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This reference book provides a comprehensive overview of natural gums, resins, and latexes of plants with a focus on their chemistry, biological activities, and practical uses. The content is divided into five main sections each of which contains chapters contributed from valuable experts in their field. Naturally occuring plant products have quite diverse applications in many different industries. The book aims to highlight the important aspects of plant-based gums, resins and latexes as well as provide a strategic framework for further research and development activities on these bioproducts. It will appeal to a broad audience such as biologists, pharmacologists, pharmacists, food technologists and medical practitioners. It is also a useful resource for research investigators of the healthcare industry, academia and students of biomedical sciences.

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more. - Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases - Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided - Includes contributions from recognized experts in the field

Advanced Glycation End-Products: Sources and Effects attempts to describe the role of advanced glycation end-products, particularly dietary advanced glycation end-products, in the pathological expansion of adipose tissue as well as their implications in the development of obesity associated complications. The effects of advanced glycation end-products on vasculature and their pathological implications are also described, focusing on the epigenetic mechanisms (particularly that of miRNA) modulating their effects. The authors summarize the information available on the impact of hyperglycemia on the influencing factors of non-enzymatic glycosylation, the formation of advanced glycation end-products, and the role of advanced glycation end-products and their specific receptors in diabetes. The role of advanced glycation end-products to diabetic complications is examined in conjunction with the protective role of the endogenous secretory receptor for advanced glycation end-products (esRAGE) and the therapeutic interveentions that would mimic esRAGE activity. In closing, poly-L-lysine modified with advanced glycation end-products is prepared and used as an antigen to generate a single-chain fragment variable monoclonal antibody (scFv mAb) through phage display technology.

Glycoconjugate Research, Volume I contains the proceedings of the Fourth International Symposium on Glycoconjugates, held in Woods Hole, Massachusetts, in September 1977. Contributors focus on the state of knowledge in the field of glycoconjugates ranging from polysaccharides and glycoproteins to glycolipids, proteoglycans, and all their varieties in plants, animals, and microorganisms. This text is organized into three sections and consists of 87 chapters. After an introductory chapter where the use of glycosidases for the structural analysis of complex carbohydrates is described, the discussion turns to other methods used for elucidating the structure of complex carbohydrates. The chapters that follow focus on the primary structure and conformation of glycans that are N-glycosically linked to peptide chains; isolation of monofuco-disialoganglioside from human and bovine brains; and partial chemical characterization of activated peptides isolated from a single cell suspension of rat colonic secretory cells. The last two sections explore cartilage proteoglycans and the structure-function relationships of glycoconjugates, touching on topics such as link proteins; the biochemical aspects of malignancy in human chondrosarcomas; defensive response of plants to a microbial oligosaccharide with a pheromone-like activity; and the interaction of saccharides with ricin. This book is intended for students and practitioners of chemistry and biochemistry; biology and microbiology; and physiology.