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In 2003, Bill Sargent bought a big pink house in Ipswich, Massachusetts. His home sits on what is known as the Great Marsh, a fascinating patch of wetland shared by Massachusetts and New Hampshire. Sargent received a grant to study some of the rare and endangered ground-nesting birds that inhabit the public land adjacent to his property. Ipswich Marsh is about these birds, but much else as well. Organized by the seasons of the year, The House on Ipswich Marsh features Sargent's trademark interplay of information about the natural world, ecology, and politics. In “Spring,” the reader learns about the geological history of the Marsh; the migration patterns of bobolinks; the courtship flights of woodcocks; ticks and Lyme disease; the mating of horseshoe crabs and the underwater arrival of zooplankton, fish eggs, and moon jellyfish. “Summer” introduces plate tectonics and glaciers; sea level rise and glacial rebound; diving at night among lobsters and stone crabs; a day on Crane's Beach; and a bike trip on Argilla Road. “Autumn” illuminates fishing; the natural and cultural history of Hog Island; harvest time on Appelton Farm; and a Native American Thanksgiving. “Winter” describes the formation of dunes and sandbars; the mating behavior of seals; coyote hunting deer at night; and a late-winter blizzard in which Sargent spies a red-tailed hawk, waiting, like the author, for the return of spring.

Surviving almost unmolested for 300 million years, the horseshoe crab is now the object of an intense legal and ethical struggle involving marine biologists, environmentalists, US government officials, biotechnologists, and international corporations. The source of this friction is the discovery 25 years ago that the blood of these ancient creatures serves as the basis for the most reliable test for the deadly and ubiquitous gram-negative bacteria. These bacteria are responsible for life-threatening diseases like menengitis, typhoid, E. coli, Legionnaire's Disease and toxic shock syndrome. Because every drug certified by the FDA must be tested using the horseshoe crab derivative known as Limulus lysate, a multimillion dollar industry has emerged involving the license to “bleed” horseshoe crabs and the rights to their breeding grounds. Since his youthful fascination with these ancient creatures, William Sargent has spent much of his life observing, studying, and collecting horseshoe crabs. As a result, he presents a thoroughly accessible insider's guide to the discovery of the lysate test, the exploitation of the crabs at the hands of multinational pharmaceutical conglomerates, local fishing interests, and the legal and governmental wrangling over the creatures'ultimate fate. In the end, the story of the horseshoe crab is a sobering reflection on the unintended consequences of scientific progress and the danger of self-regulated industries controlling a limited natural resource.