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Postbiotics: Health and Industry provides a detailed overview on the fundamentals, biological and therapeutic properties, safety, and application of postbiotics in health and industry. Sections cover the fundamentals of postbiotics, which include insights on probiotic microorganisms, postbiotics, and host–microbe interaction, analysis, and characterization of postbiotics. The book goes on to delve into the different types of postbiotics and their mechanisms. Remaining sections explore various health, pharmaceutical, and industrial applications of postbiotics. - Provides an overview on the separation, characterization, and identification of postbiotics from probiotic microbes - Includes classes of postbiotics and their mechanisms of action - Discusses the safety of postbiotics in humans and animals and the use of multiomics to understand the effect of postbiotics on human physiology - Analyzes existing regulatory framework for postbiotics

This Volume 2 of a two-volume work provides an up-to-date overview of the latest advances in live biotherapeutics research, engineered and genome-edited probiotics. It focuses on key areas within probiotics and microbiome studies in human medicine, including their translation into commercial applications. The book is divided into three sections, comprising (I) biomedical and nutritional benefits of probiotics for human health, (II) post-genomic technologies in probiotics sciences and genome engineering, and (III) biosafety aspects and prospects of biotherapeutics. The broad spectrum of industry-relevant contributions makes this work a valuable resource for industry professionals as well as researchers in functional food and feed biotechnology, applied microbiology and gastroenterology. Presenting novel and evidence-based research, this volume will drive the commercial enterprise and meets the great demand for good probiotic products in the human medical sector.

Human Organs-on-a-Chip Technology focuses on the technology advancement from'organ-on-a-chip to'multi organs-on-a-chip to the newest stage of'human organs-on-a-chip. Chapters investigate the design, simulation studies, device development and application of microfluidic systems. They also offer expert perspectives on the development of an alternative test system in the biological evaluation of drugs, cosmetics, chemicals, medical devices and many others. Lastly, the book addresses issues related to the development of microfluidic devices and alternative test systems in biological and biomedical research. - Explores organs-on-a-chip technology, from the basics, to advanced developments and existing challenges and recent research trends and applications - Reviews every aspect of microfluidic devices, including biological evaluation and targeted delivery - Includes the latest information on regulatory updates

This book compiles recent studies about edible coatings and how they have improved food products, packaging techniques, and product quality to cause fewer health risks. Food Coatings and Preservation Technologies presents the most recent studies about the application of edible coatings to a wide variety of foods. Edible coatings are globally utilized for preventing food product contamination from harmful microorganisms and pathogens. This book highlights the developments made in designing new edible coatings. Herein, particular attention is given to the main components, manufacturing methods, and their application to specific products. The book also discusses the current state-of-the-art alternative to conventional package usage, providing the main features biodegradable packaging should meet for distinct uses for the conservation and improvement of various food products. This information will be helpful for processors to select the best coating material and its effective concentration for different fresh and minimal processed vegetables. Each chapter delves into edible-based coating research and critical developments to enhance food preservation standards. The first section focuses on biopolymer-based edible coatings, food packaging, and preservation. It provides a comprehensive understanding of the current state and critical developments in biodegradable polymer packaging systems for food applications. As technology advances, the next section highlights ongoing research focusing on optimizing coating effectiveness and the development of eco-friendly and sustainable materials. This section's objective is to identify edible materials and combine the most recent information available to provide a comprehensive understanding of formulation methods and approaches to enhancing the properties of the coatings applied to food products. The final section discusses encapsulation techniques and levels of retention to improve shelf-life. Readers will find in this book information concerning: The efficiency and functional properties of edible coating materials; Feasibility studies performed on new process evaluation, safety and toxicity determination, regulatory assessment, and consumer studies regarding the commercial uses of edible coatings; Coating technologies that present a promising avenue to enhance the delivery, stability, and efficacy of medical foods and nutraceuticals; Shelf-life testing that suggests future directions; Novel practical and reliable tools that are applicable in the industrial process. Audience The book is aimed at chemists, food technologists, food scientists, nutritionists, dietitians, pharmaceutical technologists, biochemists, and engineers, as well as postgraduate, PhD students and postdocs working in the area of edible food coatings and prevention technologies.

This book comprehensively reviews the theranostic applications of nanomaterials against various neurological disorders. The initial chapters briefly introduce various neurological disorders, their molecular mechanism, available treatments, and the latest research. It further reviews the challenges associated with the current theranostics strategies, including blood-brain-barrier. This book examines the synthesis of nanoparticles, development of efficient biosensors, fabrication of nanomaterials, diagnosis through nano-chips, and their interaction with neuronal cells. The chapter also discusses the various nanoformulations or nanocarriers of natural therapeutics, including herbal products, peptides, nootropics, and dietary supplements used to prevent and delay neurological disorders. Additionally, the book provides information on the commonly used molecular imaging tools and biosensors, using different nanomaterials for the early detection of neurological disorders. Towards the end,the book covers the imaging techniques like gold nanocages and photoacoustic imaging for diagnosing and targeted drug delivery for neurological disorders. The chapter presents the current challenges in using nanotechnology for neurological disorders and their potential solutions.

This book highlights the potential of biomass for cosmetics applications. It covers the discussion on biomass as a source for cosmetics from savanna, marine and tropical forest, trend and market outlook of biobased cosmetics, active substances from biomass for cosmetics, extractives from biomass for cosmetics, other non-wood forest products such as essential oil, tengkawang, and bee pollen. Besides that, the potency of biopolymers such as lignin, and polysaccharides are presented. The book also discusses activated carbon as a cosmetic source. To present more comprehensive information, it covers biomass as anti-aging, anti-acne, sunscreen, anti-melanin, and antimicrobial. Regarding the close contact system with the human in daily life, cosmetic needs to comply with the human system. Therefore, one special chapter is dedicated to presenting the compatibility view of biobased cosmetics in the human body system. Nanomaterials in cosmetics have started to be used by many beauty companies asindicated by nano-related patents. The nanotechnology applications in cosmetics also provide future trends in bio-based cosmetics. Some forms of nanomaterials that have been reported include liposomes, nanoemulsion, nanocapsules, solid lipid nanoparticles, nanocrystals, nano-silver, nano-gold, hydrogel, etc. Iodinated Aloe Vera formulations within polymeric complexes present examples of bio-antimicrobials and such compounds are at the crossroads between pharmaceutics and cosmetics. Finally, the environmental and safety impacts of biobased cosmetic development are discussed as the closure in the last chapter.This book is expected to provide insightful information for those dealing with biomass or doing research on biomass for sustainable living. Moreover, it is also suitable for policymakers to get the new and latest information on valorizing local biomass while expanding its usage for cosmeceutical purposes. Due to the current environmental problems occurring in our surroundings, this book is seen to be an important tool to spread awareness of the smart way of utilizing our precious biomass and transforming it into valuable products.

This contributed volume covers all fundamental principles for researchers and professionals interested in the field of Biomaterials and Tissue Engineering, an interdisciplinary field of research with contributions from biomedical scientists, engineers, and physicians. With a strong focus on biomaterials and scaffolds, the book also covers testing and evaluation pathways for in vitro and in vivo studies. This book also presents a broad range of topics including fundamentals of 3D printing and bioprinting, followed by contemporary technology used in tissue engineering applications as well as currently available biomaterials suitable for tissue repair and regeneration. This volume provides information on: (i) why humans need biomaterials, especially in medical applications, (ii) different types of tissue engineering strategies, and (iii) modeling, characterization, and evaluation of outputs of those strategies. This book is a reference material in the field of tissueengineering, and it is very useful for bachelor, M.Sc., and Ph.D. students, researchers, academics, medical, industry, and healthcare professionals from diverse backgrounds.

This book encompasses current knowledge of soil microbiomes and their potential biotechnological application for plant growth, crop yield, and soil health under the natural as well as harsh environmental conditions for sustainable agriculture. The microbes are ubiquitous in nature. The soil is a natural hotspot of the soil microbiome. The soil microbiome plays a critical role in the maintenance of global nutrient balance and ecosystem functioning. The soil microbiomes are associated with plant ecosystems through the intense network of plant–microbe interactions. The microbes present in bulk soil move toward the rhizospheric region due to the release of different nutrients by plant systems. The rhizospheric microbes may survive or proliferate in rhizospheric zone depending on the extent of influences of the chemicals secreted into the soil by roots. The root exudates contain the principal nutrients factors (amino acids, glucose, fructose, and sucrose). The microbes present in rhizospheric region have capabilities to fix atmospheric nitrogen, produce different phytohormones, and solubilize phosphorus, potassium, and zinc. The plant systems take these nutrients for their growth and developments. These soil and plant associated microbes also play an important role in protection of plants from different plant pathogenic organisms by producing different secondary metabolites such as ammonia, hydrogen cyanide, siderophores, and hydrolytic enzymes. The soil microbiomes with plant growth-promoting (PGP) attributes have emerged as an important and promising tool for sustainable agriculture. The soil microbiomes promote the plant growth and enhance the crop yield and soil fertility via directly or indirectly different plant growth-promoting mechanism. The soil microbes help the plant for adaptation in extreme habitats by mitigating the abiotic stress of high/low temperatures, hypersalinity, drought, and acidic/alkaline soil. These PGP microbes are used as biofertilizers/bioinoculants to replace the harmful chemical fertilizers for sustainable agriculture and environments.The aim of the book “Soil Microbiomes for Sustainable Agriculture” is to provide the recent advances in mechanisms of plant growth promotion and applications of soil microbiomes for mitigation of different abiotic stresses in plants. The book is useful to scientists, researchers, and students related to microbiology, biotechnology, agriculture, molecular biology, environmental biology, and related subjects.

Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal is to present a comprehensive collection on most of the therapeutic aspects of plant-derived natural products and molecular mechanisms thereof.

This book covers all aspects of probiotic bacteria and their metabolites, as well as their role and significance in human and animal health. Given the role of probiotic bacterial strains in the production of short chain fatty acids, butyrate etc probiotics may be considered as an alternative approach for the prevention or treatment of intestinal dysbiosis, cancers, cardiovascular diseases, hypertensions. Additionally, the significance of probiotics added in aquaculture systems for improving health, performance and growth of aquatic organisms has been highlighted. In this book, the multi-functional role of probiotics and their post-biotic metabolites in improving overall health status of man and animals, is discussed. It is a comprehensive compilation useful for researchers, academics, veterinarians and students in the field of microbiology, food technology and biotechnology.

Stem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells. This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer, biotechnology and plant sciences.

Recent research in science establishes a direct relation between human gut and skin. Several species of live microbes inhabit the human skin and intestines which far outnumbers the mammalian cells in the human body. Research interest of Nextgen scientists is focused on beneficially harnessing this microbial population to address skin disorders like acne, rosacea, eczema, premature aging, and skin cancer which are established to be a result of skin-microbiome dysbiosis. This volume highlights evidence-based endeavours of the scientific community in this sector. Currently there is no concrete literature which gives a detailed vision on the relationship between gut microbiota and skin related disorders. This volume is an attempt to put together available data in the area and demonstrate usefulness of probiotics as a new therapeutic option for management of these skin diseases which currently show poor prognosis, high cost of treatment and compromised quality of life of the patient.

The volume sheds new light on role of gut dysbiosis in cancer and immunological diseases and their clinical manifestations. Contributions in the volume discuss about the gut microbiota as a therapeutic target and the role of probiotics in its management. The volume explores application of probiotics in the treatment of various cancers viz. colorectal, gastric, lung, and breast cancer and immunological diseases. The volume comprises of chapters from expert contributors organized into various important themes which include, introduction, relationship between gut microbiota and disease condition, mechanisms involved, clinical and in vivo status, conclusion and future directions. This is a highly informative and carefully presented book, providing recent and innovative insight for scholars and researchers with an interest in probiotics and its applications in cancer and immunological diseases.

Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, “Plant-derived Bioactives: Chemistry and Mode of Action” discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, “Plant-derived Bioactives: Production, Properties and Therapeutic Applications” explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of new drugs.