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This operations manual offers an accessible, step-by-step guide to launching, running, and achieving success with a life science and biotechnology business incubator. Written by the founder and President Emeritus of the Pennsylvania Biotechnology Center (PABC), one of the most successful biotech and drug discovery incubators in the United States, it is designed to introduce researchers and funders to the broad considerations and minute details of managing an incubation program.As of 2023, there are more than 1100 business incubators in the United States alone, and more than 5000 worldwide. One of the fastest-growing industries of the'new economy,'science business incubators are a tool for regional economic stimulation and commercial development for universities and research organizations. The PABC was founded in 2006 as a state-of-the-art research facility; its purpose and operation is unusual and its success has been remarkable. It was created by the nonprofit Hepatitis BFoundation and its research arm, the Baruch S. Blumberg Institute, to help their effort to find a cure for hepatitis B. But it has proved to be more than a source of funding for those nonprofits – it has become a major economic driver for its region and Pennsylvania, creating thousands of jobs and bringing in billions of dollars to the local economy. The PABC's model has drawn attention from economists, legislators, and the research community. The strategy of bringing nonprofit research organizations and biotech startups under one roof was a founding principle, and has created powerful, lasting collaborations between scientific innovators, entrepreneurs and investors. The partnerships forged at the PABC have led to the discovery, testing, and FDA approval of new drugs for cancer and gastrointestinal diseases and medical devices, as well as multiple multimillion-dollar IPOs, and thousands of jobs. There are currently more than 50 startups housed in the Center's offices, ranging in focusfrom pharmaceuticals and diagnostics, to medical wearables and nanomedicine research.Curing Disease from the Ground Up: How to Operate a Biotechnology Business Incubator tells both a personal story about the ups and downs of leveraging a business incubator to fund and find a cure for a deadly disease, as well as providing a practical guide to running a business incubator. It is a first-hand, expert perspective for running a science business incubator, and explains how the success of the PABC can be learned and replicated. Whether it is developing a mission-focused framework, the practicalities of managing a scalable, business-savvy research nonprofit, identifying ideal tenant partners, or planning for the infrastructure needs of a large research facility, this manual is the first and last stop for entrepreneurial thinkers in this field.

NANOMATERIALS AND NANOTECHNOLOGY IN MEDICINE A comprehensive introduction to nanomaterials and their application in the field of medicine The use of nanotechnology and nanomaterials more generally is an emerging field that has generated a lot of interest in the last few years. To this point, there have been few books that deal with the recent advances in nanomaterials or nanocomposites in the medical discipline. Intended as a one-stop reference, Nanomaterials and Nanotechnology in Medicine provides the reader with the most-up-to-date and comprehensive exploration of the field of nanomedicine. The scope of the topic is huge, with nano applications in every medical specialization—from diagnostics to pharmaceuticals, from biological therapies to surgical devices, and from regenerative therapies to gene therapy. As such, this volume provides the most comprehensive coverage of this intriguing field of study. Nanomaterials and Nanotechnology in Medicine readers will also find: An application-oriented book dedicated towards helping researchers find solutions to both fundamental and applied problems Chapters written by leading researchers from industry, academy, government, and private research institutions across the globe Nanomaterials and Nanotechnology in Medicine is a useful reference for medical doctors, medical practitioners, post-doctoral research fellows, senior graduate students, and medical libraries.

Machine Learning and Deep Learning in Medical Data Analytics and Healthcare Applications introduces and explores a variety of schemes designed to empower, enhance, and represent multi-institutional and multi-disciplinary machine learning (ML) and deep learning (DL) research in healthcare paradigms. Serving as a unique compendium of existing and emerging ML/DL paradigms for the healthcare sector, this book demonstrates the depth, breadth, complexity, and diversity of this multi-disciplinary area. It provides a comprehensive overview of ML/DL algorithms and explores the related use cases in enterprises such as computer-aided medical diagnostics, drug discovery and development, medical imaging, automation, robotic surgery, electronic smart records creation, outbreak prediction, medical image analysis, and radiation treatments. This book aims to endow different communities with the innovative advances in theory, analytical results, case studies, numerical simulation, modeling, and computational structuring in the field of ML/DL models for healthcare applications. It will reveal different dimensions of ML/DL applications and will illustrate their use in the solution of assorted real-world biomedical and healthcare problems. Features: Covers the fundamentals of ML and DL in the context of healthcare applications Discusses various data collection approaches from various sources and how to use them in ML/DL models Integrates several aspects of AI-based computational intelligence such as ML and DL from diversified perspectives which describe recent research trends and advanced topics in the field Explores the current and future impacts of pandemics and risk mitigation in healthcare with advanced analytics Emphasizes feature selection as an important step in any accurate model simulation where ML/DL methods are used to help train the system and extract the positive solution implicitly This book is a valuable source of information for researchers, scientists, healthcare professionals, programmers, and graduate-level students interested in understanding the applications of ML/DL in healthcare scenarios.Dr. Om Prakash Jena is an Assistant Professor in the Department of Computer Science, Ravenshaw University, Cuttack, Odisha, India.Dr. Bharat Bhushan is an Assistant Professor of Department of Computer Science and Engineering (CSE) at the School of Engineering and Technology, Sharda University, Greater Noida, India.Dr. Utku Kose is an Associate Professor in Suleyman Demirel University, Turkey.

Security and Privacy Issues in Internet of Medical Things addresses the security challenges faced by healthcare providers and patients. As IoMT devices are vulnerable to cyberattacks, and a security breach through IoMT devices may act as a pathway for hackers to enter hospital networks, the book covers a very timely topic. The incorporation of blockchain in the healthcare environment has given birth to the Internet of Medical Things (IoMT), which consists of a collection of healthcare systems that espouse groundbreaking technologies. Systems consist of inter-linked sensors, wearable technology devices and clinical frameworks that perform explicit, secure machine-to-machine and cloud platform communications. The significance of IoMT in the field of healthcare is undoubtedly a win-win situation for patients through technology enhancements and a collection of analytics that helps in better diagnosis and treatment. Due to higher accuracy levels, IoMT devices are more reliable in reporting and data tracking and help avoid human errors and incorrect reporting. - Provides methods for constructing novel IoMT architectures and middleware services for healthcare applications to protect and secure patient data and privacy - Presents readers with information security and privacy models for IoMT, including Artificial Intelligence and Deep Learning, Data Storage security, Cloud, Fog and Edge computing security, and Wireless sensor device security - Provides readers with case studies for real-world applications of IoMT security, including risk assessment for IoMT, Ethical issues in IoMT, Security assessment frameworks, and Threat-based security analysis for IoMT

NANOTECHNOLOGY IN MEDICINE Discover thorough insights into the toxicology of nanomaterials used in medicine In Nanotechnology in Medicine: Toxicity and Safety, an expert team of nanotechnologists delivers a robust and up-to-date review of current and future applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nano-nutraceuticals, dermatology, and gene therapy. The editors offer resources that address nanomaterial safety, which tends to be the greatest hurdle to obtaining the benefits of nanomedicine in healthcare. The book is a one-stop resource for recent and comprehensive information on the toxico logical and safety aspects of nanotechnology used in human health and medicine. It provides readers with cutting-edge techniques for delivering therapeutic agents into targeted cellular compartments, cells, tissues, and organs by using nanoparticulate carriers. The book also offers methodological considerations for toxicity, safety, and risk assessment. Nanotechnology in Medicine: Toxicity and Safety also provides readers with: A thorough introduction to the nanotoxicological aspects of nanomedicine, including translational nanomedicine and nanomedicine personalization Comprehensive introductions to nanoparticle toxicity and safety, including selenium nanoparticles and metallic nanoparticles Practical discussions of nanotoxicology and drug delivery, including gene delivery using nanocarriers and the use of nanomaterials for ocular delivery applications In-depth examinations of nanotechnology ethics and the regulatory framework of nanotechnology and medicine Perfect for researchers, post-doctoral candidates, and specialists in the fields of nanotechnology, nanomaterials, and nanocarriers, Nanotechnology in Medicine: Toxicity and Safety will also prove to be an indispensable part of the libraries of nanoengineering, nanomedicine, and biopharmaceutical professionals and nanobiotechnologists.

Digital Health: Mobile and Wearable Devices for Participatory Health Applications is a key reference for engineering and clinical professionals considering the development or implementation of mobile and wearable solutions in the healthcare domain. The book presents a comprehensive overview of devices and appropriateness for the respective applications. It also explores the ethical, privacy, and cybersecurity aspects inherent in networked and mobile technologies. It offers expert perspectives on various approaches to the implementation and integration of these devices and applications across all areas of healthcare. The book is designed with a multidisciplinary audience in mind; from software developers and biomedical engineers who are designing these devices to clinical professionals working with patients and engineers on device testing, human factors design, and user engagement/compliance. - Presents an overview of important aspects of digital health, from patient privacy and data security to the development and implementation of networks, systems, and devices - Provides a toolbox for stakeholders involved in the decision-making regarding the design, development, and implementation of mHealth solutions - Offers case studies, key references, and insights from a wide range of global experts

Machine Learning and the Internet of Medical Things in Healthcare discusses the applications and challenges of machine learning for healthcare applications. The book provides a platform for presenting machine learning-enabled healthcare techniques and offers a mathematical and conceptual background of the latest technology. It describes machine learning techniques along with the emerging platform of the Internet of Medical Things used by practitioners and researchers worldwide. The book includes deep feed forward networks, regularization, optimization algorithms, convolutional networks, sequence modeling, and practical methodology. It also presents the concepts of the Internet of Things, the set of technologies that develops traditional devices into smart devices. Finally, the book offers research perspectives, covering the convergence of machine learning and IoT. It also presents the application of these technologies in the development of healthcare frameworks. - Provides an introduction to the Internet of Medical Things through the principles and applications of machine learning - Explains the functions and applications of machine learning in various applications such as ultrasound imaging, biomedical signal processing, robotics, and biomechatronics - Includes coverage of the evolution of healthcare applications with machine learning, including Clinical Decision Support Systems, artificial intelligence in biomedical engineering, and AI-enabled connected health informatics, supported by real-world case studies

U-Healthcare Monitoring Systems: Volume One: Design and Applications focuses on designing efficient U-healthcare systems which require the integration and development of information technology service/facilities, wireless sensors technology, wireless communication tools, and localization techniques, along with health management monitoring, including increased commercialized service or trial services. These u-healthcare systems allow users to check and remotely manage the health conditions of their parents. Furthermore, context-aware service in u-healthcare systems includes a computer which provides an intelligent service based on the user's different conditions by outlining appropriate information relevant to the user's situation. This volume will help engineers design sensors, wireless systems and wireless communication embedded systems to provide an integrated u-healthcare monitoring system. This volume provides readers with a solid basis in the design and applications of u-healthcare monitoring systems. - Provides a solid basis in the design and applications of the u-healthcare monitoring systems - Illustrates the concept of the u-healthcare monitoring system and its requirements, with a specific focus on the medical sensors and wireless sensors communication - Presents a multidisciplinary volume that includes different applications of the monitoring system which highlight the main features for biomedical sensor devices

Big data and the Internet of Things (IoT) play a vital role in prediction systems used in biological and medical applications, particularly for resolving issues related to disease biology at different scales. Modelling and integrating medical big data with the IoT helps in building effective prediction systems for automatic recommendations of diagnosis and treatment. The ability to mine, process, analyse, characterize, classify and cluster a variety and wide volume of medical data is a challenging task. There is a great demand for the design and development of methods dealing with capturing and automatically analysing medical data from imaging systems and IoT sensors. Addressing analytical and legal issues, and research on integration of big data analytics with respect to clinical practice and clinical utility, architectures and clustering techniques for IoT data processing, effective frameworks for removal of misclassified instances, practicality of big data analytics, methodological and technical issues, potential of Hadoop in managing healthcare data is the need of the hour. This book integrates different aspects used in the field of healthcare such as big data, IoT, soft computing, machine learning, augmented reality, organs on chip, personalized drugs, implantable electronics, integration of bio-interfaces, and wearable sensors, devices, practical body area network (BAN) and architectures of web systems.Key Features: Addresses various applications of Medical Big Data and Internet of Medical Things in real time environment Highlights recent innovations, designs, developments and topics of interest in machine learning techniques for classification of medical data Provides background and solutions to existing challenges in Medical Big Data and Internet of Medical Things Provides optimization techniques and programming models to parallelize the computationally intensive tasks in data mining of medical data Discusses interactions, advantages, limitations, challenges and future perspectives of IoT based remote healthcare monitoring systems. Includes data privacy and security analysis of cryptography methods for the Web of Medical Things (WoMT) Presents case studies on the next generation medical chair, electronic nose and pill cam are also presented.

Addresses recent advances from both the clinical and technological perspectives to provide a comprehensive presentation of m-Health This book introduces the concept of m-Health, first coined by Robert S. H. Istepanian in 2003. The evolution of m-Health since then—how it was transformed from an academic concept to a global healthcare technology phenomenon—is discussed. Afterwards the authors describe in detail the basics of the three enabling scientific technological elements of m-Health (sensors, computing, and communications), and how each of these key ingredients has evolved and matured over the last decade. The book concludes with detailed discussion of the future of m-Health and presents future directions to potentially shape and transform healthcare services in the coming decades. In addition, this book: Discusses the rapid evolution of m-Health in parallel with the maturing process of its enabling technologies, from bio-wearable sensors to the wireless and mobile communication technologies from IOT to 5G systems and beyond Includes clinical examples and current studies, particularly in acute and chronic disease management, to illustrate some of the relevant medical aspects and clinical applications of m-Health Describes current m-Health ecosystems and business models Covers successful applications and deployment examples of m-Health in various global health settings, particularly in developing countries

By covering the science, business, and societal impact of nanomedicine, this book makes a strong case for funding of basic research, for effective translation of scientific breakthroughs into clinical care of patients, and for close collaboration among all stakeholders in the healthcare ecosystem. It covers the underlying science and technology of

Human enhancement has become a major concern in debates about the future of contemporary societies. This interdisciplinary book is devoted to clarifying the underlying ambiguities of these debates, and to proposing novel ways of exploring what human enhancement means and understanding what practices, goals and justifications it entails.

Bioengineering and biotechnology are exploding—the number of career opportunities is expected to increase twice as fast as for other science and engineering fields over the next decade. Bioengineers and biotechnologists have enormous potential to meet employment needs ranging from traditional careers in science and engineering through a host of alternative career pathways. This book provides a roadmap to the broad and varied career development opportunities in bioengineering, biotechnology, and related fields. Eminent practitioners lay out career paths related to academia, industry, government and regulatory affairs, healthcare, law, marketing, entrepreneurship, and more. Lifetimes of experience and wisdom are shared, including'war stories,'strategies for success, avoidance of common pitfalls, and discussions of the authors'personal views and motivations. Career Development in Bioengineering and Biotechnology is an indispensable guide to some of the most exciting career and professional growth opportunities in science, engineering, and beyond, and a'must read'for anyone interested in a career related to this burgeoning field. From the Foreword by Institute Professor Robert Langer, Massachusetts Institute of Technology and U.S. National Medal of Science Laureate :'This book provides a wealth of information and should serve as an excellent resource…The editors have gone to great effort to discuss a variety of critical topics in the burgeoning areas of bioengineering and biotechnology.'From the Introduction by Dr. Bruce Alberts, President Emeritus of the U.S. National Academy of Sciences and Co-chair of the InterAcademy Council:'I am very impressed with the enormous dedication and skill that created this major, highly-original contribution – I know of nothing like it.'From theEditorial by Dr. Joachim Nagel, President, International Union for Physical and Engineering Sciences in Medicine, and past president of the International Federation for Medical and Biological Engineering:'This book provides all the answers and can be highly recommended as the ultimate guide to anyone interested in bioengineering and biotechnology. The book arrives at a crucial time, and catapults bioengineering and biotechnology to the forefront of disciplines and to a rightly held pinnacle of inspiration for engineers, scientists, and technologists.'From the Afterword by Dr. Shu Chien, President, Biomedical Engineering Society and past president of the American Physiological Society and of the American Institute of Medical and Biological Engineering:'…this is truly an outstanding book that is the first of its kind...certainly a pioneering contribution.'Praise for the Book'Bioengineering and Biotechnology are emerging as distinct disciplines amid the biological revolution and during a period of rapid globalization. These interesting times offer us unprecedented opportunities for professional and personal growth. This book covers many important areas of opportunity, including entrepreneurship, finance, law, and education, with a global perspective. The legacy of our times will include how well we used our rapidly advancing technologies to improve the world around us. This book provides a roadmap for the contributions of Bioengineering and Biotechnology in this quest.'-James E. Moore, PhD, Texas A&M University'This book will be essential reading for all those seeking career guidance in bioengineering and biotechnology.'-Tony Bradshaw, PhD, Director bioProcessUK - BioIndustry Association (BIA), Chairman, The Royal Academy of Engineering/BIA Life Scientists'CareerSeminars'...the topics [are] quite e

The combination of biology and nanotechnology has led to a new generation of nanodevices that make it possible to characterize the chemical, mechanical, and other molecular properties, as well as discover novel phenomena and biological processes occurring at the molecular level. These advances provide science with a wide range of tools for biomedical applications in therapeutic, diagnostic, and preventive medicine. Nanotechnology in Biology and Medicine: Methods, Devices, and Applications integrates interdisciplinary research and recent advances in instrumentation and methods for applying nanotechnology to various areas in biology and medicine. Pioneers in the field describe the design and use of nanobiosensors with various analytical techniques for the detection and monitoring of specific biomolecules, including cancer cells. The text focuses on the design of novel bio-inspired materials, particularly for tissue engineering applications. Each chapter provides introductory material including a description of methods, protocols, instrumentation, and applications, as well as a collection of published data with an extensive list of references. An authoritative reference written for a broad audience, Nanotechnology in Biology and Medicine: Methods, Devices, and Applications provides a comprehensive forum that integrates interdisciplinary research to present the most recent advances in protocols, methods, instrumentation, and applications of nanotechnology in biology and medicine.

Nanoscale Technology in Biological Systems reviews recent accomplishments in the field of nanobiology and introduces the application of nanoscale matrices to human biology. It focuses on the applications of nanotechnology fabrication to biomedical devices and discusses new physical methods for cell isolation and manipulation and intracellular commu

Embryo adoptions, stem cells capable of transforming into any cell in the human body, intra- and inter-species organ transplantation—these and other biomedical advances have unsettled ideas of what it means to be human, of when life begins and ends. In the first study to consider the cultural impact of the medical transformation of the entire human life span, Susan Merrill Squier argues that fiction—particularly science fiction—serves as a space where worries about ethically and socially charged scientific procedures are worked through. Indeed, she demonstrates that in many instances fiction has anticipated and paved the way for far-reaching biomedical changes. Squier uses the anthropological concept of liminality—the state of being on the threshold of change, no longer one thing yet not quite another—to explore how, from the early twentieth century forward, fiction and science together have altered not only the concept of the human being but the contours of human life.Drawing on archival materials of twentieth-century biology; little-known works of fiction and science fiction; and twentieth- and twenty-first century U.S. and U.K. government reports by the National Institutes of Health, the Parliamentary Advisory Group on the Ethics of Xenotransplantation, and the President's Council on Bioethics, she examines a number of biomedical changes as each was portrayed by scientists, social scientists, and authors of fiction and poetry. Among the scientific developments she considers are the cultured cell, the hybrid embryo, the engineered intrauterine fetus, the child treated with human growth hormone, the process of organ transplantation, and the elderly person rejuvenated by hormone replacement therapy or other artificial means. Squier shows that in the midst of new phenomena such as these, literature helps us imagine new ways of living. It allows us to reflect on the possibilities and perils of our liminal lives.