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The book “Oxadiazole in Material and Medicinal Chemistry” is based on the utility of organic motifs that contain oxadiazole units in their molecular architecture. Most of the common and alternate ways to synthesize oxadiazole-based probes have been discussed. The book also features some of the advanced applications of such organic motifs in liquid crystals, OLEDs, imaging agents, and medicines. Few practical applications of oxadiazole-based molecules in material and electronic areas have also been outlined. The book focuses on understanding the role of oxadiazole scaffolds in biological events, disease monitoring, and detection. The therapeutic effect of oxadiazole-based probes on cancer, inflammation, and neurodegeneration have also been covered in the book. Oxadiazole probes in inhibitor design and the corresponding inhibitory potency as drug development have been outlined. The authors hope that the book will garner positive interest among students and researchers associated with material and medicinal chemistry.