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Based on a translated Japanese title published in 2012, this book provides fundamental aspects of experimental and computational methods, the properties and structure of solvents, ion solvation and equilibria and reactions of metal complexes in solution. It includes state-of-the-art details on metal complexes in newly developing sustainable liquids and applications in real life. Appealing to researchers working in coordination chemistry, including students and industrialists, the text uses exercises, tables and figures to help the reader with their understanding of the topic.

Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades.This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. - Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development - Highlights the use of functionalized carbohydrates as synthons for the construction of various systems - Covers recent developments in the synthesis of various glycohybrid molecules and vaccines - Highlights the significance of heparin mimetics as tools for the modulation of biology - Provides an impact of glycan microarrays and carbohydrate– protein interaction

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

This book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars.• Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design• Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field• Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development

by Professor D. E. Games, Mass Spectrometry Research Unit, University College of Swansea Sample preparation can be viewed as occupying a Cinderella role in analytical science. However, the quality of sample preparation plays a key role in high In the past decade, there has been quality analysis and deserves higher stature. considerable interest in the use of supercritical fluid extraction (SFE) as an alternative to conventional procedures for the preparation of samples for ana­ lysis. The driving force for this development is the need for automated, sim­ pler, faster, non-destructive and selective methods for extraction, preferably using non-toxic extraction media which are easily disposed of. Utilization of supercritical fluids for extraction fulfils these requirements because of their unique physical chemical properties and usually low toxicity. Selectivity can be achieved by suitable selection of pressure (density), temperature and modi­ fier conditions which enable solvating power to be varied. The high diffusivity of supercritical fluids provides rapid sample penetration and extraction. Use of fluids with low critical temperatures enables extraction to be conducted under mild thermal conditions ensuring that thermally labile compounds do not decompose. The technique can be used off-line, and the extracts analysed by appropriate techniques, or it can be used on-line, by coupling with a variety of chromatographic techniques. These can then, if necessary, be coupled fur­ ther with spectroscopic techniques, such as Fourier transform infrared, ultra­ violet or mass spectrometry, to provide specific identification or structural information.

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems. - Presents the latest research in the field of drug discovery - Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry - Available as an online resource via ScienceDirect

Nearly a hundred different ring systems are included in this volume: a clear indication of the variety of possible structures that can be formed by including three or more heteroatoms in a five-membered ring. Some of these rings systems, such as the thiadiazoles, triazoles, and tetrazoles, are common and stable structures with hundreds of known deriva-tives, whereas others, such as the thiatriazoles and pentazoles, are thermally unstable species with little known chemistry.

For'better solutions'- this practical guide describes how to take advantage of supercritical fluids in chemical synthesis. Well-established in extractions and materials processing, supercritical fluids are becoming increasingly popular as media for modern chemical syntheses. Historically, the application of compressed gases has been restricted mainly to the production of bulk chemicals. In the last decade, however, research has turned to exploiting the unique properties of supercritical fluids for the synthesis of fine chemicals and specialized materials. Now that the necessary equipment is more readily available, the use of supercritical fluids should become more widespread in both laboratory and industrial scale syntheses. More than merely a concise introduction to the properties of supercritical fluids, here leading experts give a thorough, up-to-date account of chemistry in these alternative media. In-depth scientific commentary, detailed reaction protocols, descriptions of necessary equipment, and an outline of spectroscopic techniques add to the value of this handbook aimed at innovative synthetic chemists.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.