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Teaches and enables students to build confidence in drawing and manipulating curly arrows, a fundamental skill for all organic chemists This book is an interactive approach to learning about chemistry of the carbonyl group—inviting students to work through its pages with pencil and paper in hand. It educates with the belief that the most effective way to learn is by practice and interaction. With this in mind, the reader is asked to predict what would happen under a specific set of reaction conditions. The book is divided into frames: each frame poses a question and invites the reader to predict what will happen. Subsequent frames give the solution but then pose more questions to develop a theme further. Chemistry of the Carbonyl Group: A Programmed Approach to Organic Reaction Mechanisms, Revised Edition provides a solid grounding in the fundamental reactions of carbonyls. Presented in full colour to enhance the understanding of mechanisms within chemistry, the chapters of this step-by-step guide cover: nucleophilic addition to the carbonyl group; nucleophilic substitution; nucleophilic substitution at the carbonyl group with complete removal of carbonyl oxygen; carbanions and enolisation; and building organic molecules from carbonyl compounds. A must-have book for undergraduate chemists to emphasise understanding in carbonyl group chemistry Goes through all the stages of basic carbonyl chemistry, detailing even the simplest mechanisms A step-by-step learning guide to synthetic chemistry for the first year of a chemistry degree, with all the information needed for independent learning Provides a solid grounding in the fundamental reactions of carbonyls which will inform the understanding of many other organic chemistry reactions Chemistry of the Carbonyl Group: A Programmed Approach to Organic Reaction Mechanisms - Revised Edition is packed with all the information on synthetic chemistry that every first-year student will need in order to learn independently.

The application of knowledge of drug disposition, and skills in pharmacokinetics, are crucial to the development of new drugs and to a better understanding of how to achieve maximum benefit from existing ones. The book takes the reader from basic concepts to a point where those who wish to will be able to perform pharmacokinetic calculations and be ready to read more advanced texts and research papers. The book will be of benefit to students of medicine, pharmacy, pharmacology, biomedical sciences and veterinary science, including those who have elected to study the topic in more detail, such as via electives and special study modules. It will be of benefit to those involved in drug discovery and development, pharmaceutical and medicinal chemists, as well as budding toxicologists and forensic scientists who require the appropriate knowledge to interpret their findings and as an introductory text for clinical pharmacologists. Early chapters describe the basic principles of the topic while the later ones illustrate the application of those principles to modern approaches to drug development and clinical use. Full colour illustrations facilitate the learning experience and supporting material for course leaders and students can be found on the Companion Web Site'Another book on PK? Yes and there should be and it should be DD & PK. It is good, unique, and does fill a currently unmet need for those working in the xenobiotic arena. DD & PK is just like the perfect mystery novel—the one “you just can't put down.” However, unlike a mystery novel which requires only one reading to find the answer, the reader of DD & PK will learn more than an answer to a single question. The reader will find many solutions to a wide variety of mysterious problems associated with the time course and actions of xenobiotics.'—International Journal of Toxicology, John A. Budny, PhD, President, PharmaCal, Ltd, 2018'This book has many innovations that make a welcome addition to the bookshelves of a wide range of pharmaceutical scientists. The effective use of figures and tables to summarize and clarify a wide range of issues is to be commended, as are the learning objectives at the start of the chapter coupled with the summary at the end providing a succinct way in understanding the objectives of the chapter and together with links to a website provides accessibility for all from the neophyte pharmacokineticist to the consultant physician. A book all in the Pharma industry should be aware of.'—Int. J. of Pharmacokinetics, Howard M. Hill, ResolvPharma, 2018'Overall, Introduction to Drug Disposition and Pharmacokinetics offers its readership an in-depth view of classic pharmacokinetic concepts. This book would be an excellent choice for a pharmacokinetics elective or as an adjunctive text for an introductory course. This book reviews a wide array of clinically relevant topics and encourages the reader to apply the knowledge gained to all medi-cations. A robust and varied amount of online material is provided to enhance understanding and encourage discussion. It is likely that all readers, novice or experienced pharmacists, would find value in this textbook.'— Currents in Pharmacy Teaching and Learning, Milena McLaughlin, Midwestern University Chicago College of Pharmacy, 2018'In summary, this is an excellent textbook for students new to the field of pharmaceutics and medical, pharmacy, and veterinary students, particularly those who envision a career in drug development research in either academia or industry.'—Veterinary Pathology Review, John K. Amory, University of Washington, 2018

Advanced tools for developing new functional materials and applications in chemical research, pharmaceuticals, and materials science Cycloadditions are among the most useful tools for organic chemists, enabling them to build carbocyclic and heterocyclic structures. These structures can then be used to develop a broad range of functional materials, including pharmaceuticals, agrochemicals, dyes, and optics. With contributions from an international team of leading experts and pioneers in cycloaddition chemistry, this book brings together and reviews recent advances, trends, and emerging research in the field. Methods and Applications of Cycloaddition Reactions in Organic Syntheses focuses on two component cycloadditions, with chapters covering such topics as: N1 unit transfer reaction to C–C double bonds [3+2] Cycloaddition of α, β-unsaturated metal-carbene complexes Formal [3+3] cycloaddition approach to natural product synthesis Development of new methods for the construction of heterocycles based on cycloaddition reaction of 1,3-dipoles Cycloreversion approach for preparation of large π-conjugated compounds Transition metal-catalyzed or mediated [5+1] cycloadditions Readers will learn methods for seamlessly executing important reactions such as Diels-Alder and stereoselective dipolar reactions in order to fabricate heterocyclic compounds, natural products, and functional molecules. The book not only features cutting-edge topics, but also important background information, such as the contributors'process for developing new methodologies, to help novices become fully adept in the field. References at the end of each chapter lead to original research papers and reviews for facilitating further investigation of individual topics. Covering the state of the science and technology, Methods and Applications of Cycloaddition Reactions in Organic Syntheses enables synthetic organic chemists to advance their research and develop new functional materials and applications in chemical research, pharmaceuticals, and materials science.

A contemporary compilation of recent achievements in organometallic chemistry The prestigious International Conference on Organometallic Chemistry (ICOMC) was launched in 1963, providing a forum for researchers from around the world to share their findings and explore new paths to advance our knowledge and application of organometallic chemistry. The 25th ICOMC, held in Lisbon in 2012, gathered more than 1,200 participants from 54 countries. This volume celebrates the 25th Silver Edition and the 50th Gold Year of the ICOMC. Featuring contributions from invited 25th ICOMC speakers, Advances in Organometallic Chemistry and Catalysis highlights recent achievements and new and emerging areas of research in the field. Its seven sections cover: Activation and Functionalization of Carbon Single Bonds and Small Molecules Organometallic Synthesis and Catalysis Organometallic Polymerization Catalysis Organometallic Polymers and Materials Organometallic Chemistry and Sustainable Energy Bioorganometallic Chemistry Organometallic Electrochemistry Chapters discuss fundamental underlying concepts, offer illustrative examples and cases, and explore future avenues for continued research. Readers will discover basic principles and properties of organometallic compounds, reaction mechanisms, and detailed descriptions of current applications. Collectively, these chapters underscore the versatility, richness, and potential of modern organometallic chemistry, including its interrelationships with other scientific disciplines. All the contributions are extensively referenced, providing a gateway to the most important original research papers and reviews in organometallic chemistry. Presenting a contemporary understanding of organometallic chemistry and its many applications, Advances in Organometallic Chemistry and Catalysis is recommended for all researchers in the field, from students to advanced investigators.

Comprehensive resource covering toxicology fundamentals, distribution of pollutants in the environment, and research methodologies for toxicological assessment of chemical mixtures Toxicological Assessment of Combined Chemicals in the Environment offers an in-depth exploration of various approaches and molecular mechanisms regarding how minor alterations in chemical mixtures can influence an organism's toxicity, along with discussion of the challenges associated with assessing mixtures. The first section of the book provides a concise introduction to the background and significance of combined toxicity. Section two delves into the primary sources and enrichment mechanisms of different chemical mixtures, elucidating the biological exposure pathways of these compounds. Section three introduces both classical and emerging toxicological research models in detail. Building on the descriptions of compound emission, migration, accumulation, and transformation processes, and the analysis of combined molecular toxicity in the preceding sections, section four introduces computer mathematical modeling methods for hazard assessment of compound mixtures. The final section details the challenges and future trends in this field. Written by a highly qualified author and seasoned research contributor in the field, Toxicological Assessment of Combined Chemicals in the Environment covers sample topics including: The degradation, oxidation, absorption, distribution, biotransformation, and excretion of various compounds in both the environment and in organisms A variety of cell models and in vivo research models of model organisms, supplemented with case studies Combined molecular toxicity mechanisms of heavy metals, pesticides, persistent organic pollutants (POPs), and pharmaceutical and personal care products (PPCPs) Principal sources, fate, and mechanism of chemical mixtures in the environment, as well as experimental designs and sampling strategies for combined toxicity studies based on concentrations Toxicological Assessment of Combined Chemicals in the Environment serves as a valuable reference for researchers, students, and policymakers involved in environmental management and protection. It is particularly relevant for toxicologists, risk assessors, and those engaged in the molecular modeling of toxic mixtures.

Discover the biology, biochemistry, and medical aspects of lipoproteins in this comprehensive overview of its historic and contemporary development The fatty substance known as cholesterol is found in every cell of the human body and carries out several important functions. It is transported through the bloodstream as a part of particles called lipoproteins, which are divided into classes including low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Distinguishing between these two classes, along with the ‘remnant cholesterol'particles that have recently been associated with heightened risk of heart disease and stroke, is a crucial part of managing health and developing novel pharmaceuticals. Cholesterol, Lipoproteins, and Cardiovascular Health offers a thorough and rigorous overview of these particles, their properties, and their methods of categorization. Surveying both the characteristics of lipoproteins and their interactions with diet, lifestyle, therapeutics, and general health, it's an indispensable guide to these particles that can literally mean the difference between life and death. Cutting-edge and grounded in the latest research, it's a one-stop shop for understanding blood plasma lipoproteins in all their major forms. Cholesterol, Lipoproteins, and Cardiovascular Health readers will also find: Detailed discussion of topics including basic lipoprotein biochemistry, targeted therapeutics and drug development, and many moreEasily readable overview of the current state of research into lipoproteins and their likely future applicationsRich illustrative material enhanced by a graphical abstract at the beginning of each section offering a summary of crucial content Cholesterol, Lipoproteins, and Cardiovascular Health is suited for professionals, clinicians, and readers looking for a comprehensive overview of all aspects of plasma lipoproteins and their role in heart disease and stroke.

Case studies of 20 successful FDA-approved drugs, from biological rationale to clinical efficacy studies and state-of-the-art applications Chemistry and Pharmacology of Drug Discovery illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines, discussing a total of 20 drugs that are all FDA-approved post 2021—some of which are first-in-class and revolutionary. The four sections in this book cover Infectious Disease, Cancer Drugs, CNS Drugs, and Miscellaneous Drugs. Each chapter covers background material on the drug class and/or disease indication and key aspects relevant to the discovery of the drug, including structure-activity relationships, pharmacokinetics, drug metabolism, efficacy, and safety. This book is contributed to by various veterans and well-known experts in medical chemistry, many of whom discovered the drugs they reviewed, leading to tremendous quality and depth of insight. Some of the drugs covered in Chemistry and Pharmacology of Drug Discovery include: Nirmatrelvir (Paxlovid with Ritonavir), a 3-chymotrypsin-like protease inhibitor for treating SARS-CoV-2 infectionDoravirine (Pifeltro), a third-generation non-nucleoside reverse transcriptase inhibitor for the treatment of HIV-1 infectionOteseconazole (Vivjoa), a CYP51 inhibitor for treating recurrent vulvovaginal candidiasis, and Rimegepant (Nurtec ODT), a CGRP antagonist for treating migraineCiprofol (Cipepofol), a γ-Aminobutyric acid receptor agonist for induction of anesthesia, and Ozanimod (Zeposia), an S1P receptor antagonist for treating multiple sclerosisDeucravacitinib (Sotyktu), a first-in-class deuterated TYK2 inhibitor for the treatment of plaque psoriasis Chemistry and Pharmacology of Drug Discovery serves as an excellent and highly authoritative learning resource for medicinal, organic, synthetic, and process chemists as well as research scientists in lead optimization and process development.

Learn the various microbiological aspects one deals with in environment management and the remediation of toxic contaminants in the environment In recent years, the accumulation of hazardous contaminants has caused a broad-based deterioration in global environmental quality. These have had wide-ranging negative social impacts, affecting climate, soil and water ecosystems, and more. As traditional methods of contaminant mitigation have proven inadequate to the task, microbial-based remediation offers the clearest, most environmentally friendly path forward for this crucial aspect of global environmental stewardship. Microbes Based Approaches for the Management of Hazardous Contaminants offers comprehensive coverage of novel and indigenous microbes and their applications in contaminant mitigation. Surveying all the major microbial products and methods for degrading and remediating hazardous pollutants, it offers a key tool in the fight against global environmental degradation. The result is a cutting-edge introduction to an essential subject. Microbes Based Approaches for the Management of Hazardous Contaminants will also find: Current and future approaches to microbial degradation Detailed discussion of biofilms, exopolysaccharides, enzymes, metabolites, and many more Coverage of metabolic engineering as an alternative strategy Microbes Based Approaches for the Management of Hazardous Contaminants is ideal for those working in the field for the application of microbes in the remediation of hazardous pollutants and environment management, particularly those interested in environmental sciences, microbiology and microbial technology, environmental biotechnology, and molecular biology.

Comprehensive reference examining activated sludge technologies in industrial wastewater treatment, combining a theoretical framework with practical methodologies Application of Sewage Sludge in Industrial Wastewater Treatment provides a roadmap to the methodologies for the treatment of industrial wastewaters from several major sectors integrating theory and practice, highlighting the importance of sewage sludge technologies in industrial wastewater treatment to clean up the environment from pollution caused by human activities, and assessing the applications of several existing activated sludge techniques and introduces new emerging technologies. All discussion within the text is based on a solid theoretical background. Application of Sewage Sludge in Industrial Wastewater Treatment covers key topics such as: Issues related to activated sludge treatment, such as biodegradability-based characterization, modelling, assessment of stoichiometric, and kinetic parameters and design Issues related to industrial pollution control, such as in-plant control, effect of pretreatment, and more Recently increasing quantity and complexity of toxic effluents, which can be bio remediable for plants and suitable microbes, whether natural or customized for specific purposes Ecological, profitable, and natural solutions designed to eliminate heavy metals, radionuclides, xenobiotic compounds, organic waste, pesticides, and more This reference provides an essential, one-of-a-kind, integrated approach for environmental microbiologists, biochemical engineers, environmental engineers, effluent treatment plant operators, and biologists and chemists at wastewater treatment plants.

Molecules Engineered Against Oncogenic Proteins and Cancer A comprehensive review of the latest molecular advances in cancer treatment Featuring 91 total small molecule kinase/KRAS inhibitors, 80 of which are FDA-approved, Molecules Engineered Against Oncogenic Proteins and Cancer documents the recent scientific advances that have transformed one of medicine's most challenging areas—cancer treatment. Most of these inhibitors specifically block oncogene-induced carcinogenic proteins with results that have dramatically advanced the treatment of cancer. In addition, the structural formulas of more than 100 kinase/KRAS inhibitors in clinical trials are presented. With a very well-known chemist as an author, Molecules Engineered Against Oncogenic Proteins and Cancer includes information on: Each molecule's structure, function of the kinase target and relevance to cancer, the drug discovery process, and molecular details of drug action Mutated protein kinases as oncoproteins and targets for inhibition, along with the details of discovery for each antitumor antikinase agent History of oncoprotein inhibitors and their role in advancing the treatment and understanding of cancer The discovery process as a whole, effective strategies for innovation, ongoing challenges, and a glimpse of the future of the field Combining the most significant recent discoveries in a unique and useful way, Molecules Engineered Against Oncogenic Proteins and Cancer is an essential resource for researchers and students in bioscience, medicine, chemistry, and oncology as well as for those at industrial companies involved in therapeutic discovery.

Comprehensive resource covering computational tools and techniques for the development of cost-effective drugs to combat diseases, with specific disease examples Computational Methods for Rational Drug Design covers the tools and techniques of drug design with applications to the discovery of small molecule-based therapeutics, detailing methodologies and practical applications and addressing the challenges of techniques like AI/ML and drug design for unknown receptor structures. Divided into 23 chapters, the contributors address various cutting-edge areas of therapeutic importance such as neurodegenerative disorders, cancer, multi-drug resistant bacterial infections, inflammatory diseases, and viral infections. Edited by a highly qualified academic with significant research contributions to the field, Computational Methods for Rational Drug Design explores topics including: Computer-assisted methods and tools for structure- and ligand-based drug design, virtual screening and lead discovery, and ADMET and physicochemical assessmentsIn silico and pharmacophore modeling, fragment-based design, de novo drug design and scaffold hopping, network-based methods and drug discoveryRational design of natural products, peptides, enzyme inhibitors, drugs for neurodegenerative disorders, anti-inflammatory therapeutics, antibacterials for multi-drug resistant infections, and antiviral and anticancer therapeuticsProtac and protide strategies in drug design, intrinsically disordered proteins (IDPs) in drug discovery and lung cancer treatment through ALK receptor-targeted drug metabolism and pharmacokinetics Helping readers seamlessly navigate the challenges of drug design, Computational Methods for Rational Drug Design is an essential reference for pharmaceutical and medicinal chemists, biochemists, pharmacologists, and phytochemists, along with molecular modeling and computational drug discovery professionals.

Explore in-depth the relationships between biological contaminants and human health found in diverse settings such as homes, hospitals, businesses, and schools Indoor air quality has an immense impact on human health and well-being. Indoor air environments can contain a huge range of biological contaminants, including bacteria, fungi, viruses, insects, and their various harmful byproducts. Indoor biocontamination has been under-studied as an aspect of public and occupational health, and there is an urgent need for an introduction to this vital subject. Airborne Biocontaminants and Their Impact on Human Health meets this need with a thorough, rigorous overview of major indoor airborne contaminants. Gathering and summarizing a huge range of data regarding biocontaminants in settings from homes to schools to workplaces, it investigates patterns of morbidity and their connections to major contaminants. The result is an essential tool in the broader fight for human health at home and elsewhere. Airborne Biocontaminants and Their Impact on Human Health readers will also find: Analysis of the indoor role of gases, particulate matter, and others Detailed coverage of contaminant byproducts including endotoxins, mycotoxins, volatile organic compounds, and more Methods for generating awareness and therefore reduced risk of exposure to harmful contaminants Airborne Biocontaminants and Their Impact on Human Health is ideal for researchers—biologists, environmentalists, civil and environmental engineers, industrial hygienists, safety regulators, and public health officials—interested in the area of biological contamination in different environments.

ORGANIC NANOCHEMISTRY How-to guide for entry-level practitioners to quickly learn the cutting-edge research concepts and methodologies of modern organic nanochemistry Organic Nanochemistry describes the fundamentals of organic nanochemistry research, encompassing modern synthetic reactions, supramolecular strategies, nanostructure and property characterization techniques, and state-of-the-art data analysis and processing methods, along with synthetic chemistry as applied to organic nanomaterials and molecular devices. Accompanying each of these principles are case studies (from basic design to detailed experimental implementation) to help the reader fully comprehend the concepts and methods involved. Various theories suitable for nanoscale simulations, including quantum mechanics, semi-empirical quantum mechanics, and molecular dynamics theories, are discussed at an introductory level. Computational examples are provided, allowing interested readers to grasp essential modelling techniques for better understanding of organic nanochemistry. The content is paired with online supplementary material that includes instructional materials and guides to using common scientific software for computational modelling and simulations. Written by a highly qualified professor, Organic Nanochemistry includes discussion on: Key concepts and theories of organic chemistry, which are essential to understand the fundamental properties of organic molecular and supramolecular systems Useful synthetic methodologies for the synthesis and functionalization of organic nanomaterials, and the chemistry and application of exotic carbon nanomaterials Supramolecular aspects in organic nanochemistry, especially the well-developed disciplines of host-guest chemistry and organic self-assembly chemistry Construction and testing of molecular devices and molecular machines and state-of-the-art computational modelling methods for properties of nanoscale organic systems Guiding the reader on a journey from familiar chemical concepts and principles to cutting-edge research of nano-science and technology, Organic Nanochemistry serves as an excellent textbook learning resource for advanced and graduate students, as well as a self-study guide or how-to reference for practicing chemists.

A carefully curated review of the scientific literature, Volume 115 of Organic Reactions presents critical discussions of widely used organic reactions or particular steps of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method. Launched in 1942, the Organic Reactions series today is a leading secondary- and tertiary-level source for organic chemists across the world.

Organic Reaction Mechanisms 2020, the 56th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2020. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements Transition Metal Coupling Radicals An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.

Organic chemistry is a challenging subject, with many students expecting it to require many hours of memorization. Author David Klein's Second Language books prove this is not true—organic chemistry is one continuous story that actually makes sense if you pay close attention. Klein's books use a conversational tone making them more accessible and easier to read for students. Organic Chemistry as a Second Language: Second Semester Topics, 6e builds on the principles explored in the first half of the course, delving deeper into molecular mechanisms, reactions, and analytical techniques. Using Klein's one-of-a-kind SkillBuilder approach, the book includes hands-on exercises and thoroughly explained solutions designed to further reinforce student comprehension of chemical concepts and organic principles. An indispensable supplement to the primary text, this resource covers aromatic compounds, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, nucleophilic and electrophilic aromatic substitution, ketones and aldehydes, carboxylic acid derivatives, and much more. Organic Chemistry as a Second Language: Second Semester Topics, 6e teaches students how to ask the right questions to solve problems, study more efficiently, and learn to speak the language of organic chemistry. Like its first-semester companion title, it is an essential ‘guide on the side'for any organic chemistry student no matter what textbook or instructor-provided lecture material is used. The inclusion of new end of chapter problems, providing both practice and challenge, will prepare students and build confidence come exam time, as well as outside the classroom.

SOLUTIONS MANUAL FOR PERSPECTIVES ON STRUCTURE AND MECHANISM IN ORGANIC CHEMISTRY Based on the author's first-hand classroom experience, this solutions manual complements the 3rd edition of Perspectives on Structure and Mechanism in Organic Chemistry. The solutions to the 438 textbook problems help students increase their understanding of physical organic chemistry, and more than 550 references stimulate their engagement with the chemical literature.Felix A. Carroll, PhD is the Joseph R. Morton Professor of Chemistry Emeritus at Davidson College. His research focuses on organic photochemistry and photophysics, kinetics, the synthesis and characterization of insect pheromone analogues, the correlation of molecular structure with physical properties, the combustion characteristics of organic compounds, and chemical education. Dr. Carroll has published extensively in the peer-reviewed literature and was awarded a patent in the field of insect pheromones.

Microplastics in the Ecosphere Discover the environmental impact of microplastics with this comprehensive resource Microplastics are the minute quantities of plastic that result from industrial processes, household release and the breakdown of larger plastic items. Widespread reliance on plastic goods and, particularly, single-use plastics, which has been increased by the COVID-19 pandemic, has made microplastics ubiquitous; they can be found throughout the ecosphere, including in the bloodstreams of humans and other animals. As these plastics emerge as a potential threat to the environment and to public health, it has never been more critical to understand their distribution and environmental impact. Microplastics in the Ecosphere aims to cultivate that understanding with a comprehensive overview of microplastics in terrestrial ecosystems. It analyzes microplastic distribution in aerosphere, hydrosphere, and soil, tracing these plastics from their production on land to their distribution—overwhelmingly—in maritime ecosystems. The result is a book that will inform researchers and policymakers as we look to tackle this emerging challenge globally. Microplastics in the Ecosphere readers will also find: Introductory information about the production and distribution of single-use plastics An emphasis on management and mitigation strategies designed to reduce contamination over time A multidisciplinary approach, combining concepts and analytical techniques from a range of scientific fields Microplastics in the Ecosphere is a valuable guide for researchers and scientists, advanced undergraduate and graduate students, industry professionals, and policymakers looking to understand the impact of these widespread materials.

Organogermanium Compounds Understand the chemistry of organogermanium compounds with this thorough and cutting-edge reference Discovered comparatively late in the history of chemistry, germanium has become one of the most technology-critical elements in modern industry. Germanium and its inorganic and organic derivatives found widespread applications in fiber- and infrared-optics, electronics, polymerization catalysis, solar electric technology, nanotechnology, chemotherapy, and more. Organogermanium compounds containing carbon to germanium chemical bonds, have applications in microelectronics, medicinal and health industries, and beyond. Organogermanium Compounds: Theory, Experiment, and Applications, 2 Volume Set provides a comprehensive review of this class of compounds in two thorough volumes. It covers all modern aspects of these critically important compounds, including theoretical, synthetic, physico-chemical, and applied research. Reflecting the latest breakthroughs in this rapidly growing field, this book promises to serve as the high-level reference for those readers who are interested in organogermanium chemistry. Organogermanium Compounds readers will also find: 19 chapters produced by leading global experts Descriptions of pivotal historical achievements in organogermanium research Coverage of the latest computational, synthetic, and applied breakthroughs Organogermanium Compounds is a critical reference for researchers and professionals in a wide range of academic and industrial fields working with these fascinating compounds. This will also be helpful for university and college students, at both graduate and undergraduate levels.

Microscale Organic Chemistry: With Multistep and Multiscale Syntheses offers a modern approach to the laboratory experience within the organic division. Notable features include inquiry-driven experimentation, validation of the purification process, and the implementation of greener processes (including microwave use) to perform traditional experimentation. In addition to offering alternative methods to perform microscale experiments, this text offers strong pedagogy to promote student success through empowerment and encouragement.

An expert resource for chemists using stereochemical analysis methods In Chiral Separations and Stereochemical Elucidation: Fundamentals, Methods, and Applications, a team of distinguished researchers delivers a robust and authoritative discussion of the theoretical fundamentals of chiral separation, the most commonly used chiral selectors, and stereochemical elucidation methods. The book offers expert discussions of a variety of chiral separation methods by gas chromatography (GC), supercritical fluid chromatography (SFC), capillary electrophoresis (CE), and liquid chromatography (LC). The authors also describe several methods for stereochemical elucidation, including X-ray crystallography, nuclear magnetic resonance spectroscopy, and chiroptical methods. The explored material is ideal for practicing chemists seeking a resource to help them guide method development and optimization or to explain quality control-complements during target compound production. Readers will also find: A thorough introduction to the most important advances and applications in LC, GC, CE, SFC, and preparative chromatography Comprehensive explorations of the role of 2D-LC for chiral separation methods development and applications Practical discussions of the design, mechanisms, and applications of the most commonly used chiral selectors Fulsome treatments of the theoretical backgrounds, advantages, limitations, and applications of stereochemical elucidation methodsPerfect for academic and industrial chemists specially in organic, analytical chemistry and pharmaceutical analysis. Chiral Separations and Stereochemical Elucidation: Fundamentals, Methods, and Applications will also benefit biochemists, environmental analysts, forensic and medicinal chemists as well as natural product chemists and those involved with stereochemistry or structural elucidation.

Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field. Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Transition-Metal-Catalyzed C-H Functionalization of Heterocycles A comprehensive guide to recent advances in this field Constituting the majority of all known compounds, heterocycles are structures that incorporate one or more heteroatoms within their core, thus exhibiting properties that are quite different from their all-carbon analogs. They are fundamental to all fields of chemistry and, therefore, their synthesis and modification has attracted a great deal of attention in the recent years. In this vein, transition-metal-catalyzed C-H bond functionalization forms a crucial tool for generating and analyzing heterocyclic compounds. Transition-Metal-Catalyzed C-H Functionalization of Heterocycles, Two-Volume Set, showcases diverse C-H functionalization methodologies and their incorporation into the latest research. The chapters serve as an essential tool depicting detailed site-selective functionalization of heterocyclic cores, along with a comprehensive discussion on their mechanistic approaches. Readers of Transition-Metal-Catalyzed C-H Functionalization of Heterocycles, Two-Volume-Set will also find: A detailed introduction to C-H activation along with the mechanistic aspects of transition-metal-catalyzed C-H bond activation reactions Easy-to-use structures with each chapter dedicated to a type of heterocycle and its specific functionalization methodologies A leading team of international authors in C-H bond functionalization Transition-Metal-Catalyzed C-H Functionalization of Heterocycles, Two-Volume-Set is a valuable guide for students and researchers in organic synthesis and process development, in both academic and industrial contexts.

Natural Products and their Bioactives in Antidiabetic Drug Discovery Enables researchers to effectively understand and use bioactive compounds to target, prevent, and manage diabetes Natural Products and Their Bioactives in Antidiabetic Drug Discovery provides readers with an overview of recent research in new drug discovery against diabetic complications based on bioactives from NPs, bridging the gap between the public research institutes and private companies working to find drugs to treat diabetes. To aid in reader comprehension, the text includes case studies and illustrated examples in relevant chapters. Part one presents chapters on fundamental concepts of diabetes mellitus (DM) and recent drug discovery progress along with the various druggable targets and challenges. Part two covers bioactive compounds targeting Type-1 Diabetes. Part three focuses on Type-2 Diabetes. In Part four, the contributors address gestational DM prevention and management with natural compounds. Written by a global team of experts in the field, Natural Products and their Bioactives in Antidiabetic Drug Discovery covers sample topics such as: Obesity risk factor in patients with T1DM and possible role of nutritional therapy in its management Use of natural non-insulin drugs as a novel approach to enhance therapeutic outcomes against T1DM Effectiveness of functional foods in intervening the diabetic complications and realistic results in clinical trials Implementation of nanotechnology in improving the bioavailability and reducing the threshold dose of bioactive compounds Various antidiabetic mechanisms of action of different polyphenols and immunomodulatory role of NPs bioactives relevance in T1DM therapy Effects of natural products on genetics of gestational diabetes With comprehensive coverage of recent research in new drug discovery against diabetic complications based on bioactives from NPs, Natural Products and Their Bioactives in Antidiabetic Drug Discovery is an essential resource for researchers and professionals involved in drug discovery and development, health care, medicinal chemistry, phytochemistry, plant science, and toxicology.

Organic Reaction Mechanisms 2019, the 55th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2019. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements Radicals An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.

ENABLING TOOLS AND TECHNIQUES FOR ORGANIC SYNTHESIS Provides the practical knowledge of how new technologies impact organic synthesis, enabling the reader to understand literature, evaluate different techniques, and solve synthetic challenges In recent years, new technologies have impacted organic chemistry to the point that they are no longer the sole domain of dedicated specialists. Computational chemistry, for example, can now be used by organic chemists to help predict outcomes, understand selectivity, and decipher mechanisms. To be prepared to solve various synthetic problems, it is increasingly important for chemists to familiarize themselves with a range of current and emerging tools and techniques. Enabling Tools and Techniques for Organic Synthesis: A Practical Guide to Experimentation, Automation, and Computation provides a broad overview of contemporary research and new technologies applied to organic synthesis. Detailed chapters, written by a team of experts from academia and industry, describe different state-of-the-art techniques such as computer-assisted retrosynthesis, spectroscopy prediction with computational chemistry, high throughput experimentation for reaction screening, and optimization using Design of Experiments (DoE). Emphasizing real-world practicality, the book includes chapters on programming for synthetic chemists, machine learning (ML) in chemical synthesis, concepts and applications of computational chemistry, and more. Highlights the most recent methods in organic synthesis and describes how to employ these techniques in a reader's own research Familiarizes readers with the application of computational chemistry and automation technology in organic synthesis Introduces synthetic chemists to electrochemistry, photochemistry, and flow chemistry Helps readers comprehend the literature, assess the strengths and limitations of each technique, and apply those tools to solve synthetic challenges Provides case studies and guided examples with graphical illustrations in each chapter Enabling Tools and Techniques for Organic Synthesis: A Practical Guide to Experimentation, Automation, and Computation is an invaluable reference for scientists needing an up-to-date introduction to new tools, graduate students wanting to expand their organic chemistry skills, and instructors teaching courses in advanced techniques for organic synthesis.

A thorough discussion of the structure, pharmacology, function, and role of G protein-coupled receptors In GPCRs as Therapeutic Agents, distinguished researcher Dr. Annette Gilchrist delivers an authoritative and in-depth compendium of a vibrant and active area of academic and industrial drug discovery. The book serves as an important reference for new and experienced researchers studying G protein-coupled receptors and discusses the molecular pharmacology of this important target class. It also includes up-to-date material on GPCR structures and structure-based drug design. The book explores the role of GPCRs in the treatment of disease and novel approaches to their study. In addition to providing information on the structure, pharmacology, and function of GPCRs, it discusses their role in disease states, and advances new methods for measuring GPCR activity in an accessible and engaging way. The book includes: A thorough introduction to the molecular pharmacology of G protein-coupled receptors, including up-to-date material on GPCR structures and structure-based drug design In-depth discussions of the evolving pharmacology for GPCRs, intracellular trafficking, and subcellular GPCR signaling Comprehensive explorations of allosteric modulation, receptor dimerization, deorphanization, and ubiquitination Fulsome treatments of the role played by GPCRs in the treatments of cancer, substance use disorders, cerebrovascular diseases, and metabolic diseasesPerfect for researchers in biochemistry, cell biology, and pharmacology, GPCRs as Therapeutic Agents will also earn a place in the libraries of professionals working in medicinal chemistry, structural biology, and clinical pharmacology.

Current Drug Synthesis The latest entry in the widely read Drug Synthesis series In Current Drug Synthesis, accomplished medicinal chemist and researcher Dr. Jie Jack Li and 27 expert coauthors deliver an authoritative and comprehensive discussion of the medicinal chemistry of current drugs, as well as the cutting-edge science involved in their synthesis. The book demystifies the process of modern drug discovery for both industry practitioners and students, while capturing the state-of-the-art techniques used to discover some of the most impactful medicines on the market today. Covering six different disease areas – including infectious disease, cancer, cardiovascular and metabolic disease, the central nervous system, anti-inflammatory disease, and a miscellaneous section – the book explores 18 different drugs before concluding with chapters on computational drug discovery and peptide drugs. Each chapter includes coverage of background material on a relevant drug class or disease indication and key aspects of drug discovery, including structure-activity relationships, pharmacokinetics, drug metabolism, efficacy, and safety. Readers will also find: Thorough introductions to drugs for infectious diseases, including relebactam, vaborbactam, and baloxavir marboxil In-depth treatments of cancer-treating drugs, including darolutamide, venetoclax, and osimertinib Comprehensive explorations of central nervous system drugs, including zuranolone and risdiplam Extensive discussions of computational drug discovery and peptide drugs Perfect for medicinal, organic, synthetic, and process chemists, Current Drug Synthesis will also earn a place in the libraries of research scientists working in lead optimization and process development, as well as graduate students studying organic chemistry, heterocyclic chemistry, or medicinal chemistry.

The Waste Crisis Explore modern solutions to the most critical issues in waste management policy and design In The Waste Crisis: Roadmap for Sustainable Waste Management in Developing Countries, an accomplished team of sustainability researchers deliver a concise insight of modern waste management practices that acts as a handbook for waste management professionals. Along with flow charts and example problems, the authors offer readers the information necessary to support decision making based on country, city size, population, waste generation volume, type, geographical location, and more. The book begins with an overview of current waste management practices, including waste generation, collection, processing, composting, recycling, and disposal. It moves on to a series of case studies from over ten countries and presentations of sustainable waste management strategies. The Waste Crisis: Roadmap for Sustainable Waste Management in Developing Countries concludes with a series of practical and effective final recommendations for future best practices. It also includes: Practical discussions of material flow, cost-effective material recovery, anaerobic digestion, composting, recycling, disposal, training, and human capacity building Comprehensive explorations of unique and robust decision-making strategies for designers, policy makers, and regulators In-depth treatments of ready-to-implement waste management systems perfect for systems designers The Waste Crisis: Roadmap for Sustainable Waste Management in Developing Countries is an indispensable resource for waste, recycling, and resource management professionals. It???s also perfect for waste management system designers and decision makers seeking a one-stop guide to issues of sustainability in the developing world.

INTRODUCTION TO DESALINATION Explore the principles, methods, and applications of modern desalination processes Introduction to Desalination: Principles, Processes, and Calculations delivers a comprehensive and robust exploration of desalination highlighted with numerous illustrative examples and calculations. The book is divided into three sections, the first of which offers an introduction to the topic that includes chapters covering global water scarcity and the need for “new water.” The second section discusses the desalination process, including evaporation, reverse osmosis, crystallization, hybrid systems, and other potable water processes. The final part covers topics that include water conservation, environmental considerations of desalination, economic impacts of desalination, optimization, ethics, and the future of desalination. The book also includes: A comprehensive introduction to desalination, including discussions of engineering principles, the physical, chemical, and biological properties of water, and water chemistry An extensive engineering analysis of the various desalination processes Practical discussions of miscellaneous desalination topics, including the environmental and economic effects of the technology Perfect for process, chemical, mechanical, environmental, and civil engineers, Introduction to Desalination: Principles, Processes, and Calculations is also a valuable resource for materials scientists, operators, and technicians working in the field.

Outlines recent advances in the field of polar organometallic chemistry, particularly in the context of the emergent areas of synergic and cooperative species. Polar Organometallic Reagents provides a critical overview of developments in the field of modern polar organometallic chemistry. With a particular focus on the emergent area of synergic heterometallic reagents, this timely volume describes our attempts to understand recently developed polar organometallics and their application in a range of new directions. Contributions from leading researchers present new synthetic work and discuss recent advances in characterization techniques, synthetic applications, and mechanistic understanding of heterometallic complexes. In-depth chapters provide detailed information on fundamental, structural, and theoretical aspects of polar organometallic chemistry while articulating the need and rationale for the advent of new reagents. Topics include alkali and alkaline earth organometallics, synergy and cooperativity, cationic p-block clusters and other developments in main group catalysis, synthetic trends in alkenyl copper, ate complex and borylmetal chemistry, non-traditional reaction environments, and trends in developing greener processes. Designed to keep readers updated with the latest progress in the field, this much-needed book: Includes an introductory chapter outlining the development of synergic bases and the logic behind their creation Highlights the role of solid-state structural work in elucidating the bonding and reactivity displayed by modern polar organometallics Examines the use of calculations in catalyst design and plotting more sustainable reaction pathways Discusses modern trends in solution techniques that have achieved new insights into the structures of active species Presents striking advances in the ease of handling of polar organometallics and the emergence of main group catalysis Polar Organometallic Reagents is essential reading for researchers in chemical disciplines including synthetic inorganic and coordination chemistry, main group chemistry, organometallic chemistry, organic synthesis and catalysis.

Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems An indispensable compendium detailing the toxicology of nanoparticles with a focus on mechanisms, emerging issues, and new approaches Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems provides authoritative information on the toxicology of ultrafine and nanoparticulate matter that contaminate terrestrial or aquatic environments and present unique challenges in applied public health and toxicological research. Detailed chapters by a panel of world-renowned experts examine the complementary and dynamic interdependence of aquatic, terrestrial, and human systems and the toxicological impacts on exposure to engineered and manufactured nanoparticles and nanomaterials. Organized into four sections, the book opens with a thorough overview of the field, including known challenges and the necessity for current research activity. The second section describes terrestrial and aquatic systems and the ecotoxicological impact of nanomaterials, followed by critical analysis of the many human health effects of nanomaterials. The book concludes with an in-depth discussion of current gaps in knowledge, future directions, new approach methodologies, alternatives to animal models, and the emerging environmental threat from nanoplastics. Presenting case exemplars of the ecotoxicological impact of nanoparticles in aquatic and terrestrial systems, this important resource: Presents in-depth coverage of ecosafety, environmental behavior, fate and transport, interactive effects with other contaminants, and current challenges in soil nano-ecotoxicology Addresses rising concerns regarding air pollution and neurological disorders, and the roles played by the gastrointestinal system, the mucosal microbiome, and the immunotoxicology and vasculotoxicity of metal-based nanoparticles Provides detailed coverage of nanomaterial health effects from both animal and in vitro models, including the gut microbiome, innate immunity, neurological and cardiovascular impacts, mechanisms of action, and hazard characterization Analyzes key topics in ecological nanotoxicology such as environmental micro- and nano-plastic pollution and applied risk assessment Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems is essential reading for toxicologists, applied biologists, ecotoxicologists, research scientists, medical professionals, regulators, and advanced students in fields such as public health, environmental ecotoxicology and medicine, immunotoxicology, neurotoxicology, cardiovascular and systems biology, hazard identification, and risk assessment.

Organic Chemistry 13th Edition continues Solomons, Fryle, and Snyder's tradition of excellence in teaching and preparing students for success in both the classroom and beyond. Central to the authors is their approach in emphasizing organic chemistry's relationship between structure and reactivity. To accomplish this, the content is organized in a way that combines the most useful features of a functional group approach with one largely based on reaction mechanisms. The authors'philosophy is to emphasize mechanisms and their common aspects as often as possible, and at the same time, use the unifying features of functional groups as the basis for most chapters. The structural aspects of the authors'approach show students what organic chemistry is. Mechanistic aspects of their approach show students how it works. And wherever an opportunity arises, the authors show students what it does in living systems and the physical world around us.

Organic Chemistry, Student Study Guide and Solutions Manual, 13th Edition offers the full solutions for select exercises from the text.

The 111th volume in this series for organic chemists in academia and industry presents critical discussions of widely used organic reactions or particular steps of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method. Volume contents: RING-OPENING REACTIONS OF EPOXIDES WITH TITANIUM(III) REAGENTS T. V. (Babu) RajanBabu, William A. Nugent, and Sandipan Halder REDUCTIVE CYCLIZATION OF 2-NITRO- AND β-NITROSTYRENES, 2-NITROBIPHENYLS, AND 1-NITRO-1,3-DIENES TO INDOLES, CARBAZOLES, AND PYRROLES Björn C. G. Söderberg and William F. Berkowitz

Biodegradable Waste Management in the Circular Economy Presents the major developments in new technologies and strategies for more effective recovery of matter, resources, and energy from biodegradable waste The volume of biodegradable waste produced worldwide is progressively increasing—a trend that is predicted to continue well into the foreseeable future. Developing sustainable, cost-effective, and eco-friendly approaches for processing food waste, agricultural and organic industrial waste, cardboard, biodegradable plastics, sewage sludge, and other types of biodegradable waste is one of the most significant challenges of the coming decades. Biodegradable Waste Management in the Circular Economy provides a detailed overview of the latest advances in the management of biomass for economic development. Featuring contributions from an interdisciplinary team of experts, this comprehensive resource addresses various technologies and strategies for recycling organic matter and many other renewable compounds. In-depth chapters describe the concept of circular economy, identify new sources of biodegradable waste, explore technologies for the production of biodegradable waste end-products, discuss the positive and negative effects of end-products on soil and the environment, and more. Throughout the text, the authors explore systematic approaches for secure biodegradable management in various countries and regions around the world. Explores the social, governance, and economic aspects of'waste as a resource'Addresses metal recovery, biofuel and fertilizer production, and biosorbents and biochar derived from biomass waste Discusses nutrient recovery and energy and bio-methane production from biodegradable waste Covers use cases, collection systems, and regulation of agricultural, industrial, and municipal biodegradable waste streams Presents various technologies for the production of biodegradable waste end-products, including biorefineries, anaerobic digestion, and hybrid methods Reflecting the latest trends in the rapidly changing field, Biodegradable Waste Management in the Circular Economy is essential reading for researchers, engineers, scientists, and consultants working in waste engineering and management, resource recovery, renewable resources, environmental science, agricultural and environmental engineering, soil science, and bioenergy.

CARBON MONOXIDE IN DRUG DISCOVERY An insightful reference for the latest physiological and therapeutic studies of carbon monoxide In Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential, a team of distinguished authors delivers foundational knowledge, the latest research, and remaining challenges regarding the physiological roles and therapeutic efficacy of carbon monoxide (CO). The editors have included a broad selection of resources from leading experts in the field that discuss the background and physiological roles of CO, a variety of delivery forms including CO prodrugs using benign carriers, CO sensing, therapeutic applications, and clinical trials. Organized by topic to allow each chapter to be read individually, the book covers a wide range of topics, from physiological and patho-physiological mechanisms at the molecular level to clinical applications for multiple disease processes. The editors of Carbon Monoxide in Drug Discovery have created a compelling argument for shifting the accepted understanding of CO from poison to bioactive molecule with enormous clinical benefits. Readers will also benefit from: A thorough introduction to the background and physiological actions of carbon monoxide, including endogenous CO production in sickness and in health Comprehensive explorations of CO delivery forms, including non-carrier formulations, metal-carbonyl complexes, and organic CO donors Practical discussions of carbon monoxide sensing and scavenging, including fluorescent probes for intracellular carbon monoxide detection In-depth examinations of the therapeutic applications of CO, including CO in solid organ transplantation Perfect for professors, graduate students, and postdocs in the fields of biology, pharmacology, immunology, medicinal chemistry, toxicology, and drug delivery, Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential is also an invaluable resource for industrial scientists in these areas.

Photocatalysts and Electrocatalysts in Water Remediation Comprehensive resource describing the fundamentals, synthesis, and commercial applications of photocatalysts and electrocatalysts in water decontamination Photocatalysts and Electrocatalysts in Water Remediation introduces the fundamentals of both photo- and electro-catalysts and highlights the potentials of photo- and electro-catalysis towards water decontamination, covering strategies to improve photo- and electro-catalytic efficacies, functions of photo- and electro-catalysts and involved chemical reactions, and challenges and recent developments in the field, with additional discussion of both lab-scale and commercial-scale materials and processes. As a forward-thinking resource, the text also discusses the scope of further research on photo-, electro- and electrophoto-catalysts. Edited by three highly qualified professionals, with significant experience in the field, the text is further enriched with critically analyzed and expertly opined contributions from several well-known researchers around the world. In Photocatalysts and Electrocatalysts in Water Remediation, readers can expect to find information on: Fundamentals and functional mechanisms of photocatalysis in water treatment, and different synthetic routes and band gap engineering of photocatalysts Photocatalytic decontamination of organic pollutants from water and photocatalytic removal of heavy metal ions from water Smart photocatalysts in water remediation Fundamentals and functional mechanisms of electrocatalysis in water treatment Electrocatalytic degradation of organic pollutants and removal of heavy metal ions from water Different synthetic routes of electrocatalysts and fabrication of electrodes and combined electro-photocatalytic techniques in water remediation Photocatalysts and Electrocatalysts in Water Remediation serves as one of the most comprehensive and authoritative resources that has ever been published in this field and is a thoroughly complete source of information on the subject for researchers across a myriad of disciplines along with water industry professionals.

HYDROGEN SULFIDE Covers H2S interactions, methods of detection and delivery in biological environments, and a wide range of applications Research on hydrogen sulfide (H2S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H2S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H2S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities. Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies provides the foundation required for understanding the fundamental chemical biology of H2S while highlighting the compound's therapeutic potential and medicinal applications. This book covers key aspects of H2S chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H2S in biological environments; and the therapeutic and medicinal uses of exogenous H2S delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field. Provides approaches for delivering H2S with relevance to biological and therapeutic applications Describes complex interactions of H2S with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species Summarizes advances in available tools to detect, measure, and modulate H2S levels in biological environments, such as real-time methods for H2S fluorescence imaging in live cell and animal systems Helps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action Includes in-depth case studies of different systems in which H2S plays an important role Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.

Green Stormwater Infrastructure Fundamentals and Design Discover novel stormwater control measures to make for a greener tomorrow! The protection of our aquatic resources is growing in importance as the effects of climate change and continued urbanization are felt throughout the world. While most rain that falls onto vegetated spaces infiltrates the soil, rain that falls onto impervious surfaces will not, increasing downstream flooding and erosion and causing impaired water quality. Impervious surfaces such as road infrastructure, rooftops, and parking areas all increase runoff and mobilize many pollutants that have deposited on these surfaces that are then carried into our waterways. Proper management of this stormwater through green infrastructure is essential to address these challenges and reduce the environmental and ecological impacts brought about by this runoff. This book brings into focus resilient stormwater control measures (SCMs) for the reduction of stormwater flows and associated pollutants that can detrimentally impact our local environmental and ecological systems. These interventions are green infrastructure based, utilizing natural hydrologic and environmental features using soil and vegetation to manage stormwater. These technologies include water harvesting, bioretention and bioinfiltration, vegetated swales and filter strips, permeable pavements, sand filters, green roofs, and stormwater wetlands, among others. The basic science and engineering of these technologies is discussed, including performance information and best maintenance practices. Green Stormwater Infrastructure readers will also find: Research-informed resilient SCM design fundamentals Diagrams developed by the authors to enhance understanding Case studies to illustrate the points elucidated in the book End-of-chapter problems with a separate solutions manual Green Stormwater Infrastructure is an ideal resource for environmental, civil, and biological engineers and environmental scientists in the consulting field. Landscape architects, managers and engineers of watershed districts, and members of federal, state, and local governmental agencies—especially those in the departments of environmental protection and transportation—will find many uses for this guidebook. It will also be of interest to professors, upper-level undergraduates and graduate students in environmental, civil, and biological engineering programs.

More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles An authoritative collection of resources discussing the latest trends in the synthesis of nonaromatic nitrogen heterocycles Widely distributed in nature, nitrogen heterocycles are extremely common in synthetic substances found in pharmaceuticals, agrochemicals, and materials. The literature is evolving rapidly and explores newly emerging structures and medicines. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles offers R&D professionals the opportunity to easily access a collection of the latest relevant research in the area. In the second two-volume set of this practical reference distinguished researcher Dr. Ana Maria M. M. Faisca Phillips delivers a collection of resources focusing on the newest and most widely applicable trends emerging in synthetic strategies for nonaromatic nitrogen heterocycles. With coverage of topics including organocatalysis, cascade reactions, flow chemistry in synthesis, cycloaddition reactions, metathesis, cross-coupling reactions, and electrochemistry, the book provides quick access to critical new avenues of synthesis. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles: Volume 1 and 2 also offers readers: A thorough introduction to recent advances in the design and synthesis of cyclic peptidomimetics Comprehensive explorations of fused heterocycles and transition metal promoted synthesis of isoindoline derivatives Practical discussions of 1,4-diazepane ring-based systems and recent advances in the synthesis of azepane-based compounds In-depth examinations of strained aziridinium ions, asymmetric organocatalysis in alternative media, and the electrochemical synthesis of non-aromatic N-heterocycles Perfect for academic and industrial researchers in organic chemistry and synthesis, organometallic chemistry, pharmaceutical chemistry catalysis, and sustainable chemistry, More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles: Volume 1 and 2 is an indispensable reference for anyone seeking an authoritative source of information on new and emerging trends in synthesis.

Enzyme-Based Organic Synthesis An insightful exploration of an increasingly popular technique in organic chemistry In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find: A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

Organic chemistry can be a challenging subject. Most students view organic chemistry as a subject requiring hours upon hours of memorization. Author David Klein's Second Language books prove this is not true—organic chemistry is one continuous story that makes sense if you pay attention. Offering a unique skill-building approach, these market-leading books teach students how to ask the right questions to solve problems, study more efficiently to avoid wasting time, and learn to speak the language of organic chemistry. Covering the initial half of the course, Organic Chemistry as a Second Language: First Semester Topics reviews critical principles and explains their relevance to the rest of the course. Each section provides hands-on exercises and step-by-step explanations to help students fully comprehend classroom lectures and textbook content. Now in the 6th edition, there are approximately 30 new end-of-chapter exercises in each chapter. These new exercises vary in difficulty, starting with exercises that focus on just one skill or concept (called Practice Problems), and continuing with exercises that focus on more than one skill or concept (called Integrated Problems), and concluding with advanced exercises (called Challenge Problems). There are also author-created, detailed solutions for all new exercises, and these detailed solutions appear in the back of the book.

A carefully curated review of the scientific literature on selected organic reactions, Volume 110 of the Organic Reactions series delivers insightful invited reviews of primary research material in the field of organic chemistry. The latest volume explores the practical and theoretical aspects of the reaction under discussion. The Organic Reactions series is a renowned, peer-reviewed reference in publication since 1942. It is one of the leading secondary- and tertiary-level sources in organic chemistry today.

The new edition of LaQue's classic text on marine corrosion, providing fully updated control engineering practices and applications Extensively updated throughout, the second edition of La Que's Handbook of Marine Corrosion remains the standard single-source reference on the unique nature of seawater as a corrosive environment. Designed to help readers reduce operational and life cycle costs for materials in marine environments, this authoritative resource provides clear guidance on design, materials selection, and implementation of corrosion control engineering practices for materials in atmospheric, immersion, or wetted marine environments. Completely rewritten for the 21st century, this new edition reflects current environmental regulations, best practices, materials, and processes, with special emphasis placed on the engineering, behavior, and practical applications of materials. Divided into three parts, the book first explains the fundamentals of corrosion in marine environments, including atmospheric corrosion, erosion, microbiological corrosion, fatigue, environmental cracking, and cathodic delamination. The second part discusses corrosion control methods and materials selection that can mitigate or eliminate corrosion in different marine environments. The third section provides the reader with specific applications of corrosion engineering to structures, systems, or components that exist in marine environments. This much-needed new edition: Presents a comprehensive and up-to-date account of the science and engineering aspects of marine corrosion Focuses on engineering aspects, descriptive behavior, and practical applications of materials usage in marine environments Addresses the various materials used in marine environments, including metals, polymers, alloys, coatings, and composites Incorporates current regulations, standards, and recommended practices of numerous organizations such as ASTM International, the US Navy, the American Bureau of Shipping, the International Organization for Standardization, and the International Maritime Organization Written in a clear and understandable style, La Que's Handbook of Marine Corrosion, Second Edition is an indispensable resource for engineers and materials scientists in disciplines spanning the naval, maritime, commercial, shipping industries, particularly corrosion engineers, ship designers, naval architects, marine engineers, oceanographers, and other professionals involved with products that operate in marine environments.

CONTEMPORARY ACCOUNTS IN DRUG DISCOVERY AND DEVELOPMENT A useful guide for medicinal chemists and pharmaceutical scientists Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners'knowledge of chemistry and biology, but also—and perhaps more importantly—on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical for advancement in the field. Contemporary Accounts in Drug Discovery and Development provides drug discovery scientists with the knowledge they need to quickly gain mastery of the drug discovery process. A thorough accounting is given for each drug covered within the book, as the authors provide pharmacology, drug metabolism, biology, drug development, and clinical studies for every case, with modern drug discovery principles and technologies incorporated throughout. Contemporary Accounts in Drug Discovery and Development readers will also find Case histories used as an engaging way of learning about the drug discovery/development process Detailed biological rational and background information, drug design principles, SAR development, ADMET considerations, and clinical studies The full history of individual marketed small molecule drugs Coverage of drug candidates that have passed Phase I clinical trials with different modalities, such as antibody drug conjugates (ADC), proteolysis-targeting chimera (PROTAC), and peptide drugs The application of new technologies in drug discovery such as DNA-encoded libraries (DEL), positron emission tomography (PET), and physics-based computational modeling employing free energy perturbation (FEP) Contemporary Accounts in Drug Discovery and Development is a helpful tool for medicinal chemists, organic chemists, pharmacologists, and other scientists in drug research and process development. It may be considered essential reading for graduate courses in drug discovery, medicinal chemistry, drug synthesis, pharmaceutical science, and pharmacology. It is also a useful resource for pharmaceutical industry labs, as well as for libraries.

Phytoantioxidants and Nanotherapeutics Discover the medicinal importance of antioxidant herbal medicines, phytochemicals, and nanodelivery systems for a wide range of diseases Phytomedicine has been—and continues to be—central to many cultures and societies due to its low toxicity, low cost, accessibility, and efficacy in treating difficult diseases. In fact, many plant-derived bioactive natural products serve as potential sources of drug leads or therapeutic agents in the treatment of a wide range of human diseases. When combined with nanotechnology, phytomedicine has the potential to affect and impact a tissue-specific site, which can reduce drug dosage and side effects while improving activity. Phytoantioxidants and Nanotherapeutics offers a comprehensive look at the significant role that phytomedicine-derived antioxidants play on the field of medicine, particularly when combined with the nanotechnology-derived drug delivery systems. The book thoroughly covers the herbs, plant extracts, and other dietary elements that may be used as sources of natural antioxidants and similarly highlights the use of phytomedicine- derived bioactive compounds including plant polyphenols and flavonoids to reducing the impact of oxidative stress induced human diseases. The text also demonstrates the biochemical and therapeutic targets of nanodrugs and discusses nanostructure toxicity, while emphasizing the challenges and regulatory issues involved with nanophytotherapeutics. Phytoantioxidants and Nanotherapeutics readers will also find: A helpful bridge between the cutting-edge field of nanotechnology delivery and phytotherapeutics The potential role of bioactive phytochemicals, particularly polyphenolic compounds and flavonoids, in oxidative stress-induced diseases Description of the latest developments on nanotherapeutics of phytoantioxidants for the treatment of certain chronic human diseases, such as cancer, inflammations, diabetes, viral, bacterial and parasitic infections, nervous system disorders, cardiovascular disorders, and neurological diseases. Phytoantioxidants and Nanotherapeutics is a useful reference for drug manufacturers and drug developers, formulation scientists, biomedical scientists, medicinal chemists, phytochemists, healthcare providers, and academics and researchers.

Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.

The 109th volume in this series for organic chemists in academia and industry presents critical discussions of widely used organic reactions or particular steps of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.

MULTI-SCALE BIOGEOCHEMICAL PROCESSES IN SOIL ECOSYSTEMS Provides a state-of-the-art overview of research in soil biogeochemical processes and strategies for greenhouse gas mitigation under climate change Food security and soil health for the rapidly growing human population are threatened by increased temperature and drought, soil erosion and soil quality degradation, and other problems caused by human activities and a changing climate. Because greenhouse gas emission is the primary driver of climate change, a complete understanding of the cycles of carbon and major nutritional elements is critical for developing innovative strategies to sustain agricultural development and environmental conservation. Multi-Scale Biogeochemical Processes in Soil Ecosystems: Critical Reactions and Resilience to Climate Changes is an up-to-date overview of recent research in soil biogeochemical processes and applications in ecosystem management. Organized into three parts, the text examines molecular-scale processes and critical reactions, presents ecosystem-scale studies of ecological hotspots, and discusses large-scale modeling and prediction of global biogeochemical cycles. Part of the Wiley - IUPAC Series on Biophysico-Chemical Processes in Environmental Systems, this authoritative volume: Provides readers with a systematic and interdisciplinary approach to sustainable agricultural development and management of soil ecosystems in a changing climate Features contributions from an international team of leading scientists Examines topics such as soil organic matter stabilization, soil biogeochemistry modeling, and soil responses to environmental changes Discusses strategies for mitigating greenhouse gas emission and improving soil health and ecosystems resilience Includes an introduction to working across scales to project soil biogeochemical responses to climatic change Multi-Scale Biogeochemical Processes in Soil Ecosystems: Critical Reactions and Resilience to Climate Changes is essential reading for scientists, engineers, agronomists, chemists, biologists, academic researchers, consultants, and other professionals whose work involves the nutrient cycle, ecosystem management, and climate change.