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This book covers lignin, a renewable source of carbonaceous material derived from biomass, which is a subject of research, development and innovation in both academia and industry. From lignin we can obtain chemicals (e.g., aromatics, phenols), materials (e.g., fibres, engineered plastics, modified polymers), specialties (e.g., additives as antioxidant), among other products in diverse levels of technology readiness. However, there are challenges to overcome in terms of chemical structure, industrial yields of conversion processes, and the quality of raw material in order to reach the best uses and applications according to the sustainability vision for products and processes. This book deals with the main biochemical pathways of synthesis; advanced analytical techniques; extraction strategies; chemical, biochemical, biological, and physical processing for chemicals and materials; circularity and sustainability aspects for actual and future production chains, allied to life cycle assessment and industrial ecology.

This book reviews the latest developments and applications in the field of biosensing, providing readers with an update of the earlier, successful edition, Biosensing for the 21st Century. In this book, readers will find comprehensive key information on the advances and challenges in biorecognition elements and transduction principles, including examples of new materials and new methods. Ranging from engineering chimeric enzymes to the progress in electrochemical sensing of drugs, the book discusses the latest innovations in the field and thus, provides the reader with a profound overview. In the field of biological recognition the focus will be on switchable sensors by engineering new proteins, the development of Molecular Imprinted Polymers (MIPs) for proteins or even larger biological entities, the construction of complex nucleic acid – protein structures for affinity sensing and the application of whole microbes. The book covers new trends in signal transduction which includes graphene-based field effect transistors, nanopores designed for high selectivity and sensitivity in analysis, plasmonic and nanophotonic sensing applying metal nanostructures up to new developments in microarray construction. An introduction in to the challenges in skin-interfaced systems for continuous biochemical sensing, offers a glimpse into the future of wearable technologies. Furthermore, actual areas of application of new sensing strategies such as the detection of various types of viruses and bacteria or the analysis of drugs will be highlighted. Each chapter provides a scholarly yet accessible perspective on the latest trends in biosensor technology. Given its breadth, the book has an interdisciplinary appeal and engages a wide readership, from students and researchers to practitioners in academia and industry, interested in the fields of biochemical/biomedical engineering and in biosensing methodologies and applications.

This book offers a comprehensive perspective of herbal medicine phytochemistry and explores the application of plant extracts as bioactive compounds in disease prevention and treatment in modern or traditional medicine. The book starts with an introduction to the history and value of herbal medicine, followed by 3 parts covering the main phytochemical components and metabolites in herbal medicine, different uses and practices in herbal medicine, including a region-wise analysis of methods and practices and an overview of regulations and policies for herbal medicinal practitioners, and the advances and challenges in quality assessment of herbal medicine. Plants generally have the tendency to bioaccumulate trace metals from the environment and they are easily contaminated by microorganisms from water sources and poor hygiene practices of the herbalist. Quality assessment and assurance is, thus, a pertinent challenge in herbal medicine practice (i.e., in remedy formulation and application), and this book offers an authoritative perspective on this topic, covering aspects such as quality control strategies, preparation techniques, chemical quantification in phytomedicine, and the efficacy and safety of herbal remedies. Moreover, in this book, readers will find valuable insights into the latest trends and developments in the field, and a critical review of the application of medicinal plants to treat cardiovascular, digestive, respiratory neurological and reproductive diseases. Particular attention is given to the advances and trends in the field, and readers will learn about the latest biotechnological approaches, the use of nanotechnology in herbal medicine, metabolomic analysis of medicinal plants, big data application in herbal medicine, and the value of herbal medicine towards sustainability. Given its breadth, this book is aimed at researchers, academics, practitioners and professionals working in the fields of natural, life, health, clinical, and biomedical sciences, and interested in herbal remedies, pharmacology, pharmacognosy, human nutrition and dietetics, plant biology, and biotechnology/microbiology.

This book provides new knowledge about the nutrition and metabolism, as well as the roles of nutrients in the immunity, health, and management of companion animals (dogs and cats). The domestic dog (facultative carnivore) and the domestic cat (obligate carnivore) have evolved differentially in their digestive tract, nutrition, metabolism, chemical sensing, and feeding behavior. These animals have been human companions for at least 12,000 and 9,000 years, respectively, and continue to contribute to the mental health and well-being of children, adolescents, and adults. Both dogs and cats have become increasingly popular in many countries and worldwide over the past decades. Comprehensive update about how the animals utilize dietary nutrients for optimum growth, development, and health is beneficial for their owners, as well as students and researchers. Chapter 4: Characteristics of Nutrition and Metabolism in Dogs and Cats is available open access under a Creative Commons Attribution 4.0 International License

This book covers polyextremophiles, the latest biotechnological advances, and developments in the study of extremophilic diversity with a focus on genetics, proteomics and the impact of climate change. It sets out new perspectives on the polyextremophiles'mechanism of tolerance to extreme conditions, and it also outlines their applications in bioremediation, therapeutics, and astrobiology research. Expert contributors discuss topics such as genes associated with polyextremophiles, the applications of genome editing in extremophiles, secondary metabolites from extremophiles, and the biocatalytic potential of extemozymes isolated from extremophiles. Readers will find in this book several case studies that collate the diverse applications of polyextremophiles for bioremediation, including the use of extremophilic algae in wastewater treatment, nutrient recovery and animal feed production, the treatment of industrial waste, pharmaceuticals and personal care products, and the removal of microplastics, heavy metals and E-waste. Particular attention is given to the use of polyextremophiles for bioremediation of abandoned mining sites. The book also presents bioactive compounds from halophiles and their biomedical applications and discusses the implications of polyextremophiles in astrobiology research. Given its breadth, this book is a valuable contribution to the biotechnology of polyextremophiles by overviewing research to date and exploring challenges and opportunities for future research. It also benefits a broad readership, from scholars, researchers and students to industry professionals interested in the study and development of biotechnological applications of polyextremophiles.

This book provides a comprehensive overview of piezoelectric sensor devices and instrumentation and their use for chemical and biochemical analysis. Sensors relying on established transducers, such as the quartz crystal microbalance (QCM) and the surface acoustic wave resonator (SAW) are covered, and novel devices like surface transverse wave (STW) resonators, film bulk acoustic resonators (FBAR) as well as non-piezoelectric devices with mass-sensitive properties are presented. As their name implies, such devices respond directly to mass changes on their surfaces and thus address the most fundamental quality of any analytes. First, the book presents the fundamentals of new measuring strategies with these devices. Then, it introduces a variety of chemo- and biosensing application scenarios of these devices. In addition, the book covers both the state-of-the-art of academic research and prospects concerning the commercialization of these sensors. Given its scope, the book is of interest to academics, specialists in industry, and advanced students in the areas of analytical chemistry, rapid analysis, and sensor technology, giving them the unique possibility to familiarize themselves with this chemical sensing strategy. Readers will benefit from the coverage of both cutting-edge research results and applications that help bridge the gap between academia and industry.

This book deals with analytical techniques and methods applied in several sectors of technology and industry and serves as a concise and up-to-date reference for the practical application of analytical chemistry. Divided into 10 chapters, the book starts with an introduction to the fundamentals of analytical chemistry, followed by a review of modern analytical technologies and their application in different industrial sectors and activities such as agrochemicals and pharmaceuticals, ores and mining, polymers, biotechnology, and oil & gas. Particular attention is given to industrial environmental issues, where the author discusses the advanced analytical techniques used to provide quantitative information about pollutants in aqueous and gaseous effluents and their carbon footprint. The book finishes with a chapter summarizing the main remarks and conclusions on advanced analytical techniques used in different industrial sectors, as well as on topics of sustainability, and instrumental analysis. In this book, readers will find valuable insights, including real-life examples, of how classical and instrumental techniques can be used by industry, to help professionals in the quality control of raw materials, products and processes, in the assessment of the formulation contamination, environmental pollution and in the evaluation of sustainability, among others. Given its breadth, the book appeals to professionals (mainly chemists, biochemists, and engineers), researchers, professors, and graduate students.

Living organisms are distinguished by their chemical basis. Thus, knowledge of the properties of the elements and the interactions of the resulting compounds is a prerequisite for understanding biology.Chemistry answers the questions of why, among the more than 100 elements of the periodic table (PSE), carbon and not silicon is the dominant element in biology and why precious metals, such as gold and silver, do not play a role. The PSE provides information about why phosphoric acid and not sulfuric acid acts as a bridge in polynucleic acids and why DNA had to evolve from RNA. At the same time, only chemistry makes clear why D-glucose is so central in building biopolymers such as cellulose and glycogen, and why the citrate cycle is logically self-contained and without alternative. Biochemistry is also a synthesis chemistry that differs from'man-made'synthesis chemistry'only'in terms of the framework conditions. Individuals are selected from the multitude of elements of the PSE and the almost infinite number of chemical compounds. The selection is based on the environmental conditions on Earth, such as moderate temperatures, preferably atmospheric pressure, solvent water and as primary reaction partner oxygen.The hypothesis is developed that the guiding principle of modern biology, the theory of evolution, has its roots in the underlying chemistry. This turns Darwinism from its biological head to its chemical feet. For example, the effect of phenols as radical scavengers is a priori chemical, before biological phenomena could evolve from it as differences in distinction in colored flowering plants. The book develops a completely new, chemistry-centered view of'animate nature'and challenges a changed, biologically oriented didactics of chemistry in schools and universities.

This book outlines the use of supramolecules as different pharmaceutical drugs. Supramolecular chemistry in pharmaceutical sciences is quite a young and rapidly developing field. Supramolecular assemblies might offer an alternative for existing pharmaceutical formulations, as they facilitate the improvement of physicochemical and pharmacological properties i.e., higher bioavailability, better biocompatibility and drug-targeting, fewer multidrug-resistances. This book offers an overview of the recent advances in supramolecular structures and discusses the future aspects and challenges related to the development of these molecules, providing also a perspective on how to overcome these issues. Divided into 13 chapters contributed by experts in their field, the book provides a deeper understanding of intermolecular forces playing pivotal roles in mediating the interactions between chemical molecules and biological systems by focusing on different applications of supramolecularcompounds. In this book, readers will find valuable insights into the preparation of supramolecules and the latest research and development trends of supramolecules as anticancer drugs, including liquid-crystalline supramolecular assemblies, and as antimicrobial, antiviral, anti-inflammatory and cardiovascular drugs. Particular attention is given to the application of supramolecules in the fields of biomedicine, bioimaging, and vaccine development. Given its breadth, this book will appeal to a wide readership from researchers and students interested in these fields to professionals in the pharma industry.

This book follows up the debate on the future of science and technology at the Curious2022 – Future Insight Conference, the second event in this conference series initiated on the occasion of Merck's 350th anniversary. In the chapters, some of the world's top scientists, managers and entrepreneurs explore breakthrough technologies and how they can be applied to make a better world for humanity. The book begins with an introduction to the vision of the conference “United by science for a better tomorrow” and the impacts caused by the pandemic, highlighting the importance of gathering like-minded people to discuss and support the advancement of science and technology for the benefit of humanity. In the first part of the book, readers will also find a chapter written by the Executive Board of Merck KGaA discussing the importance of curiosity for innovation and an overview of the company's contribution in the areas of life sciences, healthcare andelectronics forward-moving the scientific discovery. The second part of the book offers insights of some of the scientific topics discussed at the conference, and particular attention is given to new therapies and sustainability. In the final part of the book, readers will find some thoughts on ethical principles guiding our application of science and technology to create a bright future for humanity, and diverse perspectives on topics such as health, life sciences, nutrition, material sciences, digitalization, AI, energy, mobility, space flight, robotics, the secrets of the human mind and new ways of working together. Given its interdisciplinary appeal, the book will inspire curiosity in a wide readership, from scholars and researchers to professionals with an interest in exploring the future of science and technology, solving the problems of today, and paving the way for a better tomorrow. Chapters “From a 350th Anniversary to a Global Movement: United by Science for a Better Tomorrow” and “ Advancing Human Progress as a Twenty-First-Century Science and Technology Pioneer” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book focuses on the different compounds (polyphenols, sterols, alkaloids terpenes) that arise from the secondary metabolism of plants and fungi and their importance for research and industry. These compounds have been the backbone and inspiration of various industries like the food, pharmaceutical and others to produce synthetic counterparts. Furthermore, many of these compounds are still widely used to carry out specific functions in all these industries. This book offers a compilation of different texts from world leading scientists in the areas of chemistry, biochemistry, plant science, biotechnology which compile information on each group of secondary metabolism compounds, and their most important applications in the food, pharmaceutical, cosmetic and textile industry. By showcasing the best uses of these compounds, the chemistry behind their production in plants and fungi, this book is a valuable resource and a'go to'artifact for various audiences. The new approach this book offers, by linking research and the application of these compounds, makes it interesting as an inspiration for new research or as a hallmark of what has been done in the secondary metabolism of plants and fungi in recent years. Although this book may be technical, it is also enjoyable as an integral reading experience due to a structured and integrated flow, from the origins of secondary metabolism in organisms, to the discovery of their effects, their high intensity research in recent years and translation into various industries. Beyond learning more on their chemistry, synthesis, metabolic pathway, readers will understand their importance to different research and industry.

This textbook is for students studying medicine and other biosciences. Understanding biochemistry requires basic understanding of organic chemistry. The main purpose of this book is, therefore, to help students to understand biomolecule-related organic chemistry. Fundamental theories such as the molecular orbital method, thermodynamic law, frontier orbital theory, and molecular interactions, which have not been covered in basic organic chemistry textbooks, are.

This book provides a comprehensive and authoritative review of cyanobacteria and their applications as solar cell factories. Cyanobacteria are able to perform oxygenic photosynthesis and they are utilized in many different bioprocesses. The book covers two major aspects of a cyano-based bioprocess: the biological whole-cell catalyst and the technical environment in which the catalyst is applied. In the biocatalyst itself electron and carbon flow play an essential role for the performance of the cell and need to be tackled likewise for successful biocatalyst development. In the first chapters of this volume, cyanobacterial biotechnology and the fundamentals of cyanobacterial bioenergetics are introduced followed by an overview on tools and strategies for cyanobacteria engineering. Further on, examples of applications, engineering and production of different industrially relevant compounds in these organisms are provided, and finally process technology specific for cyanobacteria is covered. In this book, particular attention is given to topics such as cyanobacterial bioenergetics, metabolic engineering design strategies, utilizing cyanobacteria in biophotovoltaics, and production of pigments as well as photobiohydrogen in cyanobacteria, among others. This book will provide interested students and researchers in the area of photo-biotechnology with a deeper understanding of the cyanobacterial cell-factory, including the latest innovations and persistent challenges in the field.

Cholesterol is an essential component of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), although a minor phospholipid, is the most abundant membrane phosphoinositide. Both lipids play key roles in a variety of cellular functions including as signalling molecules and major regulators of protein function. Studies on these important lipids have traditionally focused on the effect of each lipid individually. Accumulating evidence indicates, however, that these lipids may cross-regulate each other's levels. Furthermore, it is becoming evident that cholesterol and PI(4,5)P2 can act together to modulate protein function and biological processes. This book provides an overview of cellular functions and molecular mechanisms in which cholesterol and PI(4,5)P2 functions extend from parallel existence to crosstalk. It includes four sections. The first section introduces the reader to cholesterol and PI(4,5)P2. The second section demonstrates the mutual influence of these two critical lipids on their levels. The third section, divided into two parts, describes the co-modulation of protein function by cholesterol and PI(4,5)P2. The first part focuses on ion channels and the second - on lipid transfer proteins. The fourth section highlights other cellular processes at the intersection of cholesterol and PI(4,5)P2 involvement. Collectively, the book portrays the emerging relationship between cholesterol and PI(4,5)P2 in a broad array of biological systems and processes. The book will be of interest to a wide audience of research scientists with an interest in the biophysical properties of lipids and the physiological consequences of their presence in biological systems, as well as graduate students, postdoctoral trainees, basic and clinical researchers, and pharmaceutical scientists. Specifically, the content will be relevant to researchers in the fields of biochemistry, molecular biophysics, pharmacology, neurobiology, cardiovascular biology, among others.Provides a comprehensive overview of the current knowledge of the interplay between cholesterol and PI(4,5) P2Provides an overview of the emerging relationship between cholesterol and PI(4,5)P2 in biological systems and processesDiscusses cellular processes and molecular mechanisms where lipid functions extend from parallel existence to crosstalk

The 3rd edition of this textbook offers clear explanations of optical spectroscopic phenomena and shows how spectroscopic techniques are used in modern chemistry, biochemistry and biophysics.Topics included are: electronic and vibrational absorption fluorescence symmetry operations and normal-mode calculations electron transfer from excited moleculesenergy transferexciton interactions electronic and vibrational circular dichroismcoherence and dephasingultrafast pump-probe and photon-echo spectroscopy single-molecule and fluorescence-correlation spectroscopyRaman scatteringmultiphoton absorption quantum optics and non-linear opticsentropy changes during photoexcitationelectronic and vibrational Stark effects studies of fast processes in single moleculestwo-dimensional electronic and vibrational spectroscopyThis revised and updated edition provides expanded discussions of laser spectroscopy, crystal symmetry, birefringence, non-linear optics, solar cells and light-emitting diodes. The explanations are sufficiently thorough and detailed to be useful for researchers, graduate students and advanced undergraduates in chemistry, biochemistry and biophysics. They are based on time-dependent quantum mechanics, but are developed from first principles so that they can be understood by readers with little prior training in the field. Additional topics and highlights are presented in special boxes in the text. The book is richly illustrated with color figures throughout. Each chapter ends with a section of questions for self-examination.

This book offers a comprehensive review of the latest developments in medicinal mushroom biochemical engineering and biotechnology, and it also analyses the circular economy of mushroom bioproduction. Divided into 13 chapters, the book begins with a historical perspective of medicinal mushrooms, followed by authoritative chapters that explore the farming of medicinal mushrooms and bioeconomy, as well as the limitations of using medicinal mushrooms to produce metabolites. Subsequent chapters cover topics such as solid-state and submerged cultivation of medicinal mushroom mycelia in bioreactors, pilot and industrial bioreactor cultivation experiences, downstream processing of medicinal mushroom products, and biochemistry of medicinal mushroom bioactive compounds. Particular attention is given to the recent genetic engineering techniques applied in mushroom cultivation. The book closes with a chapter devoted to the health and clinical benefits of medicinal fungi, where readerswill find expert insights into the therapeutic implications of medicinal fungi. In this book, readers will find an authoritative perspective on the past, present and future of medicinal mushrooms, and will also learn about some recent clinical studies with isolates from these natural products. Given its breadth, this book will appeal to biotechnologists working in mushroom cultivation, as well as to professionals interested in traditional pharmacy and medicine.

This book provides an up-to-date overview of the biological functions of melanins, their biotechnological production, and their industrial applications. The melanins form a group of polymeric pigments found in most organisms. These natural products are generated by the oxidation of phenolic and indolic molecules yielding melanins, which include eumelanin, pheomelanin, pyomelanin, and the allomelanins. These pigments have diverse biological functions, including photoprotection, thermoregulation, antioxidation, virulence, and metal ion sequestration. Melanins have physicochemical properties that have proven useful in the optical, electronic, material, agriculture, cosmetic, pharmaceutical, and medical industries. The chapters in this book provide an in-depth analysis of the current issues and challenges in this field. Topics covered include the properties, biogenesis, and evolution of melanosomes. The book also addresses the synthesis and industrial production of melanins by microorganisms. The metabolic pathways for the synthesis of several types of polymeric pigments in microorganisms and their role in pathogenesis are reviewed. The large-scale production and purification of melanins to provide this product for industrial applications is a formidable challenge. Two chapters present and discuss the state-of-the-art used for the generation of microbial melanin-production strains and the processes for the biotechnological synthesis and purification of these pigments. Melanins are polymers that can interact with metals, a chapter reviews this capacity in the context of technological applications, including electrochemical energy storage and metal recovery. These polymers are materials having favorable characteristics for photonic applications, including UV blocking and broadband absorption. The current advances in the application of these pigments in optically active materials are presented and discussed.

This proceedings volume results from the NATO Advanced Research Workshop on'Biomarkers of Radiation in the Environment: Robust Tools for Risk Assessment (BRITE)'. The BRITE workshop discussed insights from cancer research, epigenetics, non-human and human risk assessment, since many of the state-of-the-art biomarkers being developed for humans deserve consideration for environmental applications and vice versa. Sessions were very wide-ranging covering methods, mechanisms, cross disciplinary application and regulation.The chapters in this book have been grouped into five major themes that were covered by the BRITE workshop:· Techniques for biomarker development· Low-dose effect mechanisms· Biomarkers for risk evaluation· Biomarkers in wildlife· Biomarker use and responses Each chapter has been written independently and reflects the views of the chapter author(s). Therefore, the readers can form their own balanced view of the different perspectives on biomarkers of radiation in the environment. Given the breadth of topics covered and the state-of-the-art perspectives shared by leading experts in their respective fields, this book should form a valuable resource for anyone with an interest in how biomarkers can be used to improve our understanding of radiation in the environment and its potential impacts.

Plants produce secondary metabolites that humans harness for their own benefit. About half of drugs currently in clinical use are based on these chemicals found in nature. Chemistry of Natural Products covers secondary metabolites present in medicinal plants and their biosynthesis, biological activities, and isolation and separation techniques. This book is ideal for researchers in the areas of biochemistry, medicine, and pharmacology.

This book provides an interdisciplinary review of one of the great unsolved mysteries that has fascinated scientists for over 150 years: the origin of chirality in biomolecules. Current advances in fields as diverse as space exploration, prebiotic chemistry and high-energy physics may help to provide an answer. Important pieces of information will come from observations at the two frontiers of science: outer space and the subatomic world. Observation of distant planets, galaxies, and even actual sampling of celestial objects from beyond the solar system are projects currently underway. At the other end of the spectrum, there are experiments that study the elemental properties of matter, such as symmetry, and interactions with the fundamental forces. Completely revised and updated this new edition once again unifies all the theories of the origin of biomolecular homochirality together in a single source. This complete, interdisciplinary review of an intriguing subject condenses a large and disparate range of contributions from journals in almost every scientific field. The various theories have been organized, interrelated and explained in a unified way. It is fundamental, comprehensive and structured to be accessible for educational purposes.

This book is a compilation of the latest achievements of leading researchers in marine natural products with extremely diverse structures and biological activities. It presents discussions of isolation, structure elucidation, biosynthesis, total synthesis, and biochemical properties of the compounds with characteristic structures such as macrolides, cyclic depsipeptides, alkaloids, and water-soluble heterocyclic low-molecular-weight compounds, from sponges, bacteria, cyanobacteria, flagellates, and other such organisms. The book especially focuses on heterocyclic natural products as a title in the book series, Topics in Heterocyclic Chemistry.

The origin of life has been investigated by many researchers from various research fields, such as Geology, Geochemistry, Physics, Chemistry, Molecular Biology, Astronomy and so on. Nevertheless, the origin of life remains unsolved. One of the reasons for this could be attributed to the different approaches that researchers have used to understand the events that happened on the primitive Earth. The origins of the main three members of the fundamental life system, as gene, genetic code and protein, could be only separately understood with these approaches. Therefore, it is necessary to understand the origins of gene, the genetic code, tRNA, metabolism, cell structure and protein not separately but comprehensively under a common concept in order to understand the origin of life, because the six members are intimately related to each other. In this monograph, the author offers a comprehensive hypothesis to explain the origin of life under a common concept. At the same time, the author offers the [GADV] hypothesis contrasting it with other current hypotheses and discusses the results of analyses of genes/proteins and the experimental data available in the exploration of the current knowledge in the field. This book is of interest for science students, researchers and the general public interested in the origin of life.

Advances in Chemical Proteomics provides essential concepts and recent applications on probes, tool compounds and concepts for chemical proteomics and then moves on to applications, including solid-phase reagents, fragment screening, designer compounds and protein lipidation. As the second volume in the Developments in Organic Chemistry series, each chapter is written by experts in the field. Users will find this to be a valuable reference for organic chemists and chemical biologists who are interested in developing tool compounds and reagents to measure and interrogate proteome, develop drug leads, and measure off-target effects and drug toxicity. Analytical chemists who are interested in better understanding organic chemistry behind commonly used reagents for quantitative proteomics and tools compounds in the emerging field of chemical proteomics will also benefit from this comprehensive resource on the topics presented. - Provides an ideal, introductory book to chemical proteomics for organic chemists, pharmaceutical chemists and chemical biologists - Includes advanced, recent applications and reviews in chemical proteomics - Presents valuable work by a global team of experts from the field of proteomics

A Dictionary of Chemistry is a popular and authoritative guide to all aspects of its discipline. With over 5,000 entries, its broad coverage includes physical chemistry and biochemistry, and is heavily informed by the most current research. For this eighth edition, the Dictionary has been fully revised, making it the most up-to-date reference work of its kind. Almost 200 entirely new entries have been added, including bioethanol, genome, molecular spintronics, oganesson, phosphorylation, and reticular chemistry. Areas such as analytical chemistry, environmental chemistry, and organic chemistry have been expanded to reflect recent developments in the field. The dictionary's supplementary material has also been enhanced as new diagrams provide readers with useful visual aids, and the appendices have been substantially updated. All web links have been revised and updated, and are easily accessible via the companion website.

Bioorganometallic Chemistry is an excellent introduction to this transdisciplinary field which is straddled with biochemistry, medicine and organometallic chemistry. The book is a comprehensive review on the latest advances of this rapidly growing area, as well as historical background and future trends, revealing a tremendous potential of bioorganometallic compounds as novel drug candidates and diagnostic tools.

Urbanization, industrialization, and unethical agricultural practices have considerably negative effects on the environment, flora, fauna, and the health and safety of humanity. Over the last decade, green chemistry research has focused on discovering and utilizing safer, more environmentally friendly processes to synthesize products like organic compounds, inorganic compounds, medicines, proteins, enzymes, and food supplements. These green processes exist in other interdisciplinary fields of science and technology, like chemistry, physics, biology, and biotechnology, Still the majority of processes in these fields use and generate toxic raw materials, resulting in techniques and byproducts which damage the environment. Green chemistry principles, alternatively, consider preventing waste generation altogether, the atom economy, using less toxic raw materials and solvents, and opting for reducing environmentally damaging byproducts through energy efficiency. Green chemistry is, therefore, the most important field relating to the sustainable development of resources without harmfully impacting the environment. This book provides in-depth research on the use of green chemistry principles for a number of applications.

“There is a continuing demand for up to date organic & bio-organic chemistry undergraduate textbooks. This well planned text builds upon a successful existing work and adds content relevant to biomolecules and biological activity”.-Professor Philip Page, Emeritus Professor, School of Chemistry University of East Anglia, UK“Introduces the key concepts of organic chemistry in a succinct and clear way”.-Andre Cobb, KCL, UKReactions in biochemistry can be explained by an understanding of fundamental organic chemistry principles and reactions. This paradigm is extended to biochemical principles and to myriad biomolecules.Biochemistry: An Organic Chemistry Approach provides a framework for understanding various topics of biochemistry, including the chemical behavior of biomolecules, enzyme activity, and more. It goes beyond mere memorization. Using several techniques to develop a relational understanding, including homework, this text helps students fully grasp and better correlate the essential organic chemistry concepts with those concepts at the root of biochemistry. The goal is to better understand the fundamental principles of biochemistry.Features: Presents a review chapter of fundamental organic chemistry principles and reactions. Presents and explains the fundamental principles of biochemistry using principles and common reactions of organic chemistry. Discusses enzymes, proteins, fatty acids, lipids, vitamins, hormones, nucleic acids and other biomolecules by comparing and contrasting them with the organic chemistry reactions that constitute the foundation of these classes of biomolecules. Discusses the organic synthesis and reactions of amino acids, carbohydrates, nucleic acids and other biomolecules.

Most lab manuals assume a high level of knowledge among biochemistry students, as well as a large amount of experience combining knowledge from separate scientific disciplines. Biochemistry in the Lab: A Manual for Undergraduates expects little more than basic chemistry. It explains procedures clearly, as well as giving a clear explanation of the theoretical reason for those steps.Key Features: Presents a comprehensive approach to modern biochemistry laboratory teaching, together with a complete experimental experience Includes chemical biology as its foundation, teaching readers experimental methods specific to the field Provides instructor experiments that are easy to prepare and execute, at comparatively low cost Supersedes existing, older texts with information that is adjusted to modern experimental biochemistry Is written by an expert in the field This textbook presents a foundational approach to modern biochemistry laboratory teaching together with a complete experimental experience, from protein purification and characterization to advanced analytical techniques. It has modules to help instructors present the techniques used in a time critical manner, as well as several modules to study protein chemistry, including gel techniques, enzymology, crystal growth, unfolding studies, and fluorescence. It proceeds from the simplest and most important techniques to the most difficult and specialized ones. It offers instructors experiments that are easy to prepare and execute, at comparatively low cost.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

This book is a comprehensive text covering the research and development trends in the booming field of transition metal catalyzed oxidative cross-coupling reactions. Oxidative cross-coupling reaction is a new method to forming chemical bonds besides the traditional cross-coupling reactions. This book provides the answers to how this coupling reaction occurs and what its advantages are. The palladium, copper and iron catalyzed oxidative cross-coupling reactions as the main focuses of interest are described in detail. The oxidative cross-coupling reactions catalyzed by other metals and transition-metal-free oxidative coupling reactions are also introduced.This book provides a useful reference source for researchers and graduates in the field of transition metal catalyzed coupling reactions. It is also valuable to researchers working in pharmaceutical companies, fine organic chemical companies, and etc.

In this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo, is discussed. Therapeutic potential of CPPs and commercial developments are discussed. The present, second edition of this book is the updated and expanded version of the first edition, published in 2019. The development of the field of cell-penetrating peptides in these five years has been obvious and exciting. This second edition of the book has been partly reorganized and comprehensively expanded with the exciting research in 2019-2023. Around 2500 novel scientific articles have become available, most of them are reviewed in the second edition. Additional rapidly growing areas of high impact presented in this second edition are therapeutic developments (Chapter 16) and delivery of oligonucleotides and proteins/peptides (Chapters 5 and 6) including novel reports on genome editing with CPP assistance. Also, several additional examples are available now on clinical trials using CPPs (Chapter 15). The book is written for researchers and students in the field.

This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring. The chapters contributed deal with methodological peculiarities of syntheses of natural and artificial sugar derived spirocycles as well as their biological applications and other utilities including marketed drugs. Carbohydrates are ubiquitous molecules in nature and participate in a vast number of biological interactions. Especially their conjugates with practically all kinds of primary and secondary metabolic small molecules (and also biomacromolecules) representing valuable tools for glycobiology research and also lead compounds for drug discovery. While monosaccharides per se appear as heterocycles, their natural conjugates frequently exhibit spiro(hetero)cyclic derivatives, in many cases of high therapeutical relevance. As a consequence, the field of carbohydrate-spiro-heterocycles attracts intense interest from both chemical and biomedical aspects therefore this volume will be of interest for synthetic and medicinal chemists and (glyco)biologists, as well as researchers involved in various biomedical fields.

The book is the first thorough study of the role of phosphorus chemistry in the origin of life. This book starts with depiction of the phosphorus role in life creation and evolution. Then it outlines in vital processes how different phosphorus-containing compounds participate as biomarker in life evolution. Written by renowned scientists, it is suitable for researchers and students in organic phosphorus chemistry and biochemistry.

This book provides a modern and easy-to-understand introduction to the chemical equilibria in solutions. It focuses on aqueous solutions, but also addresses non-aqueous solutions, covering acid–base, complex, precipitation and redox equilibria. The theory behind these and the resulting knowledge for experimental work build the foundations of analytical chemistry. They are also of essential importance for all solution reactions in environmental chemistry, biochemistry and geochemistry as well as pharmaceutics and medicine. Each chapter and section highlights the main aspects, providing examples in separate boxes. Questions and answers are included to facilitate understanding, while the numerous literature references allow students to easily expand their studies.

Advances in Bioorganometallic Chemistry examines the synthesis, structure and reactivity of bioorganometallics, their pharmaceutical applications, hydrogenase, vitamin B12-like systems, and metalloproteins. It is written by the top researchers in the field and compiled by editors Toshikazu Hirao and Toshiyuki Moriuchi. Developments in this new field of bioorganometallic chemistry, a hybrid between biology and organometallic chemistry, happen very quickly and this comprehensive reference offers the latest research and findings in the field. The book features a discussion of the synthesis, structure, and reactivity of bioorganometallics, and an examination of hydrogenase-like systems, which were designed to demonstrate catalytic activities and functional properties. Advances in Bioorganometallic Chemistry also includes a discussion of bioorganometallics as they relate to medicinal chemistry, specifically applications of metalloproteins, metalloenzymes, and applications in bioimaging. The book concludes with coverage of vitamin B12-like systems, including the latest developments in derivatives designed to perform bio-inspired catalytic reactions. This work is a valuable resource for chemists working in organometallic chemistry and biology, including biochemists, bioorganic chemists, bioinorganic chemists, as well as pharmaceutical scientists, medicinal chemists, and students studying in these areas. Representative authors: R. H. Fish, T. Moriuchi, T. Hirao, H.-B. Kraatz, H. Takaya, T. P. Curran, G. van Koten. E. Rosenberg, J. M. Lynam, C. G. Hartinger, U. Schatzschneider, G. S. Smith, R. Alberto, S. Takenaka, T. Ihara, T. Hayashi, T. Ueno, P. Schollhammer, Y. Shomura, Y. Hisaeda, H. Shimakoshi, B. Kräutler - Provides a balanced overview of the latest research in the field of bioorganometallic chemistry, drawing together the top researchers from around the world - Covers topics in the areas of synthesis, reactivity, hydrogenase-like systems, medicinal chemistry, applications of metalloproteins, metalloenzymes, and applications in bioimaging

This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the development of useful medicines that are highly safe and show potent pharmacological effects in small doses. Recently, it has been shown that there is an important drug-like space in the mid-sized region between low- and high-molecular-weight compounds. Thus, mid-size drugs such as peptide compounds are being focused on. To date, several peptidomimetics that mimic primary, secondary, and tertiary structures of peptides have been developed to maintain and improve biological activities and actions of peptides. In this book, the features and advantages of mid-size drugs are described in detail. In addition, the merits of utilizing peptidomimetics in the development of mid-size drugs are referred to. Understanding such peptide-derived mid-size drugs will lead to a comprehensive expansion of medicinal chemistry.

This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry.Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans. In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal ofthis important book.

This well-established textbook on biocatalysis provides a basis for undergraduate and graduate courses in modern organic chemistry, as well as a condensed introduction into this field. After a basic introduction into the use of biocatalysts—principles of stereoselective transformations, enzyme properties and kinetics—the different types of reactions are explained according to the'reaction principle', such as hydrolysis, reduction, oxidation, C–C bond formation, etc. Special techniques, such as the use of enzymes in organic solvents, immobilization techniques, artificial enzymes and the design of cascade-reactions are treated in a separate section. A final chapter deals with the basic rules for the safe and practical handling of biocatalysts.The use of biocatalysts, employed either as isolated enzymes or whole microbial cells, offers a remarkable arsenal of highly selective transformations for state-of-the-art synthetic organic chemistry. Over the last two decades, this methodology has become an indispensable tool for asymmetric synthesis, not only at the academic level, but also on an industrial scale. In this 7th edition new topics have been introduced which include alcohol and amine oxidases, amine dehydrogenases, imine reductases, haloalkane dehalogenases, ATP-independent phosphorylation, Michael-additions and cascade reactions. This new edition also emphasizes the use of enzymes in industrial biotransformations with practical examples.

Aerobic organisms have evolved to utilise the intrinsic oxidising power of oxygen from the atmosphere. This so-called'activation'of oxygen is often catalysed by a heme-containing enzyme. This book highlights the many and varied catalytic activities of O2-dependent heme–iron enzymes, including monoxygenases and cytochrome P450, dioxygenases, oxidases and model heme systems. Dioxygen-dependent Heme Enzymes will be a useful resource for postgraduate students and researchers in biochemistry and metallobiology working in, or moving into, research areas involving heme proteins.

This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.

Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations andmechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology.Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.Please note that Garland Science flashcards are no longer available for this text. However, the solutions can be obtained through our Support Material Hub link below, but should only be requested by instructors who have adopted the book on their course.

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating onthe methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Advances in Carbohydrate Chemistry and Biochemistry, Volume 74, presents a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry. Since its inception in 1945, the series has provided critical and informative articles written by research specialists that integrate the industrial, analytical and technological aspects of biochemistry, organic chemistry and instrumentation methodology to the study of carbohydrates. - Features contributions from leading authorities and industry experts who specialize in carbohydrate chemistry, biochemistry and research - Integrates the industrial, analytical and technological aspects of biochemistry, organic chemistry and instrumentation methodology in the study of carbohydrates - Informs and updates on all the latest developments in the field

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects ofdrug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

The book presents the current state of the art on phytocannnabinoid chemistry and pharmacology and will be of much use to those wishing to understand the current landscape of the exciting and intriguing phytocannabinoid science. The focus is on natural product cannabinoids which have been demonstrated to act at specific receptor targets in the CNS.

Following the successful and proven concept used in'Bioactive Heterocyclic Compound Classes'by the same editors, this book is the first to present approved pharmaceutical and agrochemical compounds classified by their carboxylic acid functionality in one handy volume. Each of the around 40 chapters describes one or two typical syntheses of a specific compound class and provides concise information on the history of development, mode of action, biological activity and field of application, as well as structure-activity relationships. In addition, similarities and differences between pharmaceuticals and agrochemicals are discussed in the introduction. Written by a team of experts in the field, this is a useful reference for researchers in academia and chemical or pharmaceutical companies working in the field of total synthesis and natural product chemistry, drug development, and crop protection research.

This thesis focuses on the study of interactions between protein and peptides and their potential applications in cell imaging and nanoparticle surface modification. Drawing inspiration from naturally occurring coiled-coil binding pairs, it proposes a novel covalent peptide tag and probe system, based on the concept of “affinity guided covalent conjugation.” This newly established methodology provides complementary resolution to protein labeling, imaging and trafficking. By systematically investigating the coordination interaction between protein and quantum dots using various engineered protein ligands, this thesis proposes a general rule for protein self-assembly on the surface of quantum dots and reports a revolutionized nanobelt protein in accordance with this rule. It is an extraordinary example of interdisciplinary research, providing answers to real-life biological problems from a chemistry perspective.

In the context of the continual increase in the global incidence of diabetes, this book focuses on particular aspects of the disease such as the socio-economic burden and the effects on individuals and their families. It addresses a wide range of topics regarding its physiological relevance, metabolic angles, biochemistry, and discusses current and upcoming treatment approaches. It is unique in offering a chapter dedicated to herbal remedies for diabetes. Appealing to a broad readership, it is a valuable resource for students, researchers and practitioners working in the area of glucose metabolism, diabetes and human health.

This book presents advanced expression technologies for the production of protein complexes. Since complexes lie at the heart of modern biology, the expression, purification, and characterization of large amounts of high-quality protein complexes is crucial for the fields of biomedicine, biotechnology, and structural biology. From co-expression in E. coli, yeast, mammalian and insect cells to complex reconstitution from individual subunits, this book offers useful insights and guidance for successful protein expressionists. Across several sections readers will discover existing opportunities for the production of protein complexes in bacterial systems (including membrane proteins and cell-free co-expression), methylotrophic and non-methylotrophic yeasts, protozoa (Leishmania terantolae and Dictyostelium discoideum), baculovirus-infected insect cells, mammalian cells, plants and algae. Complex reconstitution from individually purified subunits or subcomplexes is discussed as a complementary strategy. A last section introduces briefly some of the biophysical and structural characterization techniques for macromolecular complexes using state-of-the-art solution scattering and nuclear magnetic resonance. This work is a guided tour over some of the most powerful and successful protein expression technologies, with a focus on co-expression and high-throughput applications. It is addressed to everyone interested in the production and characterization of macromolecular complexes, from university students who want an accessible description of the major co-expression systems to researchers in biomedicine and the life sciences seeking for an up-to-date survey of available technologies.

Since ancient times, plants have been used as a prime natural source of alternative medicines and have played an important role in our lives. The old tradition of medicinal plant application has turned into a highly profitable business in the global market, resulting in the release of a large number of herbal products. People have tried to find different sources of medicines to alleviate pain and cure different illnesses. Due to severe constraints of synthetic drugs and the increasing contraindications of their usage, there is a growing interest world over in the usage of natural products based on medicinal herbs, hence, there is an ever expanding market of herbs and herbal based medicinal preparations all over the world. This has culminated into an exponential increase in number of research groups in different geographical locations and generation of volume of research data in the field in a short span of time. The path breaking advancement in research methods and interdisciplinary approaches is giving birth to newer perspectives. Therefore, it becomes imperative to keep pace with the advancement in research and development in the field of medicinal herbs. There are a large number of researchers in different parts of the world working on various aspects of medicinal plants and ‘herbal medicines'. The idea is to bring their recent research work into light in the form of a book. The proposed book contains chapters by the eminent researchers in different countries and working with different disciplines of medicinal plants. Articles pertain to different disciplines such as: 1. Resources and conservation of medicinal plants 2. Biosynthesis and metabolic engineering of medicinal plants 3. Tissue culture, propagation and bioreactor technology of medicinal plants 4. Phytochemical research on medicinal plants 5. Herbal medicines and plant-derived agents in cancer prevention and therapy 6. Herbal medicines and plant-derived agents in metabolic syndrome management 7. Herbal medicines and plant-derived agents in modulation of immune-related disorders 8. Herbal medicines and hepatotoxicity The book will prove itself an asset for the researchers, professionals and also students in the area of medicinal plants and mechanism of their action.