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Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.

The efficient synthesis of heterocycles has become one of the main branches in organic chemistry due to their use in the synthesis of natural products and pharmaceuticals. Current sythentic strategies based on C-H activation methodologies are met with many problems like harsh reaction conditions and low reaction efficiency. Double functionalized chemicals offer a perfect alternative for the synthesis of heterocycles. Heterocycles from Double-Functionalized Arenes starts with a short discussion on the importance of heterocycles and a brief introduction on the preparation of double-functionalized arenes. Specific chapters then look at five-membered heterocycles synthesis, six-membered heterocycles synthesis and macroheterocycles synthesis. This is the first book dedicated to the topic of transition metal catalyzed coupling reactions of double functionalized arenes in heterocycle synthesis and can be used as a handbook for senior researchers and as an introduction for organic chemistry students.

Conducting polymers (CPs) such as polyaniline (PANI), polypyrrole (PPY), poly(3,4-ethylene dioxythiophene) (PEDOT), and poly(3-hexylthiophene) (P3HT), have been recognized as promising organic semiconductors due to their controllable chemical/electrochemical properties, light weight, low cost, good biocompatibility, facile processability, and adjustable electrical conductivities. This book presents current research in the field of polymers. Topics discussed include resonance raman of polyanilines nanofibers; conducting polymer micro-/nano- structures via template-free method; charge transfer and electrochemical reactions at electrodes modified with pristine and metal-containing films of conducting polymers; and conducting polymer-functionalized carbon nanotubes hybrid nanostructures based bioanalytical sensors.

The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. - Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers - Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction - Includes more than10,000 schemes and images - Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively

Progress in Heterocyclic Chemistry is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on new, developing topics of particular interest to heterocyclic chemists. The highlight chapters in Volume 25 are all written by leading researchers in their field, and these chapters constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2012. As with previous volumes in the series, Volume 25 will enable academic and industrial chemists and advanced students to keep abreast of developments in heterocyclic chemistry in a convenient way. - Recognized as the premiere review of heterocyclic chemistry - Contributions from leading researchers in the field - Systematic survey of the important 2012 heterocyclic chemistry literature

'A comprehensive review of the current state of the theoretical development in this important area of potential application of conducting polymers, and is very timely...The editor-author is to be congratulated for his marathon efforts and the production of a significant contribution to the literature.'-TRIP This three-part series provides undergraduate and graduate students in electrochemistry and materials science with a broad understanding of electroactive polymers. In Part I, renowned scientists examine the fundamental principles underlying electrochemical behavior of electroactive polymer materials. Contributors focus on the fundamentals of charge percolation and conductivity behavior associated with the membrane properties of electroactive polymer films. Part I also includes coverage of the phenomenon of heterogeneous redox catalysis at electroactive polymer modified electrodes.

Natural products are used by the food, pharmaceutical and cosmetics industries, and extraction technologies and potential applications for plant extracts are of interest to many industrial sectors. Extraction of natural products in an economic and environmentally friendly way is of high importance to all industries involved. The second edition of this book presents an updated, holistic, in-depth view of the more environmentally benign techniques available for the extraction of natural products, along with their newest applications and case studies. Conventional and emerging extraction techniques are discussed in detail. New topics include enzymes, pulsed electric energy, and on-line/in-line analysis. Written for academics and industrialists working in both natural product extraction and green chemistry, this new edition provides a valuable update on current trends in the field.

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area—one of great importance to organic chemists, polymer chemists and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. - Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area - one of great importance to organic chemists, polymer chemists and many biological scientists - Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties

Progress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on emerging topics of particular interest to heterocyclic chemists. The chapters in Volume 22 constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2009. • Covers the heterocyclic literature published in 2009 • Includes specialized reviews • Features contributions from leading researchers in their fields

The fifth volume in the Harte Research Institute's landmark scientific series on the Gulf of Mexico provides the first comprehensive study that covers the major core subjects of chemical oceanography in the Gulf. It synthesizes a tremendous amount of established research, together with the most recent information emerging from studies conducted during and after the Macondo Well oil spill that resulted from the explosion of the Deepwater Horizon drilling platform. Situated within the boundaries of a changing semi-tropical region, the Gulf of Mexico is a particularly important body to its bordering countries—the United States, Mexico, and Cuba—and directly influences the economies of these nations through shipping, oil and gas extraction, mineral mining, fisheries, and myriad ecosystem services and recreational opportunities. The changing chemistry of the Gulf also has wide-ranging effects on weather patterns as many of the hurricanes that reach land in the US and Mexico pass through this ocean basin. We are already seeing some of the consequences of climate change, including, to name one example, the increased frequency of harmful algal blooms, the cause of which is still unknown in most cases. This book brings together a team of expert chemical oceanographers from the US and Mexico to provide a foundational understanding of the complex chemistry of North America's only marginal sea. Gulf of Mexico Origin, Waters, and Biota: Volume 5, Chemical Oceanography serves as an important reference for understanding the basic science, management, and economic issues facing the Gulf of Mexico while pointing out key topics in critical need of additional research.

Carbohydrate Chemistry provides review coverage of all publications relevant to the chemistry of monosaccharides and oligosaccharides in a given year. The amount of research in this field appearing in the organic chemical literature is increasing because of the enhanced importance of the subject, especially in areas of medicinal chemistry and biology. In no part of the field is this more apparent than in the synthesis of oligosaccharides required by scientists working in glycobiology. Clycomedicinal chemistry and its reliance on carbohydrate synthesis is now very well established, for example, by the preparation of specific carbohydrate- based antigens, especially cancer-specific oligosaccharides and glycoconjugates. Coverage of topics such as nucleosides, amino-sugars, alditols and cyclitols also covers much research of relevance to biological and medicinal chemistry. Each volume of the series brings together references to all published work in given areas of the subject and serves as a comprehensive database for the active research chemist Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Since its inception in 1945, this serial has provided critical and informative articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry. - Features contributions from leading authorities and industry experts - Informs and updates on all the latest developments in the field