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Ultrastructure of Protein Fibers covers the papers presented at a symposium of the 19th annual meeting of the Electron Microscope Society of America, held at the Pittsburgh Hilton Hotel in Pittsburgh, Pennsylvania on August 21, 1961. The book focuses on the composition, characteristics, properties, and reactions of protein fibers. The selection first offers information on some essential aspects of protein fiber research, including the elucidation of the fundamental ultra-architecture of proteins in general; identification of the biological role played by fibrous proteins in living organisms; and the use of protein fibers as a natural resource in the form of raw materials and finished products. The manuscript then examines the physical, chemical, and mechanical properties of protein fibers, collagen, and keratins. The text takes a look at some aspects of the ultrastructure of bacterial flagella and feather keratin and fibrous protein systems in muscles. Topics include possible change in myofilament structure underlying the catch function; physiological functions of the fibrous proteins of muscles; organization of the fibrous proteins in muscles; and other functions of fibrous proteins in muscles. The selection is a valuable reference for researchers interested in the ultrastructure of protein fibers.

Chemical Determinations is a collection of papers that discusses chemical methods used in hormone investigation. One paper explains the physicochemical procedures used to separate estrogens from interfering material which leads to the possible determination of small amounts of hormones in biological fluids. One approach is through simpler methods for routine use, designed principally for the determination of estrogens in urine and in plasma. Another way is through more elaborate methods, designed to establish the presence and identity of various estrogens in small numbers of biological samples. Another paper explains the methods for the analysis of 17-ketosteroids of blood and urine, and a method for the assay of testosterone in plasma which correlates with the state of virilism of an individual. One paper describes the techniques utilized for extraction, preliminary purification, isolation, and quantitative estimation of progesterone. Another paper reviews the occurrence of pregnanetriolone (an inactive urinary metabolite), the significance of its estimation as an aid in differential diagnosis, the methods of estimation, as well as the metabolic pathways leading to the excretion of pregnanetriolone and related steroids. The collection is suitable for researchers, scientists, medical practitioners, or academicians involved in endocrinology, metabolism, and bio-research.

Basic Mechanisms in Hearing is a collection of papers that discusses the function of the auditory system covering its ultrastructure, physiology, and the mechanism's connection with experimental psychology. Papers review the mechanics, morphology, and physiology of the cochlear, including the physiology of individual hair cells and their synapses. One paper examines the combined physiological and anatomical studies of stimulus coding in the mammalian auditory nervous system. The results of these studies pertain to the latency, frequency selectivity, and time pattern of responses to short tone bursts. Other research compare the cochlear nerve, behavioral, and psychophysical frequency selectivity which show that frequency selectivity of the auditory system occurs at the level of the cochlear nerve, becoming downgraded in end-organ deafness. Other papers discuss neural coding at higher levels such as the feature extraction in the auditory system of bats. Some papers also analyze the specialized hearing mechanisms in animals, for example, the echolocation of bats and in some insects, the function of the swimbladder in fish hearing, as well as the'invertebrate frequency analyzer'in the locust ear. Physiologists, neurophysiologists, neurobiologists, general medical practioners, and EENT specialists will find this collection valuable.

Energy Metabolism and the Regulation of Metabolic Processes in Mitochondria contains papers presented at the 1972 symposium on metabolic regulation, held at the University of Nebraska Medical School in Omaha, Nebraska. The contributors provide alternative views and ideas in some aspects of metabolic regulation directly concerned with mitochondrial function. Separating 16 papers into chapters, this book first discusses the general aspects of control of the biological energy regulation and the kinetic and thermodynamic control of mitochondrial electron transport and energy coupling. It then covers significant topics on citric acid cycle, including its replenishment and depletion; anion transport and regulation; dynamics and substrate compartmentation; and feedback control. Other chapters examine the mechanisms of gluconeogenesis, lipogenesis, redox reaction, and phosphorylation in the mitochondria. Discussions on hormonal regulation of selected enzyme system directly related to mitochondrial function are provided in the concluding chapters. Biochemists, physiologists, pharmacologists, physicians, researchers, and all others interested in the concepts of mitochondrial function will find this book of great value.

The Interpretation of Ulstrastructure is a collection of papers dealing with techniques in ulstrastructural research such as in fixation, reversed staining, ultrastructure in embryos and in plants, control of observations by light microscopy, and cytochemistry at the electron microscope level. One paper describes various fixatives used on rat liver tissue including a standard osmium tetroxide solution, pure melted osmium tetroxide, and strong osmium tetroxide solutions in carbon tetrachloride. Another paper points out that the use of electron micrographs of the cell nucleus and chromosomes should include approaches to chromosome analysis. For the investigator studying the three dimensional organization of chromosomes, his approaches should include classical cytology and cytogenetics, chemical and cytochemical studies on nuclei, as well as chemical and physical analysis of nucleic acid and nucleoprotein molecules. Several papers discuss the study of natural and artificial DNA-plasma by thin sections, an assessment of negative staining techniques for revealing ultrastructure, and other approaches in the study of biological ultrastructure by high-resolution electron microscopy. The collection will benefit microbiologists, biotechnologists, and academicians connected with the biological sciences.

Reproduction: Molecular, Subcellular, and Cellular is a collection of papers presented at the Twenty-Fourth Symposium of The Society for Developmental Biology, held at Carleton, Minnesota in June 1965. The papers in the compendium focus on the clarification and definition of specific aspects of reproduction at different levels of biological organization. Topics discussed include the transcription and translation of genes; interactions between plant viruses and host cells; chromosome reproduction in mitosis and meiosis; cell and tissue interactions in the reproduction of cell type; and aging as a consequence of growth cessation. Biologists, microbiologists, and cytologists will find the book insightful.

Molecular Properties, Volume II is a collection of papers that deals with the physical and chemical properties of iron-sulfur proteins, with emphasis on the theory and application of physicochemical techniques related to metalloproteins. One paper describes the chemical properties of simple iron-sulfur proteins focusing on chloroplast, bacterial-type ferredoxins, and the nature of the active site in the ferredoxins. Another paper notes that rubredoxin sequences can offer phylogenetic, evolutionary, or genetic data. The paper shows that rubredoxins from aerobic and anaerobic bacteria have originated from some common ancestor. One paper analyzes the chemical and physical properties of rubredoxin and the way they relate to the structure resulting from an X-ray diffraction. The investigator can use electron paramagnetic resonance (EPR), electron nuclear double resonance (ENDOR) spectroscopy, or nuclear magnetic resonance (NMR) to determine the structural and functional features of simple and conjugated iron-sulfur proteins. He can also use a proton magnetic resonance (PMR) spectroscopy to study the structures and interactions of proteins in solution, such as ribonuclease, lysozyme, and the heme proteins (hemoglobins or myoglobins). Cellular biologists, micro-biologists, bio-chemists, and scientists involved in biological systems research will find this collection very informative.

The Eye: Volume 1, Vegetative Physiology and Biochemistry is a compendium of papers that describes the physiology of the eye, particularly its gross anatomy and embryology including its intra-ocular fluids, the intra-ocular pressure, the vitreous body, lens, cornea, and sciera. Several papers review the eyeball, the protective apparatus of the eye, the structure of the tissue in relation to the intra-ocular fluids, and the flow of aqueous humor. Several methods can be used to measure the intra-ocular pressure such as the manometric method and the tonometer. Giles (1959) reports that tonometer measurements in the newborn are within the normal adult range. One paper notes that in man, liquefaction of the vitreous body (the clear jelly-like structure which fills the space between retina and lens,) which is caused by dissolution of the fibrous network, is never repaired. This suggests that new fibers are either not formed or are formed in insufficient amounts. Another paper examines the relationship between pressure in the eye vessels and eye tension. Investigators and researches in the fields of physiology, psychology, ophthalmology, and in all branches of ocular physiology will find the compendium very rewarding.

Amines and Schizophrenia is a collection of articles that survey and discuss the biochemical basis present, if any, in schizophrenia, focusing on the role of certain amines. The book discusses certain hypotheses dealing with the field of bio-chemistry as the basis for diseases such as schizophrenia, manic-depressive psychosis, and related diseases. Discussions start with the properties of mescaline, because the psychotic effect of the drug has some aspects similar to that of a schizophrenic syndrome. One paper examines the presence of certain amines, such as norepinephrine, dopamine, and serotonin in the brain, including their role in the synaptic transmission of nerve impulses in the central nervous system. Other papers review the role of derangements of tryptophan metabolism in psychotic behavior; the metabolic interrelationships of tryptophan and methionine in mental illness; and the results obtained with psychomimetic and non-psychomimetic congeners of three classes of indoleamines including LSD. The book gives more details on the actions of various biological amines on single neurons in the limbic system of the brain. The text also evaluates the use of hallucinogenic drugs in considering their heuristic value in the study of the biochemical basis of mental function. The selection will prove relevant for psychologists, psychiatrists, drug researchers, pharmacologists, and chemical laboratory workers and technicians.

Oxygen in the Animal Organism is a compilation of papers presented during the symposium on Oxygen in the Animal Organism, jointly sponsored by the International Union of Biochemistry and the International Union of Physiological Sciences, held at Bedford College, London in September 1963. The book provides a multidisciplinary approach to the study of the subject of oxygen in the animal organism. The papers presented cover a wide range of facts and hypotheses on the subject. Topics discussed include studies in the transport of oxygen; the fundamental physics and chemistry of oxygen; the diffusion of oxygen from the capillaries to the mitochondria; the neural and humoral components to the regulation of ventilation; and the evolution of biochemical pathways for oxygen. Biologists, biochemists, biophysicists, physiologists, and researchers will find the text informative and insightful.

Biochemical analysis is a rapidly expanding field and is a key component of modern drug discovery and research. Methods of Biochemical Analysis provides a periodic and authoritative review of the latest achievements in biochemical analysis. Founded in 1954 by Professor David Glick, Methods of Biochemical Analysis provides a timely review of the latest developments in the field.

Biochemical analysis is a rapidly expanding field and is a key component of modern drug discovery and research. Methods of Biochemical Analysis provides a periodic and authoritative review of the latest achievements in biochemical analysis. Founded in 1954 by Professor David Glick, Methods of Biochemical Analysis provides a timely review of the latest developments in the field.

Serotonin and Behavior contains the proceedings of the 1972 symposium on the behavioral effects of changes in brain serotonin, held at Stanford University in California. The papers explore the role of serotonin in behavior as well as the key biochemical and pharmacological issues involved in behavioral studies of severe psychiatric disorders in both humans and animals. The book is organized into eight sections comprised of 65 chapters, with topics ranging from the fundamental biochemistry and pharmacology of the enzymes synthesizing serotonin, particularly, tryptophan hydroxylase and its inhibitors, to the physiology and pharmacology of serotonin. Some papers discuss the link between the telencephalic content of serotonin and pain sensitivity. Other papers focus on the effects of altering serotonin on neurons in the central nervous system. There are chapters that explain the effects of altering serotonin on animal behavior, the relationship between serotonin and sleep, the use of high doses of probenecid to estimate central serotonin turnover in affective disorders and addicts, the behavioral and metabolic effects of L-tryptophan in unipolar depressed patients taking methadone, and amygdala unit activity as a reflection of functional changes in brain serotonergic neurons. Biochemists, pharmacologists, psychiatrists, psychologists, and anyone interested in psychopharmacology will find this book extremely useful.

New Approaches in Cell Biology focuses on the introduction of''new trends''in cell biology. Divided into 14 chapters, the book contains the works of authors who have diligently conducted studies on the emergence of''new trends''in cell biology. The book first provides information on the process involved in the nuclear transfer of embryonic cells, and then proceeds with discussions on cellular inheritance, genetic components of lampbrush chromosomes, and the morphology of developing systems at the ultramicroscopic level. The text also notes the origin of the nucleus following mitotic cell division, including the types of chromosomal vesicle, nuclear membrane, and nucleoplasm. The discussions also focus on biochemical approaches to cell morphology; the relationship of paper chromatography with genetics and taxonomy; and the mechanisms in active transport systems. The matching of drugs to tumors, cytochemistry of proteins and nucleic acids, and the use of flying spot microscopy in research are also noted. The book is a vital source of information for readers interested in the pursuit of''new approaches''in cell biology.

The Proteins: Composition, Structure, and Function, Volume III, Second Edition is a collection of papers that deals with the proteins of antibodies and antigens, of the blood clotting system, plasma proteins, and the virus proteins. This volume also covers the fractionation of proteins and the criteria of purity, including the consideration of the interactions of proteins with radiant energy. One paper explains the peculiar biological usefulness and the special properties of each individual protein that can lead to its identification and separation. Other papers examine the structure and function of virus proteins, of viral nucleic acid, and of the plasma proteins. Another paper discuses the chemistry and structure of protein antigens and of antibodies, including the chemistry of their specific combination and relations with each other. The protein researcher can use convenient immunochemical techniques such as immunodiffusion and immunoelectrophoresis in his study. Other papers discuss the proteins in blood coagulation and the interactions of proteins with radiation, as well as, the infrared absorption spectra of proteins. This book can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology or in cancer research.

Advances in Comparative Physiology and Biochemistry, Volume 5, presents three papers that cover the different physiological and chemical aspects of biology, from functional morphology at one end to behavior at the other end of the spectrum. As always this serial publication emphasizes comparison, be it within a group of related organisms or related substances or mechanisms throughout the animal kingdom. The first study on the feeding and digestion in the Bivalvia examines both the feeding mechanisms and digestive processes within this class of mollusks, solidly based on functional morphology and biochemistry. The second study on isoenzymes, multiple enzymes, and phylogeny traces the evolutionary relationships between and within groups of important enzyme systems, taking evidence from representatives of the whole animal kingdom. The final paper on the comparative physiology of reproduction in arthropods examines the reproductive mechanisms in a whole phylum. It considers patterns of sexuality, germ cell formation, physiology, mating behavior and the nervous and hormonal factors governing reproduction.

Biological Properties is a collection of papers that deals with the biological properties of iron-sulfur proteins. One paper reviews the role of electron paramagnetic resonance in forwarding knowledge about iron-sulfur proteins. Iron-sulfur proteins are iron proteins where sulfur is a ligand of the iron, of which the iron is not simultaneously held by a stronger ligand such as porphyrin. Another paper discusses the role of bacterial ferredoxins in coupled oxidation-reduction reactions, the role of hydrogenase in oxidation-reduction, as well as the bacterial iron-sulfur proteins, such as azoferredoxin and molybdoferredoxin. Abiological models of nitrogenase involve molybdenum and iron with sulfur ligands; these abiological systems can be the first models that show the biological activity of iron-sulfur enzymes which these systems try to copy. One paper investigates the role of iron-sulfur proteins in photosynthesis, particularly the photoreduction of ferrodoxin, the mechanism of NADPH formation, and the possible role of ferrodoxin in cyclic photophosphorylation. This collection is suitable for bio-chemists, cellular biologists, micro-biologists, and scientists involved in research in the biological disciplines.

Frontiers in Catecholamine Research is a collection of papers presented at the Third International Catecholamine Symposium, held at the University of Strasbourg, Strasbourg, France, on May 20-25, 1973. This book is organized into nine parts encompassing 205 chapters. The text begins with a discussion on clinically and experimentally used drugs that have been developed or whose mechanism of action has been clarified through monoamine research. Parts II and III deal with enzymes related to catecholamine studies, their properties, regulation, genetics, mechanism of action, and localization. Parts IV and V examine the concepts of synaptic dynamics of brain regulators and the isolation, characterization, methods of analysis, and mechanism of action of catecholamines. Part VI focuses on the complexities that surround the extrapolation of catecholamine function into the realms of electrophysiology and behavior. Part VII discusses the metabolism, behavioral, neurological, and physiological effects of amphetamine and other drugs of abuse. The concluding parts describe the role of catecholamine and its metabolism in neurologic diseases, such as schizophrenia.

Structure and Function of Oxidation–Reduction Enzymes is a collection of papers presented at the Wenner-Gren Symposium held at the Wenner-Gren Center, Stockholm on August 23-27, 1970. It provides important understanding of the structure and function of oxidation-reduction enzymes: iron, flavin, and nicotinamide enzymes. This book discusses the functional differences among varying structures such cytochrome c, haemoglobins, dehydrogenases, flavins, oestrogens, and peroxidases. It concludes by presenting future expectations, including some questions that need to be addressed. This volume will be of great value to those interested in the present-day research on oxidation-reduction enzymes.

Biochemistry of the Glycosidic Linkage: An Integrated View is a collection of papers presented at The Pan-American Association of Biochemical Societies Symposium, held in San Carlos de Bariloche, Argentina on November 8-11, 1971. This symposium is organized as a tribute to Luis F. Leloir and his contributions in the field glycosidic linkage. This book is divided into six sessions encompassing 57 chapters. The opening session discusses the role of biochemical mechanisms in the glycosidic linkage formation. The following sessions examine the metabolic functions of some disaccharides, such as trehalose, sucrose, glucose, and starch. These sessions also look into the biosynthesis, function, and properties of carbohydrates containing polymers. The discussion then shifts to the control of enzyme biosynthesis involved in the glycosidic linkage metabolism, with particular emphasis on alpha-amylase, lactose synthetase, phosphorylase, and neuraminidase enzymes. Another session is devoted to the regulatory mechanisms and control of glycogen metabolism. The concluding session covers the genetic analysis and biochemical characterization of the enzymes involved in the glycosidic linkage metabolism. Biochemists and carbohydrate researchers will find this text invaluable.

Biochemical analysis is a rapidly expanding field and is a key component of modern drug discovery and research. Methods of Biochemical Analysis provides a periodic and authoritative review of the latest achievements in biochemical analysis. Founded in 1954 by Professor David Glick, Methods of Biochemical Analysis provides a timely review of the latest developments in the field.

Biochemical analysis is a rapidly expanding field and is a key component of modern drug discovery and research. Methods of Biochemical Analysis provides a periodic and authoritative review of the latest achievements in biochemical analysis. Founded in 1954 by Professor David Glick, Methods of Biochemical Analysis provides a timely review of the latest developments in the field.

Biochemical analysis is a rapidly expanding field and is a key component of modern drug discovery and research. Methods of Biochemical Analysis provides a periodic and authoritative review of the latest achievements in biochemical analysis. Founded in 1954 by Professor David Glick, Methods of Biochemical Analysis provides a timely review of the latest developments in the field.

Biochemical analysis is a rapidly expanding field and is a key component of modern drug discovery and research. Methods of Biochemical Analysis provides a periodic and authoritative review of the latest achievements in biochemical analysis. Founded in 1954 by Professor David Glick, Methods of Biochemical Analysis provides a timely review of the latest developments in the field.

The Composition, Structure and Reactivity of Proteins

Glutathione: A Symposium covers the proceedings of the symposium held in Ridgefield, Connecticut in November 1953. The book focuses on the chemistry, characteristics, reactions, and properties of glutathione (GSH). The selection first offers information on mercaptans and disulfides, reactivity of the sulfhydryl group in GSH and related peptides, and chemistry and properties of GSH. Discussions focus on isolation and occurrence of GSH, properties of GSH, general chemistry of acidity, oxidation, and disulfides, and application to the structure of GSH. The text then examines thiol-thiolester complex formation, methods of GSH assay, and paper chromatography of GSH and its hydrolysis products. The publication takes a look at histochemical experiments on sulfhydryls and disulfides, enzymatic oxidation and reduction of GSH, and biosynthesis of GSH. Topics include synthesis of GSH from the constituent amino acids, enzymatic oxidation of GSH, and methods for demonstrating protein-bound sulfhydryl and disulfide groups in tissues. The selection is a dependable reference for researchers interested in the chemistry, reactions, and properties of glutathione.

Biological and Biochemical Oscillators compiles papers on biochemical and biological oscillators from a theoretical and experimental standpoint. This book discusses the oscillatory behavior, excitability, and propagation phenomena on membranes and membrane-like interfaces; two-dimensional analysis of chemical oscillators; and chemiluminescence in oscillatory oxidation reactions catalyzed. The problems associated with the computer simulation of oscillating systems; mechanism of single-frequency glycolytic oscillations; excitation wave propagation during heart fibrillation; and biochemical cycle of excitation are also elaborated. This compilation likewise covers the physiological rhythms in Saccharomyces cerevisiae populations; integral and indissociable property of eukaryotic gene-action systems; and role of actidione in the temperature jump response of the circadian rhythm in Euglena gracilis. This publication is valuable to biochemists interested in biochemical and biological oscillations.

Chemicals Controlling Insect Behavior consists of papers originally presented at the Symposium on Chemicals Controlling Insect Behavior at the 157th National Meeting of the American Chemical Society in Minneapolis, Minnesota, on April 16, 1969. Organized into seven chapters, this book presents information on insect pheromones, insect defense mechanisms, and other insect attractants and repellent. It specifically describes the sex pheromones of the Lepidoptera, the attractant pheromones of Coleoptera, and the boll weevil sex attractant. The chemical basis of insect sociality and arthropod defensive secretions are also explained. Lastly, the practice in programs within the USDA relating toinsect attractants and repellents is discussed. This book will serve as groundwork for even greater and more rapid progress in this field of interest. It will be useful to chemists, biochemists, biologists, entomologists, and others working to control insect pests.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Biochemical analysis is a rapidly expanding field and is a key component of modern drug discovery and research. Methods of Biochemical Analysis provides a periodic and authoritative review of the latest achievements in biochemical analysis. Founded in 1954 by Professor David Glick, Methods of Biochemical Analysis provides a timely review of the latest developments in the field.

Cholinergic Ligand Interactions presents the papers read at a symposium held at the State University of New York at Buffalo, 25-26 May 1970. The recent purification and crystallization of acetylcholinesterase together with real progress in the purification of receptor components indicated the desirability of organizing a symposium to discuss not only these aspects but also the structural bases for cholinergic ligand interaction with these macromolecules, the conformational changes involved with ligand binding, the quantitation of cholinergic ligand binding sites, and the roles of acetylcholinesterase and its isozymes in muscle disease. The volume contains nine chapters and begins with a study on possible conformational changes in acetylcholinesterase. This is followed by separate chapters on the subunits of acetylcholinesterase; in vitro studies with the cholinergic receptor of the eel electroplax; identification and isolation of acetylcholine receptors; assay and properties of essential (junctional) cholinesterases of the rat diaphragm; and structural variations in cholinergic ligands. Subsequent chapters deal with ligand interactions at the muscarinic receptors and changes in cholinesterases isozymes during normal and dystrophic muscle development.

Habituation Volume I is a collection of papers about the phenomenon of habituation, the waning of responsiveness to repeated or constant stimulation, from different experts on the field. The book covers topics such as the nature of habituation; the behavioral habituation of different invertebrates; fish with special reference to intraspecific aggressive behavior, and lower tetrapod vertebrates such as amphibians and reptiles. Also covered is the species-meaningful analysis of habituation, the relationship of habituation with habituality and conditioning; the dual-process theory of habituation and evidence for the dual-process theory. The text is recommended for biologists and zoologists who are interested with the process of habituation, the factors that affect it, its effects on behavior, its development in different animal species, its analysis, and its underlying theories.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Advances in Comparative Physiology and Biochemistry, Volume 4, presents five papers on the different aspects of comparative physiology. The first two studies deal with movement. The first examines the effects of environmental conditions on the motile behavior of amoebas. The second investigates the mechanisms and coordination of cellular movement. The third study on the endocrine functions of the hypothalamus in the fishes, amphibians, and reptiles provides the comparative endocrinologist with a basis for integrating the state of knowledge on non-mammalian and mammalian function of this organ complex. The fourth study deals with the central and peripheral control of arthropod movements. The final study surveys the comparative physiology of populations of gametes. Aside from providing readers with a comparative vista of reproductive physiology from a unique perspective, it introduces a new hypothesis on the overproduction of gametes commonly found in living organisms — a hypothesis which may have far-reaching consequences for the interpretation of the reproductive process.

Protein Phosphorylation in Control Mechanisms contains the proceedings of the Miami Winter Symposia entitled''Protein Phosphorylation in Control Mechanisms,''held on January 15-16, 1973, in Miami, Florida, and organized by the Department of Biochemistry at the University of Miami School of Medicine. The papers explore the role of protein phosphorylation in control mechanisms, including muscle metabolism and function, cell division, and histone and protamine binding to DNA. This volume is comprised of 28 chapters and begins with an overview of Earl W. Sutherland's scientific work and the involvement of cyclic AMP in enzyme inductions. The discussion then turns to the regulation of muscle metabolism and function by protein phosphorylation; the link between hormonally regulated enzymes in adipose tissue and cyclic AMP-dependent protein kinase; and regulation of the mammalian pyruvate dehydrogenase complex by phosphorylation and dephosphorylation. Subsequent chapters focus on the role of histone phosphorylation in cell division; histone phosphorylation and regulation of nuclear function; and protein phosphorylation in retinal photoreceptors. The final chapter is devoted to acetylation of nuclear proteins in rat testis. This book should be a valuable resource for biochemists.

Sulfur in Proteins is a collection of papers presented at the 1958 Symposium on Sulfur in Proteins, held in Falmouth, Massachusetts. The symposium primary aims to explore the varied and unusual roles of –S–S– and –SH groups in proteins. This book is organized into eight chapters that cover a wide variety of proteins, including serum, iron, copper, and muscle proteins, as well as enzymes and viruses. The opening chapter describes the various protein reactions involving sulfur, emphasizing the chemical modification of thiol and disulfide groups. Considerable chapters are devoted to the chemical properties, biogenesis, reactivity, and oxygenation of specific proteins. A chapter highlights some aspects of protein structure in relation to the role of –S–S– and –SH groups in enzymic catalysis. This chapter also describes the properties of sulfhydryl groups in yeast alcohol dehydrogenase. The final chapters examine the role of sulfur groups in several virus proteins and in cell division. This work will be of great value to protein scientists and researchers.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Chemistry and Functions of Colicins contains the proceedings of a Conference on the Structure and Functions of Colicins, held during the 72nd Annual Meeting of the American Society for Microbiology in Philadelphia, Pennsylvania in May 1972. The papers explore the chemistry and functions of colicins, colicinogenic factors, and the colicin E receptor, as well as the mode of action of colicin E2 and E3. This book is comprised of six chapters and begins with a brief overview of the history of colicin research, with emphasis on advances in understanding the action of various colicins on sensitive cells, followed by a summary of studies on colicins E1 and EK. Two early stages in the action of these colicins are defined, the second stage of which is characterized by damage to membrane-associated cellular functions. Subsequent chapters focus on the chemistry of colicins, colicinogenic factors, and the colicin E receptor, together with the mechanism of action of colicins E2 and E3. The results of experiments with endonuclease-deficient cells are presented. The effect of E3 on ribosomes is also examined, along with the resistance, tolerance, and immunity of bacterial cells to colicins. This monograph should be of interest to students and practitioners of chemistry and molecular biology.

Lysozyme contains the proceedings of the Lysozyme Conference held in New York on October 29-31, 1972 on the occasion of the 50th anniversary of the discovery of lysozyme by Sir Alexander Fleming. The papers explore the chemistry and structure of lysozymes, their interactions with substrates and inhibitors, and distribution in tissues. Changes associated with various disease states are also discussed, along with evidence indicating that lysozyme may significantly alter certain mammalian cell constituents. Comprised of 42 chapters, this book begins with an overview of the structure of various lysozymes, including avian and mammalian lysozymes. The use of X-ray crystallography for lysozyme analysis is also considered. Subsequent chapters focus on the structure of bacterial cell walls; affinity labeling of lysozyme; substrate requirements of glycosidases for lytic activity on bacterial walls; and the solution behavior of hen egg white and human lysozyme. The role of lysozyme in hematology and its relation to myeloperoxidase and lactoferrin are also examined, together with lysozyme measurements in acute leukemia; serum and urine lysozyme in sarcoidosis; lysozyme as a component of human cartilage; and agglutination of rat liver mitochondria by lysozyme. This monograph should be of interest to practitioners and researchers in the fields of biophysics, chemistry, microbiology, physiology, and clinical medicine.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Advances in the Biosciences 9 is a collection of presented papers on the International Conference on Prostaglandins, held in Vienna, Austria on September 25 to 28, 1972. The book consists of 114 chapters of various topics in the field of prostaglandins. The meeting touches on several main topics such as new active analogs of prostaglandins; effect of aspirin and indomethasin and other compounds relative to the study of the role of the prostaglandins in the living organism; and the evaluation of the various analytical methods for the determination of the extremely minute amounts of prostaglandin occurring in the living organism. Biologists, pharmacologists, endocrinologists, physicians, biochemists, and medical technologists will find the contents of this book invaluable.

Hormones, Brain Function, and Behavior brings together the proceedings of a conference on neuroendocrinology held in May 1956 in New York. The papers explore selected aspects of hormone actions in relation to brain function and behavior and cover topics ranging from the effects of steroid hormones on the nervous system to the behavioral consequences of sex hormones and thyroid hormones. Serotonin, epinephrine, and their metabolites are also discussed in relation to experimental psychiatry. This monograph is comprised of 12 chapters and begins with an assessment of steroid hormones in relation to neuropsychiatric disorders, as well as the influence of adrenocortical steroids on brain function and metabolism. Subsequent chapters focus on the genetic and psychological determinants of sexual behavior patterns; the role of serotonin in mental disorders; the effect of thyroid hormones on appetite for alcohol and alcoholic beverages in rats; and the link between thyroid hormones and mental health. The biochemistry of serotonin and its physiological implications are also examined. This text will appeal to biologists, neuropharmacologists, neuropsychiatrists, and psychologists.

The Control of Eye Movements presents the proceedings of the Symposium on the Control of Eye Movements organized by the Smith-Kettlewell Institute of Visual Sciences of the Pacific Medical Center and the Department of Visual Sciences of the University of the Pacific Graduate School of Medical Sciences, San Francisco, California, November 10-11, 1969. The book is organized into two parts. Part I is devoted to presentations of anatomical, physiological, pharmacological, psychological, and clinical aspects of eye movements. The material presented should provide a valuable reference source as well as increase awareness of the need for further investigation of many aspects of the basic physiology of eye movements. Part II presents a series of papers dealing with models of various parts of the oculomotor system. The modeling approach to control of eye movements is still in its infancy and the present work presents the first comprehensive survey of biophysical, mathematical, and engineering aspects of eye movement control.

Biochemical analysis is a rapidly expanding field and is a key component of modern drug discovery and research. Methods of Biochemical Analysis provides a periodic and authoritative review of the latest achievements in biochemical analysis. Founded in 1954 by Professor David Glick, Methods of Biochemical Analysis provides a timely review of the latest developments in the field.