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This Open Access book on Complications in Neurosurgery contains the proceedings of the 2nd ICCN conference held in Mumbai in 2019. The work illustrates and discusses key point of intra- and postoperative complications encountered in brain, spine and peripheral nerve surgery. In addition, this compilation addresses topics in ethics, with further contributions covering medico legal and didactic aspects. It draws from the experience of an international team of experts from all subspecialties in neurosurgery, including oncology, vascular, spine, pediatrics and others. The articles were written by renown specialists in the field who are stepping forward to share their valuable professional experience with colleagues following their joint mission to improve future patient care.

This book will discuss and cover standard treatments and advances in some of the most controversial topics in cerebrovascular surgery traversing the whole arena, including open and interventional surgeries. They will be discussed with case scenarios, bail out strategies and complication handling, followed by advances in the subject. Some of the best academic cereberovascular physician will author these chapters with their vast experience. The book will be of particular benefit to neurosurgeons, neurologists, and radiologists. It will be particularly targeting residents, young and experienced faculty in the subject, and will provide first hand up to the mark information and experiences in cerebrovascular surgery.

This book presents a detailed overview of a spectrum of pediatric neurosurgical conditions. It features detailed insight into the techniques available for examining abnormalities, hemorrhages and a variety of tumors. Relevant surgical methodologies are described in relation to a clinical problem or disorder, ensuring that the reader can systematically develop their knowledge of how to perform both routine and more-obscure procedures presently utilized to treat these conditions. Pediatric Neurosurgery for Clinicians is a comprehensive guide detailing methodologies for applying a range of surgical techniques based upon a range of clinical questions. Therefore, it is a critical resource for all practicing and trainee physicians who encounter children with disorders affecting their neurological systems in disciplines within neurosurgery, neurology, radiology, oncology and pathology.

This book gathers the proceedings of the 17th International Conference on Intracranial Pressure and Neuromonitoring, held in Leuven, Belgium in September 2019. It provides an overview of the current understanding, underlying research and future perspectives concerning pathophysiology, biophysics, monitoring and management in traumatic and non-traumatic acute brain injury, hydrocephalus and spinal cord injury, including cerebrovascular autoregulation impairment in neurological as well as non-neurological diseases. The peer-reviewed contributions were prepared by specialists in neurosurgery, neurointensive care and neuroanesthesiology, as well as prominent experts from the fields of physiology, clinical and biomedical engineering, mathematics and informatics. The book continues the time-honored tradition of publishing key presentations from the ICP Conferences in order to facilitate their dissemination within the clinical and research community.

This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and molecular pathways. It highlights the importance of animal models for addressing molecular keys and for developing targeted therapies. The second part deals with clinical management, detailing the latest results in the era of endoscopic surgery, including the major contribution of the extended nasal endoscopic approaches for suprasellar and retrochiasmatic tumors. The book also discusses the key aspects of these tumors and how to manage them. The last part of the book addresses the future therapies and recurrences after surgery and radiotherapy. This volume is of interest to neurosurgeons, endocrinologists, paediatricians, radiologists and oncologists.

This book provides a comprehensive overview of the multidisciplinary management of meningiomas, followed by evaluation and management considerations along a spectrum of benign to more malignant behavior. It outlines the management of presumed Grade 1 tumors and how to identify features of tumors radiographically and clinically that may support a benign course rather than aggressive and vice versa. Following a stepwise progression from simple to complex, chapters introduce and tackle more aggressive meningiomas and tumor recurrence (of all Grades), with paradigms for evaluation and treatment. Tumor biology and genomics are fundamental and largely focused in the book. More recent findings which have directed personalized medicine and clinical trials are also addressed. Meningiomas: Comprehensive Strategies for Management addresses all aspects of the evaluation and care of patients with all WHO grades of meningiomas. It is highly informative and provides clarity for a wide audience of neurosurgeons, reconstructive surgeons, oncologists, neurologists, radiation oncologists, pathologists, radiologists, residents and students who treat these patients and those who are training for a career in managing patients with these potentially challenging tumors.

This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks. Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supportedby a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.

Since the first edition of this book, the impressive development of neuroendoscopy has dramatically changed the surgical approach to hydrocephalus, the main pathology pediatric neurosurgeons worldwide have to deal with. This revised and updated second edition, written by worldwide leaders in the field, fully reflects this progress: not only existing chapters have been reviewed whenever required, but new ones have been added thus taking into consideration every aspect of hydrocephalus, even when associated with the rarest pathologies. The general part include now more data on history, biomechanics, circulation and molecular basis. Special consideration for fetal surgery has been added, whereas the section on neonatal hydrocephalus has been further developed. Section 4, on the different pathologies associated with hydrocephalus, has been significantly expanded. and is now amazingly detailed, as well as the section on shunt treatment. Infections are now dealt with in two different chapters, and special attention to shunt complications (the nightmare of every Pediatric Neurosurgeon.) is paid in five different chapters. A very complete overview of the endoscopic treatment, that will surely draw the reader's attention thanks to the wonderful full color images, is also included. Written by acknowledged experts in the field, this title is an indispensable tool for all those facing this pathology in their daily practice.

This book illustrates in a unique way the most common diseases affecting the human nervous system using different imaging modalities derived from radiology, nuclear medicine, and neuropathology. The features of the diseases are visualized on computerized tomography (CT)-scans, magnetic resonance imaging (MRI)-scans, nuclear medicine scans, surgical intraoperative as well as gross-anatomy and histology preparations. For each disease entity, the structural changes are illustrated in a correlative comparative way based on the various imaging techniques. The brain diseases are presented in a systematic way allowing the reader to easily find the topics in which she or he is particularly interested. In Part 1 of the book, the imaging techniques are described in a practical, straightforward way. The morphological built-up of the normal human brain and its vascular supply are presented in Part 2. The chapters of the subsequent Parts 3 to 10 deal with the following diseases involving the nervous system including: hemodynamic, vascular, infectious, neurodegenerative, demyelination, epilepsy, trauma and intoxication, and tumors. The authors incite the clinician to see the cell, the tissue, the organ, the disorder by enabling him to recognize brain lesions or interpreting histologic findings and to correlate this knowledge with molecular biologic concepts. Thus, this book bridges the gap between neuro-clinicians, neuro-imagers and neuro-pathologists. The information provided will facilitate the understanding of the disease processes in the daily routine work of neurologists, neuroradiologists, neurosurgeons, neuropathologists, and all allied clinical disciplines.

Praxisorientiert und reich bebildert sind alle Erkrankungen, die bei Kindern einen neurochirurgischen Eingriff erforderlich machen, in diesem Buch beschrieben. Der Schwerpunkt liegt auf den diagnostischen und therapeutischen Entscheidungen sowie auf den zahlreichen Unterschieden, die bei Kindern im Vergleich zum Vorgehen bei Erwachsenen zu berücksichtigen sind. Neben den Indikationen zur Operation sind mit dem Ziel übergreifender Therapiekonzepte auch die konservativen Behandlungsmöglichkeiten berücksichtigt. Experten aus dem ganzen deutschsprachigen Raum konnten als Autoren für die Kapitel zu den einzelnen Themen gewonnen werden.

Definitive guide on management of malformations of the brain, spinal cord, dura mater and arachnoid from leading international mastersWith contributions from leading multidisciplinary experts, this book is a comprehensive compendium on state-of-the-art management of intracranial arteriovenous malformations (AVMs) and arteriovenous fistulas (AVF). All major treatment approaches are encompassed including microsurgery, endovascular treatment, and radiosurgery.The text begins with in-depth coverage of cerebrovascular anatomy susceptible to abnormalities, followed by pathogenesis, physiology, hemodynamics, natural history, clinical presentation, and indications for treatment of AVMs and AVFs. Throughout the book, internationally renowned experts provide clinical pearls and insights based on hand-on surgical expertise, case studies, and evidence-based data.Key HighlightsDiagnosis and treatment of uncommon congenital syndromes including Wyburn-Mason syndrome and Parkes-Weber syndrome; and autosomal dominant genetic disorders such as Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu syndrome) and Capillary malformation/arteriovenous malformation (CM-AVM) syndrome.More than 300 high quality illustrations plus videos elucidate impacted cerebrovasculature and treatment modalities.The utilization of preoperative and postoperative imaging for AVM evaluation and intraoperative imaging for AVMs and AVFs.Surgical management of lobar AVMs, brain dural arteriovenous fistulas, cerebellar AVMs, basal ganglia, thalamic, and brainstem AVMs.Complications and controversies including hemorrhaging, inoperable malformations, pediatric cases, residual or recurrent AVMs, epilepsy, and seizures.With step-by-step tutorials and classification systems for brain AVMs and fistulas, this is a must-have guide on cerebrovascular malformations. It will benefit trainee and experienced neurosurgeons alike.

Now in two volumes–an updated atlas to help you and disorders of the brain…This thoroughly revised and expanded atlas is the ideal reference for residents, fellows, and clinicians to review surgical procedures before entering the operating room. The authors provide step-by-step descriptions of techniques, clearly delineating indications and contraindications, goals, operative preparation and anesthesia, and postoperative management. The main focus of this book is on teaching neurosurgical techniques at the most detailed level.Features of the second edition:A new chapter on proton therapyAn expanded section covering the latest radiosurgery techniquesNearly 3,000 high-quality images aid rapid comprehension of surgical proceduresOnline access to more than 100 surgical technique videosThis book should be read cover to cover by young practitioners several times during their residency, and it will keep more experienced neurosurgeons up-to-date on the latest surgical techniques in the field.

This book, written by experts from across the world, provides a comprehensive, up-to-date overview covering all aspects of posterior fossa neoplasms in pediatric patients, including medulloblastoma, ependymoma, cerebellar astrocytoma, atypical teratoid/rhabdoid tumor, chordoma, brain stem tumors, and rarer entities. For each tumor type, individual chapters are devoted to genetics, radiological evaluation using advanced imaging techniques, surgery, pathology, oncology, and radiation treatment. In addition, a separate section describes the various surgical approaches that may be adopted and offers guidance on the treatment of hydrocephalus and the role of intraoperative mapping and monitoring. Useful information is also provided on anatomy, clinical presentation, neurological evaluation, and molecular biology. The book closes by discussing in detail immediate postoperative care, the management of surgical complications, and longer-term rehabilitation and support. Posterior fossa tumors are the most common pediatric brain tumors but are often difficult to treat owing to their proximity to critical brain structures and their tendency to cause marked intracranial hypertension. Practitioners of all levels of experience will find Posterior Fossa Tumors in Children to be a richly illustrated, state of the art guide to the management of these tumors that will serve as an ideal reference in clinical practice.

This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology of Nervous System Tumors is of great value and utility for physicians and scientists involved with or interested in the up-to-date diagnosis and treatment of patients with brain tumors.

Principles and Practice of Pediatric Neurosurgery, Third Edition is a completely revised edition of the most authoritative guide to the management of pediatric neurosurgical disorders encountered in clinical practice. Written by leaders in the field, it provides pediatric neurosurgeons with a clear understanding of the current standards of practice and treatment in the subspecialty.Key Features:Now in full color, with more than 1,000 imagesAn increased emphasis on clinical management strategies in pediatric neurosurgerySeven new chapter topics, including cellular therapy for pediatric neurosurgical disease, conjoined twins, lipomeningoceles, and skeletal syndromesPearls and pitfalls in every chapterThis book is an essential reference for all residents and practitioners in pediatric neurosurgery and pediatric neurology.

The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme. The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stemcells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme.

Principles of Neurosurgery, by Drs. Richard G. Ellenbogen, Saleem I. Abdulrauf and Laligam N Sekhar, provides a broad overview of neurosurgery ideal for anyone considering or training in this specialty. From general principles to specific techniques, it equips you with the perspectives and skills you need to succeed. Comprehensive without being encyclopedic, this new edition familiarizes you with the latest advances in the field-neuroimaging, the medical and surgical treatment of epilepsy, minimally invasive techniques, and new techniques in position and incisions-and shows you how to perform key procedures via an online library of surgical videos at www.expertconsult.com. No other source does such an effective job of preparing you for this challenging field!Get comprehensive coverage of neurosurgery, including pre- and post- operative patient care, neuroradiology, pediatric neurosurgery, neurovascular surgery, trauma surgery, spine surgery, oncology, pituitary adenomas, cranial base neurosurgery, image-guided neurosurgery, treatment of pain, epilepsy surgery, and much more. Gain a clear visual understanding from over 1,200 outstanding illustrations-half in full color-including many superb clinical and operative photographs, surgical line drawings, and at-a-glance tables. Apply best practices in neuroimaging techniques, minimally invasive surgery, epilepsy surgery, and pediatric neurosurgery. Master key procedures by watching experts perform them in a video library online at www.expertconsult.com, where you can also access the fully searchable text, an image gallery, and links to PubMed. Keep up with recent advances in neurosurgery with fully revised content covering neuroimaging, the medical and surgical treatment of epilepsy, minimally invasive techniques, new techniques in position and incisions, deep brain stimulation, cerebral revascularization, and treatment strategies for traumatic brain injury in soldiers. Apply the latest guidance from new chapters on Cerebral Revascularization, Principles of Modern Neuroimaging, Principles of Operative Positioning, Pediatric Stroke and Moya-Moya, Anomalies of Craniovertebral Junction, and Degenerative Spine Disease. Tap into truly global perspectives with an international team of contributors led by Drs. Richard G. Ellenbogen and Saleem I. Abdulrauf. Find information quickly and easily thanks to a full-color layout and numerous detailed illustrations.

The topography of the brainstem is complex, and even experienced neurologists find it challenging to localize brainstem lesions and diagnose brainstem disorders. This richly illustrated book provides a comprehensive review of brainstem disorders and presents the clinical knowledge necessary for diagnosis. The opening sections document the brainstem neuroanatomy and discuss current diagnostic methods. The entire spectrum of clinical findings in brainstem disorders is then described, and topodiagnostic aspects of the neurological findings are explained in detail. The descriptions of brain stem disorders are consistently structured and are supported by many MR images and short case reports. In addition to primary brainstem lesions, such as vascular brainstem syndromes, other disorders are considered that do not exclusively show brainstem symptoms or signs, e.g., multiple sclerosis. This book will serve as an invaluable reference work for neurologists in clinical practice or further education.

Pediatric CNS Tumors is a detailed review of childhood brain tumors with a particular emphasis on providing treatment algorithms for each tumor type. Controversies and current therapeutic agents under development are also discussed. The second edition includes expanded chapters on embryonal tumors, rare tumor types, and supportive care for patients with brain tumors.