damage during and post percutaneous coronary interventions; troponin as markers of myocardial injury in trauma; and the significance of increased serum troponin in an acute stroke and other non-cardiac diseases. Contributed by experts in the field, this broad collection provides a unique reference for healthcare workers, medical students and research investigators who have an interest in troponin-based laboratory tests. Readers will not only acquire and in depth state-of-the-science understanding of troponin structure and diagnostic applications, but they will also be exposed to visions leading into future developments toward advancing troponin detection and improving clinical applications.

This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.

This book summarizes present knowledge of different mechanisms involved in the development of positive and negative consequences of cardiac adaptation. Particular attention is paid to the still underestimated adaptive cardiac responses during development, to adaptation to the frequently occurring pressure and volume overload as well as to cardiac changes, induced by enduring exercise and chronic hypoxia. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.

Nach Definition, Einteilung und Chemie werden in Band 3 Pharmakologie, Neurobiochemie/Wirkmechanismus sowie Klinik (Indikationen, Dosierung, unerwünschte Wirkungen, Interaktionen, Kontrolluntersuchungen, allgemeine Behandlungsrichtlinien) der trizyklischen und nicht-trizyklischen Antidepressiva sowie der Monoaminoxidase-Hemmer und der atypischen Antidepressiva abgehandelt. Auf die Kombinationstherapie MAO-Hemmer/trizyklische Antidepressiva, die Antidepressiva-Infusionstherapie, die Behandlung'therapieresistenter'Depressionen sowie die Rezidivprophylaxe mit Antidepressiva wird in speziellen Abschnitten eingegangen. Ein eigenes Kapitel ist Antidepressiva mit neuartigen Wirkmechanismen gewidmet. Neben den Aminpräkursoren werden die Phasenprophylaktika Lithium sowie Carbamazepin und andere Antikonvulsiva beschrieben.'...'Es ist genau das drin, was draufsteht!'... Selten hat sich ein Buch derart mit diesem Thema beschäftigt, so daß diese Publikation wirklich genau für jene Berufsgruppe geschrieben ist, die Hintergrundinformation am nötigsten haben.... Resümee: Pflichtlektüre für die Exekutive!'Die Bundespolizei