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Synthetic biology is enabling scientists to use engineered genetic circuits in the cells as the basis for the development of new living therapeutics and as a powerful new weapon in the fight against diseases, especially cancer. Bacteria-mediated therapy is a promising alternative cancer treatment. The book covers the recent developments of cellular therapies from a synthetic biology perspective including engineered microbial therapies, CAR-T therapies etc. and is an indispensable guide to scientists in both biotechnology and medicine.

Postbiotics: Health and Industry provides a detailed overview on the fundamentals, biological and therapeutic properties, safety, and application of postbiotics in health and industry. Sections cover the fundamentals of postbiotics, which include insights on probiotic microorganisms, postbiotics, and host–microbe interaction, analysis, and characterization of postbiotics. The book goes on to delve into the different types of postbiotics and their mechanisms. Remaining sections explore various health, pharmaceutical, and industrial applications of postbiotics. - Provides an overview on the separation, characterization, and identification of postbiotics from probiotic microbes - Includes classes of postbiotics and their mechanisms of action - Discusses the safety of postbiotics in humans and animals and the use of multiomics to understand the effect of postbiotics on human physiology - Analyzes existing regulatory framework for postbiotics

This book provides an in-depth exploration of microbial biodiversity and its crucial role in diverse biotechnological and industrial sectors. It covers topics such as the integration of molecular approaches for identifying industrially significant strains, omics roles in the production of bioproducts, and modern genetic engineering techniques. It discusses biostatistical investigations and the impact of microbial biotechnology on healthcare and emerging contaminants. It highlights the significance of food microbiology, fermentation, and the latest technologies in improving human health. Additionally, the book delves into emerging trends in oligosaccharide production, biobased approaches for a sustainable future, and the importance of microbial biomolecules and secondary metabolites. It also explores the identification and production of industrially significant biocatalysts/enzymes, the valorization of agro-industrial waste using microorganisms for green energy generation, and the development of bioreactor systems for the biobased economy. The book covers advancements in solid-gaseous biofuels production, impact assessment of synthetic microfiber pollution, sustainable management strategies for waste management, and the impact of emerging technologies in medical microbiology. The book also discusses the development of healthcare products using nano-biotechnological advancements, the impact of novel remediation technology, and the utilization of microbial products in biomaterial development. It further explores microbial regulatory systems, gene expression studies, and the significance of mutations in microbial technology. This book serves as a great reference for researchers, environmentalists, microbiologists, biotechnologists, and graduate, post-graduate students, and doctoral students working on microbial biotechnology and industrial microbiology.

Emergence of lifestyle diseases, e.g., type II diabetes, cancers, obesity, cardiovascular disorders, liver cirrhosis, etc., are exponentially increasing day by day. Modern drifts toward the utilization of herbal medicines in different healthcare aspects necessitate (demand) the replacement of synthetic molecules with phytoconstituents because of their biocompatibility, biodegradability, economic extraction process, and ready availability from the natural source. This book provides a thorough insight into the comprehensive and up-to-date trends of phytomedicines in the management of lifestyle diseases and its mechanisms, modern methods of extraction and purification of phytoconstituents, and chemical characterization as well as standardization of phytoconstituents using modern equipments.

Deep Learning Applications in Translational Bioinformatics, a new volume in the Advances in Ubiquitous Sensing Application for Healthcare series, offers a detailed overview of basic bioinformatics, deep learning, various applications of deep learning in translational bioinformatics including deep learning ensembles, deep learning in protein classification, detection of various diseases, prediction of antiviral peptides, identification of antibiotic resistance, computer aided drug design and drug formulation. This new volume helps researchers working in the field of machine learning and bioinformatics to foster future research and development in ensemble deep learning and inspire new bioinformatics applications that cannot be attained by using traditional machine learning models. - Addresses the practical application of deep learning algorithms to a wide range of bioinformatics challenges - Presents integrative and multidisciplinary approaches to ubiquitous healthcare - Includes case studies to illustrate the concepts discussed

The book provides information on the sources of arsenic contamination of groundwater and their impacts in the first part of the book consisting of 8 chapters. Process developments such as nano-adsorbents for removal of arsenic and other heavy metals are discussed in the second part of the book that comprises of 4 chapters. The third part of the book includes 4 chapters on technological interventions for the removal of arsenic such as indigenous ceramic membranes and Subterranean Arsenic Removal (SAR). The fourth part of the book deals with arsenic contamination in food materials and food chain systems, and consists of 5 chapters. Arsenic has long been associated with a variety of health complications in the human body. In order to address this, a chapter on arsenic contamination and impacts on human health has been included in the fifth part of the book. The book would be a valuable reference material for the scientific community in developing countries working on community water supply and treatment, food safety, public health and policy.

This concise text on biologically active substances of the food, pharmaceutical and agricultural industries presents data on natural compounds of vegetable and animal origin. Various nutrients in food, phytochemicals and zoochemicals are discussed, including their uses for prophylactic, metaphylactic and therapeutic purposes in personalized medicine. Along with these compounds, prebiotics isolated by biotechnological methods from plant tissues are reviewed, with the aim of obtaining compounds with an oligoglucide structure. Metabolism of nutrients and the biodegradation of xenobiotics are hot topics and access routes into the human body for the various biologically active substances are covered.Features: Biologically active substances and related chemistry, biochemistry and agrochemistry data are rigorously discussed Data regarding natural compounds of vegetable origin detected from plants present in the spontaneous flora and plants obtained in agricultural crops (medicinal plants, aromatic plants and more) are presented Discusses the natural compounds of animal origin detected in the organisms of some terrestrial and aquatic animals Covers prebiotics isolated by technological and biotechnological methods from plant tissues, with the aim of obtaining compounds with oligoglucide structure Broad audience including all those in biochemistry, the food and pharmaceutical industries and agricultural fields

This book discusses the recent advancements in chemical engineering and their role in achieving the United Nations'2030 Agenda and Sustainable Development Goals (SDGs). Addressing these goals involves tackling intricate and interdisciplinary challenges.Chemical engineers have been diligently addressing a diverse array of issues across academia, society, and industry, with the aim of positively impacting these goals.The book offers essential insights and detailed analyses for each SDG. It explores the challenges encountered within various applications and proposes solutions based on foundational engineering principles. The book's content is tailored to professionals, students, and researchers across diverse fields, including engineering, environmental science, and biotechnology.

This reference book discusses the role of synbiotics in a wide range of disease states, including cardiovascular, reproductive, metabolic, neurodegenerative, gastrointestinal, thrombotic, skin, and inflammatory disorders. It reviews the functions of probiotics in the diagnosis, prevention, or treatment of various disease states. The book further covers improving the targeting efficiency of synbiotics through advanced drug delivery systems such as nanoparticles, microparticles, liposomes, microemulsion, solid lipid nanoparticles, and nano lipid carriers. The chapter addresses the implications of oral and topical delivery of synbiotics in different diseases and presents the safety assessment of synbiotics and clinical trials associated with synbiotics containing drug delivery systems for the treatment of diseases. The book also explores the synergistic welfare of synbiotics nutraceuticals in various conditions such as chronic respiratory diseases, gut health, and neurological functions and examines the toxicological profile, and regulatory aspects of nutraceutical supplements. As such, this book is a valuable resource for academics, research and industry professionals working in Pharmaceutical Sciences, Food Biotechnology, Immunology, and Health Sciences.​

This book explores the role of nanotechnology in the delivery of natural phytoconstituents and cosmeceuticals. It presents polymeric nanocarriers, lipid-based nanocarriers, metal/metal oxide nanocarriers, protein nanocarriers, and dendrimers for the delivery of phytoconstituents. Further, it focuses on the usage of phytocompounds in various cosmeceutical products and nano delivery technologies used in the delivery of various cosmeceuticals. Finally, the book reviews the toxicity issues of nanoparticles in the delivery of phytoconstituents and cosmeceuticals and regulatory aspects for clinical applications of nano phytomedicines. This book is helpful for academicians and researchers working in pharmaceutical sciences, nano science, material science, plant science, and cosmetic science.

Microbial oxidative enzymes are in need of today and in the future also. Several microbial oxidative enzymes are being used by various sectors like food, agriculture, medicine, detergents, leather, paper, etc. Microbial oxidative enzymes are a natural product, hence, the application of these enzymes is eco-friendly. Oxidative enzymes from microbes like bacteria, and fungi will be helpful in numerous applications including plant-soil health management, and waste treatments. This book will be more informative as well as useful for related industries and end users and will be of great value to those interested in present-day research on oxidation-reduction enzymes. In the coming years, this book will be a game changer for the field of oxidative enzyme development and its applications.

This book goes in depth about the lymphatic system and the functions of the lymphatic organs, lymphatic tissues, and lymphatic vessels. The book addresses various types of diseases in which the lymphatic system can act as a targeting site for drug absorption and suggests strategies to treat these different infections of the lymphatic system. This book is intended for academicians who work in fields related to the lymphatic system, novel drug delivery systems, pharmaceutical science, novel-material sciences, as well as professionals in the medical, nursing, or other health care industries.

This book provides a comprehensive view for plant microbe interactions towards stress management and microbiome-assisted approaches in sustainable agriculture. It is divided into four major sections. The book gives insights into the increasing threat of abiotic and biotic stresses and the accompanying challenges to modern agriculture. Through different chapters, the book shows how various microorganisms could ameliorate abiotic and biotic stress, and contribute towards food sustainability and restore ecosystem functioning. It provides a deep understanding of soil microbiome and its interaction with plants, to enhance food security. It further talks about metagenomic approaches for methodological tool for studying the soil microbiome. Separate sections on stress, talk at length about the various abiotic and biotic stresses that plants are faced it. The book culminates with an exciting section on microbiome-assisted approaches for combating stress. It talks about the different microbiomes such as rhizosphere, soil, phyllosphere and endophytic microbiome. The book would be beneficial to students, researchers and course instructors in microbiology, botany, plant pathology and agriculture.

This book covers all aspects of anaerobic waste conversion technologies using anaerobes, particularly in anaerobic digestion and fermentation processes. It provides the latest advances in waste-to-energy techniques for converting solid and liquid wastes to valuable fuel and energy. It goes beyond traditional municipal waste, including energy recovery from various industrial wastewater and biomass. Topics include biomass pretreatment, metabolic pathways, anaerobic reactor design, product recovery, and conversion technology applications. Essential information is provided, and individual chapters are dedicated to each topic. The book assists academicians, postgraduate students, biochemical engineers, environmental engineers, analysts, chemical engineers, and industrial entrepreneurs in acquiring the skills needed for real-time implementation of anaerobic digestion technologies.

The field of biology and technology is constantly changing and growing. However, the abundance and intricacy of biological data present significant challenges for researchers, educators, and students. Deciphering this vast sea of information to extract meaningful insights can be difficult. Traditional approaches often fail to provide comprehensive solutions to these intricate problems, leaving many struggling to navigate the complexities of bioinformatics. Effective Techniques for Bioinformatic Exploration brings new clarity to the world of bioinformatics, offering a comprehensive solution to the challenges scholars face. Through its meticulously crafted chapters, this book provides a structured approach to understanding and applying bioinformatics principles. Bridging the gap between theory and practice equips readers with the tools needed to tackle complex biological problems effectively. Whether delving into genomics, proteomics, or machine learning models, this book offers a roadmap for success. This book empowers readers to overcome challenges and make meaningful contributions to the field by embracing the scientific method and showcasing the practical application of bioinformatics techniques.

Embark on an illuminating voyage into the realm of botanical brilliance with Benefits and Uses of Plant Extracts. This captivating book is your passport to unlocking the extraordinary potential hidden within nature's green treasures. Dive into the depths of botanical knowledge as each chapter unfolds, revealing the incredible diversity of bioactive compounds found in plants. From terpenes to alkaloids, phenolic compounds to flavonoids, you'll discover a wealth of natural wonders waiting to be explored. Learn the art and science behind extracting these precious compounds in Chapter 1, where you'll uncover the secrets to optimizing extraction processes for maximum efficacy. Then, journey through the plant kingdom as subsequent chapters illuminate the therapeutic properties of specific species, from Smilax fluminensis to Morinda citrifolia L., and beyond. Prepare to be inspired as you uncover the myriad uses of plant extracts in combating diseases, enhancing well-being, and promoting sustainable living. Whether you're passionate about natural health remedies, eco-friendly living, or simply curious about the wonders of the natural world, this book is your essential guide to harnessing the power of plants for a healthier, happier life. Packed with invaluable insights, practical tips, and fascinating research, this book is a must-read for anyone seeking to unlock the full potential of nature's pharmacy. Join us on this transformative journey and discover the endless benefits of plant extracts for yourself!

This book explores the intricate mechanisms underlying the stress responses of phototrophs, which play a critical and foundational role in shaping and sustaining life on Earth.The photoautotrophic entities encounter a spectrum of natural and anthropogenic stresses, inducing a multitude of responses at the physiological, biochemical, genetic, and developmental levels. The comprehension of how these phototrophs adeptly counter stressors transcends mere scientific pursuit; it stands as an essential endeavor for predicting their adaptability in an ever-evolving world and, crucially, for conserving our delicate ecosystems. The book will shed light on the sophisticated interplay of stress signaling pathways and the nuanced engagement of stress-responsive hormones within these life forms. Furthermore, it unveils the cryptic genetic and epigenetic controls dictating stress-related gene expression, yielding profound insights into the enduring recollection of their responses to environmental challenges.This book is an essential read for researchers, educators, and students alike. It offers a comprehensive panorama of stress biology, unveiling the innermost mechanisms at play within photosynthetic organisms discussing their resilience and adaptation.

This textbook provides an introduction to the fundamental and applied aspects of biophysics foradvanced undergraduate and graduate students of physics, chemistry, and biology.The application of physics principles and techniques in exploring biological systems has longbeen a tradition in scientific research. Biological systems hold naturally inbuilt physical principlesand processes which are popularly explored. Systematic discoveries help us understand the structuresand functions of individual biomolecules, biomolecular systems, cells, organelles, tissues, and eventhe physiological systems of animals and plants. Utilizing a physics- based scientific understandingof biological systems to explore disease is at the forefront of applied scientific research.This textbook covers key breakthroughs in biophysics whilst looking ahead to future horizonsand directions of research. It contains models based on both classical and quantum mechanicaltreatments of biological systems. It explores diseases related to physical alterations in biomolecularstructures and organizations alongside drug discovery strategies. It also discusses the cutting- edgeapplications of nanotechnologies in manipulating nanoprocesses in biological systems.Key Features:• Presents an accessible introduction to how physics principles and techniques can be used tounderstand biological and biochemical systems.• Addresses natural processes, mutations, and their purposeful manipulation.• Lays the groundwork for vitally important natural scientific, technological, and medicaladvances.Mohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate aboutinvestigating biological and biochemical processes utilizing physics principles and techniques. Heis a professor of biophysics at King Saud University's Biochemistry Department in the College ofScience, Riyadh, Saudi Arabia; the co- founder of MDT Canada Inc., and the founder of Child LifeDevelopment Institute, Edmonton, Canada. He has authored Biophysics and Nanotechnology ofIon Channels, Nanoscale Biophysics of the Cell, and Membrane Biophysics. He has also publishedabout 50 peer- reviewed articles and several patents, edited two books, and has been servingon the editorial boards of Elsevier and Bentham Science journals. Dr. Ashrafuzzaman has heldresearch and academic ranks at Bangladesh University of Engineering & Technology, Universityof Neuchatel (Switzerland), Helsinki University of Technology (Finland), Weill Medical College ofCornell University (USA), and University of Alberta (Canada). During 2013– 2018 he also served asa Visiting Professor at the Departments of Oncology, and Medical Microbiology and Immunology,of the University of Alberta. Dr. Ashrafuzzaman earned his highest academic degree, Doctor ofScience (D.Sc.) in condensed matter physics from the University of Neuchatel, Switzerland in 2004.

Short Blurb This handbook covers the different aspects of the aquatic environment, microbiology, and microbial applications. It highlights the role of microorganisms as pollution indicators and as bio-control agents. The book covers the impact of pollution on microorganisms, biofilms, cyanobacterial blooms, and the metagenomics approach to isolate microbes. Standard Blurb This comprehensive handbook covers the different aspects of the aquatic environment, microbiology, and microbial applications. The world's aquatic environment is facing a serious threat due to inappropriate planning, implementation, and management. This book compiles effective strategies for managing the aquatic environment. It highlights the role of microorganisms as pollution indicators, in bioremediation, and as bio-control agents. The book also covers the impact of pollution on microorganisms, biofilms, cyanobacterial blooms, and the metagenomics approach to isolate microbes. This book is essential for students and researchers of microbiology, environmental sciences, and biotechnology Seasonal Blurb This comprehensive handbook covers the different aspects of the aquatic environment, microbiology, and microbial applications. The world's aquatic environment is facing a serious threat due to inappropriate planning, implementation, and management. This book compiles effective strategies for managing the aquatic environment. It highlights the role of microorganisms as pollution indicators, in bioremediation, and as bio-control agents. The book also covers the impact of pollution on microorganisms, biofilms, cyanobacterial blooms, and the metagenomics approach to isolate microbes. This book is essential for students and researchers of Microbiology, Environmental Sciences, and Biotechnology. 1 Includes key themes like environmental DNA application, metagenomes, extremophiles, microbial population genetics and statistical aspects of aquatic microbiology 2 Discusses the beneficial microbes of the aquatic environment 3 Covers applications of microbes in bioremediation, as pollution indicators and as algicidal agents 4 Reviews freshwater biogeochemical cycles and sediment microbiology 5 Explores microbial communities of biofloc and microbiomes in aquaponics

This book explains the advancements of plant biotechnology and advanced molecular biology and explores the details of influential tools that complement conventional breeding and accelerate the development of plants resilient to adverse agroclimatic conditions and biofortified plants. Plant biotechnology from the basic sciences to current applications, such as pathway engineering, precursor feeding, transformation, elicitation with biotic and abiotic elicitors, and scaling up in bioreactors, have been included in these chapters to improve the production of secondary metabolites from different medicinal plants. It also highlights important factors often overlooked by methodologies used to develop plants'tolerance against biotic and abiotic stresses and in developing special foods, bio-chemicals, and pharmaceuticals. This book is valuable for researchers or students working on biosciences. It is also an updated and advanced reference material for the agriculture and pharmaceutical industries.

Fundamentals of Recombinant Protein Production, Purification and Characterization is organized into nine chapters in a logical fashion that cover an introduction to recombinant proteins and expression in different host expression systems, extraction, purification and analysis of proteins. This important reference features protocols, along with the advantages and disadvantage of each expression hosts and characterization technique (presented in tabular format) and offers detailed coverage of all aspects of protein production and processing (upstream and downstream processing) in one place. Finally, the book ends with different characterization techniques. Production of recombinant proteins for biotechnological and therapeutic applications at a large scale is an essential need of mankind. With the huge application potential of therapeutic and industrial proteins, there has been increasing demand for effective and efficient bioprocessing strategies. Recent progress around recombinant DNA technologies and bioprocessing strategies has paved the way for efficient production of recombinant proteins. Important factors such as insolubility and cost of production need to be considered for large scale production of these recombinant proteins. - Includes step-by-step reproducible protocols while also providing updated information on the rationale and latest developments in expression systems - Can also be used as a handbook for protein expression and purification as expression systems and chromatographic methods are explained in detail - Consists of notes on troubleshooting from the eminent researchers in the field - Provides comprehensive information on protein production, purification and characterization in a single volume - Describes different purification methods for comparatively difficult to obtain proteins - Brings the topics of recombinant protein expression, purification and characterization together, thereby making it the first resource on how to solve problems with respect to upstream and downstream processing of heterologous proteins

Based on the author's extensive research experience in collagen textiles and tissue engineering, this book presents a comprehensive introduction and guidelines for engineering artificial tissue using collagen-based fibrous material as a therapeutic candidate for regenerative medicine. The book covers different aspects of fibrous collagen material, including its chemistry, sourcing, fabrication, and applications in tissue engineering and regenerative medicine. Collagen-Based Biotextiles for Tissue Engineering provides a state-of-the-art overview of fibrous collagen-based materials and their application in tissue engineering and regenerative medicine for academic researchers, material scientists, and bioengineers.

This edited book is a comprehensive compilation of applications of plant molecular farming in various fields including agriculture, industry and medicine, using different plant/crop systems as bioreactors for the bulk production of products of interest. The book places special emphasis on plant molecular farming being utilized for the bulk production of biologics, industrial enzymes, vaccines, drugs and recombinant pharmaceutical proteins.Plant molecular farming (PMF) is an upcoming promising interdisciplinary subject, and therefore the book contains contributions from experts across the disciplines. The utilization of plant viral vectors to produce biologics, virus-like particles and antimicrobial peptides via PMF have been highlighted. Molecular farming for the bulk production of recombinant pharmaceutical proteins and various types of human and veterinary vaccines in different crops/plants and genetically modified seeds has been included. The process of scaling up to manufacturing capacity, product formation by bioprocessing of plant cell suspension culture, and bioreactor engineering have been incorporated. Lastly, the book provides special coverage on utilizing PMF made products to control neglected tropical diseases and plant-made antigens as immunotherapies for allergic and autoimmune diseases.The book has chapters from leading experts on the subject, making it equally beneficial for researchers, policy planners, industrialists, medical professionals, entrepreneurs, and students of various related disciplines.

This book presents the latest knowledge, trends, and advances in cell transplantation and innovations in developing microspheres, 3D biomaterial constructs to enhance transfer, and cell survival to specific regions of the brain. Neurodegenerative diseases and brain injury are increasing. Medications currently only temporarily reduce some of the symptoms but do not cure or delay progression of the disease. Development of effective treatments dramatically improves the independent living and quality of life of patients. Cell transplantation strategies offer an approach to facilitating brain repair, but efficacy is often limited by low in vivo survival rates of cells that are injected in suspension. Transplanting cells that are attached to or encapsulated within a biomaterial construct has the advantage of maintaining cell-cell and cell-material interactions and improving cell survival in vivo. Biomaterials that have been used in preclinical studies to assist with in vivo cell transfer and survival include heparin-chitosan microspheres, poly(lactic-co-glycolic acid) microspheres, RADA 16 microspheres, poly(desaminotyrosyl tyrosine ethyl ester carbonate) microscale scaffolds, carbon nanotubes, collagen-chitosan scaffolds, poly(L-lactic acid) scaffolds, agarose hydrogels, gelatin methacrylate hydrogels, and agarose micro-columns with an extracellular matrix interior. Incorporating growth factors (e.g., glial-derived neurotrophic factor, neurotrophin 3) into the biomaterial constructs increased cell survival and incorporation into the host tissue. International experts in the fields of both experimental and clinical neurological research contribute chapters to this book and discuss the latest achievements in cell transplantation and matrix-assisted cell transfer/survival technologies for diseases such as Alzheimer's disease, Parkinson's disease, and brain injuries such as stroke and traumatic brain injury. It is envisaged that research findings in experimental animal models of Alzheimer's disease, Parkinson's disease, traumatic brain injury, and stroke promote clinical trials using biomaterial-assisted transfer of cells.

This book provides an in-depth overview of marine greens and their environmental and biotechnological applications. It addresses concepts such as the niche adaptation strategies of marine greens in their natural habitats, as well as their global distribution, and factors affecting their distribution and proliferation.Marine greens are posited as an alternative to fossil fuels, mitigating global climate change and thereby fostering future environmental sustainability. In addition, the book explains the remediation of xenobiotics, wastewater, microplastics, marine debris and marine green contamination. Expert authors from around the world explore the industrial and agricultural applications of marine greens in the production of enzymes and marine bioenergy, and what is needed to improve its production potential.This is important reading for government and non-governmental organizations as well as industries and research institutions looking for ways to combat current industrial and environmental challenges.

This book highlights recent advances focusing on the synthesis methods of engineered biomaterials and their applications. The book discusses recent applications of various approaches and technology in improving the functional properties and biological activities of biopolymers. It includes two major sections: the first section introduces a range of methods which lead to materials with enhanced properties for a range of practical applications, along with the positives and limitations of the techniques. The second section covers recent trends and advances in application of engineered biomaterials that assist materials scientists and researchers in mapping out the future of these new improved materials through value addition in order to enhance their use. Contributions in the book are done by prominent researchers from industry, academia, and government/private research laboratories across the globe. The book summarizes in a fairly comprehensive manner many of the recent technical advancements in the area of biopolymers. The book is intended to serve as a reference resource in the area of polymers science.

Valorization of Wastes for Sustainable Development: Waste to Wealth highlights the various valorization of organic and non-organic waste to offer a way forward to a sustainable world. Categorizing the various types of waste valorization for renewable fuel production and other valorizations utilizing organic and non-organic waste, this book offers the reader a comprehensive view of various waste valorizations together with their potential applications. Split into four sections, the book's chapters cover the general scenarios and challenges of current waste management and the valorization of waste specifically for renewable fuels as the alternative energy source to depleting fossil fuels. Other chapters cover waste valorizations categorized into organic and non-organic waste for various applications and the future prospect of waste valorizations with possible plans and strategies for effective global waste management. - Comprehensively discusses the various types of global waste - Discusses the latest technologies used for waste valorizations - Includes future prospects and strategies for waste valorizations

This unique book addresses the bioinformatic and statistical modelling and also the analysis of microbiome data using cutting-edge QIIME 2 and R software. It covers core analysis topics in both bioinformatics and statistics, which provides a complete workflow for microbiome data analysis: from raw sequencing reads to community analysis and statistical hypothesis testing. It includes real-world data from the authors'research and from the public domain, and discusses the implementation of QIIME 2 and R for data analysis step-by-step. The data as well as QIIME 2 and R computer programs are publicly available, allowing readers to replicate the model development and data analysis presented in each chapter so that these new methods can be readily applied in their own research. Bioinformatic and Statistical Analysis of Microbiome Data is an ideal book for advanced graduate students and researchers in the clinical, biomedical, agricultural, and environmental fields, as well as those studying bioinformatics, statistics, and big data analysis.

Nanotechnology is gaining importance in every field of science and technology. Green synthesis of nanomaterials involves the use of microorganisms such as bacteria, fungi, viruses; and different lower and higher plants. Green synthesis of nanomaterials from plant extracts becoming popular in comparison to synthesis using microorganisms. Plant based-nanomaterials synthesis is easy, have no need to bring back from the culture medium, and is safe. Additionally, plant-based nanomaterials are eco-friendly, in comparison to physical and chemical modes of synthesis. Several lower and higher plants are rich in terms of secondary metabolites. These metabolites have been used as medicine in crude extract form or with some other formulations. They have been also used to isolate the bioactive compounds in modern medicine as well as in herbal medicine systems. Thus, phytochemicals present in the plant and their parts play an important role in nanomaterials synthesis, mainly due to the presence of a significant number of secondary metabolites, for instance, alkaloids, flavonoids, saponins, steroids, tannins, etc. Further, essential and aromatic oils have been also explored for nanomaterials synthesis, and they are also equally useful in terms of their various biological applications. These organic ingredients come from a wide range of plant components, such as leaves, stems, roots, shoots, flowers, bark, and seeds. Globally, the presence of different plants has shown a capability to produce huge and diverse groups of secondary metabolites. The functional groups present in the plant extract acts as capping and stabilizing agent. Most of the time, pure isolated bioactive compounds are more biologically active; hence scholars are focusing their research on the synthesis of nanomaterials using some particular class of secondary metabolites. Investigations have shown that the green synthesized nanomaterials were found to be more biologically active in comparison to chemicallysynthesized nanomaterials. These nanomaterials and or nanocomposites found different applications especially in drug delivery, detection and cure of cancer cells, diagnosis of a genetic disorder, photoimaging, and angiogenesis detection. They have also shown several applications in agricultural, horticultural as well as forestry sectors. The book in hand covers a wide range of topics as mentioned above. It incorporates chapters that the authors have skilfully crafted with clarity and precision, reviewing up-to-date literature with lucid illustrations. The book would cater to the need of graduate students as a textbook and simultaneously be useful for both novices and experienced scientists and or researchers working in the discipline of nanotechnology, nanomedicine, medicinal plants, plant science, economic botany, chemistry, biotechnology, pharmacognosy, pharmaceuticals, industrial chemistry, and many other interdisciplinary subjects. It should also inspire industrialists and policy makers associated with plant-based nano products.

Biotechnology for Beginners, Third Edition presents the latest developments in the evolving field of biotechnology which has grown to such an extent over the past few years that increasing numbers of professional's work in areas that are directly impacted by the science. This book offers an exciting and colorful overview of biotechnology for professionals and students in a wide array of the life sciences, including genetics, immunology, biochemistry, agronomy and animal science. This book will also appeals to lay readers who do not have a scientific background but are interested in an entertaining and informative introduction to the key aspects of biotechnology. Authors Renneberg and Loroch discuss the opportunities and risks of individual technologies and provide historical data in easy-to-reference boxes, highlighting key topics. The book covers all major aspects of the field, from food biotechnology to enzymes, genetic engineering, viruses, antibodies, and vaccines, to environmental biotechnology, transgenic animals, analytical biotechnology, and the human genome. - Covers the whole of biotechnology - Presents an extremely accessible style, including lavish and humorous illustrations throughout - Includes new chapters on CRISPR cas-9, COVID-19, the biotechnology of cancer, and more

Molecular self-assembly has been exploited by nature for developing the higher functional macromolecular structures of both the genome and proteome. Inspired by nature, there has been a surge of research, in the last two decades, for the molecular engineering of peptide-based self-assembling nanostructures, adopting the bottom-up design approach. This book gives the reader an overview on the design rules for de novo self-assembling peptide and reviews the diverse range of bioinspired peptide nanostructures such as β-sheet and β-hairpin, α-helical and coiled coil, self-assembling short peptides and peptidomimetics, collagen-based and elastin-like peptides, silk peptides, peptide amphiphiles, peptides co-polymers and others. The book also covers the wide variety of responsive and functional biomaterials that have been innovated based on those nanostructures for various applications ranging from tissue engineering, therapeutics and drug delivery to antimicrobial nanomaterials and biosensors. Finally, the book also discusses the peptide bionanomaterials global market and the future of the emerging industry.Chapter “Characterization of Peptide-Based Nanomaterials” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This contributed volume covers all fundamental principles for researchers and professionals interested in the field of Biomaterials and Tissue Engineering, an interdisciplinary field of research with contributions from biomedical scientists, engineers, and physicians. With a strong focus on biomaterials and scaffolds, the book also covers testing and evaluation pathways for in vitro and in vivo studies. This book also presents a broad range of topics including fundamentals of 3D printing and bioprinting, followed by contemporary technology used in tissue engineering applications as well as currently available biomaterials suitable for tissue repair and regeneration. This volume provides information on: (i) why humans need biomaterials, especially in medical applications, (ii) different types of tissue engineering strategies, and (iii) modeling, characterization, and evaluation of outputs of those strategies. This book is a reference material in the field of tissueengineering, and it is very useful for bachelor, M.Sc., and Ph.D. students, researchers, academics, medical, industry, and healthcare professionals from diverse backgrounds.

This book addresses the structural and biological properties of the extracellular matrix component and glycosaminoglycan polymer hyaluronan (or hyaluronic acid, HA).The book discusses various aspects of HA biology, e.g., HA synthesis and degradation, as well as the role of HA in embryogenesis, development, and cell maintenance. The reader will learn about the role of HA in different tissues as well as its biological activities triggered by the interaction with different HA receptors. A closer look is had at the involvement of HA in human pathologies such as cancer, kidney fibrosis and wound healing. Biotechnological and biomedical applications for HA such as scaffold generation and drug delivery, including the novel synthetic sulphated HA are explored.This work will appeal to a wide readership within the extracellular matrix and hyaluronan field. It can serve as an introduction to the field for junior scientists but can also help senior scientists to gain a broader view of the field beyond their area of specialization.The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

This book addresses the recent trends and clinical research being reported in last 5 to 10 years in the field of nasal drug delivery systems. In recent years, interest in using nasal passage as drug absorption site has received increased attention from formulation scientists. Nasal passages, even though a small surface area of the body as compared to other absorption passage such as Gastrointestinal tract or skin, show significant possibility for drug absorption at a quicker rate. There is also a possibility of delivering drugs to the brain using this passage and targeting drugs through the nasal passage. The book has 19 chapters addressing various aspects of nasal drug delivery systems such as an overview of anatomy and physiology of the nasal passage from a drug delivery point of view to global market opportunities for nasal drug delivery. In between, it addresses various aspects of nasal drug delivery. There are very few titles exclusively dedicated to nasal drug delivery, covering the formulation and developmental aspects, and addressing the challenges and solutions. The primary audiences for the book are graduate students in field of medicine, pharmacy and also various researchers who are working in the area of nasal drug delivery in addition to students who are specializing in field of medicine in ENT. This book provides comprehensive information on all the aspects related to the nasal drug delivery of various drug molecules.

This edited book collates the research done mainly in Africa on vermicomposting and related technologies that can assist African smallholder farmers in making nutrient rich organic fertilizers from their animal and crop residue wastes. Information on the development of organic sources of liquid fertilizer development for hydroponics is also presented. The book presents research findings on vermicomposting in a simplified way that will allow farmers and extension workers to adopt the indicated technologies. The book also covers critical aspects of standardization of vermicompost preparation, earthworm biology, nutrient enrichment of composts and organic liquid fertilizer production.Vermicomposting is a technology that employs earthworms to enhance the biodegradation and fertilizer value of organic wastes. The earthworms optimize the biodegradation ecosystem during composting, resulting in a final nutrient rich product with more recalcitrant forms of carbon and much lower levels of veterinary antibiotics and their metabolites. Vermicompost as an organic fertilizer is highly preferred over other forms of soil enhancers. A lot of research has been done on vermicompost and related activities in Africa but remain scattered across various publications.The book is an invaluable source of information for farmers especially those practicing organic crop production, vermicomposting researchers, as well as extension workers.

The origin story and emergence of molecular biology is muddled. The early triumphs in bacterial genetics and the complexity of animal and plant genomes complicate an intricate history. This book documents the many advances, as well as the prejudices and founder fallacies. It highlights the premature relegation of RNA to simply an intermediate between gene and protein, the underestimation of the amount of information required to program the development of multicellular organisms, and the dawning realization that RNA is the cornerstone of cell biology, development, brain function and probably evolution itself. Key personalities, their hubris as well as prescient predictions are richly illustrated with quotes, archival material, photographs, diagrams and references to bring the people, ideas and discoveries to life, from the conceptual cradles of molecular biology to the current revolution in the understanding of genetic information.Key Features Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

This book summarizes the principles, protocols, and applications of enzyme-based biosensors in healthcare. After providing a brief history and discussing the development of various biosensors used for medical applications, it explores the principles of enzyme-based biosensors and reviews a number of enzyme immobilization techniques. It then addresses the potential of enzyme-based biosensors in the diagnosis of infectious and non-infectious diseases; illustrates the potential of enzyme-based biosensors for non-invasive monitoring of biochemical biomarkers; and assesses the application of paper-based and microfluidic-based nanobiosensors in medical diagnostics. A one-stop resource on recent advances in enzyme-based biosensors in healthcare, this book will appeal to students, researchers and scientists in a range of disciplines, as well as entrepreneurs, and medical/healthcare professionals.

This book addresses the phenomenon of biological autoluminescence (also known as ultraweak photon emission, UPE, biochemiluminescence, or biophotons) and deals with a very broad spectrum of subjects, ranging from basic observational studies to molecular mechanisms, free-radical processes, physics of electron excitation and photon emission, as well as detection techniques. The chapter topics include UPE in plants, animals, and the human body; microorganisms and subcellular structures; and model systems, illustrating its high prevalence. Several sections of the book provide some backstory, with emphasis on methodology, unresolved questions, and existing controversies. The authors raise and discuss complex, potentially divisive aspects: Are there any reasons to assume the existence of non-chemical interaction in biological systems? Can research results in the field of mitogenetic radiation, delayed luminescence, and oxychemiluminescence of model systems, be correctly interpreted? Whatdoes the future hold for this area of research? Altogether, this publication gives the reader a thorough overview of biological autoluminescence (UPE, biophotonics) research, making it ideal for students and researchers who are new to the area as well as those who are specializing in it.

This contributed volume compiles the latest improvements in the field of nanobiotechnology, with a special emphasis on microbial-synthesized nanoparticles. It focuses on topics that comprise the microbials synthesized nanoparticles, their characterization, and applications in the field of medicine and biotechnology, which are organized in three parts, respectively. Ranging from micro-scale studies to macro, it covers a huge domain of nanotechnology in relevance to microbiology. Overall, the book portrays the importance of microbial processes in the sustainable production of nanomaterials to reduce the environmental burden caused by nanomaterials produced by chemical processes. The book is a ready reference for practicing students, researchers of nanobiotechnology, environmental biotechnology, and other allied fields likewise.

This book covers biotechnology and applications of diatoms including various applications such as the use of diatom biogenic silica in drug delivery and their cultivation for wastewater remediation. It contains case studies in diatom biorefinery and provides information about the bioactive compounds, antioxidants, and lipids from diatoms. It also discusses the latest innovations in the genetic engineering of diatoms. Key Features: Discusses the applications of diatoms in drug delivery Covers the application and cultivation of diatoms for wastewater bioremediation Describes the innovations and gaps in genetic engineering of diatoms Throws light on the lipid content, antioxidant content, and various bioactive compounds present in diatoms Includes extraction technologies in diatoms The book is meant for academicians and microbiologists, biotechnologists, and marine biologists.

This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox).The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.

This book presents a complete overview of COVID-19 and provides a series of in-depth analyses of the literature and a comprehensive discussion and perspectives on promising anti-SARS-CoV-2 agents based on the system of ethnopharmacology, which covers Chinese medicine, traditional medicines of India and Africa, Turkish folk medicine, essential oils, and some well-known medicinal plants. In this book, the current status of therapeutic strategies against COVID-19 was summarized and a perspective of potential options for the future was proposed. Based on ethnopharmacology, some well-established traditional herbal formulations and bioactive compounds with anti-virus activity were repurposed for managing COVID-19 and post-illness, including neurological disorders and kidney illness. Using drug discovery tools, promising immune enhancers were explored from phytochemicals against SARS-CoV-2. Nutraceuticals from dietary plants, spices, and fruits with anti-virus and antioxidant activities were recommended to prevent infection or severe illness caused by emerging variants. With the aid of systems pharmacology, researchers have gained insights into possible molecular mechanisms of anti-SARS-CoV-2 activity and have predicted a range of candidate compounds from medicinal plants to combat COVID-19. This book explores the current knowledge of drug discovery and ethnopharmacology for managing coronavirus diseases. The content proved the anti-SARS-CoV-2 activity from natural products and traditional herbal medicines. It contributes to the management of global public health and fits the goal of establishing “Good Health and Well-Being,” which is one of “The Sustainable Development Goals (SDGs) 2030'.

This book reports on the latest research and developments in Biomedical Engineering, with a special emphasis on topics of interest and findings achieved in Latin America. This first volume of a 4-volume set covers advances in modeling and simulation of biological and biomedical systems, mechanical characterization, and biological evaluation of biomaterials for medical applications, including tissues regeneration. It also covers some related special topics, such as advanced methodologies for agricultural and food production and public health management. Throughout the book, a special emphasis is given to low-cost technologies and to their development for and applications in clinical settings. Based on the IX Latin American Conference on Biomedical Engineering (CLAIB 2022) and the XXVIII Brazilian Congress on Biomedical Engineering (CBEB 2022), held jointly, and virtually on October 24-28, 2022, from Florianópolis, Brazil, this book provides researchers and professionals in the biomedical engineering field with extensive information on new technologies and current challenges for their clinical applications..

This edited book is an in-depth compilation of recent tools and techniques, concepts and strategies used globally in plant molecular farming (PMF) for the cost-effective bulk production of recombinant proteins, secondary metabolites, and other biomolecules. The book presents an overview of success stories of PMF applications from developing countries to address poverty, achieve zero hunger, good health and well-being, thus achieving the UN SDGs 1, 2, and 3.The book deep dives into recent extraction and downstream processing methodologies, its co-existence with conventional agriculture, global governance and finally opportunities, challenges, and future perspectives in plant molecular farming. It focuses on plastid/chloroplast transformation (transplastomics) and its application in plant molecular farming. The books highlight recent advances in genome editing, synthetic biology, glycosylation and glyco-engineering for improved plant molecular farming by marker-free andtissue-specific systems via cisgenic and transgenic crops. In depth discussions on biosafety issues and bio-containment strategies have also been included.The book has 15 chapters authored by globally leading experts on the subject, presenting opportunities & challenges for bio-industrial researchers and entrepreneurs. It is useful to researchers, industrialists, entrepreneurs, policy planners, academician, and students across the disciplines.

This book explains the fundamental characteristics and biofunctionality of Alzheimer's Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer's Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer's disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer's disease treatment.

This textbook is an introductory guide to applied machine learning, specifically for biology students. It familiarizes biology students with the basics of modern computer science and mathematics and emphasizes the real-world applications of these subjects. The chapters give an overview of computer systems and programming languages to establish a basic understanding of the important concepts in computer systems. Readers are introduced to machine learning and artificial intelligence in the field of bioinformatics, connecting these applications to systems biology, biological data analysis and predictions, and healthcare diagnosis and treatment. This book offers a necessary foundation for more advanced computer-based technologies used in biology, employing case studies, real-world issues, and various examples to guide the reader from the basic prerequisites to machine learning and its applications.

The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future.A total of four books are covered under the series of Infectious drug diseases.- Malarial drug delivery systems- Tubercular drug delivery systems- Viral drug delivery systems- Infectious disease drug delivery systemsInfectious diseases are the world's greatest killers that present one of the most significant health and security challenges. Humans have lived with emerging and re-emerging pathogens since before the documented history of civilization. The only determining fact today is - If the situation is “worse” or “better” than in past. The answer is probably “worse”, may be due significant increase in human population, increased cross-continent mobility, imbalanced (stressed) life style, irregular food habits leading to compromised innate immunity and over or under practiced hygiene routine. When the incidence of such a disease in people increases over 20 years or threatens to increase, it is called an “emerging” disease, and a growing number have made watch lists andheadlines in nearly every country -like highly pathogenic H5N1 avian influenza, severe acute respiratory syndrome (SARS), Ebola virus, food- and waterborne illnesses, and a range of antimicrobial-resistant bacterial diseases TB. This book addresses current and new therapy developments in treating such infectious diseases, updates on finding new drugs, identification of innovative diagnostic methods, understanding of disease research models and clinical trials performances of new treatment modalities.Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of infectious diseases and related research.

This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of informationfor industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.

This book reviews the development of cell-free production platforms and offers an authoritative perspective of the latest advances and methodologies in cell-free production systems. Readers will discover the biomanufacturing potential of in vitro biotransformation (ivBT) employing purified cascade multi-enzymes, the development of hydrogel-based multi-enzymatic systems for biosynthesis, and novel insights into the optimization of biocatalytic processes. Additionally, the book explores the cell-free production and regeneration of cofactors, shedding light on strategies to enhance the efficiency and sustainability of cellular processes. In this book, particular attention is given to the progress of cell-free in vitro evolution techniques for optimizing enzyme performance, and the book also presents the integration of rapid and finely-tuned expression systems for deployable sensing applications, revolutionizing the field of biosensing. The synthesis and electrophysiological analysis of multipass voltage-gated ion channels tethered in microsomal membranes are explored, providing a deep understanding of cellular function at the molecular level. Lastly, the book covers compartmentalized cell-free expression systems for building synthetic cells, showcasing the potential for constructing artificial cellular systems with unique functionalities. Given its breadth, this book appeals to academics, researchers, and professionals interested in the forefront of biotechnology, and together with the companion volume “Cell-free Macromolecular Synthesis”, both books highlight the research progresses on the basic and applied research of cell-free production systems in the last few years, being invaluable resources in the field.Chapter “Cell-free synthesis and electrophysiological analysis of multipass voltage-gated ion channels tethered in microsomal membranes” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book encompasses the fundamental concepts of Nanochemistry that involve the self-assemblage of nanostructures, surface stabilization, and functionalization of nanoparticles. It's a review of the work of world-renowned scientists and is the first of its kind that gives a detailed fundamental understanding of physical, chemical, and biological methods of nanoparticle synthesis. There is a comprehension of different characterization techniques of nanoparticles. This book, for the first time, explains applications of such nanochemicals in nanomedicine, nanoimmunomedicine, lab-on-a-chip, organ-on-a-chip, bioimplants, cyborgs, hydrogen storage, electrochemical splitting of water, and construction industries.