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Computational methods and understanding computational models are important in modern drug discovery. The book focuses on computational approaches that can improve the development of in silico methodologies. It includes lead hit methods, docking algorithms, computational chiral compounds, structure-based drug design, GROMACS and NAMD, structural genomics, toxicity prediction, enzyme inhibitors and peptidomimetic therapeutics

This new volume provides comprehensive coverage of the family Rutaceae, emphasizing its diverse phytochemistry and medicinal uses.The volume provides an introduction to the family Rutaceae and then goes on to delineate its phytochemical and pharmacological properties and uses. Also addressed are the nutritional, clinical, and toxicological profiles of the family Rutaceae, elaborating on the nutritional value of Rutaceae plants, their healthcare and clinical applications, and their possible toxic side effects.This volume provides an information overview of the Rutaceae family, which comprises numerous ornamental as well as economically significant fruit-bearing trees with significant phytochemistry and medicinal uses that are important for new drug discovery for pharmaceutical industries. The chapters may also direct researchers to isolate/extract pure compounds from Family Rutaceae for new and novel drug discoveries.

The book in hand, namely “Metal and Metal-Oxide Based Nanomaterials (Synthesis, Agricultural, Biomedical and Environmental Interventions”, focuses on the synthesis methods, characterization techniques, and diverse interventions utilizing these nanomaterials in the fields of agriculture, biomedicine, and environmental remediation. The specific applications discussed include food packaging, post-harvest disease management, crop production, drug delivery systems, other biomedical applications, photocatalytic degradation of environmental pollutants, and wastewater treatment. Additionally, it also addresses the potential risks associated with zinc nanoparticles in aquatic ecosystems and emphasizes the importance of further research and regulation in this field. Overall, the book provides valuable insights and serves as a comprehensive resource for researchers and scientists across various interdisciplinary subjects. It serves as a valuable resource for scientists, researchers, and students in nanotechnology, nanomedicine, environmental science, plant science, agriculture, chemistry, biotechnology, pharmacognosy, pharmaceuticals, industrial chemistry, and other interdisciplinary subjects. Moreover, this also inspires further research, innovation, and the development of sustainable solutions for a better future.

The book presents a comprehensive overview of the historical, current, and prospective application realms of nanobiotechnological research pertaining to graphene, a carbon-based nanomaterial, and its diverse forms in the fields of food and agriculture, as well as health sciences and technology. Young nanotechnologists and businesses will have access to nanobioanalytical methods. Given the present circumstances, it is crucial to underscore the potential ramifications that diverse forms of graphene nanomaterials could have on the food sector, agricultural methodologies, and healthcare. This book presents an analysis of the potential advantages of graphene-based nanomaterials over traditional materials in the food, agriculture, and health care sectors.This book employs case studies, academic and theoretical literature, technology transfer, innovation, economics, and policy management to underscore the intricate issues associated with graphene nanomaterials. The pioneering text Graphene-Based Nanomaterials: Application in Food, Agriculture, and Healthcare has the potential to serve as a valuable resource for interdisciplinary researchers, academics, practitioners, policymakers, and professionals operating within the fields of science, technology, engineering, innovation, management, and economics.Features· Discusses the different aspects of graphene as a two-dimensional material and its underlying unique physicochemical properties, synthesis methods, and protocols.· Considers the implications of graphene in the food sciences and its different spoilage detection mechanisms have been encompassed in the book.· Explores graphene nanomaterials'medical and biomedical uses. With examples, the unique and tailor-made material's uses and prospects in health sciences, pharmaceutics, and biomedical research are highlighted.· Elaborates on graphene's applications in agriculture and briefs the potential of biocompatible planar conductive nanoscale materials to boost agri-product production, crop development, and crop-infection surveillance.

Comprehensive Chirality, Second Edition is the definitive ten-volume reference, offering a thorough exploration of chiral research and application. This extensively updated edition features 121 new chapters and 70 revised ones, focusing on the latest advancements in chiral research across synthesis, catalysis, analytical chemistry, and bioactive compound synthesis. Edited by a world-class editorial board, with contributions from leading experts, Comprehensive Chirality, Second Edition bridges theoretical principles with practical applications, making it an invaluable resource for advanced students, researchers, and professionals. Key highlights include:- Innovative Reactions and Methods: advanced diastereo- and enantioselective techniques for controlling stereogenic centers in complex natural products and pharmaceuticals.- Chiral Auxiliaries and Modern Reagents: transformative uses of chiral auxiliaries and cutting-edge reagents such as hypervalent iodide.- Catalytic Methodologies: comprehensive coverage of C-C bond formation, emphasizing transition metals, biocatalysis, and multicatalysis.- Asymmetric Photochemistry: light-induced asymmetric transformations.- Olefin Functionalization and Cycloaddition: asymmetric oxidation and reduction methods.- Biocatalysis and Enzyme Engineering: in-depth analysis of enzyme design and engineering as powerful synthesis catalysts.- Industrial Applications: practical insights into asymmetric synthesis for industrial applications, illustrated through recent case studies.- Spectroscopic Techniques: updated spectroscopic methods for separating and analyzing enantiomers. - Unites different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts - Includes different areas of research and deep foundational reviews - Helps users apply context to diverse journal literature, aiding them in identifying areas for further research and/or for solving problems - Serves as a valuable, critical tool for instructors, practicing experimentalists, and students of the field, as well as those curious to gain appreciation of the chirality landscape and its vast expanse

Explore the comprehensive landscape of polymer membrane applications in this book, encompassing gas separation, organic solvent nanofiltration, water desalination, and fuel cells. The text delves into the subtle influence of polymer membranes on energy efficiency across diverse industries, spotlighting advanced variants such as bio-based, mixed matrix, and polyimides-based membranes. Offering an in-depth analysis, the book elucidates the discovery, development, and challenges associated with these state-of-the-art materials, underscoring their role in achieving enhanced performance and energy efficiency.

This book presents a complete study of natural orbitals in quantum impurity problems, revealing a certain simplicity in these interacting many-body problems. These systems consist of a few localized degrees of freedom that undergo strong interactions and hybridize with a larger system of free particles; they are central in the study of strongly correlated systems. In a first step, the standard non-perturbative numerical renormalization group method is employed to demonstrate the hierarchical structure of correlations unveiled by natural orbitals. This simplification brought new insights for simulating quantum impurity problems, and a new algorithm is developed to generate an optimized subset of natural orbitals independently of existing methods, going beyond their usual limitations. This algorithm is presented in detail in the book, and a careful benchmark on known results is carried out to guarantee the validity of the method. It is then used to study spatial entanglement structures under various conditions that were not accessible with previous methods, such as representing the electron bath by a realistic 2D square lattice or taking account of static disorder in the metallic host. In the last chapter, the non-interacting problem in the presence of disorder is studied through random matrix theory, reproducing some of the results presented in the previous chapters. The main original result of this chapter lies in the analytical calculation of the joint distribution of one-particle orbitals energies and amplitudes of the impurity, which makes it possible to calculate any disordered averaged local correlation functions. Starting from this result, calculations in the large-N limit are compared with numerical simulations.

This volume outlines the physical and methodical concepts of X-ray photoelectron spectroscopy (XPS) specifically for surface studies using both inner and valence electron levels. It discusses the theory and practice of XPS qualitative and quantitative analysis of solid state surfaces and provides lists of extended experimental and theoretical data necessary for the determination of concentration and thin film thicknesses. In addition it covers the many problems concerning in-depth profiling, ion sputtering rate and damages of the structure of altered layers, as well as applications of angular dependence of the intensities and photoelectron diffraction for surface studies. Also provided are the applications of XPS for the investigations of catalysts, adsorption, electronic surface states, oxydation of semi-conductors and alloys, minerals, including lunar regolith and natural gold, glasses, radiation damage, surface diffusion, polymers, etc.

Specific topics include: eco-friendly products green catalysts ionic liquids supercritical fluids green solvents photo-Fenton reaction photocatalysis sonochemistry microwave-assisted organic synthesis ultrasound-assisted reactions green composites green manufacturing processes

Volume 24, entitled Targeted Metallo-Drugs: Design, Development, and Modes of Action, of the series Metal Ions in Life Sciences (MILS), fosters inter-disciplinary research in the vibrant field of Biological Inorganic Chemistry. Inspired by the clinical success of cisplatin as a leading anticancer drug but mindful of the shortcomings associated with its use including dose-limiting toxic side effects and acquired or intrinsic drug resistance, scientists across the globe have been endeavoring to identify new metallo-drugs for therapeutic exploitation. This has led to innovative metallo-drug candidates that (i) enhance cancer cell selectivity, thus reducing toxic side effects, and/or (ii) possess new modes of action to improve efficacy and also target resistance pathways. This and more are captured in MILS- 24 which consists of 12 comprehensive, well-illustrated, and up to date chapters with over 1600 citations, 100 figures, and 10 tables with key contributions from 32 international experts from Europe, Asia, and North and South America. MILS- 24 not only keeps the scientific community abreast of latest developments, it also serves as an invaluable resource to stimulate further research on targeted metallo-drug design and development. It covers anticancer, antimicrobial, antiviral, and other agents, such as those targeting tropical diseases and cyanide poisoning and radiometals in molecular imaging and therapy It highlights recent metallo-drug developments targeting COVID-19 It features advanced spectroscopic methods and metallomics as important tools to elucidate the modes of actions of metallo-drugs

This book offers a comprehensive overview of the environmental challenges posed by emerging pollutants and the innovative strategies available for their management. Divided into 16 chapters, the book begins with an introduction to the origin and management of both inorganic and organic contaminants, offering a detailed examination of their sources and the potential risks they pose to ecosystems. It also explores current regulations and management practices aimed at mitigating their impact. In the following chapters, experts in the field cover topics such as conventional wastewater treatment methods for the removal of emerging pollutants, biotechnology-based strategies for the removal of emerging contaminants, microbial electro-deionization technologies, and algae-based bioremediation. Particular attention is given to specific remediation techniques, including phytomediated approaches, microbial fuel cells, and the novel application of microbial endophytes. Furthermore, the book explores the potential of nano-bioremediation and enzyme immobilization technologies, shedding light on their mechanism of interaction with nanomaterials and microbes for efficient treatment. Other chapters highlight the role of graphene-based nanocomposites, bio-based porous materials, and biosurfactants in the remediation of emerging pollutants, showcasing their unique capabilities and potential applications. In the final chapter of the book, readers will discover more about the impacts of emerging pollutants on environmental microbial communities and the consequential public health concerns that arise from their presence. Given its breadth, this book is a valuable resource for environmental scientists, policymakers, and industry professionals seeking to mitigate the ecological risks associated with these contaminants.

The book Organic Light Emitting Diode (OLED) Toward Smart Lighting and Displays Technologies, edited by Laxman Singh, Rituraj Dubey, and Prof. R. N. Rai, strives to address the multiple aspects of OLEDs and their applications in developing smart lightings and displays. OLEDs have been used in almost all kinds of digital displays like those of mobile phones, laptops, tablets, phablets, TVs, etc., due to their outstanding features, including superior color quality, low cost, wide viewing angle, easy fabrication, mercury-free manufacture, tenability, stretchability, flexibility, etc. Investigations related to the synthesis of new organic materials and fabrication techniques have inspired us to write this book, which will fulfil the desire and thirst of OLEDs-based researchers.Features Nanolithographic techniques used and the challenges involved Printing technology for fabrication Designing of hybrid perovskites Stretchable and flexible materials used Metal–dielectric composites and efficiency of organic semiconductor via molecular doping for OLEDs applications Organic small molecule materials and display technologies involved New generation of organic materials with respect to photophysical approach Mixed valence π-conjugated coordination polymers used Electroluminescent polymer used Blue fluorescent and phosphorescent organic materials used In comparison to other books available related to similar topics, this book aims at those audiences who are looking for a single source for a comprehensive understanding of strategies and their challenges with respect to material fabrication of OLEDs. This book covers the pace and productivity at a uniform level in each chapter with respect to the audiences, from doctoral student to postdoctoral researchers or from postdoctoral researchers to multidisciplinary field researchers with a background in physics, chemistry, materials science, and engineering, who are already working with organic materials and their applications.

This comprehensive volume provides current, state-of-the-art information on specialty polymers that can be used for many advanced applications. The book covers the fundamentals of specialty polymers, synthetic approaches, and chemistries to modify their properties to meet the requirements for special applications, along with current challenges and prospects. Chapters are written by global experts, making this a suitable textbook for students and a one-stop resource for researchers and industry professionals. Key Features: - Presents synthesis, characterization, and applications of specialty polymers for advanced applications. - Provides fundamentals and requirements for polymers to be used in many advanced and emerging areas. - Details novel methods and advanced technologies used in polymer industries. - Covers the state-of-the-art progress on specialty polymers for a range of advanced applications.

This book covers the morphological characteristics, ethnopharmacological properties, isolated and identified structurally diverse secondary metabolites, biological and pharmacological activities of medicinal plants. Ethnopharmacology is the systematic study of folklore/traditional medicines, which continue to provide innovative drugs and lead molecules for the pharmaceutical industry. In fact, plant secondary metabolites, used as a single molecule or as a mixture, are medicines that can be effective and safe even when synthetic drugs fail. Therefore, the description of these secondary metabolites as well as methods for the targeted expression and/or purification is of high interest.In addition to surveying the morphological features, ethnopharmacological properties, biological and pharmacological activities, and studies of clinical trials, this book offers a comprehensive treatment of 56 plant species. It also presents the cell culture conditions and various methods used for increasing the production of medicinally important secondary metabolites in plant cell cultures.This volume: Provides the morphological features, habitat, and distribution of each species of 56 genera selected from the different regions of the world. Presents ethnopharmacological applications of various species of the 56 genera in this book. Different species of 56 genera are used for ethnomedicinal uses by the people of various countries of the world. Describes structures of various secondary metabolites identified in 56 plant species together with their biological and pharmacological activities. Discusses strategies of secondary metabolites production, such as organ culture, pH, elicitation, hairy root cultures, light, and mutagenesis. Provides a complete overview of each species of 56 genera and the complete information up to 2022. Ethnopharmacological Properties, Biological Activity and Phytochemical Attributes of Medicinal Plants is an important book for undergraduate and postgraduate students, pharmacologists, phytochemists, Ayurvedic practitioners, medical doctors, and biotechnologists interested in the ethnopharmacological properties, phytochemistry, biological, and pharmacological activities of plants.

Advances in Carbohydrate Chemistry and Biochemistry, Volume 83, the latest release in a serial that highlights new advances in the field, includes a variety of highly sourced chapters written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Advances in Carbohydrate Chemistry and Biochemistry serials - Edited by leading scientists in the field

Microbial enzymes are important because they can be used for a wide variety of industrial purposes. There is dispersed and scanty information available with respect to microbial enzymes and their industrial applications. In this edited book, leading scientists have covered the various aspects of microbial enzymes and their industrial applications. Using microbial enzymes can help expedite various manufacturing processes and contribute to sustainable development, which is a priority worldwide. Research gaps in the entrainment of microbial enzymes with their direct application in product development are a major focus of this volume.Key Features• Covers microbial enzymes with comprehensive and in-depth information• Benefits students by describing recent advancements into microbial enzymology• Provides updates regarding microbial enzymes for researchers and industrial scientists• Includes findings on the microbial actions for better life

This book, as part of the “Natural Products Chemistry of Global Plants” series, describes in detail the health-promoting wild edible and medicinal mushrooms specific to the Himalayas region. The focus of the book is to draw on the rich culture, folklore, and environment of the Upper Himalayas, which represents a scientifically significant region. The Himalayas has rich plant resources and a large diversity of plants and mushrooms, which can provide important health benefits as detailed throughout the text. Drawing attention to these mushrooms with detailed scientific descriptions may help in the awareness and in developing sustainable growth of these important resources.Features Provides an opportunity to describe the wild edible and medicinal mushrooms from this scientifically significant region. Represents a wider variety of mushrooms than previously published in other books. Presents more content related to traditional uses, phytochemistry, pharmacology, distribution, processing, toxicology, conservation, and future prospective of individual mushrooms. The plants and mushrooms of the region are valuable resources not only to local populations but to those living outside the region. Scientists are monitoring the rich Himalayan plant resources and the consequences of climate change on this precarious ecosystem.

This book details the advances in drug discovery and delivery and the present need for emerging technologies. Throughout the text new micro and nanofabrication techniques are described, including methods such as electrohydrodynamic processes, additive manufacturing, and microfluidics, which have the potential to produce drug delivery systems that were not possible a few years ago. This book is of great use to both entry-level and experienced researchers in the field of emerging technologies for the manufacturing of drug delivery devices.Features: Describes technologies that are significantly enhancing the delivery of drugs and biologics Presents new data on mobile and wearable point-of-care testing systems Features hot topics such as electrospinning, 3D printing and micro-needles Focuses on additive manufacturing (AM) which can be used to provide customized treatment for patients Will appeal to experienced researchers and those considering entering the field of emerging technologies for the manufacturing of drug delivery devises

Electrospinning is a versatile method to synthesize fiber materials. Electrospun Nanofibres: Materials, Methods, and Applications explores the technical aspects of electrospinning methods used to derive a wide range of functional fiber materials and their applications in various technical sectors. As electrospinning is a process that can be modified strategically to achieve different fibers of interest, this book covers the wide spectrum of electrospinning methodologies, such as coaxial, triaxial, emulsion, suspension, electrolyte and gas-assisted spinning processes. It: Discusses a broad range of materials, including synthetic polymers, biodegradable polymers, metals and their oxides, hybrid materials, nonpolymers, and more Reviews different electrospinning methods and combined technologies Describes process-related parameters and their influence on material properties and performance Examines modeling of the electrospinning process Highlights applications across different industries This book is aimed at researchers, professionals, and advanced students in materials science and engineering.

Advances in Heterocyclic Chemistry, Volume 140 is the latest release in this definitive series in the field of heterocyclic chemistry, one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Chapters in this new release include The chemistry of citrazinic acid (2,6-dihydroxyisonicotinic acid), Aza-Diels-Alder Reaction in the Synthesis of Tetrahyroquinoline Structures, and more. Additional chapters delve into Recent Developments in the Synthesis of 4-, 5-, 6- and 7-Azaindoles, Fluoroheterocycle formation using fluoroalkynes and their synthetic equivalents, Advances in applications of dihydropyridines in organic chemistry, and Recent Developments in the Chemistry of Triphyrins (2.1.1). - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds

The modernization of science and technology using nanomaterials will open a new paradigm to meet the increasing energy demand. This book provides an in-depth understanding of theoretical perspectives from molecular and atomic levels. The modern analytical techniques explored provide an understanding of the interactions of particles at interfaces. This book gives a holistic view of materials synthesis, analysis, application, and safe handling.

This book, as the fourth volume, continues on ultra-high temperature materials with melting (sublimation or decomposition) points around or over 2500 °C. In this quality the book has over-branched cross-links with the sections and tables of the previous Volumes I-III. Similarly to Volumes I-III, the book includes a thorough treatment of the physical and chemical properties of ultra-high temperature materials, namely such as W semi- and monocarbides, and continues the description of refractory carbides, which was begun from Volume II of the series.The book will be of interest to researchers, engineers, postgraduate, graduate and undergraduate students alike. The readers are provided with the full qualitative and quantitative assessment, which is based on the latest updates in the field of fundamental physics and chemistry, nanotechnology, materials science, design and engineering.

Plant-based drugs play an important role in all cultures and have been crucial in maintaining health and fighting diseases, and by using contemporary methods of biotechnology, plants with explicit chemical compositions are propagated and genetically upgraded for the mining of pharmaceuticals. Phytopharmaceuticals and Biotechnology of Herbal Plants presents the latest advances in the development of transgenic plants, covering phototherapeutics, secondary metabolite production, metabolomics, metabolic engineering, bioinformatics, quality control of herbal plant products, crop improvement using various breeding techniques, tissue culture techniques, and the future of phytopharmaceuticals.Features: Describes developments and applications of phytopharmaceuticals of herbal plants. Highlights the importance of phytopharmaceutical of plants and potential applications in the food and pharma industries. Provides an overview of research on key anticancer drugs to elucidate the biotechnological approaches for their production in cell cultures. Places special emphasis on the biosynthetic pathway mapping and metabolic engineering. Phytopharmaceuticals and Biotechnology of Herbal Plants will be an invaluable resource to academics and researchers associated with plant science, herbal drug manufacturers, and phytochemists.

Diverse Quasiparticle Properties of Emerging Materials: First-Principles Simulations thoroughly explores the rich and unique quasiparticle properties of emergent materials through a VASP-based theoretical framework. Evaluations and analyses are conducted on the crystal symmetries, electronic energy spectra/wave functions, spatial charge densities, van Hove singularities, magnetic moments, spin configurations, optical absorption structures with/without excitonic effects, quantum transports, and atomic coherent oscillations.Key Features Illustrates various quasiparticle phenomena, mainly covering orbital hybridizations and spin-up/spin-down configurations Mainly focuses on electrons and holes, in which their methods and techniques could be generalized to other quasiparticles, such as phonons and photons Considers such emerging materials as zigzag nanotubes, nanoribbons, germanene, plumbene, bismuth chalcogenide insulators Includes a section on applications of these materials This book is aimed at professionals and researchers in materials science, physics, and physical chemistry, as well as upper-level students in these fields.

Advances in Heterocyclic Chemistry, Volume 138, the latest release in this definitive series on the field of heterocyclic chemistry, combines descriptive synthetic chemistry and mechanistic insights to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. Topics in this new release include The Paal Knorr reaction in Heterocyclic Chemistry, Synthesis and Applications of Heterocyclic Sulfoximines, Recent advances in the synthesis of 4H-chromen-4-ones (2012-2021), Recent Developments in the Chemistry of Heteroporphyrins and Heterocarbaporphyrins, The Chemistry of 1,4-Dihydropyrrolo[3,2-b]pyrroles, and more. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds

The research and development activities in energy conversion and storage are playing a significant role in our daily lives owing to the rising interest in clean energy technologies to alleviate the fossil-fuel crisis. Polymers are used in energy conversion and storage technology due to their low-cost, softness, ductility and flexibility compared to carbon and inorganic materials. Polymers in Energy Conversion and Storage provides in-depth literature on the applicability of polymers in energy conversion and storage, history and progress, fabrication techniques, and potential applications.Highly accomplished experts review current and potential applications including hydrogen production, solar cells, photovoltaics, water splitting, fuel cells, supercapacitors and batteries. Chapters address the history and progress, fabrication techniques, and many applications within a framework of basic studies, novel research, and energy applications.Additional Features Include: Explores all types of energy applications based on polymers and its composites Provides an introduction and essential concepts tailored for the industrial and research community Details historical developments in the use of polymers in energy applications Discusses the advantages of polymers as electrolytes in batteries and fuel cells This book is an invaluable guide for students, professors, scientists and R&D industrial experts working in the field.

Smart Nanodevices for Point-of-Care Applications examines the latest trends on the capabilities of nanomaterials for point-of-care (PoC) diagnostics and explains how these materials can help to strengthen, miniaturize, and improve the quality of diagnostic devices. A thorough explanation of all-in-one nanosmart devices is included, incorporating all of the applications and fundamentals of these smart devices. This book provides practical information on the following: novel and effective smart materials, better-quality health management, effective management of a disease, potential point-of-care devices, and mobile nanosensors.Additional Features Includes in-depth research based collation of the latest trends of smart devices Provides practical information on all-in-one nanosmart devices Explains how nanomaterials can help to strengthen and improve the quality of diagnostic devices Emphasizes the development of smart nanodevices, especially the miniaturization aspect

This book focuses on recent advances in dental gold alloys and gold nanoparticles (GNPs) for biomedical applications. Dental gold alloys combine several highly desirable mechanical properties, such as high strength, ductility, and elasticity, with an extremely robust chemical stability in the mouth. Moreover, astonishing progress has been made in the use of GNPs as novel gold biomaterials that provide a multifunctional platform for cellular imaging, biosensing, and targeted drug delivery in tumour immunotherapy and photothermal therapy. Beginning with a comprehensive overview of the development and use of dental gold alloys, the book addresses the materials properties that are crucial for dental applications, focusing on aspects such as microstructure, chemical and mechanical stability, ageing, biocompatibility, and colour retention. The book then shifts focus to the use of GNPs in dental applications, delving into different techniques of GNP synthesis for specifically tailoring the size, shape, and stability of GNPs in biological media. In addition to these factors, it addresses how their exposure route, surface chemistry, as well as how the steric effects of their coating impact biodistribution and determine the level of GNP toxicity in the human body. Featuring topical literature reviews alongside up-to-date published experimental results, this book offers an attractive resource for practicing scientists and engineers working in the field of gold-based biomaterials.

Volume 23, entitled Molecular Bio-Sensors and the Role of Metal Ions, of the series Metal Ions in Life Sciences (MILS) represents a milestone of contemporary progress and understanding of molecular bio-sensors for metal ions. It is bringing together the latest research in academia and industry, and it also emphasizes the spectrum of evolving regulations from regulatory bodies. This vibrant research area is covered by 31 internationally recognized experts. The impact of MILS-23 is manifested by more than 1300 references and close to 200 figures, more than 100 of them in color; further information is summarized in several tables. In conclusion, Volume 23 significantly advances our understanding of Molecular Bio-Sensors, it is therefore an essential resource for scientists working in the wide range from earth sciences, material sciences, physics, pharmacology, enzymology, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic. • It provides an understanding of the roles that metals play in living systems. • It offers an insight for the demands needed in the clinic. • It reveals the interplay between bio-sensors and therapies. The Series METAL IONS IN LIFE SCIENCES increases our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of Biological Inorganic Chemistry and coordinate the efforts of researchers in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, toxicology, environmental chemistry, biophysics, pharmacy, and medicine. The volumes deal with the formation, stability, structure, and reactivity of metal-containing biological compounds of low and high molecular weight. The metabolism and transport of metal ions and their complexes as well as new models of complicated natural structures and processes are in the focus. Consequently, the volumes are an essential source for researchers in the mentioned fields as well as for teachers preparing courses, e.g., in Bioinorganic Chemistry.

Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists'education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Special Volume in Memory of Hidetoshi Yamada, Part Two, Volume 82 in the Advances in Carbohydrate Chemistry and Biochemistry series, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors. Updates in this new release include Automated and/or Electrochemical Synthesis, In Vivo Chemistry, Pseudo-Glycoconjugates with C-Glycoside linkage, Boron-Mediated Aglycon Delivery (BMAD) for the Stereoselective Synthesis of 1,2-cis Glycosides, and Conformationally Restricted Donors for Stereoselective Glycosylation. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Carbohydrate Chemistry and Biochemistry serial - Updated release includes the latest information on the serial

Clean environment and green energy are the basic requirements of a sustainable human life. Semiconductor materials play a crucial role in addressing the issues related to increased global energy demand and environmental remediation. The development of photocatalysts has experienced almost exponential progress since their popularization in the early 1970s. Therefore, researchers have started to consider the diversity of photocatalysts globally by approaching this domain from a materials science perspective for applications in various areas. Recently, heterojunction photocatalytic materials have attracted a great amount of multidisciplinary research to face the global concerns of energy production and environmental protection. The unique potential of these technologies has been the stimulus to develop heterojunction photocatalysts with improved structural, morphological, and electronic properties, effectively increasing their efficiency. This book overviews the latest advances in this field, offering insights into the materials and applications of the latest generation of photocatalytic materials. It presents the challenges, future directions, and strategies for design within the area of heterojunction photocatalysts and will be a useful resource to enhance understanding of students, researchers, and academicians for promoting research in this field.

This book focus on COVID-19 topics, with emphasis on metabolomics and diagnosis. The chapters cover the chemical science for prevention and understanding outbreaks of infectious diseases. This book compiles the most widespread methodologies of application of quality statistical tools added to the evaluation of diagnostic tests for detection of SARS-CoV-2, metabolic behavior of COVID infection severity, and trends in rapid test for COVID-19.

Germanium (Ge) is a lustrous, hard-brittle, grayish-white chemical element with applications in electronic devices and fluorescent lamps, among others. This volume includes four chapters that cover germanium from a variety of perspectives. Chapter One presents recent studies and developments in hydrometallurgical extraction of Ge from base metals production waste. Chapter Two reviews the current knowledge of high-k gate oxides based on Ge semiconductor substrate. Chapter Three focuses on the biocoordination chemistry of Ge and the role Ge plays in the human body. Lastly, Chapter Four presents a dual material Fin Field Effect Transistor structure using Ge as channel material.

Comprehensive Heterocyclic Chemistry IV provides a first point of entry for scientists interested in heterocyclic ring systems. Given the rapid expansion of publications in this field, this compilation of definitive reviews is especially important and invaluable. Written by leading scientists who have evaluated and summarized the most important data published over the last decade, this book is an invaluable addition to the reference library of anyone working with heterocyclic ring systems. Spanning 14 volumes, over 13,000 pages, and 240 chapters, this new edition builds on, and complements, the material in previous editions. This comprehensive resource is designed to be used both as a standalone resource and in conjunction with earlier works. Comprehensive – CHEC IV offers a comprehensive review of current heterocycles research and critical insight into the future direction of the field with an emphasis on useful and reliable synthesis and reactions, negating the need for individual searches in the primary literature and across various databases Reputation – This 4th edition matches the impressive reputation of the previous editions as the go-to foundational reference in heterocyclic chemistry Clearly structured - Meticulously organized, articles are split into 14 sections on key topics and clearly cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily Interdisciplinary - chapters written by academics and practitioners from various fields and regions ensures that the knowledge within is easily understood by and applicable to a large audience

One of the biggest questions in today's biochemistry is how biological molecules became essential for the processes that occur within living cells. This new book from outstanding Metal Ions in Life Science series gives an overview about biochemical evolution of organic molecules and metabolic pathways in living systems and outlines the vital biochemical processes in microbial cells in which metals are involved.

Advances in Carbohydrate Chemistry and Biochemistry, Volume 79 highlights new advances in the field, with this new volume presenting interesting chapters on a range of topics, including Vinyl Sulfone-Modified Carbohydrates: Michael Acceptors and 2p Partners for the Synthesis of Functionalized Sugars, Enantiomerically Pure Carbocycles and Heterocycles and a Biographical Memoire for Leslie Hough. - Features contributions from leading authorities and industry experts who specialize in carbohydrate chemistry, biochemistry and research - Integrates the industrial, analytical and technological aspects of biochemistry, organic chemistry and instrumentation methodology in the study of carbohydrates - Informs and updates on all the latest developments in the field

Chiral Organic Pollutants introduces readers to the growing challenges of chirality in synthetic chemicals. In this volume, contributors brilliantly summarize the characteristics of chiral pollutants to provide tools and techniques for effectively assessing their environmental and human health risks. Chapters cover recent research on the physicochemical properties, sources, exposure pathways, environmental fate, toxicity, and enantioselective analysis of chiral organic pollutants. Chiral Organic Pollutants also provides comprehensive discussions on the current trends in the synthesis and legislation of chiral chemicals.Key Features: Includes sampling and analytical methods for the enantioselective analysis of a wide array of chiral organic pollutants in food and the environment Summarizes recent research on the sources, fate, transport, and toxicity of chiral organic pollutants in the environment Critically examines the sources and pathways of chiral organic pollutants such as pesticides, pharmaceuticals, and flame retardants in food Includes a comprehensive discussion on current trends in the enantioselective synthesis and chiral switching of pesticides and pharmaceuticals Provides analysis of current national and international regulations of chiral synthetic chemicals The use of chiral synthetic chemicals such as pesticides, pharmaceuticals, personal care products, and halogenated flame retardants has significantly grown in the past 60 years. Hence, understanding the human and environmental health effects of chiral organic pollutants is crucial in the industry, academia, and policymaking. Chiral Organic Pollutants is an excellent textbook and reference for students, scientists, engineers, and policymakers interested in food quality, environmental pollution, chemical analysis, organic synthesis, and toxicology.Also available in the Food Analysis and Properties Series:Analysis of Nanoplastics and Microplastics in Food, edited by Leo. M.L. Nollet and Khwaja Salahuddin Siddiqi (ISBN: 9781138600188)Proteomics for Food Authentication, edited by Leo M.L. Nollet, and Semih Ötleş (ISBN: 9780367205058)Mass Spectrometry Imaging in Food Analysis, edited by Leo M.L. Nollet (ISBN: 9781138370692)For a complete list of books in this series, please visit our website at:www.crcpress.com/Food-Analysis--Properties/book-series/CRCFOODANPRO

Spherical nucleic acids (SNAs) comprise a nanoparticle core, and a densely packed and highly oriented nucleic acid shell. They have novel structure-dependent properties that differ from those of linear nucleic acids and that makes them useful in chemistry, biology, the life sciences, medicine, materials science, and engineering. This book is a reprint volume that compiles 101 key papers that have been published by the Mirkin Group at Northwestern University, USA, and their collaborators over the past more than two decades. Volume 1 provides an overview and a historical framework of SNAs and discusses their enabling features, which set them apart from all other forms of matter. Volume 2 covers the general design rules for colloidal crystal engineering with DNA, spanning the building blocks and DNA- and RNA-based'programmable bonds'that can be utilized in preparing such structures. Volume 3 continues the discussion of colloidal crystallization processes and routes to hierarchical assembly, featuring dynamic nanoparticle superlattices and lattices prepared on surfaces or via templating strategies, and explores what one can uniquely learn from and do with colloidal crystals prepared from nucleic acid–functionalized nanomaterials in optics, plasmonics, and catalysis. Volume 4 covers the role of SNAs in biomedicine, especially as diagnostic probes both inside and outside of cells, and treatments based on gene regulation and immunotherapy.

Spherical nucleic acids (SNAs) comprise a nanoparticle core, and a densely packed and highly oriented nucleic acid shell. They have novel structure-dependent properties that differ from those of linear nucleic acids and that makes them useful in chemistry, biology, the life sciences, medicine, materials science, and engineering. This book is a reprint volume that compiles 101 key papers that have been published by the Mirkin Group at Northwestern University, USA, and their collaborators over the past more than two decades. Volume 1 provides an overview and a historical framework of SNAs and discusses their enabling features, which set them apart from all other forms of matter. Volume 2 covers the general design rules for colloidal crystal engineering with DNA, spanning the building blocks and DNA- and RNA-based'programmable bonds'that can be utilized in preparing such structures. Volume 3 continues the discussion of colloidal crystallization processes and routes to hierarchical assembly, featuring dynamic nanoparticle superlattices and lattices prepared on surfaces or via templating strategies, and explores what one can uniquely learn from and do with colloidal crystals prepared from nucleic acid–functionalized nanomaterials in optics, plasmonics, and catalysis. Volume 4 covers the role of SNAs in biomedicine, especially as diagnostic probes both inside and outside of cells, and treatments based on gene regulation and immunotherapy.

Spherical nucleic acids (SNAs) comprise a nanoparticle core, and a densely packed and highly oriented nucleic acid shell. They have novel structure-dependent properties that differ from those of linear nucleic acids and that makes them useful in chemistry, biology, the life sciences, medicine, materials science, and engineering. This book is a reprint volume that compiles 101 key papers that have been published by the Mirkin Group at Northwestern University, USA, and their collaborators over the past more than two decades. Volume 1 provides an overview and a historical framework of SNAs and discusses their enabling features, which set them apart from all other forms of matter. Volume 2 covers the general design rules for colloidal crystal engineering with DNA, spanning the building blocks and DNA- and RNA-based'programmable bonds'that can be utilized in preparing such structures. Volume 3 continues the discussion of colloidal crystallization processes and routes to hierarchical assembly, featuring dynamic nanoparticle superlattices and lattices prepared on surfaces or via templating strategies, and explores what one can uniquely learn from and do with colloidal crystals prepared from nucleic acid–functionalized nanomaterials in optics, plasmonics, and catalysis. Volume 4 covers the role of SNAs in biomedicine, especially as diagnostic probes both inside and outside of cells, and treatments based on gene regulation and immunotherapy.

Essential Oils: Contact Allergy and Chemical Composition provides a full review of contact allergy to essential oils along with detailed analyses of the chemical composition of essential oils known to cause contact allergy. In addition to literature data, this book presents the results of nearly 6,400 previously unpublished sample analyses, by far the largest set of essential oils analyses ever reported in a single source of scientific literature.Covering 91 essential oils and two absolutes, the book presents an alphabetical list of all 4,350 ingredients that have been identified in them, a list of chemicals known to cause contact allergy and allergic contact dermatitis, and tabular indications of the ingredients that can be found in each essential oil.The book discusses contact allergy and allergic contact dermatitis for each of the oils and absolutes, sometimes able to provide only one or two reports but drawing upon considerable amounts of literature in other cases, such as with tea tree oil, ylang-ylang oil, lavender oil, rose oil, turpentine oil, jasmine absolute, and sandalwood oil.While limited information on the main components and their concentrations would be enough for most dermatologists, this book gives extensive coverage not only to improve levels of medical knowledge and quality of patient care, but also for the benefit of professionals beyond clinical study and practice, such as chemists in the perfume and cosmetics industries, perfumers, academic scientists working with essential oils and fragrances, aromatherapists, legislators, and those involved in the production, sale, and acquisition of essential oils.

Applications of Heterocycles in the Design of Drugs and Agricultural Products, Volume 134 in the Advances in Heterocyclic Chemistry series represents the most definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Chapters in this updated volume cover Hydroxy azoles as carboxylic acid bioisosteres, Cyclic sulfoxides and sulfones in drug design, Thiazoles and topological control in drug design, Applications of fused pyrrolidine [3.3.0] heterocycles in drug design, 1,4 Disubstituted and 1,4,5 trisubstituted-1,2,3-triazoles in drug discovery and development: from the flask to the clinic, and Conformationally restricted [3.2.2]- and [3.2.1]-3-azabicyclic diamines. Because biology and organic chemistry increasingly intersect, the associated nomenclature is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and biological scientists - Provides the latest, comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Öffentliche Diskussionen um die Glaubwürdigkeit von Erkenntnissen zeigen die große Bedeutung eines adäquaten Verständnisses der Vorläufigkeit und der soziokulturellen Eingebundenheit naturwissenschaftlicher Erkenntnisse. Studien weisen allerdings darauf hin, dass Lehramtsstudierende diesbezüglich vielfach über naive oder inkonsistente Ansichten verfügen und diese darüber hinaus resistent gegenüber Veränderungen sind. In der vorliegenden Arbeit werden zunächst Arbeitsdefinitionen für die Vorläufigkeit und die soziokulturelle Eingebundenheit für die Chemielehrer•innenbildung hergeleitet, indem beide Aspekte sowohl aus wissenschaftstheoretischer als auch aus naturwissenschaftsdidaktischer Perspektive analysiert werden. Darüber hinaus werden die Fragen untersucht, welche Vorstellungen Chemielehramtsstudierende über die beiden Aspekte aufweisen, inwiefern diese Vorstellungen resistent gegenüber Veränderungen sind und wie sich ein adäquates Verständnis fördern lässt. Zur Beantwortung wurden drei empirische Studien mit insgesamt N = 133 Lehramtsstudierenden durchgeführt. Dabei wurden unter Berücksichtigung der Gütekriterien qualitativer Forschung verschiedene Datenerhebungs- (u.,a. Fragebögen und Interviews) und Datenauswertungsmethoden eingesetzt (u.,a. qualitative Inhaltsanalyse). Die Ergebnisse zeigen, dass die Förderung des Verständnisses über die Vorläufigkeit und über die soziokulturelle Eingebundenheit mit unterschiedlichen Schwierigkeiten behaftet ist. Beispielsweise scheint die Thematisierung der Vorläufigkeit einige Studierende zu verunsichern, sodass in gleichem Maße auch die Beständigkeit naturwissenschaftlicher Erkenntnisse thematisiert werden sollte.

This collection presents papers from the 150th Annual Meeting & Exhibition of The Minerals, Metals & Materials Society.

Comprehensive Coordination Chemistry III, Nine Volume Set describes the fundamentals of metal-ligand interactions, provides an overview of the systematic chemistry of this class of compounds, and details their importance in life processes, medicine, industry and materials science. This new edition spans across 9 volumes, 185 entries and 6600 printed pages. Comprehensive Coordination Chemistry III is not just an update of the second edition, it includes a significant amount of new content. In the descriptive sections 3-6, emphasis is placed upon material that has appeared in primary and secondary review literature since the previous edition published. The material in other sections is newly written, with an emphasis on modern aspects of coordination chemistry and the latest developments. The metal-ligand interaction is the link between the award of the 1913 Nobel Prize in Chemistry to Alfred Werner, the father of Coordination Chemistry, the 1987 prize for supramolecular chemistry and the 2016 award for molecular machines. The key role of coordination chemistry in the assembly of hierarchical nano- and micro-dimensioned structures lies at the core of these applications and so this Major Reference Work bridges several sub-disciplines of chemistry, thus targeting a truly interdisciplinary audience. - Provides the go-to foundational resource on coordination chemistry research, providing insights into future directions of the field - Written and edited by renowned academics and practitioners from various fields and regions this authoritative and interdisciplinary work is of interest to a large audience, including coordination, supramolecular and molecular chemists - Presents content that is clearly structured, organized and cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily

This book focuses on both recent advances and the applications of two-dimensional (2D) nanomaterials in different fields. This book encapsulates all the aspects related to 2D nanomaterials and their applications. It provides scientific and technological insights on novel routes of design and fabrication of few layered nanostructures and their hetero structures based on a variety of 2-D layered materials. It also covers a wide range of industrial applications of 2D nanomaterials. It emphasizes on the detailing of the various characterization techniques used. The book will be a valuable reference for beginners, researchers, and professionals interested in nano-materials and allied fields.

In this monograph, the graphene-based field-effect transistor (FET) biosensors are shown to be an emerging sensing platform. Divided into two parts the first set of chapters are devoted to basic knowledge of graphene, graphene FET and its biosensing. In the second part of this book the applications of graphene FET biosensors combined with various biotechnologies are presented. As well as discussing the existing technologies the authors also introduce their own ideas and concepts. Finally the remaining problems in graphene FET biosensors are discussed, along with proposed solutions and prospects for future applications. This monograph allows readers to grasp the basic knowledge and future direction of graphene-based FET biosensors.

This book demonstrates the basic and fundamental aspects of nanotechnology and potential application as a photocatalysis in multiple application especially in environment and energy harvesting. This book also contains methods of preparation and characterization of unique nanostructured photocatalysts, and details about their catalytic action. The book consists of seven chapters, including the principles and fundamentals of heterogeneous photocatalysis; the mechanisms and dynamics of surface photocatalysis; research on pure and composites based materials with unique nanostructures; the latest developments and advances in exploiting photocatalyst alternatives to WO3; and photocatalytic materials for applications other than the traditional degradation of pollutants, such as carbon dioxide reduction, water oxidation, a complete spectrum of selective organic transformations and water splitting by photocatalytic reduction. This book will appeal to a wide readership of the academic and industrial researchers and it can also be used in the classroom for undergraduate and graduate students focusing on heterogeneous photocatalysis, sustainable chemistry, energy conversion and storage, nanotechnology, chemical engineering, environmental protection, optoelectronics, sensors, and surface and interface science.