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Cerebrospinal fluid (CSF) rhinorrhea is a rare but potentially devastating condition that can lead to significant morbidity and mortality. CSF Rhinorrhea: Management and Practice covers the current concepts in the etiology, diagnosis, and treatment of the condition, as well as long-term management of patients following successful treatment. It provides broad insight into the causes for leakage of CSF from the nose and helps in diagnosis and subsequent treatment. Its multidimensional approach caters to medical undergraduates and postgraduates along with specialists in various fields such as ENT, neurosurgery, neurology, medicine and endocrinology, thus providing a comprehensive plan for management of CSF rhinorrhea. Key features Focuses on trans-nasal endoscopic repair of CSF rhinorrhea Explores minimally invasive techniques and recent advances in CSF rhinorrhea Reviews clinical presentation and case diagnosis with special emphasis pertaining to general practitioners Discusses post-operative care in an exclusive chapter Includes videos of surgical procedures Dr Jyotirmay S Hegde is currently a consultant ENT, head and neck and endoscopic skull base surgeon at Columbia Asia Hospital, Whitefield, Bangalore, India. He has also worked as a faculty member in various capacities at the Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, India. Dr Hegde completed his Masters in Otolaryngology-Head & Neck Surgery at Karnataka Institute of Medical Sciences, Hubli, Karnataka, India and his Fellowship in Rhinology and Endoscopic skull base surgery from Aintree University Hospital, Liverpool, UK. Dr Hegde is a fellow of the European Board of Otolaryngology (FEBORL). He has published in several peer-reviewed scientific publications and presented in national and international conferences, courses, and workshops. Dr Hemanth Vamanshankar graduated from K.S. Hegde Medical Academy, Mangalore, India in 2008 and completed a diploma in Otolaryngology from St John's Medical College, Bangalore, India in 2011 and DNB-ENT from Southern Railway Hospital, Ayanavaram, Chennai, India in 2014. He was awarded MRCS-ENT from the Royal College of Surgeons, Edinburgh, UK. He has to his credit 25 indexed publications of national and international repute. He is currently working as a medical officer and consultant ENT surgeon at the Divisional Railway Hospital, Bangalore, India (South Western Railway).

The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identified. However, properly interpreting the test results requires a high level of expertise and cannot be achieved by just reporting on individual analytic values. This book covers essential aspects of cerebrospinal fluid analysis and its use in the diagnosis of common neurological diseases. The first part addresses preclinical aspects such as the history of CSF, as well as the anatomical, physiological, and biological background of this valuable fluid. In addition, CSF collection, its preanalytical and methodological implications, and the increasing number of disease-specific markers in CSF are discussed in detail. Lastly, CSF analyses are put into context with clinical syndromes, demonstrating their diagnostic value in neurological clinical practice. Cerebrospinal Fluid in Clinical Neurology helps readers understand the preanalytical and analytical aspects of CSF diagnostics and offers a valuable reference guide for interpreting CSF results during the clinical work-up for neurological patients.

For centuries the great minds of medical science puzzled over the importance of the cerebrospinal fluid. As far back as Hippocrates, it was thought that this'phlegm'that flooded the intracranial contents had pathological significance. However, not until the late 1800s, when Quincke introduced and popularized lumbar puncture, did physicians take an interest in the study of this fluid in relation to clinical illness. Since then a variety of techniques for obtaining cerebrospinal fluid from various sites have developed, and the relationship of cerebrospinal fluid to a variety of disease processes has received considerable study. In this volume, we have attempted to assemble reviews of some of these important developments during the past century. Chapter 1 contains a historical review of key investigations that helped shape our concepts of cerebrospinal fluid from the earliest recorded description by the author of the Edwin Smith Surgical Papyrus in the seventeenth century B. C. to contemporaries such as Kabat, Glusman, and Knaub, who introduced quantitative determinations of cerebrospinal fluid gamma globulin levels. In Chapter 2 there is a description of our current understanding of the anatomical compartment for the cerebrospinal fluid and the physiology of its formation, circulation, and absorption. Dr. Richard Leech in Chapter 3 contributes a comprehensive description of the disorders associated with excessive quanti­ ties of cerebrospinal fluid-commonly referred to as hydrocephalus. A variety of techniques for properly collecting and evaluating cerebrospinal fluid are detailed in Chapter 4.