Search

The chemical synthesis of isotopically labelled compounds is a pre-requisite for many chemical, biochemical and medicinal investigations. The constraints imposed by the requirements for regiospecific labelling and, in some instances, the time-scale of the synthesis often lead to quite different synthetic strategies to those that are used for the unlabelled material. Whilst there are many specialist papers, reviews and long books devoted to particular isotopes, there is no currently available short introductory book devoted to the organic chemistry of isotopic labelling. The aim of this book is to introduce research workers to a variety of methods that have been used to achieve these synthetic labelling objectives before exploring a particular method in detail. It covers a number of different isotopes and the methods that have been used to introduce them into organic compounds. Labelling methods also provide useful undergraduate teaching examples of modern synthetic reactions and their stereochemical consequences using relatively simple substrates. The book will therefore have a wider appeal than just those involved in using isotopes in research such as environmental and pharmaceutical chemists as well as organic chemists.

In the late 1990s, there was an explosion of research on ionic liquids and they are now a major topic of academic and industrial interest with numerous existing and potential applications. Since then, the number of scientific papers focusing on ionic liquids has risen exponentially, including a few edited multi-author books covering the latest advances in ionic liquids chemistry and several volumes of symposium proceedings. Much of the content in these books and volumes is written using technical jargon that only scientists at the cutting edge of ionic liquids research will understand and ionic liquids are hardly covered in most modern chemistry textbooks. This is the first single-author book on ionic liquids and the first introductory book on the topic. It is written in a clear, concise and consistent way. The book provides a useful introduction to ionic liquids for those readers who are not familiar with the topic. It is also wide ranging, embracing every aspect of the chemistry and applications of ionic liquids. The book draws extensively on the primary scientific literature to provide numerous examples of research on ionic liquids. These examples will enable the reader to become familiar with the key developments in ionic liquids chemistry over recent years. The book provides an introduction to: ionic liquids; their nomenclature; history; physical, chemical and biological properties; and their wide ranging uses and potential applications in catalysis, electrochemistry, inorganic chemistry, organic chemistry, analysis, biotechnology, green chemistry and clean technology. Notable and important chapters include'The Green Credentials of Ionic Liquids'and'Biotechnology.'The chapter on'Applications'includes sections with brief descriptions of recent research on the development of ionic liquids: - for the construction of a liquid mirror for a moon telescope - for use as rocket propellants - for use as antimicrobial agents that combat MRSA - as active pharmaceutical ingredients and antiviral drugs - for embalming and tissue preservation Science students, researchers, teachers in academic institutions and chemists and other scientists in industry and government laboratories will find the book an invaluable introduction to one of the most rapidly advancing and exciting fields of science and technology today.

Chromic or colour related phenomena are produced in response to a chemical or physical stimulus. This new edition will update the information on all those areas where chemicals or materials interact with light to produce colour, a colour change, or luminescence especially in the imaging, analysis, lighting and display areas. The book has been restructured to show greater emphasis on applications where'coloured'compounds are used to transfer energy or manipulate light in some way therefore reducing the details on classical dyes and pigments. In the past eight years, since the previous edition, there has been a remarkable increase in the number of papers and reviews being produced reflecting the growth of interest in this area. This ongoing research interest is matched by a large number of new technological applications gaining commercial value covering e.g. biomedical areas, energy, data storage, physical colour, bio-inspired materials and photonics. This book appeals to industrial chemists, professionals, postgraduates and as high level recommended reading for colour technology courses.

Nitroxide-mediated polymerization is an important branch of controlled radical polymerization, which has revolutionised the preparation of polymer architectures and compositions. This is the first book dedicated to the topic and covers the history and development of nitroxide-mediated polymerization, as well as current techniques of academic and industrial interest. Nitroxide-Mediated Polymerization gathers together and comprehensively discusses all aspects of nitroxide-mediated polymerization, from fundamental principles through to industrial applications. A specific focus will be dedicated to the principle of the technique, its kinetics aspects, the synthesis of the controlling agents, the range of polymerizable monomers, its potential for preparation of advanced organic and hybrid materials and its status at the industrial stage. The book details all stages of the field, with chapters detailing the history, recent developments and novel materials in this fast developing area. Edited and written by expert researchers working in the field and academia this book focuses on highlighting the kinetic aspects of nitroxide-mediated polymerization, providing insight into the kinetics that can sometimes be hard to follow in published papers. The book will be of interest to polymer chemists and materials scientists at graduate level and above.

Antibiotic resistance is a global health concern. Strains of pathogenic microorganisms that have developed resistance to multiple antibiotics, such as MRSA, are extremely difficult to treat, and alternative methods for tackling pathogenic microorganisms are in demand. One potential target for new therapeutics is inhibition of quorum sensing: how microorganisms communicate and form biofilms in a density-dependent manner. Inhibiting this system via ‘quorum quenching'(QQ) is a promising route to new pharmaceuticals and for controlling biofilm formation and growth. Quorum sensing also provides interesting possibilities in synthetic biology for producing novel products, biosensors, bioactive molecules, and so on. This book covers the biology of quorum sensing and quenching, and potential sources of QQ enzymes and other inhibitors, as well as an overview of their mechanism and potential biotech applications. The book also covers the potential for new drug development from QQ, covering a range of related topics including protein engineering, imaging and computational studies, and integrated systems. This book is an ideal companion to researchers in chemical biology and medicinal chemistry, particularly those interested in biofilm formation, quorum sensing, novel antimicrobial development, synthetic biology and enzymology.

This annual review of the literature provides a comprehensive and critical survey of a vast field of study involving organophosphorus compounds, ranging from phosphines and their chalcogenide derivatives, phosphonium salts and P-ylides, to tervalent and quinquevalent phosphorus acid derivatives and penta- and hexa-coordinated phosphorus compounds. Recent developments in applications as reagents in green synthetic procedures are also given. With an emphasis on interdisciplinary content, this book will appeal to the worldwide organic chemistry and engineering research communities.

This book delves into the world of natural sources from medicinal plants, microbes, and fungi, to lichen, algae, and clay minerals that have been used for centuries in traditional medicine. These sources are rich in bioactive secondary metabolites that have a wide range of applications in various industries, including cosmetics and personal care products. This book provides a comprehensive guide to secondary metabolites for cosmeceutical purposes, regulatory perspectives for cosmeceuticals in different countries, and allergic responses from these secondary metabolites. Additionally, this book discusses the impact of nanotechnology on cosmetic products such as skin and hair care. Bioprospecting of Natural Sources for Cosmeceuticals is a valuable resource for researchers and graduate students in chemistry, botany, biotechnology, microbiology, cosmetic science, and the pharmaceutical sciences. It is also useful for those researching traditional medicine systems and those in the microbiology, biotechnology, pharmaceutical, and nanoscience industries.

There is an increasing awareness that materials and chemicals produced from fossil fuels are not sustainable, both in terms of the pollution caused by the extraction and production processes, and the fact that there is only a finite supply of these fossil fuels. Therefore, there is a strong incentive to find sources for chemicals and materials from source materials that we know we can continue to generate. Plants are a source of a wide variety of chemicals, many with interesting properties, and these chemical feedstocks are considered renewable rather than finite. Green Chemistry and Green Materials from Plant Oils and Natural Acids covers the application of these natural materials in producing polymers, lubricants and plasticisers.

Currently the majority of carbon-based feedstocks come from fossil fuels of which there is a finite supply. Methane is an abundantly available carbon-based feedstock, with large amounts now available through fracking and renewable sources available from biogas plants. However, methane is not very chemically reactive. One of the remaining “grand challenges” in chemistry is the development of clean, efficient, affordable processes that allow methane to be converted to other high value molecules. Highlighting the recent advances in methane activation and direct conversion processes this book discusses the progress and current state of the art for a wide variety of alternative methane activation and subsequent conversion processes, including homogeneous- and heterogeneous catalytic, electrocatalytic and pyrolytic systems. It is a useful resource for anyone working in green chemistry, catalysis and chemical engineering.

Looking at modern approaches to catalysis, this volume reviews the extensive literature published on this area. Chapter highlights include Fenton chemistry, advanced manufacturing in heterogeneous catalysis, membrane reactors for light alkane dehydrogenation, and new insights and enhancement of biocatalysts for biomass conversion in the bioproducts industry. Appealing to researchers in academia and industry, the detailed chapters bridge the gap from academic studies in the laboratory to practical applications in industry, not only for the catalysis field, but also for environmental protection. The book will be of great benefit to any researcher wanting a succinct reference on developments in this area now and looking to the future.

Circadian rhythms have been shown to be ubiquitous and critically important in the experimental laboratory, accounting for the difference between life and death in response to identical stimulus. The partly endogenous nature of circadian rhythms has been well documented and methods for their characterisation have been developed enabling the cellular and molecular mechanisms to be understood. Chronobiology and Chronomedicine aims to provide a review of these mechanisms underlying circadian rhythms and illustrate the role of the brain's suprachiasmatic nuclei in the ‘pace-making'process and the effects caused by ‘clock genes'present in almost all cells. Beyond the mechanisms involved, the book discusses the relationship between body systems, disease, and proper circadian function; in particular, how disruption of the circadian rhythm is associated with ill health and disease status from observations made at the organismic level. The book is organised to be an ideal introduction for the postgraduate in various fields, reviewing developments and outlining methods to show the depth and breadth of chronobiology and chronomedicine, as well as an invaluable companion to researchers and healthcare professionals working in the field with an interest in developing novel therapeutic approaches.

Transportation currently takes up around a third of overall energy usage, of which the majority is petroleum-based gasoline. Petroleum is both a finite resource and a big contributor to the carbon emissions that are causing climate change. To continue to benefit from transportation whilst mitigating climate change it is essential to find alternatives to petroleum-based gasoline. Although a lot of recent developments have focused on electrifying transport the infrastructure for large scale uptake of electric vehicles is still lacking and it may be less practical in some parts of the world than others. Biofuels, therefore, still have a role to play in improving the sustainability of our transportation systems. The term green gasoline refers to biofuels intended to be direct drop-in replacements for petroleum-based gasoline. Such products allow vehicles to run on biofuel without any engine modifications and, being made from biomass, they are both renewable and have a better carbon emission profile than petroleum-based gasoline. Green Gasoline covers a range of new technologies being used to produce these biofuels and compares them to petroleum-based fuels in terms of sustainability. It will be an interesting read for those working in fuel chemistry as well as green chemists and anyone with an interest in transport sustainability.

This publication is based on peer-reviewed manuscripts from the 2022 Conference on Current Trends in Drug Discovery, Development and Delivery (CTD4-2022) held at KL University, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good understanding of the scope of the field. Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the state of the art in drug design and discovery.

Silicon-containing Polymers reflects the growing interest worldwide in this developing field. Silicon polymers are now finding use as moulding materials, rubbers, ceramic precursors, in lithography and reprography as photosensitive materials, as conducting polymers, and in a host of other applications. This book presents up-to-date research from all over the world. It brings together research from the forefront of a multidisciplinary subject, covering the synthesis, modification, characterization, properties and applications of polysiloxanes, polysilylenes, polysilazanes and organosilicate derivatives. Silicon-containing Polymers will be of interest to researchers and postgraduates in any area of materials science, as well as some areas of inorganic chemistry.

Moving through the historical evolution of traditional amorphous 1D organic polymers to crystalline 3D networks, through 0D molecular cages and 2D frameworks, this book takes the reader on a journey on how covalently bonded materials and their hybrids can change the material world through applications relevant to energy, water and the environment. Looking at future demands from the materials that we use, strong, heavy and thermodynamically stable metals have been independently taken over by carbon allotropes and analogous materials. Equipment and instruments are becoming smaller and lighter, with research driving towards future organic materials with advanced physical, chemical, mechanical and optoelectronic properties. This book classifies and touches on every aspect of polymeric material chemistry, advanced characterizations and emerging reticular chemistry, especially organic porous materials, their design, synthesis, structure and built-in functions. The design, synthesis, structure, characterization, and properties of carbon rich framework materials are systematically reviewed to provide key information of the entire field. Arranged in chronological order to show changes made in ideas and strategies in developing these covalently framed materials to meet modern requirements, chapters cover linear polymers, organic cages, fullerene, carbon nanotubes, graphene and graphite, porous organic polymers, 2D- and 3D-covalent organic frameworks, and their hybrids. This book is an ideal introduction for students wanting to pursue this emerging field and gain knowledge on polymers and advanced organic materials. It will also update current researchers on recent developments, explored properties, and arising challenges of covalent materials.

Based on a translated Japanese title published in 2012, this book provides fundamental aspects of experimental and computational methods, the properties and structure of solvents, ion solvation and equilibria and reactions of metal complexes in solution. It includes state-of-the-art details on metal complexes in newly developing sustainable liquids and applications in real life. Appealing to researchers working in coordination chemistry, including students and industrialists, the text uses exercises, tables and figures to help the reader with their understanding of the topic.

Hydrogels are highly hydrated three dimensional networks with the ability to mimic the extracellular matrix of bodily tissues and have thus found application in a wide range of biomedical applications. Unique physiochemical properties such as biocompatibility, water permeability, stimuli responsiveness and self-healing characteristics make them especially useful for use as scaffolds and matrices drug delivery, tissue engineering/regeneration and sensing. Their weak and brittle nature, however, often limits their widespread application where improved mechanical strength is required. To resolve this problem, there has been a significant amount of research into the improvement of their mechanical properties. Among these efforts, versatile multicomponent hydrogels have received much attention as their physiochemical properties can be structurally engineered to provide a wide range of desired properties. These multicomponent formulations also allow for the combination of natural and synthetic polymers, which offers the scope to exploit the advantages of each component, with the synergistic effects resulting from mutual interactions. This book critically discusses the fundamental chemistry, synthesis, characterisation, physiochemical and biological properties of various types of multicomponent hydrogels. It reviews the different strategies employed in designing and synthesizing cutting-edge multicomponent hydrogels and their key applications in biomedical fields. The work is suitable for researchers working in the specific area of multicomponent hydrogels, and also more generally for those working in materials science, biomedical engineering, biomaterials science and tissue engineering.

Completely revised and updated, this 2nd Edition of Reactivity and Mechanism in Organic Chemistry is an ideal introduction to the quantitative description of organic reactivity for students in undergraduate and masters chemistry programmes. The book proceeds logically from qualitative molecular orbital theory as a tool for the description of bonding phenomena to combining this with thermochemical data to rationalise concepts such as molecular strain and hyperconjugation. Next, transition state theory, for examining organic reactivity phenomena, is introduced and its relation to energy surfaces and simple rate equations is discussed. On this basis more specific reactivity concepts commonly used in organic chemistry are explored such as the Bell–Evans–Polanyi principle, Marcus theory, HSAB principle, Hammett correlations, the Mayr–Patz equation, and FMO theory. How these reactivity models are applied is demonstrated for pericyclic reactions and selected rearrangement reactions involving transient intermediates such as radicals, diradicals, or carbocations, and for reactions involving classical electrophile/nucleophile combinations.

The phytochemical constituents of plants fall into two main categories based on their role in basic metabolic processes: primary and secondary. Primary metabolites are involved in basic life functions and are similar in all living cells, whereas secondary metabolites are derived from subsidiary pathways. Although traditionally referred to as secondary metabolites, more recently these compounds have been termed ‘plant specialized metabolites', as the exact biochemical boundary between primary and secondary metabolites has not been fully established. Plant specialized metabolites are the main elements in the study and use of ‘medicinal'plants and herbs, as well as in nutrition and food chemistry. In modern medicine, plant specialized metabolites provide many of the lead compounds in the production of medicines targeted at treating a broad variety of diseases. Such metabolites also play an important role in sessile plants to resist and withstand different biotic and abiotic stresses. Plant specialized metabolites are classified according to their chemical structures and this book will present the different classes in turn, while discussing their sources and distribution in plant families, their biosynthetic pathways, and their important and notable uses in phytochemistry and pharmacology. Chemical Diversity of Plant Specialized Metabolites will be a useful guide and reference point for chemists and students in many disciplines including synthetic organic chemists, medicinal chemists, plant scientists, pharmacognosists, chemical ecologists, bioengineers, and synthetic biologists, in addition to those working in related fields.

This book provides an interdisciplinary review of one of the great unsolved mysteries that has fascinated scientists for over 150 years: the origin of chirality in biomolecules. Current advances in fields as diverse as space exploration, prebiotic chemistry and high-energy physics may help to provide an answer. Important pieces of information will come from observations at the two frontiers of science: outer space and the subatomic world. Observation of distant planets, galaxies, and even actual sampling of celestial objects from beyond the solar system are projects currently underway. At the other end of the spectrum, there are experiments that study the elemental properties of matter, such as symmetry, and interactions with the fundamental forces. Completely revised and updated this new edition once again unifies all the theories of the origin of biomolecular homochirality together in a single source. This complete, interdisciplinary review of an intriguing subject condenses a large and disparate range of contributions from journals in almost every scientific field. The various theories have been organized, interrelated and explained in a unified way. It is fundamental, comprehensive and structured to be accessible for educational purposes.

Mimicking nature's efficiency and sustainability in organic chemistry is a major goal for future chemists; redox reactions are a key element in a variety of fields ranging from synthesis and catalysis to materials chemistry and analytical applications. Sustainability is increasingly becoming a consideration in synthesis and functional chemistry and an essential element for the next generation of chemistry in academia and industry. This book represents a compilation of the latest advancements in functional redox chemistry and demonstrates its importance in achieving a more sustainable future. This book is an ideal companion for any postgraduate students or researchers interested in sustainability in academia and industry.

There have been many great advances in the field of biomedical imaging in recent years, with supramolecular chemistry playing a key role in the evolution of modern imaging techniques. Non-covalent supramolecular interactions are fundamental to countless biological processes, from host–guest binding to the stabilisation of complex structures. Supramolecular chemistry techniques can be employed to create probes that can be targeted to either exploit or disrupt these interactions, giving the potential for both diagnostic and therapeutic effects. Furthermore, in techniques such as contrast enhanced MRI, controlling the interactions between solvent molecules and the imaging agent is crucial to the development of the technique.With rapid growth in the synthesis and study of molecular imaging agents, the understanding of their associated techniques has sometimes lagged behind. Supramolecular Chemistry in Biomedical Imaging will fill this gap by clarifying the state of current understanding and the nature of the underlying problems inherent to addressing problems in biology. It will cover both the techniques used in imaging and the molecular and supramolecular systems used to exploit them. This publication targets academics coming to the field from mainstream supramolecular chemistry, research graduates and undergraduates interested in supramolecular chemistry, synthesis or imaging agents and imaging techniques for biomedical applications.

The concept of nanoarchitechtonics was introduced to describe the correct manipulation of nanoscale materials in the creation of nano-devices and applications. Nanoarchitectonics has begun to spread into many fields including nanostructured materials synthesis, supramolecular assembly, nanoscale structural fabrications, materials hybridizations, materials and structures for energy and environmental sciences, device and physical application, and bio- and medical applications. Following on from the 2012 title Manipulation of Nanoscale Materials, Concepts and Design of Materials Nanoarchitectonics covers the introductory features underlying the field, presenting a unifying overview of the theoretical aspects and emerging applications that are changing the capability to understand and design advanced functional materials. Edited by pioneers of the field, this book will appeal to researchers working in nanoscience, materials science, supramolecular chemistry, physical chemistry and organic chemistry, as well as graduate students in these areas.

Vaccine development is a complex and time consuming process that differs from the development of conventional pharmaceuticals. Primarily, vaccines are intended for use in healthy individuals as a preventative measure, requiring a long and rigorous process of research and many years of testing and development prior to clinical trials and regulatory approval. The average time for the development of vaccines to clinical is 12 to 15 years. Vaccine Development: From Concept to Clinic is a detailed overview of the development of new vaccines, covering the entire process and addresses all classes of vaccines from a processing, development and regulatory viewpoint. Utilising successful case studies the book will provide insight to the issues scientists face when producing a vaccine, the steps involved and will serve as an ideal reference tool regarding state-of-the-art vaccine development. This book is an ideal companion for any researchers working in vaccine discovery and development or with an interest in the field.

In many fields, most notably medicine and molecular biology, the understanding of the structure and function of carbohydrates and glycoconjugates remains vital. This new volume contains critical reviews covering the latest findings in both chemical and biological sciences, and demonstrates the interdisciplinary nature of modern carbohydrate research. This book addresses diverse applications that continue to be major challenges for carbohydrate chemists. The book starts with a review of Gérard Descotes contribution to the field as a pioneer of French modern carbohydrate chemistry. Green nanocatalytic oxidation of free sugars, photosensitive glycomacrocycles, the application of disaccharides in supramolecular chemistry, recent advances in the radiation chemistry of polysaccharides, and the cell wall pectic rhamnogalacturonan II, an enigma in plant glycobiology are just some of the diverse topics presented in Volume 45. This set of reports will certainly benefit any researcher who wishes to learn about the latest developments in the carbohydrate field.

Implantable technologies allow for a sustained control over the release of pharmaceuticals into the bloodstream thereby achieving a controlled concentration with the potential to minimise side-effects while increasing patient compliance. Significant progress has been made in various alternative implantable delivery technologies, notably in intraocular and subcutaneous devices. Despite success in research and clinical studies, long-term clinical efficacy may be more limited and different aspects related to drug development and commercialization using these technologies are not well understood or practiced in the commercial setting. This book provides a comprehensive and cohesive picture of the latest in the field while also outlining the opportunities and challenges in implantable technology. Implantable Technologies: Pepties and Biologic Drug Development is an ideal reference for any postgraduate or researcher interested in utilising implantable technologies and novel routes of drug administration. The book will also be of interest to those involved in formulation and clinical application for a wide array of disease areas in addition to more established paradigms such as diabetes and pain management.

Drug repurposing is the development of existing drugs for new uses: given that 9 in 10 drugs that enter drug development are never marketed and therefore represent wasted effort, it is an attractive as well as inherently more efficient process. Three repurposed drugs can be brought to market for the same cost as one new chemical entity; and they can also be identified more quickly, an important benefit for patients whose diseases are progressing faster than therapeutic innovation. But repurposing also requires a fresh look at configuring pharmaceutical R&D, considering clinical, regulatory and patent issues much earlier than would otherwise be the case; a holistic gedanken experiment almost needs to be undertaken at the very start of any repurposing development. In addition to new ways of thinking, the discovery of repurposing opportunities can take advantage of artificial intelligence techniques to match the perfect new use for an existing drug. And while repurposing of medicines has been in the mind of every doctor since Hypocrates, modern clinical practice will simply have to adapt to new repurposing techniques in an age where the number of known diseases is increasing much faster than the healthcare dollars available.

Smart materials stimulated by chemical or by logical signals hold promise for many applications, including new sensors and actuators for medicine, environmental and process control. In contrast to other books on responsive materials which are restricted to sensing, this volume not only highlights fundamental chemical and physical principles but also focuses on the use of smart materials for applications such as drug delivery, wound healing, cell adhesion, tuneable vesicles, surface control, smart paints and glasses, separations, oil recovery and artificial muscles. In this completely updated and expanded edition, readers are introduced to the area with chapters reflecting the enormous expansion of the field in recent years. Different responsive material systems will be covered including hydrogels, membranes, thin layers, polymer brushes, chemomechanical and imprinted polymers, nanomaterials and silica particles. With contributions from internationally recognised experts, the book will appeal to graduate students and researchers in academia, healthcare and industry interested in functional materials and their applications.

Green chemistry has progressed from being a driver for change in the chemical and allied industries to being a critical part of chemical education at all levels. The future chemist must be able to practice their trade in the light of increasing concerns about waste and resources, the safety of chemicals in consumer products, and increasingly restrictive legislation. While there are green chemistry educational resources available including lectures and experiments as well as numerous books on green chemistry and major green chemical technologies, there is no “green equivalent” of a standard organic chemistry textbookSystematically covering a variety of well-known reactions that commonly feature in standard organic textbooks this book supplements and supports the standard organic chemistry texts. It highlights the main sustainability issues of classical and contemporary organic transformations and critically evaluates them within a metric of established Green Chemistry Principles noting where additional efforts are needed to improve their environmental footprint. Written by a team of expert authors with a multinational advisory board, this book is a fantastic resource for advanced undergraduate and postgraduate students worldwide.

Authored by leading experts in the enzymology of natural product biosynthesis, this completely revised and updated edition provides a description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500 000 – 600 000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism. This second edition integrates many new findings into the sets of principles of the first edition that parsed categories of natural product chemistries into the underlying enzymatic mechanisms and the catalytic machinery for building the varied and complex end product metabolites. New chapters include evaluation of a core set of thermodynamically activated but kinetically stable metabolites that power both primary and secondary metabolic pathways. Also, after decades of uncertainty about the existence of various pericyclase classes, a series of genome mining, heterologous expression, and enzymatic activity characterization have validated a plethora of pericyclases over the past decade. The several types of pericyclases are involved in biosynthetic complexity generation of almost every major category of natural products. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, pharmacognocists and chemical ecologists, and bioengineers and synthetic biologists.

The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life. Revised, extended, updated and lavishly illustrated, this 4th Edition of Nucleic Acids in Chemistry and Biology is a long-awaited standard text for teaching and research in nucleic acids science. It maintains the close integration of chemistry and biology that characterised the earlier editions and contains a major expansion largely focused on the burgeoning growth of RNA science. Written by an international team of leading experts, all with extensive teaching experience, this 4th Edition provides up-to-date and extended coverage of the reactions and interactions of RNA and DNA with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecule-based introduction to the structure and biological roles of DNA and RNA and the basics of Genes and Genomes. New key chapters are devoted to non-coding RNA, nucleic acids sequencing, nucleic acid therapeutics, in vitro evolution and aptamers, and protein-RNA interactions. The text is linked to an extensive list of references to make it a definitive reference source. This authoritative volume presents topics in an integrated manner and readable style with full colour illustrations throughout. It is ideal for graduate and undergraduate students of chemistry and biochemistry, biophysics and biotechnology, and molecular biology and medicine. It will be a guidebook for new researchers to the field of nucleic acids science.

Originally published in Portuguese, this book is divided into three sections: the chemistry of aldehydes, ketones, nitriles, imines and derivatives; the chemistry of carboxylic and carbonic acids and derivatives; and the chemistry of alpha, beta-unsaturated carbonyls. The authors have merged aspects of valence bond and molecular orbital theories in order to discuss structural and physico-chemical properties and reactivity and stereochemical outcomes of the most relevant reactions for these functional groups. The book provides representative experimental procedures for key reactions; highlights to contextualize the concepts; properties (industrial applications, biochemical significance and catalytic developments in order to cope with the major tenets of the green chemistry approach) and includes some biographical notes for the scientists who contributed to this field. It will help advanced level undergraduate and graduate students to understand and become well acquainted with the reactions of carbonyl compounds and derivatives. The integrated approach is considered an attractive feature of this book since students receive relatively little exposure to molecular orbital theory at the undergraduate level. The juxtaposition of conventional valence bond theory with molecular orbital theory fills a largely unmet pedagogical niche.

Perfluoroalkyl substances (PFAS) are a diverse group of human-made chemicals that are used in a wide range of consumer and industrial products. They are under intense scrutiny due to environmental concerns and there is a call to ban new PFASs entering the market. That said, this book is not intended to wave the banner against PFASs per se; rather it provides a balanced overview of the field, from basic synthesis through to applications, why some current PFASs are and may remain the right substance for the job, as well as addressing the challenges and alternatives.Covering organofluorine chemistry to fluoropolymers and their applications in various sectors from biomedical to agrochemical, energy and electrical industries, this book is a solid introduction to the topic and demonstrates why fluorinated products are still useful in many domains. With risk assessment and alternatives to PFASs included, it provides a considered account of both the positive applications of PFASs and the pressing environmental concerns.Suitable for academics and industrial practitioners working in the fields of organic and macromolecular chemistries, it will also appeal to end-users who want to learn about the technology, applications and elimination or recycling of such fluorinated products.

Recent years have seen huge growth in the area of sustainable chemistry. In order to meet the chemical needs of the global population whilst minimising impacts on health and the environment it is essential to keep reconsidering and improving synthetic processes. Sustainable Organic Synthesis is a comprehensive collection of contributions, provided by specialists in Green Chemistry, covering topics ranging from catalytic approaches to benign and alternative reaction media, and innovative and more efficient technologies.

The covalent conjugation of potent cytotoxic agents to monoclonal antibodies, known as antibody-drug conjugates (ADCs) is a powerful approach in the field of targeted treatment of cancer. Clearly, both monoclonal antibody and cytotoxic payload are crucial elements in determining the clinical value of an ADC and have receive ample attention. However, the structural element connecting the two –the chemical linker– also plays an essential role in mode-of-action, efficacy, pharmacokinetics and safety profile of an ADC, but is often underappreciated in considerations of ADC design.Chemical Linkers in Antibody–Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety. Ideal for postgraduate students and active researchers in drug discovery and development, this book provides a comprehensive description of linkers used in ADCs (clinical and late preclinical), insight into key quality attributes of linkers for ADCs, and aids the reader in understanding the role of linker chemistry and designing new ADCs.

Metal–organic frameworks (MOFs) are crystalline porous materials constructed from metal ions/clusters and organic linkers, combining the merits of both organic and inorganic components. Due to high porosity, rich functionalities, well-defined open channels and diverse structures, MOFs show great potentials in field such as gas storage and separation, catalysis, and sensing. Combining them with polymers tunes their chemical, mechanical, electrical and optical properties, and endows MOFs with processability. Covalent organic frameworks (COFs) are crystalline porous materials built from organic molecular units with diverse structures and applications. Hybrid materials with intriguing properties can be achieved by appropriate preparation methods and careful selection of MOFs/COFs and polymers, broadening their potential applications. This book documents the latest research progress in MOF/COF-polymer hybrid materials and reviews and summarises hybridization strategies to achieve MOF/COF polymeric composites. It also introduces various applications and potential applicable scenarios of hybrid MOF/COF polymers. Hybrid Metal–Organic Framework and Covalent Organic Framework Polymers offers an overview to readers who are new to this field, and will appeal to graduate students and researchers working on porous materials, polymers, hybrid materials, and supramolecular chemistry.

This annual review of the literature provides a comprehensive and critical survey of a vast field of study involving organophosphorus compounds, ranging from phosphines, their chalcogenide derivatives and phosphonium salts, phosphorus (III) acid derivatives, phosphorus (V) acids, penta- and hexa-coordinated phosphorus compounds, phosphazenes and related phosphorus-nitrogen bonded compounds. Coverage in applications as reagents in green synthetic procedures is also given. With an emphasis on interdisciplinary content, this book will appeal to the worldwide organic chemistry and engineering research communities.

Designed for teaching, this English translation of the tried and tested Organometallic Chemistry 2/e textbook from the Japan Society of Coordination Chemistry can be used as an introductory text for chemistry undergraduates and also provide a bridge to more advanced courses. The book is split into two parts, the first acts as a concise introduction to the field, explaining fundamental organometallic chemistry. The latter covers cutting edge theories and applications, suitable for further study. Beginning with fundamental reaction patterns concerning bonds between transition metals and carbon atoms, the authors show how these may be combined to achieve a desired reaction and/or construct a catalytic cycle. To understand the basics and make effective use of the knowledge, numerous practice questions and model answers to encourage the reader's deeper understanding are included. The advanced section covers the chemistry relating to bonds between transition metals and main group elements, such as Si, N, P, O and S, is described. This chemistry has some similarities to transition metal-carbon chemistry, but also many differences and unique aspects, which the book explains clearly. Organometallic complexes are now well known and widely used. In addition, transition metal complexes with main group element other than carbon as a ligating atom are becoming more important. It is thus important to have a bird's-eye view of transition metal complexes, regardless of the ligand type. This book acts as solid introduction for chemistry students and newcomers in various fields who need to deal with transition metal complexes.

Why are some plants so important to humans? The chemistry of the plants has a lot to do with it! The plant world offers a fascinating way to explore basic chemistry concepts. The spectacular variety of colors, fragrances and other characteristics of plants are driven by the seemingly subtle differences in the structure and properties of organic compounds. Well-known flowers, like daffodils and narcissus, are examples of plants that provide ample perfumes, pigments and poisons as part of their intricate and fascinating chemistry. This second edition retains it accessibility, expanding on the first edition and combining scientific concepts with colorful pictures and stories in simple, clear language. Readers will find introductory information on some chemistry and plant biology. This prepares them for the more complex chemical structures that compose plant substances, many of them of vital importance to humans. The final chapter has been expanded, in particular the sections on medicinal plants and on genetic modification. The end-of chapter references have been thoroughly updated with articles, books, and relevant websites that illustrate the topics discussed. Dr Margareta Sequin, an organic chemist and plant enthusiast, has taught popular undergraduate college level courses on plant chemistry to non-chemistry majors and has led numerous field seminars for the general public. The comments and questions from these audiences and the topics that especially captured people's interest have greatly shaped this book. The Chemistry of Plants addresses an audience with little previous chemistry knowledge, but will appeal to the expert reader looking for an understanding of more complex plant compounds. It can be used both as a text to introduce organic chemistry as it relates to plants and as a text of reference for more advanced readers.

There is an immense variety of research on polymer functionalized graphene (PFG). Functionalization of graphene is necessary for improvement of the compatibility with polymers. Applications of these graphene polymer hybrids include in chemical and biological sensing, photovoltaic devices, supercapacitors and batteries, dielectric materials and drug/gene delivery vehicles. This book will shed light on the synthesis, properties and applications of these new materials, covering two methods (covalent and noncovalent) for producing polymer functionalized graphene. Chapters cover physical, optical, mechanical and electronic properties, applications of polymer functionalized graphene in energy harvesting and storage, and uses in biomedicine and bioengineering. Written by an expert in the field, Polymer Functionalized Graphene will be of interest to graduate students and researchers in polymer chemistry and nanoscience.

This annual review of the literature, the 50th volume in the present series, provides a comprehensive and critical survey of a vast field of study involving organophosphorus compounds, ranging from phosphines, their chalcogenide derivatives and phosphonium salts, phosphorus (III) acid derivatives, phosphorus (V) acids, penta- and hexa-coordinated phosphorus compounds, phosphazenes and related phosphorus-nitrogen bonded compounds. Coverage is also presented of applications of organophosphorus compounds in homogeneous catalysis for synthesis of bulk and fine chemicals and also in applications as reagents in green synthetic procedures.

Functional, flexible and lightweight products are in high demand for modern technologies ranging from microelectronics to energy storage devices. The majority of polymers are thermal and electrical insulators, which hinder their use in these applications. The conductivity of polymers can be significantly enhanced by the incorporation of conducting inorganic nanoparticles. However, this relies not only on the structure and function of the inorganic particles, but is highly determined by the morphology and dispersion of the nanoparticles, interfacial interactions and fabrication technologies of the composites. This book highlights the synthesis, chemistry and applications of two-dimensional (2D) inorganic nanoplatelets in polymer nanocomposites. Chapters cover technical challenges, such as surface functionalisation, compatibilization, interfacial interaction, dispersion, and manufacturing technologies of the polymer nanocomposites. The book also discusses the applications of these polymer nanocomposites in electronics and energy storage. With contributions from global experts, the book provides a much-needed overview of the field, giving advanced undergraduates, postgraduates and other researchers with a convenient introduction to the topic.

Photochemistry is an important facet in the study of the origin of life and prebiotic chemistry. Solar photons are the unique source of the large amounts of energy likely required to initiate the organisation of matter to produce biological life. The Miller–Urey experiment simulated the conditions thought to be present on the early earth and supported the hypothesis that under such conditions complex organic compounds could be synthesised from simpler inorganic precursors. The experiment inspired many others, including the production of various alcohols, aldehydes and organic acids through UV-photolysis of water vapour with carbon monoxide. This book covers the photochemical aspects of the study of prebiotic and origin of life chemistry an ideal companion for postgraduates and researchers in prebiotic chemistry, photochemistry, photobiology, chemical biology and astrochemistry.

Nanoparticles can be synthesised via a number of methods, including chemical vapor deposition, ball milling, laser ablation, thermal decomposition and chemical reduction. Chemical reduction is usually preferred, due to its ease and cost-effectiveness. There are several types of compound used as reducing agents in nanoparticle synthesis, and one recent development is the use of biological entities as environmentally friendly reductants. This book will highlight the role of reducing agents in the chemical synthesis of nanoparticle systems, presenting the main categories of reducing agents, which vary on reactivity, selectivity, availability and toxicity. It will provide a comprehensive presentation of both modern and more conventional types of reagents. Emphasis will be given on the presentation not only of the functionality, but also of all the different advantages and limitations of each kind of reducing agent. With contributions from global experts, this title will be appropriate for graduate students and researchers in nanochemistry, colloidal synthesis, inorganic chemistry, organometallic chemistry, chemical engineering, physical chemistry, materials science, biology and physics.

CHEMISTRY STUDENT GUIDES. GUIDED BY STUDENTSWhy did the drug thalidomide cause birth defects? What is the chemical difference between sucrose and lactose in your food? Stereochemistry holds the answer and is essential to the understanding of the chemistry of life. Stereochemistry is an important concept that often causes confusion amongst students when they learn it for the first time. Unlike most other areas of chemistry, it requires the chemist to visualise molecules in 3D, which can be difficult. In this book we deal with tricky concepts like conformation and configuration, how to represent them accurately and how to use the correct terms to describe them in both organic and inorganic chemistry. We involved students in the writing process to ensure we deal with areas that you find difficult, in an understandable language. With problems designed to focus on common errors and misconceptions, real life examples, and practical hands-on exercises coupled with visualisation tips, our intention is to give you the tools to become confident in stererochemistry. Complementing mainstream organic textbooks, or self-study, this book is for anyone who has struggled with describing alkenes as E or Z, assigning R and S absolute configurations, drawing Newman projections or chair representations of cyclohexanes, axial chirality, understanding the stereochemistry of octahedral metal complexes and indeed explaining complexities observed in NMR spectra. Chemistry Student Guides are written with current students involved at every stage, guiding the books towards the most challenging aspects of the topic. Student co-authors for Introduction to Stereochemistry are Caroline Akamune, Michael Lloyd and Matthew Taylor.

New antiviral drugs are urgently needed. Recent outbreaks caused by viruses with great epidemiological impact such as Zika, or extraordinary virulence such as Ebola, Nipah, Lassa, Crimean-Congo haemorrhagic fever highlight the current lack of clinically proven vaccines and treatments for these potentially catastrophic agents. Antiviral Discovery for Highly Pathogenic Emerging Viruses comprehensively outlines the state of the art in antiviral drug discovery including identification of targets, screening strategies and the current pipeline of antiviral candidates including regulatory issues. The book also addresses the challenges faced in proceeding from pre-clinical studies to animal models and clinical trials with these highly pathogenic agents. Ideal for drug discovery scientists and medicinal chemists with an interest in antiviral drug discovery and development, this book provides a complete overview of the latest progress in the field, recent advances and the challenges that remain in developing these highly pathogenic agents. Illustrated throughout with case studies this book is a valuable resource in this complex and multidisciplinary field.

All-carbon composites are carbon materials reinforced with other carbon materials, typically nanostructures such as carbon nanofibers or nanotubes. There are a large number of all-carbon materials, many of which demonstrate unique and useful sets of properties. Combining and hybridising different carbon materials and nanomaterials together also opens up a number of possibilities to fine-tune the materials for desirable combinations of these properties. All-carbon Composites and Hybrids provides a broad overview of these materials including discussions of synthesis, characterisation and the applications of a wide variety of all-carbon composite materials. This will be a useful volume for any researchers interested in carbon and nanotechnology.

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.

Porphyrin-based Supramolecular Architectures focuses on the most recent developments in the field, emphasizing the cutting-edge research in a diverse range of applications. Designed for readers considering the unprecedented prosperity of porous materials research, chapters will cover both strategies for structure design (such as MOFs and COFs) as well as emerging applications including CO2 fixation, catalysis and photodynamic therapy. With contributions from global experts, this title will be of interest to graduate students and researchers in supramolecular chemistry, organic chemistry, inorganic chemistry, physical chemistry, organometallic chemistry, solid-state chemistry, catalysis and (porous) materials science.

Nitroxides are versatile small organic molecules possessing a stabilised free radical. With their unpaired electron spin they display a unique reactivity towards various environmental factors, enabling a diverse range of applications. They have uses as synthetic tools, such as catalysts or building blocks; imaging agents and probes in biomedicine and materials science; for medicinal antioxidant applications; and in energy storage. Polynitroxides (polymers bearing pendant nitroxide sidechains) have been used in organic radical batteries, oxidation catalysts and in exchange reactions for constructing complex architectures. Chapters in this book cover the synthesis of nitroxides, EPR studies and magnetic resonance applications, physiochemical studies, and applications including in batteries, imaging and organic synthesis. With contributions from leaders in the field, Nitroxides will be of interest to graduate students and researchers across chemistry, physics, biology and materials science.